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Volumn 6, Issue 7, 1999, Pages 1202-1209

A role for intracellular immunization in chemosensitization of tumor cells?

Author keywords

Cancer; Chemosensitivity; Drug resistance; Gene therapy; Intracellular immunization

Indexed keywords

ANTIBODY; ANTISENSE OLIGONUCLEOTIDE; CELL PROTEIN; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PROTEIN BCL 2; RAS PROTEIN; RIBOZYME;

EID: 0032774070     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300952     Document Type: Review
Times cited : (8)

References (119)
  • 1
    • 0026594392 scopus 로고
    • High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis
    • Godwin AK et al. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci USA 1992; 89: 3070-3074.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3070-3074
    • Godwin, A.K.1
  • 2
    • 0024456990 scopus 로고
    • Molecular basis of cisplatin resistance in human carcinomas: Model systems and patients
    • Scanlon KJ et al. Molecular basis of cisplatin resistance in human carcinomas: model systems and patients. Anticancer Res 1989; 9: 1311-1312.
    • (1989) Anticancer Res , vol.9 , pp. 1311-1312
    • Scanlon, K.J.1
  • 3
    • 0025353691 scopus 로고
    • Cellular pharmocology of cisplatin: Perspectives on mechanisms of acquired resistance
    • Andrews PA, Howell SB. Cellular pharmocology of cisplatin: perspectives on mechanisms of acquired resistance. Cancer Cells 1990; 2: 35-13.
    • (1990) Cancer Cells , vol.2 , pp. 35-113
    • Andrews, P.A.1    Howell, S.B.2
  • 4
    • 0031460718 scopus 로고    scopus 로고
    • Enhanced topoisomerase I activity and increased topoisomerase II content in displatin-resitant cancer cell lines
    • Minagawa Y et al. Enhanced topoisomerase I activity and increased topoisomerase II content in displatin-resitant cancer cell lines. Jpn J Cancer Res 1997; 88: 1218-1223.
    • (1997) Jpn J Cancer Res , vol.88 , pp. 1218-1223
    • Minagawa, Y.1
  • 5
    • 0024278459 scopus 로고
    • Inhibitors of DNA topoisomerases
    • Drlica K, Franco RJ. Inhibitors of DNA topoisomerases. Biochemistry 1988; 27: 2253-2259.
    • (1988) Biochemistry , vol.27 , pp. 2253-2259
    • Drlica, K.1    Franco, R.J.2
  • 6
    • 0024548599 scopus 로고
    • Expression of a multidrug resistance gene in human cancers
    • Goldstein LJ et al. Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst 1989; 81: 116-124.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 116-124
    • Goldstein, L.J.1
  • 7
    • 0023616968 scopus 로고
    • Multidrug resistance in ovarian cancer
    • Fojo A, Hamilton TC, Young RC, Ozols RF. Multidrug resistance in ovarian cancer. Cancer 1987; 60 (Suppl. 8): 2075-2080.
    • (1987) Cancer , vol.60 , Issue.SUPPL. 8 , pp. 2075-2080
    • Fojo, A.1    Hamilton, T.C.2    Young, R.C.3    Ozols, R.F.4
  • 8
    • 0024249048 scopus 로고
    • A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines
    • Chan HS et al. A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines. Lab Invest 1989; 59: 870-875.
    • (1989) Lab Invest , vol.59 , pp. 870-875
    • Chan, H.S.1
  • 9
    • 0025990960 scopus 로고
    • P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma
    • Chan HS et al. P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma. New Engl J Med 1991; 325: 1608-1614.
    • (1991) New Engl J Med , vol.325 , pp. 1608-1614
    • Chan, H.S.1
  • 10
    • 0025855920 scopus 로고
    • MDR1 gene expression and treatment outcome in acute myeloid leukemia
    • Pirker R et al. MDR1 gene expression and treatment outcome in acute myeloid leukemia. J Natl Cancer Inst 1991; 83: 708-712.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 708-712
    • Pirker, R.1
  • 11
    • 0025914062 scopus 로고
    • Multidrug resitance (mdr1) gene expression in adult acute leukemias: Correlations with treatment outcome and in vitro drug sensitivity
    • Marie JP, Zittoun R, Sikic BI. Multidrug resitance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity. Blood 1991; 78: 586-592.
    • (1991) Blood , vol.78 , pp. 586-592
    • Marie, J.P.1    Zittoun, R.2    Sikic, B.I.3
  • 12
    • 0026602155 scopus 로고
    • Clinical significance of multidrug resistance P-glycoprotein expression on acute non-lymphagocytic leukemia cells at diagnosis
    • Campos L et al. Clinical significance of multidrug resistance P-glycoprotein expression on acute non-lymphagocytic leukemia cells at diagnosis. Blood 1992; 79: 473-476.
    • (1992) Blood , vol.79 , pp. 473-476
    • Campos, L.1
  • 13
    • 0026781491 scopus 로고
    • Clinical correlates of MDR1 P-glycoprotein gene expression in ovarian and small-cell lung carcinomas
    • Holzmayer TA, Hilsenbeck S, Von Hoff DD, Roninson IB. Clinical correlates of MDR1 P-glycoprotein gene expression in ovarian and small-cell lung carcinomas. J Natl Cancer Inst 1992; 84: 1486-1491.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1486-1491
    • Holzmayer, T.A.1    Hilsenbeck, S.2    Von Hoff, D.D.3    Roninson, I.B.4
  • 14
    • 0027314191 scopus 로고
    • Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: Prognostic implications
    • Goasguen JE et al. Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications. Blood 1993; 81: 2394-2398.
