Classical conditioning of insulin effects in healthy humans

Psychosomatic Medicine

Volumn 61, Issue 4, 1999, Pages 424-435

  Stockhorst, Ursula ^a   Gritzmann, Eva ^a   Klopp, Kerstin ^a   Schottenfeld Naor, Yolanda ^a   Hübinger, Achim ^a   Berresheim, Hans Walter ^a   Steingrüber, Hans Joachim ^a   Gries, Friedrich Arnold ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Blood glucose; Classical conditioning; Counterregulatory hormones; Humans; Insulin; Symptoms

Indexed keywords

CATECHOLAMINE; GLUCAGON; GLUCOSE; HYDROCORTISONE; INSULIN; NEUTRAL INSULIN; NORADRENALIN;

ARTICLE; CLINICAL TRIAL; CONDITIONING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; INSULIN BLOOD LEVEL; MALE; NORMAL HUMAN; PREDICTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGULATORY MECHANISM; STIMULUS RESPONSE;

EID: 0032775784     PISSN: 00333174     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006842-199907000-00004     Document Type: Article

References (49)

1. Dworkin BR. Learning and physiological regulation. Chicago: University of Chicago Press; 1993.
2. Ramsay DS, Woods SC. Biological consequences of drug administration: implications for acute and chronic tolerance. Psychol Rev 1997;104:170-93.
3. Niijima A. Nervous regulation of metabolism. Prog Neurobiol 1989;33:135-47.
4. Woods SC. Insulin and the brain: a mutual dependency. Prog Psychobiol Physiol Psychol 1995;16:53-81.
5. Banks WA, Jaspan JB, Huang W, Kastin AJ. Transport of insulin across the blood-brain barrier: saturability at euglycemic doses of insulin. Peptides 1997;18:1423-9.
6. Cryer PE. Does central nervous system adaptation to antecedent glycemia occur in patients with insulin-dependent diabetes mellitus? Ann Intern Med 1985;103:284-6.
7. Lichko AE. Conditioned reflex hypoglycaemia in man. Pavlov J High Nerv Activ 1959;9:731-7.
8. Woods S, Makous W, Hutton A. A new technique for conditioned hypoglycemia. Psychon Sci 1968;10:389-90.
9. Woods SC, Makous W, Hutton RA. Temporal parameters of conditioned hypoglycemia. J Comp Physiol Psychol 1969;69:301-7.
10. Woods SC. Conditioned hypoglycemia. J Comp Physiol Psychol 1976;90:1164-8.
11. Hutton RA, Woods SC, Makous WL. Conditioned hypoglycemia: pseudoconditioning controls. J Comp Physiol Psychol 1970;71: 198-201.
12. Woods SC, Shogren RE. Glycemic responses following conditioning with different doses of insulin in rats. J Comp Physiol Psychol 1972;81:220-5.
13. Flaherty CF, Uzwiak AJ, Levine J, Smith M, Hall P, Schuler R. Apparent hyperglycemic and hypoglycemic conditioned responses with exogenous insulin as the unconditioned stimulus. Anim Learn Behav 1980;8:382-6.
14. Woods SC. Conditioned hypoglycemia: effect of vagotomy and pharmacological blockade. Am J Physiol 1972;223:1424-7.
15. Woods SC, Hutton RA, Makous W. Conditioned insulin secretion in the albino rat (34605). Proc Soc Exp Biol Med 1970;133: 964-8.
16. Flaherty CF, Becker HC. Influence of conditioned stimulus context on hyperglycemic conditioned responses. Physiol Behav 1984;33:587-93.
17. Flaherty CF, Becker HC, Rowan GA, Voelker S. Effects of chlordiazepoxide on novelty-induced hyperglycemia and on conditioned hyperglycemia. Physiol Behav 1984;33:595-9.
18. Flaherty CF, Rowan GA, Pohorecky LA. Corticosterone, novelty-induced hyperglycemia, and chlordiazepoxide. Physiol Behav 1986;37:393-6.
19. Grigson PS, Flaherty CF. The effect of chlordiazepoxide and propranolol on glycemic conditioning in rats. Psychobiology 1990;18:422-7.
20. Woods SC, Alexander KR, Porte D. Conditioned insulin secretion and hypoglycemia following repeated injections of tolbutamide in rats. Endocrinology 1972;90:227-31.
21. Morrell EM, Surwit RS, Kuhn CM, Feinglos MN, Cochrane C. Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse. Psychosom Med 1988;50:586-90.
22. Fehm-Wolfsdorf G, Beermann U, Kern W, Fehm HL. Failure to obtain classically conditioned hypoglycemia in man. In: Lehnert H, Murison R, Weiner H, Hellhammer D, Beyer J, editors. Endocrine and nutritional control of basic biological functions. Seattle (WA): Hogrefe and Huber; 1993. p. 257-61.
