Intact antigen receptor-mediated calcium signals in patients with early stage HIV-1 infection

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 4012-4017

  Hickey, Thomas E ^a,e   Blair, Patrick J ^a   Perfetto, Steve ^b   Smoot, Douglas S ^a   Wagner, Kenneth F ^b,d   St Louis, Daniel C ^b   Mayers, Douglas L ^c,d   Siegel, Jeffrey N ^a,b,d   June, Carl H ^a,d  

^a NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d Uniformed Services University of the Health Sciences   (United States)

^e Naval Medical Research Center Detachment   (Peru)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CD4 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; OKT 3;

ADULT; ANTIGEN DETECTION; ANTIGEN RECOGNITION; ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CLINICAL ARTICLE; CONTROLLED STUDY; EARLY DIAGNOSIS; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RECEPTOR BINDING; SIGNAL TRANSDUCTION; T LYMPHOCYTE RECEPTOR GENE;

ADULT; CALCIUM; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION;

EID: 0029919240     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Pantaleo, G., and A. S. Fauci. 1995. New concepts in the immunopathogenesis of HIV infection. Annu. Rev. Immunol. 13:487.
2. + T cells from human immunodeficiency virus-infected asymptomatic individuals J. Exp Med 175.331.
3. Ho, D D., A U Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection Nature 373:123.
4. Banda, N. K , J Bernier, D. K. Kurahara, R. Kurrle, N. Haigwood, R P. Sekaly, and T. H Finkel. 1992 Cross-linking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis J. Exp. Med. 176:1099.
5. Lane, H. C., and A S. Fauci. 1985. Immunologic abnormalities in the acquired immunodeficiency syndrome. Annu. Rev. Immunol. 3:477.
6. Shearer, G. M., and M. Clerici. 1994 In vitro analysis of cell-mediated immunity: clinical relevance. Clin. Chem 40.2162.
7. + T cell function in the course of human immunodeficiency virus infection J Clin. Invest. 94:1947
8. Margolick, J. B., D. J. Volkman, H C. Lane, and A. S. Fauci. 1985. Clonal analysis of T lymphocytes in the acquired immunodeficiency syndrome, evidence for an abnormality affecting individual helper and suppressor T cells. J. Clin. Invest. 76:709.
9. - T cell population. J Immunol. 144:1696.
10. De, S. K., and J. W. Marsh. 1994. HIV-1 Nef inhibits a common activation pathway in NIH-3T3 cells. J. Biol. Chem 269.6656.
11. Mittler, R. S., and M. K. Hoffmann. 1989. Synergism between HIV gp120 and gp120-specific antibody in blocking human T cell activation. Science 245.1380
12. + influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41. J. Immunol 144:3928.
13. Skowronski, J., D. Parks, and R. Mariani. 1993 Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene EMBO J 12.703
14. Li, C J., D. J. Friedman, C Wang, V. Metelev, and A. B. Pardee. 1995. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein Science 268:429.
15. Chirmule, N., S Than, S A. Khan, and S. Pahwa 1995. Human immunodeficiency virus Tat induces functional unresponsiveness in T cells. J. Virol 69.492
16. Pinching, A. J., and K. E. Nye 1990. Defective signal transduction, a common pathway for cellular dysfunction in HIV infection? Immunol. Today 11:256
17. Linette, G. P , R. J. Hartzman, J A. Ledbetter, and C. H. June. 1988. HIV-1-infected T cells show a selective signaling defect after perturbation of CD3/ antigen receptor. Science 241:573.
18. Cefai, D , P. Debre, M. Kaczorek, T. Idziorek, B. Autran, and G. Bismuth 1990 Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphomositide transduction pathway J. Clin. Invest. 86:2117.