    • (1993) Blood , vol.81 , pp. 2394-2398
    • Goasguen, J.E.1
  • 15
    • 0028025563 scopus 로고
    • Apoptosis in cancer therapy
    • Fisher DE. Apoptosis in cancer therapy. Cell 1994; 78: 539-542.
    • (1994) Cell , vol.78 , pp. 539-542
    • Fisher, D.E.1
  • 16
    • 0028972616 scopus 로고
    • Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance
    • Reed JC. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol 1995; 7: 541-546.
    • (1995) Curr Opin Oncol , vol.7 , pp. 541-546
    • Reed, J.C.1
  • 17
    • 0028958030 scopus 로고
    • Bcl-2: Prevention of apoptosis as a mechanism of drug resistance
    • Reed JC. Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol/Oncol Clin North Am 1995; 9: 451-473.
    • (1995) Hematol/Oncol Clin North Am , vol.9 , pp. 451-473
    • Reed, J.C.1
  • 18
    • 0028880293 scopus 로고
    • The control of apoptosis and drug resistance in ovarian cancer: Influence of p53 and Bcl-2
    • Eliopoulos AG et al. The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2. Oncogene 1995; 11: 1217-1228.
    • (1995) Oncogene , vol.11 , pp. 1217-1228
    • Eliopoulos, A.G.1
  • 19
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed JC. Double identity for proteins of the Bcl-2 family. Nature 1997; 387: 773-776.
    • (1997) Nature , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 20
    • 0029835487 scopus 로고    scopus 로고
    • Gene therapy for lung cancer: Enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer
    • Nguyen DM et al. Gene therapy for lung cancer: enhancement of tumor suppression by a combination of sequential systemic cisplatin and adenovirus-mediated p53 gene transfer. J Thorac Cardiovasc Surg 1996; 112: 1372-1377.
    • (1996) J Thorac Cardiovasc Surg , vol.112 , pp. 1372-1377
    • Nguyen, D.M.1
  • 21
    • 0030969022 scopus 로고    scopus 로고
    • P53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy
    • Pirollo KF et al. P53 mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy. Oncogene 1997; 14: 1735-1746.
    • (1997) Oncogene , vol.14 , pp. 1735-1746
    • Pirollo, K.F.1
  • 22
    • 0028953478 scopus 로고
    • Implications of the p53 tumor-suppressor gene in clinical oncology
    • Chang F, Syrjanem S, Syrjanem K. Implications of the p53 tumor-suppressor gene in clinical oncology. J Clin Oncol 1995; 13: 1009-1022.
    • (1995) J Clin Oncol , vol.13 , pp. 1009-1022
    • Chang, F.1    Syrjanem, S.2    Syrjanem, K.3
  • 23
    • 0029810919 scopus 로고    scopus 로고
    • Sensitivity to cis-diammine-dichloroplatinum in human cancer cells is related to expression of cyclin D1 but no c-Raf-1 protein
    • Warenius HM, Seabra LA, Maw P. Sensitivity to cis-diammine-dichloroplatinum in human cancer cells is related to expression of cyclin D1 but no c-Raf-1 protein. Int J Cancer 1996; 67: 224-231.
    • (1996) Int J Cancer , vol.67 , pp. 224-231
    • Warenius, H.M.1    Seabra, L.A.2    Maw, P.3
  • 24
    • 0029778442 scopus 로고    scopus 로고
    • Effect of cyclin D1 overexpression on drug sensitivity in human fibrosacrcoma cell line
    • Hochhauser D et al. Effect of cyclin D1 overexpression on drug sensitivity in human fibrosacrcoma cell line. J Natl Cancer Inst 1996; 88: 1269-1275.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1269-1275
    • Hochhauser, D.1
  • 25
    • 0028579733 scopus 로고
    • Oncogenes and the strategy of growth factors
    • Baserga R. Oncogenes and the strategy of growth factors. Cell 1994; 79: 927-930.
    • (1994) Cell , vol.79 , pp. 927-930
    • Baserga, R.1
  • 27
    • 0027494496 scopus 로고
    • Increased epidermal growth factor receptor in an estrogen-responsive, adriamycin-resistant MCF-7 cell line
    • Dickstein B et al. Increased epidermal growth factor receptor in an estrogen-responsive, adriamycin-resistant MCF-7 cell line. J Cell Physiol 1993; 157: 110-118.
    • (1993) J Cell Physiol , vol.157 , pp. 110-118
    • Dickstein, B.1
  • 28
    • 0023679801 scopus 로고
    • A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo
    • Vicker PJ, Dickson RB, Shoemaker R, Cowan KH. A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo. Mol Endocrinol 1988; 2: 886-892.
