Adrenalectomy increases sensitivity to central insulin

Physiology and Behavior

Volumn 62, Issue 3, 1997, Pages 631-634

  Chavez, Mark ^a   Seeley, Randy J ^a   Green, Pamela K ^d   Wilkinson, Charles W ^b,e   Schwartz, Michael W ^a,c   Woods, Stephen C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Veterans Affairs Puget Sound   (United States)

^d Fred Hutchinson Cancer Research Center   (United States)

^e South Central Mental Illness Research Education and Clinical Center (MIRECC)   (United States)

Author keywords

Adrenalectomy; Body weight; Corticosterone; Food intake; Insulin

Indexed keywords

CORTICOSTERONE; GLUCOCORTICOID; INSULIN;

ADRENALECTOMY; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BRAIN; BRAIN THIRD VENTRICLE; CONTROLLED STUDY; FOOD INTAKE; HYPERPHAGIA; INSULIN SENSITIVITY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030981703     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(97)00188-1     Document Type: Article

References (24)

1. Baura G., Foster D., Porte D. Jr., Kahn S. E., Bergman R. N., Cobelli C., Schwartz M. W. Saturable transport of insulin from plasma into the central nervous system of dogs in vivo: a mechanism for regulated insulin delivery to the brain. J. Clin. Invest. 92:1993;1824-1830.
2. Bray G. A., Fisler J., York D. A. Neuroendocrine control of the development of obesity: understanding gained from studies of experimental animal models. Frontiers Neuroendocrinol. 11:1990;128-181.
3. Chavez M., Kaiyala K., Madden L. J., Schwartz M. W., Woods S. C. Intraventricular insulin and the level of maintained body weight in rats. Behav. Neurosci. 109:1995;528-531.
4. Chavez M., Seeley R. J., Woods S. C. A comparison between the effects of intraventricular insulin and intraperitoneal LiCl on three measures sensitive to emetic agents. Behav. Neurosci. 109:1995;547-550.
5. Chavez M., van Dijk G., Arkies B. J., Woods S. C. Third ventricular insulin infusion attenuates NPY-induced feeding at the level of the paraventricular nucleus. Obes. Res. 3:1995;335s.
6. Clark J. T., Kalra P. S., Crowley W. R., Kalra S. P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 115:1984;427-429.
7. Gosink P. D., Chavez M., Green P. K., Woods S. C., Figlewicz D. P., Wilkinson C. W., Baskin D. G., Schwartz M. W. Central insulin administration lowers body weight via a glucocorticoid-sensitive mechanism. Clin. Res. 40:1991;55A.
8. Green P. K., Wilkinson C. W., Woods S. C. Intraventricular corticosterone increases the rate of body weight gain in underweight adrenalectomized rats. Endocrinology. 130:1992;269-275.
9. Heinrichs S. C., Menzaghi F., Merlo-Pich E., Hauger R. L., Koob G. F. Corticotropin releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain Res. 611:1993;18-24.
10. Kalra S. P., Dube M. G., Sahu A., Phelps C. P., Kalra P. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA. 88:1991;10931-10935.
11. Kermani, R.; Richardson, R. D.; Chavez, M.; Woods, S. C. Central insulin potentiates the ability of corticotropin releasing hormone to reduce meal size. Am. J. Physiol. (in press).
12. Marks J. L., Porte D. Jr., Stahl W. L., Baskin D. G. Localization of insulin receptor mRNA in rat brain by in situ hybridization. Endocrinology. 127:1990;3236-3239.
13. McGowan M. K., Andrews K. M., Kelly J., Grossman S. P. Effects of chronic intrahypothalamic infusion of insulin on food intake and diurnal meal patterning in the rat. Behav. Neurosci. 104:1990;373-385.
14. Olefsky J. M. Effects of dexamethasone on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. J. Clin. Invest. 56:1975;442-448.
15. Polonsky B. D., Given E., Carter V. Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J. Clin. Invest. 81:1988;442-448.
16. Riedy C. A., Chavez M., Figlewicz D. P., Woods S. C. Central insulin enhances sensitivity to cholecystokinin. Physiol. Behav. 58:1995;755-760.
17. Sahu A., Dube M. G., Phelps C. P., Sninsky C. A., Kalra P. S., Kalra S. P. Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: A putative hypothalamic site for energy homeostasis. Endocrinology. 136:1995;5718-5724.
18. Schwartz M. W., Figlewicz D. P., Baskin D. G., Woods S. C., Porte D. Jr. Insulin in the brain: a hormonal regulator of energy balance. Endocr. Rev. 13:1992;387-414.
19. Schwartz M. W., Marks J., Sipols A. J., Baskin D. G., Woods S. C., Kahn S. E., Porte D. Jr. Central insulin administration reduces neuropeptide Y mRNA expression in the arcuate nucleus of food-deprived lean (Fa/Fa) but not obese (fa/fa) Zucker rats. Endocrinology. 128:1991;2645-2647.
20. Schwartz M. W., Sipols A. J., Marks J. L., Sanacora G., White J. D., Scheurinck A., Kahn S. E., Baskin D. G., Woods S. C., Figlewicz D. P., Porte D. Jr. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology. 130:1992;3608-3616.
21. Sipols A. J., Baskin D. G., Schwartz M. W. Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes. 44:1995;147-151.
22. Stanley B. G. Suppression of neuropeptide Y-elicited eating by adrenalectomy or hypophysectomy: reversal with corticosterone. Brain Res. 501:1989;32-36.
23. Stanley B. G., Daniel D. R., Chin A. S., Leibowitz S. F. Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion. Peptides. 6:1985;1205-1211.
24. Strack A. M., Sebastian R. J., Schwartz M. W., Dallman M. F. Glucocorticoids and insulin: reciprocal signals for energy balance. Am. J. Physiol. 268:1995;142-149.