Participation of imidazoline receptors and alpha2--adrenoceptors in the central hypotensive effects of imidazoline-like drugs

Annals of the New York Academy of Sciences

Volumn 881, Issue , 1999, Pages 272-278

  Bousquet, P ^a   Bruban, V ^a   Schann, S ^a   Greney, H ^a   Ehrhardt, J D ^a   Dontenwill, M ^a   Feldman, J ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; IDAZOXAN; IMIDAZOLINE; IMIDAZOLINE RECEPTOR; LNP 509; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; BRAIN STEM; CONFERENCE PAPER; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; INDUCED HYPOTENSION; INTRACISTERNAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; RECEPTOR AFFINITY; SYMPATHETIC NERVE;

ANIMALIA;

EID: 0032775814     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb09369.x     Document Type: Conference Paper

References (19)

1. Bousquet, P., J. Feldman & J. Schwartz. 1984. Central cardiovascular effects of alpha-adrenergic drugs: Differences between catecholamines and imidazolines. J. Pharm. Exp. Ther. 230: 232-236.
2. Bousquet, P. 1995. Recent advances in imidazoline receptor research. Exp. Opin. Invest. Drugs. 4: 431-442.
3. Molderings, G. J. 1997. Imidazoline receptors: Basic knowledge, recent advances and future prospects for therapy and diagnosis. Drugs Future. 22: 757-772.
4. Regunathan, S. & D. J. Reis. 1996. Imidazoline receptors and their endogenous ligands. Annu. Rev. Pharmacol. Toxicol. 36: 511-544.
5. Ernsberger, P., R. Giuliano, R. N. Willette & D. J. Reis. 1990. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostro-ventrolateral medulla. J. Pharm. Exp. Ther. 253: 408-418.
6. 1-imidazoline receptor: From binding site to therapeutic target in cardiovascular disease. J. Hypertens. 15: S9-S23.
7. Bousquet, P. 1997. Imidazoline receptors. Neurochem. Int. 30: 3-7.
8. Head, G. A. & S. L. Burke. 1998. Relative importance of medullary brain nuclei for the sympathoinhibitory actions of rilmenidine in the anesthetized rabbit. J. Hypertens. 16: 503-517.
9. 1-imidazoline binding site is a functional receptor mediating vasodepression via the ventral medulla. Am. J. Physiol. 273: R1572-1579.
10. Tibirica, E., J. Feldman, C. Mermet, F. Gonon & P. Bousquet. 1991. An imidazoline-specific mechanism for the hypotensive effect of clonidine: A study with yohimbine and idazoxan. J. Pharm. Exp. Ther. 256: 606-613.
11. Schmitt, H., H. Schmitt & S. Fenard. 1973. Action of α-adrenergic blocking drugs on the sympathetic centres and their interactions with the central sympatho-inhibitory effect of clonidine. Arzneim. Forschung. 23: 40-44.
12. 2-adrenoceptors. Pharm. Rev. 35: 143-170.
13. 2-adrenoceptors in the cardiovascular effects of moxonidine. Eur. J. Pharmacol. 282: 19-28.
14. 2A-adrenergic receptor subtype. Science 273: 801-803.
15. Zandberg, P., W. De Jong & D. De Wied. 1979. Effect of catecholamine-receptor stimulating agents on blood pressure after local application in the nucleus tractus solitarii of the medulla oblongata. Eur. J. Pharmacol. 55: 43-56.
16. 2-adrenoceptors in the human central nervous system. Neuroscience. 59: 589-598.
17. Feldman, J., E. Tibiriça, G. Bricca, M. Dontenwill, A. Belcourt & P. Bousquet. 1990. Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit. Br. J. Pharmacol. 100: 600-604.
18. Greney, H., F. Bennaï, A. Molines, A. Belcourt, M. Dontenwill & P. Bousquet. 1994. Isolation of a human cerebral imidazoline-specific binding protein. Eur. J. Pharmacol. 265: R1-R2.
19. Head, G. A., S. L. Burke & C. K. Chan. 1997. Central imidazoline receptors and centrally acting anti-hypertensive agents. Clin. Exp. Hypertens. 19: 591-605.