    • (1988) Mol Endocrinol , vol.2 , pp. 886-892
    • Vicker, P.J.1    Dickson, R.B.2    Shoemaker, R.3    Cowan, K.H.4
  • 29
    • 0026625217 scopus 로고
    • Prognostic importance of c-erbB-2 expression in breast cancer
    • Gusterson BA et al. Prognostic importance of c-erbB-2 expression in breast cancer. J Clin Oncol 1992; 10: 1049-1056.
    • (1992) J Clin Oncol , vol.10 , pp. 1049-1056
    • Gusterson, B.A.1
  • 30
    • 0022600388 scopus 로고
    • The neu oncogene encodes an epidermal growth factor receptor related protein
    • Bergmann C, Hung M, Weinberg R. The neu oncogene encodes an epidermal growth factor receptor related protein. Nature 1986; 319: 226-229.
    • (1986) Nature , vol.319 , pp. 226-229
    • Bergmann, C.1    Hung, M.2    Weinberg, R.3
  • 31
    • 0025281906 scopus 로고
    • Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer
    • Berchuck A et al. Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 1990; 50: 4087-4091.
    • (1990) Cancer Res , vol.50 , pp. 4087-4091
    • Berchuck, A.1
  • 32
    • 0028927113 scopus 로고
    • Overexpression of c-erbB-2 in epithelial ovarian cancer, prognostic value and relationship with response to chemotherapy
    • Felip E et al. Overexpression of c-erbB-2 in epithelial ovarian cancer, prognostic value and relationship with response to chemotherapy. Cancer 1995; 75: 2147-2152.
    • (1995) Cancer , vol.75 , pp. 2147-2152
    • Felip, E.1
  • 33
    • 0028943683 scopus 로고
    • Enhanced chemoresistance by elevation of p185neu levels in HER/neu-transfected human lung cancer cells
    • Tsai CM et al. Enhanced chemoresistance by elevation of p185neu levels in HER/neu-transfected human lung cancer cells. J Natl Cancer Inst 1995; 87: 682-684.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 682-684
    • Tsai, C.M.1
  • 34
    • 0027215146 scopus 로고
    • Correlation of intrinsic chemoresistance of non-small cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations
    • Tsai CM, Chang KT, Perng RP. Correlation of intrinsic chemoresistance of non-small cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations. J Natl Cancer Inst 1993; 85: 897-901.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 897-901
    • Tsai, C.M.1    Chang, K.T.2    Perng, R.P.3
  • 35
    • 0024299563 scopus 로고
    • Gene therapy: Intracellular immunization
    • Baltimore D. Gene therapy: intracellular immunization. Nature 1988; 335: 395-396.
    • (1988) Nature , vol.335 , pp. 395-396
    • Baltimore, D.1
  • 36
    • 0030051756 scopus 로고
    • Antisense-oligonucleotide therapy
    • Aslaro FK, McDonnell WM. Antisense-oligonucleotide therapy. New Engl J Med 1995; 334: 316-318.
    • (1995) New Engl J Med , vol.334 , pp. 316-318
    • Aslaro, F.K.1    McDonnell, W.M.2
  • 37
    • 0031973036 scopus 로고    scopus 로고
    • The therapeutic potential of ribozymes
    • James HA, Gibson I. The therapeutic potential of ribozymes. Blood 1997; 91: 371-382.
    • (1997) Blood , vol.91 , pp. 371-382
    • James, H.A.1    Gibson, I.2
  • 38
    • 0031016269 scopus 로고    scopus 로고
    • Intrabodies: Turning the humoral immune system outside in for intracellular immunization
    • Marasco W. Intrabodies: turning the humoral immune system outside in for intracellular immunization. Gene Therapy 1997; 4: 11-15.
    • (1997) Gene Therapy , vol.4 , pp. 11-15
    • Marasco, W.1
  • 39
    • 0029993609 scopus 로고    scopus 로고
    • Novel genetic immunotoxins and intracellular antibodies for cancer therapy
    • Chert S-Y, Marasco WA. Novel genetic immunotoxins and intracellular antibodies for cancer therapy. Semin Oncol 1996; 23: 148-153.
    • (1996) Semin Oncol , vol.23 , pp. 148-153
    • Chert, S.-Y.1    Marasco, W.A.2
  • 40
    • 0025978976 scopus 로고
    • Man-made antibodies
    • Winter G, Milstein C. Man-made antibodies. Nature 1991; 349: 293-299.
    • (1991) Nature , vol.349 , pp. 293-299
    • Winter, G.1    Milstein, C.2
  • 42
    • 0022600388 scopus 로고
    • The neu oncogene encodes an epidermal growth factor receptor related protein
    • Bergmann C, Hung M, Weinberg R. The neu oncogene encodes an epidermal growth factor receptor related protein. Nature 1986; 319: 226-229.
    • (1986) Nature , vol.319 , pp. 226-229
    • Bergmann, C.1    Hung, M.2    Weinberg, R.3
  • 43
    • 0025281906 scopus 로고
    • Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer
    • Berchuck A et al. Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 1990; 50: 4087-4091.
    • (1990) Cancer Res , vol.50 , pp. 4087-4091
    • Berchuck, A.1
  • 44
    • 0029893166 scopus 로고    scopus 로고
    • Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemo-sensitivity
    • Barnes MN et al. Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemo-sensitivity. Clin Cancer Res 1996; 2: 1089-1095.
