Lymphocyte glutathione levels in children with cystic fibrosis

Chest

Volumn 116, Issue 1, 1999, Pages 201-205

  Lands, Larry C ^a,b   Grey, Vijaylaxmi ^a   Smountas, Argyrios A ^a   Kramer, Violeta G ^a   McKenna, Danielle ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

Antioxidants; Inflammation; Oxidative stress

Indexed keywords

ANTIOXIDANT; GLUTAMINE; GLUTATHIONE;

ADOLESCENT; ARTICLE; CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; HUMAN; LIVER METABOLISM; LUNG FUNCTION; LYMPHOCYTE; MALE; NUTRITIONAL STATUS; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SCHOOL CHILD;

EID: 0032778301     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.116.1.201     Document Type: Article

References (39)

1. 1 Birrer P, McElvaney NG, Rudeberg A, et al. Protease-antiprotease imbalance in the lungs of children with cystic fibrosis. Am J Respir Crit Care Med 1994; 150:207-213
2. 2 Khan TZ, Wagener JS, Bost T, et al. Early pulmonary inflammation in infants with cystic fibrosis. Am J Respir Crit Care Med 1995; 151:1075-1082
3. 3 Balough K, McCubbin M, Weinberger M, et al. The relationship between infection and inflammation in the early stages of lung disease from cystic fibrosis. Pediatr Pulmonol 1995; 20:63-70
4. 4 Cantin A. Cystic fibrosis lung inflammation: early, sustained, and severe. Am J Respir Crit Care Med 1995; 151:939-941
5. 5 Armstrong DS, Grimwood K, Carlin JB, et al. Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med 1997; 156:1197-1204
6. 6 Sahl B, Webb K, Guyan PM, et al. Aberrant free radical activity in cystic fibrosis. Clin Chim Acta 1989; 181:65-74
7. 7 Konstan MW, Hilliard KA, Norvell TM, et al. Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med 1994; 150:448-454
8. 8 Cantin A, North S, Hubbard R, et al. Normal epithelial lining fluid contains high levels of glutathione. J Appl Physiol 1987; 63:152-157
9. 9 Rahman I, Bel A, Mulier B, et al. Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells. Biochem Biophys Res Commun 1996; 229:832-837
10. 10 Kugelman A, Choy HA, Liu R, et al. Gamma-glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells. Am J Respir Cell Mol Biol 1994; 11:586-592
11. 11 van Klaveren RJ, Demedts M, Nemery B. Cellular glutathione turnover in vitro, with emphasis on type II pneumocytes. Eur Respir J 1997; 10:1392-1400
12. 12 Roum JH, Buhl R, McElvaney NG, et al. Systemic deficiency of glutathione in cystic fibrosis. J Appl Physiol 1993; 75:2419-2424
13. 13 Hull J, Vervaart P, Grimwood K, et al. Pulmonary oxidative stress response in young children with cystic fibrosis. Thorax 1997; 52:557-560
14. 14 Lauterburg BH, Adams JD, Mitchell JR. Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover. Hepatology 1984; 4:586-590
15. 15 Meister A. Metabolism and function of glutathione. In: Dolphin D, Poulsen R, Avramovic O, eds. Glutathione: chemical, biochemical, and medical aspects. New York, NY: John Wiley, 1989; 367-474
16. 16 Martensson J, Jain A, Frayer W, et al. Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defects. Proc Natl Acad Sci USA 1989; 86:5296-5300
17. 17 Mangione S, Patel DD, Levin BR, et al. Erythrocytic glutathione in cystic fibrosis: a possible marker of pulmonary dysfunction. Chest 1994; 105:1470-1473
18. 18 Toth KM, Berger EM, Beehler CJ, et al. Erythrocytes from cigarette smokers contain more glutathione and catalase and protect endothelial cells from hydrogen peroxide better than do erythrocytes from nonsmokers. Am Rev Respir Dis 1986; 134:281-284
19. 19 Beutler E, Dale GL. Erythrocyte glutathione: function and metabolism. In: Dolphin D, Poulsen R, Avramovic O, eds. Glutathione: chemical, biochemical, and medical aspects. New York, NY: John Wiley, 1989; 291-318
20. 20 Jain A, Madsen DC, Auld PA, et al. L-2-oxothiazolidine-4-carboxylate, a cysteine precursor, stimulates growth and normalizes tissue glutathione concentrations in rats fed a sulfur amino acid-deficient diet. J Nutr 1995; 125:851-856
21. 21 Taylor CG, Bauman PF, Sikorski B, et al. Elevation of lung glutathione by oral supplementation of L-2-oxothiazolidine-4-carboxylate protects against oxygen toxicity in protein-energy malnourished rats. FASEB J 1992; 6:3101-3107
22. 22 Ramsey BW, Farrell PM, Pencharz P. Nutritional assessment and management in cystic fibrosis: a consensus report. Am J Clin Nutr 1992; 55:108-116
23. 23 Polgar G, Promadhat V. Pulmonary function testing in children. Philadelphia, PA: WB Saunders, 1971
24. 24 Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 1969; 27:502-522
25. 25 Grey VL, Kramer VG, Lands LC. The determination of oxidised and reduced glutathione in circulating lymphocytes using the Cobas Mira S [abstract]. Clin Biochem 1998; 31:301
26. 26 Schunemann HJ, Muti P, Freudenheim JL, et al. Oxidative stress and lung function. Am J Epidemiol 1997; 146:939-948
27. 27 Meister A. Glutathione biosynthesis and its inhibition. Methods Enzymol 1995; 252:26-30
28. 28 Kinscherf R, Hack V, Fischbach T, et al. Low plasma glutamine in combination with high glutamate levels indicate risk for loss of body cell mass in healthy individuals: the effect of N-acetyl-cysteine. J Mol Med 1996; 74:393-400
29. 29 Droge W, Holm E. Role of cysteine and glutathione in HIV infection and other diseases associated with muscle wasting and immunological dysfunction. FASEB J 1997; 11:1077-1089
30. 30 Konstan MW, Byard PJ, Hoppel CL, et al. Effect of high-dose ibuprofen in patients with cystic fibrosis. N Engl J Med 1995; 332:848-854
31. 31 Kronborg G, Hansen MB, Svenson M, et al. Cytokines in sputum and serum from patients with cystic fibrosis and chronic Pseudomonas aeruginosa infection as markers of destructive inflammation in the lungs. Pediatr Pulmonol 1993; 15:292-297
32. 32 Elborn JS, Cordon SM, Western PJ, et al. Tumour necrosis factor-alpha, resting energy expenditure and cachexia in cystic fibrosis. Clin Sci 1993; 85:563-568
33. 33 Brouckaert P, Spriggs DR, Demetri G, et al. Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma. J Exp Med 1989; 169:2257-2262
34. 34 de Meer K, Jeneson JA, Gulmans VA, et al. Efficiency of oxidative work performance of skeletal muscle in patients with cystic fibrosis. Thorax 1995; 50:980-983
35. 35 Kretzschmar M, Muller D. Aging, training and exercise: a review of effects on plasma glutathione and lipid peroxides. Sports Med 1993; 15:196-209
36. 36 Martensson J, Meister A. Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester. Proc Natl Acad Sci USA 1989; 86:471-475
37. 37 Sen CK. Oxidants and antioxidants in exercise. J Appl Physiol 1995; 79:675-686
38. 38 Rahman I, Li XY, Donaldson K, et al. Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress. Am J Physiol 1995; 269:L285-L292
39. 39 Heffner JE, Repine JE. Pulmonary strategies of antioxidant defense. Am Rev Respir Dis 1989; 140:531-547