Ameliorative influence of a nootropic drug on motor activity of rats after bilateral carotid artery occlusion

Journal of Neural Transmission

Volumn 104, Issue 11-12, 1997, Pages 1319-1327

  Gschanes, A ^a   Valouskova V ^b   Windisch, M ^a  

^a Research Initiative Ebewe   (Austria)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Bilateral carotid artery occlusion; Cerebrolysin ; Morris water maze; Motor activity; Rats; Spatial memory

Indexed keywords

CEREBROLYSIN; NOOTROPIC AGENT; SODIUM CYANIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; DOSE RESPONSE; DRUG TOLERABILITY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY;

AMINO ACIDS; ANIMALS; BRAIN ISCHEMIA; CAROTID ARTERIES; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, INTRAVENOUS; MALE; MAZE LEARNING; MOTOR ACTIVITY; NOOTROPIC AGENTS; RATS; SWIMMING;

EID: 0031463717     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01294733     Document Type: Article

References (26)

1. Akai F, Hiruma T, Sato N, Fujimoto M, Ikou M, Hashimoto S (1992) Neurotrophic factor-like effect of FPF 1070 on septal cholinergic neurons after transections of fimbria-fornix in the rat brain. Histol Histopathol 7: 213-221
2. Albrecht E, Hingel S, Crailsheim K (1993) The effects of Cerebrolysin on the vitality and sprouting of neurons from cerebral hemispheres and from the brain stem of chicken embryos in vitro. In: Nicolini M, Zatta PF, Coraine B (eds) Alzheimer's disease and related disorders. Pergamon Press, Oxford, pp 341-342
3. Auer RN, Jensen ML, Whishaw OQ (1989) Neurobehavioral deficit due to ischemic brain damage limited to half of the CA1 sector of the hippocampus. J Neurosci 9: 1641-1647
4. Baskys A, Wojtowicz MJ (1994) Effects of brain tissue hydrolysate on synaptic transmission in the hippocampus. Pharmacol Biochem Behav 49: 1105-1107
5. Francis-Turner L, Valoušková V (1996) Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett 202: 193-196
6. Garcia J (1984) Experimental ischemic stroke: a review. Stroke 15: 5-14
7. Heim C, Sontag KH (1995) Memantine prevents progressive functional neurodegeneration in rats. J Neural Transm 46: 117-130
8. Hutter-Paier B, Eggenreich U, Windisch M (1996a) Effects of two protein-free peptide derivatives on passive avoidance behaviour of 24-month-old rats. Drug Res 46: 237-241
9. Hutter-Paier B, Eggenreich LJ, Windisch M (1996b) Dose-dependent behavioural effects of two protein-free peptide derivatives on the passive avoidance reaction of rats. Drug Res 46: 242-246
10. Kofler B, Erhart C, Harrer GA (1990) Multidimensional approach in testing nootropic drug effects (Cerebrolysin). Arch Gerontol Geriatr 10: 129-140
11. Lindner G, Grosse G, Matthies H, Kirsche W (1975) Über die Wirkung von Hirnextrakt und -hydrolysat auf das Nervengewebe unter In-vitro Bedingungen. Z Mikrosk Anat Forsch 89: 815-823
12. O'Neill M, Allain H, Bentue-Ferrer D, Bellissant E, de Certaines J, Leonard BE (1995) Pharmacological strategies in the treatment of cerebral ischemia. Eur Neurol 35: 28-36
13. Paier B, Windisch M, Eggenreich U (1992) Postnatal administration of two peptide solutions affect passive avoidance behaviour of young rats. Behav Brain Res 51: 23-28
14. Palm W (1989) Cerebrolysin-immunization: immunization experiments with 2 batches of Cerebrolysin, a peptide concentrate and an aqueous protein powder extracte (Experts report)
15. Piswanger A, Paier B, Windisch M (1990) Modulation of protein synthesis in cell-free system from rat brain by Cerebrolysin during development and aging. In: Lubec G. Rosenthal GA (eds) Amino acids. Escom Science Publishers BV, Leiden, pp 651-657
16. Rüther E, Ritter R, Apecechea M, Freytag S, Windisch M (1994) Efficacy of the peptidergic nootropic drug Cerebrolysin in patients with senile dementia of the Alzheimer type (SDAT). Pharmacopsychiatry 27: 32-40
17. Schaller R, Schwab M, Bauer R (1993) EEG analysis and comparison to morphological changes after hypoxic ischemic brain injury in rats. In: Rother M, Zwiener U (eds) Quantitative EEG analysis - clinical utility and new methods. Universitätsverlag Jena, Jena, pp 240-244
18. Schwab M, Bauer R, Zwiener U (1993) Effects of Cere on ECoG during moderate forebrain ischemia under normothermic and hypothermic conditions. In: Eiselt M. Zwiener U, Witte H (eds) Quantitative and topological EEG and MEG analysis. Universitätsverlag Jena, Jena, pp 243-247
19. Shimazu SN, Tachikawa N, Iwamoto D, Itho T, Komatsu S, Fujimoto M (1992) The neurotrophic and brain protein effect of Cerebrolysin. Neurobiol Aging 13: 107-113
20. Smith ML, Auer RN, Siesjö BK (1984) The density and distribution of ischemic brain injury in the rat following 2-10min of forebrain ischemia. Acta Neuropathol 64: 319-332
21. Sugita Y, Kondo T, Kanazawa A, Itou T, Miyuno Y (1993) Protective effect of FPF 1070 (Cerebrolysin) on delayed neuronal death in the gerbil. Detection of hydroxyl radicals with salycylic acid. Brain Nerve 45: 329-331
22. Tucker JC, McDaniel WF, Smith SR (1992) A behavioral study of bilateral middle cerebral artery hemorrhagic ischemia in rats. Neuroreport 3: 725-728
23. Windisch M, Piswanger A (1985a) Effects of a long-term treatment with a peptide derivate on brain metabolism of rats. Drug Res 35: 1353-1356
24. Windisch M, Piswanger A (1985c) In vitro effects of peptide derivates and extracts from calf blood on the oxidative metabolism of brain, liver and heart muscle homogenates of the rat. Drug Res 35: 87-89
25. Wenzel J, Stender G, Duwe G (1981) Zur Entwicklung der Neuronenstruktur der Fascia dentata bei der Ratte. Neurohistologisch-morphometrische, ultrastrukturelle und experimentelle Untersuchungen. J Hirnforsch 22: 629-683
26. Xiong H, Wojtowicz JM, Baskys A (1995) Brain tissue hydrolysate acts on presynaptic adenosine receptors in the rat hippocampus. Can Physiol Pharmacol 73: 1194-1197