    • (1996) Clin Cancer Res , vol.2 , pp. 1089-1095
    • Barnes, M.N.1
  • 45
    • 0026462618 scopus 로고
    • Clinical significance of erbB-2 (HER-2/neu) protein
    • Paik S. Clinical significance of erbB-2 (HER-2/neu) protein. Cancer Invest 1992; 10: 575-579.
    • (1992) Cancer Invest , vol.10 , pp. 575-579
    • Paik, S.1
  • 46
    • 0025986825 scopus 로고
    • A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines
    • Hancock MC et al. A monoclonal antibody against the c-erbB-2 protein enhances the cytotoxicity of cis-diamminedichloroplatinum against human breast and ovarian tumor cell lines. Cancer Res 1991; 51: 4575-4580.
    • (1991) Cancer Res , vol.51 , pp. 4575-4580
    • Hancock, M.C.1
  • 47
    • 0028500163 scopus 로고
    • Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines
    • Deshane J et al. Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines. Gene Therapy 1994; 1: 332-337.
    • (1994) Gene Therapy , vol.1 , pp. 332-337
    • Deshane, J.1
  • 48
    • 0028839655 scopus 로고
    • Targeted tumor killing via an intracellular antibody against erbB-2
    • Deshane J et al. Targeted tumor killing via an intracellular antibody against erbB-2. J Clin Invest 1995; 96: 2980-2989.
    • (1995) J Clin Invest , vol.96 , pp. 2980-2989
    • Deshane, J.1
  • 49
    • 0028823836 scopus 로고
    • Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody
    • Deshane J et al. Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody. Gynecol Oncol 1995; 59: 8-14.
    • (1995) Gynecol Oncol , vol.59 , pp. 8-14
    • Deshane, J.1
  • 50
    • 0030101361 scopus 로고    scopus 로고
    • Intracellular antibody directed against erbB-2 mediated targeted tumor cell eradication by inducing apoptosis
    • Deshane J et al. Intracellular antibody directed against erbB-2 mediated targeted tumor cell eradication by inducing apoptosis. Cancer Gene Ther 1996; 3: 89-98.
    • (1996) Cancer Gene Ther , vol.3 , pp. 89-98
    • Deshane, J.1
  • 51
    • 0028893444 scopus 로고
    • Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling
    • Graus-Porta D, Beerli RR, Hynes NE. Single-chain antibody-mediated intracellular retention of ErbB-2 impairs Neu differentiation factor and epidermal growth factor signaling. Molec Cell Biol 1995; 15: 1182-1191.
    • (1995) Molec Cell Biol , vol.15 , pp. 1182-1191
    • Graus-Porta, D.1    Beerli, R.R.2    Hynes, N.E.3
  • 53
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol/Hematol 1995; 19: 183-232.
    • (1995) Crit Rev Oncol/Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardello, F.3    Normanno, N.4
  • 54
    • 0025505265 scopus 로고
    • Epidermal growth factor: Receptor and ligand expression in human breast cancer
    • Murphy LC et al. Epidermal growth factor: receptor and ligand expression in human breast cancer. Semin Cancer Biol 1990; 1: 305-315.
    • (1990) Semin Cancer Biol , vol.1 , pp. 305-315
    • Murphy, L.C.1
  • 55
    • 0027254405 scopus 로고
    • The prognostic significance of transforming growth factors in human breast cancer
    • Murray PA et al. The prognostic significance of transforming growth factors in human breast cancer. Br J Cancer 1993; 67: 1408-1412.
    • (1993) Br J Cancer , vol.67 , pp. 1408-1412
    • Murray, P.A.1
  • 56
    • 0024261027 scopus 로고
    • Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice
    • Aboud-Pirak E et al. Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. J Natl Cancer Inst 1988; 80: 1605-1611.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1605-1611
    • Aboud-Pirak, E.1
  • 57
    • 0027428571 scopus 로고
    • Antitumor effect of antiepidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografs
    • Fan Z, Baselga J, Massui H, Mendelsohn J. Antitumor effect of antiepidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografs. Cancer Res 1993; 53: 4637-4642.
    • (1993) Cancer Res , vol.53 , pp. 4637-4642
    • Fan, Z.1    Baselga, J.2    Massui, H.3    Mendelsohn, J.4
  • 58
    • 0027290650 scopus 로고
    • Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
    • Baselga J et al. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst 1993; 85: 1327-1333.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1327-1333
    • Baselga, J.1
  • 59
    • 0029776415 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27 and induces G1 arrest in prostatic cancer cell line DU145
    • Peng D et al. Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res 1996; 56: 3666-3669.
    • (1996) Cancer Res , vol.56 , pp. 3666-3669
    • Peng, D.1
  • 60
    • 0029812091 scopus 로고    scopus 로고
    • Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells
    • Jannot CB et al. Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells. Oncogene 1996; 13: 275-282.
    • (1996) Oncogene , vol.13 , pp. 275-282
    • Jannot, C.B.1
  • 61
    • 0028030096 scopus 로고
    • Autocrine inhibition of the epidermal growth factor receptor by intracellular expression of a single-chain antibody
    • Beerli RR, Wels W, Hynes NE. Autocrine inhibition of the epidermal growth factor receptor by intracellular expression of a single-chain antibody. Biochem Biophy Res Commun 1994; 204: 666-672.