23. Fehm-Wolfsdorf G, Gnadler M, Kern W, Klosterhalfen W, Kerner W. Classically conditioned changes of blood glucose level in humans. Physiol Behav 1993;54:155-60.
24. Frier BM. Hypoglycaemia unawareness. In: Frier BM, Fisher BM, editors. Hypoglycaemia and diabetes. London: Edward Arnold; 1993. p. 284-301.
25. Gerich JE, Mokan M, Veneman T, Korytkowski M, Mitrakou A. Hypoglycemia unawareness. Endocr Rev 1991;12:356-71.
26. Havrankova J, Roth J, Brownstein MJ. Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. J Clin Invest 1979;64:636-42.
27. Frati AC, Iniestra F, Ariza CR. Acute effect of cigarette smoking on glucose tolerance and other cardiovascular risk factors. Diabetes Care 1996;19:112-8.
28. Tremblay A, Pinsard D, Coveney S, Catellier C, Laferrière G, Richard D, Nadeau A. Counterregulatory response to insulin-induced hypoglycemia in trained and nontrained humans. Metabolism 1990;39:1138-43.
29. Drost H. Untersuchungen zur Glukagonsekretion und deren metabolische Bedeutung bei Erkrankungen des Kohlenhydrat-und Fettstoffwechsels. Düsseldorf: Habilitationsschrift Medizinische Fakultät der Universität Düsseldorf; 1977.
30. Hepburn DA. Symptoms of hypoglycaemia. In: Frier BM, Fisher BM, editors. Hypoglycaemia and diabetes. London: Edward Arnold; 1993. p. 93-103.
31. Towler DA, Havlin CE, Craft S, Cryer P. Mechanism of awareness of hypoglycemia: perception of neurogenic (predominantly cholinergic) rather than neuroglycopenic symptoms. Diabetes 1993;42:1791-8.
32. Lam FC, Longnecker MT. A modified Wilcoxon rank sum test for paired data. Biometrika 1983;70:510-3.
33. Matysiak J, Green L. On the directionality of classically-conditioned glycemic responses. Physiol Behav 1984;32:5-9.
34. Flaherty CF. Animal learning and cognition. New York: Knopf; 1985.
35. Wilkinson CW. Endocrine rhythms and the pineal gland. In: Patton HD, Fuchs AF, Hille B, Scher AM, Steiner R, editors. Textbook of physiology. Vol 2. Philadelphia: WB Saunders; 1989. p. 1239-61.
36. Alvarez-Buylla R, de Alvarez-Buylla ER. Hypoglycemic conditioned reflex in rats: preliminary study of its mechanisms. J Comp Physiol Psychol 1975;88:155-60.
37. 2-receptor binding, norepinephrine, and circulating glucose. Brain Res 1986;384:404-8.
38. Jennings JR, McKnight JD. Inferring vagal tone from heart rate variability [editorial]. Psychosom Med 1994;56:194-6.
39. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability. Circulation 1996;93:1043-65.
40. Ziegler D. Diabetic cardiovascular autonomic neuropathy: prognosis, diagnosis and treatment. Diabetes Metab Rev 1994;10: 339-83.
41. Schwartz MW, Figlewicz DP, Woods SC, Porte D, Baskin DG. Insulin, neuropeptide Y, and food intake. Ann N Y Acad Sci 1993;692:60-71.
42. Woods SC, Chavez M, Park CR, Riedy C, Kaiyala K, Richardson RD, Figlewicz DP, Schwartz MW, Porte D, Seeley RJ. The evaluation of insulin as a metabolic signal influencing behavior via the brain. Neurosci Biobehav Rev 1996;20:139-44.
43. Strack AM, Sebastian RJ, Schwartz MW, Dallman MF. Glucocorticoids and insulin: reciprocal signals for energy balance. Am J Physiol 1995;268:R142-9.
44. Chavez M, Seeley RJ, Green PK, Wilkinson CW, Schwartz MW, Woods SC. Adrenalectomy increases sensitivity to central insulin. Physiol Behav 1997;62:631-4.
45. Riedy CA, Chavez M, Figlewicz DP, Woods SC. Central insulin enhances sensitivity to cholecystokinin. Physiol Behav 1995;58: 755-60.
46. Woods SC. The eating paradox: how we tolerate food. Psychol Rev 1991;98:488-505.
47. Pohl J, Kerner W, Frohnau G, Fehm-Wolfsdorf G. Symptom awareness is affected by the subjects' expectations during insulin-induced hypoglycemia. Diabetes Care 1997;20:796-802.
48. Cryer PE. Glucose counterregulation: the physiological mechanisms that prevent or correct hypoglycaemia. In: Frier BM, Fisher BM, editors. Hypoglycaemia and diabetes. London: Edward Arnold; 1993. p. 34-55.
49. Heller SR, Cryer PE. Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans. Diabetes 1991;40:223-6.