19. Horak, I. D., M. Popovic, E. M Horak, P. J. Lucas, R. E. Gress, C. H. June, and J. B Bolen. 1990. No T cell tyrosine protein kinase signaling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120 Nature 348:557.
20. Tani, Y., H. Tian, H. C. Lane, and D. I. Cohen. 1993. Normal T cell receptor-mediated signaling in T cell lines stably expressing HIV-1 envelope glycoproteins. J. Immunol. 151:7337.
21. lck in CD4 T cells from HIV-1 infected patients. Int. Immunol. 6:611.
22. Cohen, D. I., Y. Tani, H. Tian, E. Boone, L. E. Samelson, and H. C. Lane. 1992. Participation of tyrosine phosphorylation in the cytopathic effect of human immunodeficiency virus-1. Science 256.542.
23. Gaulton, G. N., L. F. Brass, D. Kozbor, C. H. Pletcher, and J. A. Hoxie. 1992. Inhibition of T cell antigen receptor-dependent phosphorytation of CD4 in human immunodeficiency virus type 1-infected cells. J. Biol. Chem 267:4102.
24. lck/CD3-T cell receptor interactions and inhibits CD3 signaling. Eur J. Immunol 25:1417.
25. lck activation and TCR desensitization independent of TCR tyrosine phosphorylation. J. Immunol. 153:2905.
26. lck dissociation. J. Immunol. 154:2996
27. Gale, M. J., J. A. Ledbetter, G. L. Schieven, M. Jonker, W. R. Morton, R. E. Benveniste, and E. A. Clark. 1990. CD4 and CD8 T cells from SIV-infected macaques have defective signaling responses after perturbation of either CD3 or CD2 receptors. Int. Immunol. 2.849.
28. 2+: relationship to human immunodeficiency virus (HIV)-induced cellular hyporesponsiveness. Proc. Soc. Exp. Biol Med. 207:284.
29. Redfield, R. R , D. C. Wright, and E C. Tramont. 1986. The Waiter Reed staging classification for HTLV-III/LAV infection. N. Engl. J. Med. 314:131.
30. June, C. H., and P. S. Rabinovitch. 1994. Intracellular ionized calcium. Methods Cell Biol 41:149.
31. Roederer, M., L. A. Herzenberg, and L. Herzenberg. 1996 Changes in antigen densities on leukocyte subsets correlate with progression of HIV disease. Int. Immunol 8:1.
32. Rabinovitch, P. S., C. H. June, A. Grossmann, and J. A. Ledbetter. 1986. Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry J. Immunol. 137:952.
33. Ledbetter, J. A., C. H. June, L. S. Grosmaire, and P. S. Rabinovitch. 1987. Cross-linking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes. Proc. Natl Acad. Sci. USA 84:1384.
34. Ceuppens, J. L., F. J. Bloemmen, and J. P Van Wauwe. 1985 T cell unresponsiveness to the mitogenic activity of OKT3 antibody results from a deficiency of monocyte Fcγ receptors for murine IgG2a and an inability to cross-link theT3-Ti complex. J. Immunol 135:3882.
35. Bierer, B. E., G. Hollander, D. Fruman, and S. J. Burakoff 1993. Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. Curr. Opin. Immunol. 5:763.
36. Greenway, A., A. Azad, and D McPhee. 1995 Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T cell lines. J. Virol. 69.1842.
37. lck in human CD4 T lymphocytes. Eur. J. Immunol. 23:600.
38. Bank, I., and L. Chess. 1985. Perturbation of the T4 molecule transmits a negative signal to T cells. J. Exp Med. 162:1294.
39. lck protein tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc. Natl. Acad. Sci. USA 92:349.
40. Rhee, S. S., and J. W. Marsh. 1994. Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4. J. Virol. 68:5156.
41. lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J. 13:774.
42. lck together with impairment of T cell activation. J. Immunol. 149:285.
43. lck with CD4 in human T lymphocytes. J. Biol. Chem. 266:11176.
44. Quill, H. 1996 Anergy as a mechanism of peripheral T cell tolerance. J. Immunol. 156.1325.