    • (1994) Biochem Biophy Res Commun , vol.204 , pp. 666-672
    • Beerli, R.R.1    Wels, W.2    Hynes, N.E.3
  • 62
    • 0031030334 scopus 로고    scopus 로고
    • Analysis of Bax and Bcl-2 expression in p53-immunopositive breast cancers
    • Krajewski S et al. Analysis of Bax and Bcl-2 expression in p53-immunopositive breast cancers. Clin Cancer Res 1997; 3: 199-208.
    • (1997) Clin Cancer Res , vol.3 , pp. 199-208
    • Krajewski, S.1
  • 63
    • 0028325283 scopus 로고
    • The prevalence of Bcl-2 immunoreactivity in breast carcinomas and its clinicopathological correlates with particular reference to estrogen receptor status
    • Doglioni C et al. The prevalence of Bcl-2 immunoreactivity in breast carcinomas and its clinicopathological correlates with particular reference to estrogen receptor status. Virchows Arch 1994; 424: 47-51.
    • (1994) Virchows Arch , vol.424 , pp. 47-51
    • Doglioni, C.1
  • 64
    • 0028114913 scopus 로고
    • bcl-2 protein expression in tumors of the central nervous system
    • Nakasu S et al. bcl-2 protein expression in tumors of the central nervous system. Acta Neuropathol 1994; 88: 520-526.
    • (1994) Acta Neuropathol , vol.88 , pp. 520-526
    • Nakasu, S.1
  • 65
    • 0028935145 scopus 로고
    • Human gliomas with wild-type p53 express bcl-2
    • Alderson LM et al. Human gliomas with wild-type p53 express bcl-2. Cancer Res 1995; 55: 999-1001.
    • (1995) Cancer Res , vol.55 , pp. 999-1001
    • Alderson, L.M.1
  • 66
    • 0028814213 scopus 로고
    • The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model
    • Bronner MP, Culin C, Reed JC, Furth EE. The bcl-2 proto-oncogene and the gastrointestinal epithelial tumor progression model. Am J Pathol 1995; 146: 20-26.
    • (1995) Am J Pathol , vol.146 , pp. 20-26
    • Bronner, M.P.1    Culin, C.2    Reed, J.C.3    Furth, E.E.4
  • 67
    • 0029927494 scopus 로고    scopus 로고
    • Predominant expression of the long isoform of Bcl-X in human lymphomas
    • Xerri L et al. Predominant expression of the long isoform of Bcl-X in human lymphomas. Br J Haematol 1996; 92: 900-907.
    • (1996) Br J Haematol , vol.92 , pp. 900-907
    • Xerri, L.1
  • 68
    • 0029001395 scopus 로고
    • High expression of the Bcl-X gene in Reed-Sternberg cells of Hodgkin's disease
    • Sclaifer D et al. High expression of the Bcl-X gene in Reed-Sternberg cells of Hodgkin's disease. Blood 1995; 85: 2671-2677.
    • (1995) Blood , vol.85 , pp. 2671-2677
    • Sclaifer, D.1
  • 69
    • 0029945789 scopus 로고    scopus 로고
    • Elevated expression of Bcl-X and reduced BAK in primary colorectal carcinoma
    • Krajewski M et al. Elevated expression of Bcl-X and reduced BAK in primary colorectal carcinoma. Cancer Res 1996; 56: 2422-2429.
    • (1996) Cancer Res , vol.56 , pp. 2422-2429
    • Krajewski, M.1
  • 70
    • 0029919668 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Bcl-2, BAX, Bcl-X and MCL-1 expression in prostate cancers
    • Krajewski M et al. Immunohistochemical analysis of Bcl-2, BAX, Bcl-X and MCL-1 expression in prostate cancers. Am J Pathol 1996; 148: 1567-1575.
    • (1996) Am J Pathol , vol.148 , pp. 1567-1575
    • Krajewski, M.1
  • 71
    • 0031059570 scopus 로고    scopus 로고
    • Immunohistochemical analysis of Bcl-2, Bcl-X, MCL-1 and BAX in tumors of central and peripheral nervous system origin
    • Krajewski S et al. Immunohistochemical analysis of Bcl-2, Bcl-X, MCL-1 and BAX in tumors of central and peripheral nervous system origin. Am J Pathol 1997; 150: 805-814.
    • (1997) Am J Pathol , vol.150 , pp. 805-814
    • Krajewski, S.1
  • 72
    • 0031984216 scopus 로고    scopus 로고
    • Bcl-x expression in multiple myeloma: Possible indicator of chemoresistance
    • Tu Y et al. Bcl-x expression in multiple myeloma: possible indicator of chemoresistance. Cancer Res 1998; 58: 256-262.
    • (1998) Cancer Res , vol.58 , pp. 256-262
    • Tu, Y.1
  • 73
    • 0344648784 scopus 로고    scopus 로고
    • A family of plasmid vectors for the intracellular expression of single-chain antibodies
    • Submitted
    • Grim JE et al. A family of plasmid vectors for the intracellular expression of single-chain antibodies. Gene (Submitted).
    • Gene
    • Grim, J.E.1
  • 74
    • 0032523945 scopus 로고    scopus 로고
    • Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7
    • Piche A et al. Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7. Cancer Res 1998; 58: 2134-2140.
    • (1998) Cancer Res , vol.58 , pp. 2134-2140
    • Piche, A.1
  • 75
    • 0032456584 scopus 로고    scopus 로고
    • Modulation of drug-induced apoptosis by anti-Bcl-2 single-chain antibodyin ovarian cancer cells
    • Piche A et al. Modulation of drug-induced apoptosis by anti-Bcl-2 single-chain antibodyin ovarian cancer cells. Tumor Targeting 1998; 3: 147-155.
    • (1998) Tumor Targeting , vol.3 , pp. 147-155
    • Piche, A.1
  • 76
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989; 49: 4682-4689.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 77
    • 0028958222 scopus 로고
    • Increased prevalence of K-ras oncogene mutations in lung adenocarcinomas
    • Mills NE et al. Increased prevalence of K-ras oncogene mutations in lung adenocarcinomas. Cancer Res 1995; 55: 1444-1447.
    • (1995) Cancer Res , vol.55 , pp. 1444-1447
    • Mills, N.E.1
  • 79
    • 0032521206 scopus 로고    scopus 로고
    • Intracellular expression of an antibody fragment-neutralizing p21 Ras promotes tumor regression
    • Cochet O et al. Intracellular expression of an antibody fragment-neutralizing p21 Ras promotes tumor regression. Cancer Res 1998; 58: 1170-1176.
    • (1998) Cancer Res , vol.58 , pp. 1170-1176
    • Cochet, O.1
  • 80
    • 0028927887 scopus 로고
    • Constitutive expression of the c-Ha-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcome cell line
    • Nooter K et al. Constitutive expression of the c-Ha-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcome cell line. Br J Cancer 1995; 71: 556-561.
    • (1995) Br J Cancer , vol.71 , pp. 556-561
    • Nooter, K.1
  • 81
    • 0031039955 scopus 로고    scopus 로고
    • The molecular epidemiology of p53 gene mutations in human breast cancer
    • Hartmann A, Blaszyk H, Kovach JS, Sommer SS. The molecular epidemiology of p53 gene mutations in human breast cancer. Trends Genet 1997; 13: 27-33.
    • (1997) Trends Genet , vol.13 , pp. 27-33
    • Hartmann, A.1    Blaszyk, H.2    Kovach, J.S.3    Sommer, S.S.4
  • 82
    • 0030669223 scopus 로고    scopus 로고
    • A single chain Fv fragment of P-glycoprotein-specific monoclonal antibody C219
    • Hoedemaeker FJ et al. A single chain Fv fragment of P-glycoprotein-specific monoclonal antibody C219. J Biol Chem 1997; 47: 29784-29789.
    • (1997) J Biol Chem , vol.47 , pp. 29784-29789
    • Hoedemaeker, F.J.1
  • 83
    • 0028707690 scopus 로고
    • Protein kinases and cell cycle control
    • Pines J. Protein kinases and cell cycle control. Semin Cell Biol 1994; 5: 399-408.
    • (1994) Semin Cell Biol , vol.5 , pp. 399-408
    • Pines, J.1
  • 85
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
    • Hall M, Peters G. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 1996; 68: 67-108.
    • (1996) Adv Cancer Res , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 86
    • 0024374960 scopus 로고
    • Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma
    • Arnold A et al. Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. J Clin Invest 1989; 83: 2034-2040.
    • (1989) J Clin Invest , vol.83 , pp. 2034-2040
    • Arnold, A.1
  • 87
    • 0030064902 scopus 로고    scopus 로고
    • Cyclin D1 gene amplification in human laryngeal squamous cell carcinomas: Prognostic significance and clinical implications
    • Bellacosa A et al. Cyclin D1 gene amplification in human laryngeal squamous cell carcinomas: prognostic significance and clinical implications. Clin Cancer Res 1996; 2: 175-180.
    • (1996) Clin Cancer Res , vol.2 , pp. 175-180
    • Bellacosa, A.1
  • 88
    • 0345079468 scopus 로고    scopus 로고
    • Inhibition of cyclin D1 oncogene with intracellular single chain antibodies. Exploring and exploiting antibody and Ig superfamily combining sites
    • New Mexico, 22-28 February
    • Poul M-A, Teyssier C, Lefranc M-P. Inhibition of cyclin D1 oncogene with intracellular single chain antibodies. Exploring and exploiting antibody and Ig superfamily combining sites. Keystone Symposia, New Mexico, 22-28 February, 1996.
    • (1996) Keystone Symposia
    • Poul, M.-A.1    Teyssier, C.2    Lefranc, M.-P.3
  • 89
    • 0030098908 scopus 로고    scopus 로고
    • Effect of antisense c-erbB2 on biologic behaviour and chemotherapeutic drug sensitivity in human ovarian cancer cells
    • Wu L, Wu A, Jiang K. Effect of antisense c-erbB2 on biologic behaviour and chemotherapeutic drug sensitivity in human ovarian cancer cells. Chung Hua Fu Can Ko Tsa Chih 1996; 31: 169-172.
    • (1996) Chung Hua Fu Can Ko Tsa Chih , vol.31 , pp. 169-172
    • Wu, L.1    Wu, A.2    Jiang, K.3
  • 90
    • 0031856726 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (EGFR) antisense transfection reduces the expression of EGFR and suppresses the malignant phenotype of a human ovarian cancer cell line
    • Brader KR, Wolf JK, Chakrabarty S, Price JE. Epidermal growth factor receptor (EGFR) antisense transfection reduces the expression of EGFR and suppresses the malignant phenotype of a human ovarian cancer cell line. Oncol Res 1998; 5: 1269-1274.
    • (1998) Oncol Res , vol.5 , pp. 1269-1274
    • Brader, K.R.1    Wolf, J.K.2    Chakrabarty, S.3    Price, J.E.4
  • 91
    • 0030757686 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells
    • Grandis JR et al. Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogene 1997; 15: 409-416.
    • (1997) Oncogene , vol.15 , pp. 409-416
    • Grandis, J.R.1
  • 92
    • 0032528051 scopus 로고    scopus 로고
    • Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter
    • He YK et al. Inhibition of human squamous cell carcinoma growth in vivo by epidermal growth factor receptor antisense RNA transcribed from the U6 promoter. J Natl Cancer Inst 1998; 90: 1080-1087.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 1080-1087
    • He, Y.K.1
  • 93
    • 0031041268 scopus 로고    scopus 로고
    • Abrogation of cisplatin-induced programmed cell death in human breast cancer cells by epidermal growth factor antisense RNA
    • Dixit M et al. Abrogation of cisplatin-induced programmed cell death in human breast cancer cells by epidermal growth factor antisense RNA. J Natl Cancer Inst 1997; 89: 365-373.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 365-373
    • Dixit, M.1
  • 94
    • 0032518616 scopus 로고    scopus 로고
    • Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum
    • Kornmann M, Arber N, Korc M. Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum. J Clin Invest 1998; 101: 344-352.
    • (1998) J Clin Invest , vol.101 , pp. 344-352
    • Kornmann, M.1    Arber, N.2    Korc, M.3
  • 95
    • 0031278624 scopus 로고    scopus 로고
    • Cyclin D-1 antisense RNA destablilizes PRB and retards lung cancer cell growth
    • Driscoll B et al. Cyclin D-1 antisense RNA destablilizes PRB and retards lung cancer cell growth. Am J Physiol-Lung Cell & Mol Physiol 1997; 17: 941-949.
    • (1997) Am J Physiol-Lung Cell & Mol Physiol , vol.17 , pp. 941-949
    • Driscoll, B.1
  • 96
    • 0029080861 scopus 로고
    • Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of eosphagal cancer cells
    • Zhou P et al. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of eosphagal cancer cells. Oncogene 1995; 11: 571-580.
    • (1995) Oncogene , vol.11 , pp. 571-580
    • Zhou, P.1
  • 97
    • 0030949419 scopus 로고    scopus 로고
    • Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells
    • Arber N et al. Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells. Cancer Res 1997; 57: 1569-1574.
    • (1997) Cancer Res , vol.57 , pp. 1569-1574
    • Arber, N.1
  • 98
    • 0028910558 scopus 로고
    • Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C
    • Keith FJ, Bardbury DA, Ahu YM, Russell NH. Inhibition of bcl-2 with antisense oligonucleotides induces apoptosis and increases the sensitivity of AML blasts to Ara-C. Leukemia 1995; 9: 131-138.
    • (1995) Leukemia , vol.9 , pp. 131-138
    • Keith, F.J.1    Bardbury, D.A.2    Ahu, Y.M.3    Russell, N.H.4
  • 99
    • 0031907428 scopus 로고    scopus 로고
    • Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
    • Jansen B et al. Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nature Med 1998; 4: 232-234.
    • (1998) Nature Med , vol.4 , pp. 232-234
    • Jansen, B.1
  • 100
    • 0030045221 scopus 로고    scopus 로고
    • Tissue-targeted antisense c-fos retroviral vector inhibits established breast cancer xenografts in nude mice
    • Arteaga CL, Holt JT. Tissue-targeted antisense c-fos retroviral vector inhibits established breast cancer xenografts in nude mice. Cancer Res 1996; 56: 1098-1103.
    • (1996) Cancer Res , vol.56 , pp. 1098-1103
    • Arteaga, C.L.1    Holt, J.T.2
  • 101
    • 0029124127 scopus 로고
    • Liposme-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity
    • Aoki K, Yoshida T, Sugimura T, Terada M. Liposme-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity. Cancer Res 1995; 55: 3810-3816.
    • (1995) Cancer Res , vol.55 , pp. 3810-3816
    • Aoki, K.1    Yoshida, T.2    Sugimura, T.3    Terada, M.4
  • 102
    • 0030578220 scopus 로고    scopus 로고
    • Gene therapy for the treatment of metastatic breast cancer by in vivo transduction with breast-targeted retroviral vector expressing antisense c-fos RNA
    • Holt JT, Arteaga CL, Roberston D, Moses HL. Gene therapy for the treatment of metastatic breast cancer by in vivo transduction with breast-targeted retroviral vector expressing antisense c-fos RNA. Hum Gene Ther 1996; 7: 1367-1380.
    • (1996) Hum Gene Ther , vol.7 , pp. 1367-1380
    • Holt, J.T.1    Arteaga, C.L.2    Roberston, D.3    Moses, H.L.4
  • 104
    • 0028231401 scopus 로고
    • Reversal of drug sensitivity in multidrug-resistant tumor cells by an MDR1 (PGY1) ribozyme
    • Kobayashi H, Dorai T, Hooland JF, Ohnuma T. Reversal of drug sensitivity in multidrug-resistant tumor cells by an MDR1 (PGY1) ribozyme. Cancer Res 1994; 54: 1271-1275.
    • (1994) Cancer Res , vol.54 , pp. 1271-1275
    • Kobayashi, H.1    Dorai, T.2    Hooland, J.F.3    Ohnuma, T.4
  • 105
    • 0028071663 scopus 로고
    • Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells
    • Kiehntopf M et al. Ribozyme-mediated cleavage of the MDR-1 transcript restores chemosensitivity in previously resistant cancer cells. EMBO J 1994; 13: 4645-4646.
    • (1994) EMBO J , vol.13 , pp. 4645-4646
    • Kiehntopf, M.1
  • 106
    • 0030822629 scopus 로고    scopus 로고
    • Development of a hammerhead ribozyme against bcl-2. I. Preliminary evaluation of a potential gene therapeutic agent for hormone-refractory human prostate cancer
    • Dorai T, Olsson CA, Katz AE, Buttyan R. Development of a hammerhead ribozyme against bcl-2. I. Preliminary evaluation of a potential gene therapeutic agent for hormone-refractory human prostate cancer. Prostate 1997; 32: 246-258.
    • (1997) Prostate , vol.32 , pp. 246-258
    • Dorai, T.1    Olsson, C.A.2    Katz, A.E.3    Buttyan, R.4
  • 107
    • 0030830717 scopus 로고    scopus 로고
    • Development of a hammerhead ribozyme against Bcl-2. 2. Ribozyme treatment sensitizes hormone-resistant prostate cancer cells to apoptotic agents
    • Dorai T, Goluboff ET, Olsson CA, Buttyan R. Development of a hammerhead ribozyme against Bcl-2. 2. Ribozyme treatment sensitizes hormone-resistant prostate cancer cells to apoptotic agents. Anticancer Res 1997; 17: 3307-3312.
    • (1997) Anticancer Res , vol.17 , pp. 3307-3312
    • Dorai, T.1    Goluboff, E.T.2    Olsson, C.A.3    Buttyan, R.4
  • 108
    • 0031755915 scopus 로고    scopus 로고
    • Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simple virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer
    • Rancourt C et al. Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simple virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer. Clin Cancer Res 1998; 4: 2455-2461.
    • (1998) Clin Cancer Res , vol.4 , pp. 2455-2461
    • Rancourt, C.1
  • 109
    • 0344648777 scopus 로고    scopus 로고
    • Retargeting adenovirus vectors with FGF-2 leads to enhanced efficacy and decreased toxicity
    • Gu D et al. Retargeting adenovirus vectors with FGF-2 leads to enhanced efficacy and decreased toxicity. Proc Am Assoc Cancer Res 1998; 39: 512.
    • (1998) Proc Am Assoc Cancer Res , vol.39 , pp. 512
    • Gu, D.1
  • 110
    • 0030775646 scopus 로고    scopus 로고
    • Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector
    • Feng M et al. Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector. Nature Biotechnol 1997; 15: 866-870.
    • (1997) Nature Biotechnol , vol.15 , pp. 866-870
    • Feng, M.1
  • 111
    • 0030812867 scopus 로고    scopus 로고
    • HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells
    • Johnston KM et al. HSV/AAV hybrid amplicon vectors extend transgene expression in human glioma cells. Hum Gene Ther 1997; 8: 359-370.
    • (1997) Hum Gene Ther , vol.8 , pp. 359-370
    • Johnston, K.M.1
  • 112
    • 0031025998 scopus 로고    scopus 로고
    • Gene therapy for cancer: What have we done and where are we going?
    • Roth JA, Cristiano RJ. Gene therapy for cancer: what have we done and where are we going? J Natl Cancer Inst 1997; 89: 21-39.
    • (1997) J Natl Cancer Inst , vol.89 , pp. 21-39
    • Roth, J.A.1    Cristiano, R.J.2
  • 113
    • 0027787053 scopus 로고
    • In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy
    • Bi WL, Parysek LM, Warnick R, Stambrook PJ. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum Gene Ther 1993; 4: 725-731.
    • (1993) Hum Gene Ther , vol.4 , pp. 725-731
    • Bi, W.L.1    Parysek, L.M.2    Warnick, R.3    Stambrook, P.J.4
  • 114
    • 0028856844 scopus 로고
    • Effect of herpes simplex thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the 'bystander effect'
    • Chen CY et al. Effect of herpes simplex thymidine kinase expression levels on ganciclovir-mediated cytotoxicity and the 'bystander effect'. Hum Gene Ther 1995; 6: 1467-1476.
    • (1995) Hum Gene Ther , vol.6 , pp. 1467-1476
    • Chen, C.Y.1
  • 115
    • 0029997766 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells
    • Hamel W, Magnelli L, Chiarugi VP, Israel MA. Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res 1996; 56: 2697-2702.
    • (1996) Cancer Res , vol.56 , pp. 2697-2702
    • Hamel, W.1    Magnelli, L.2    Chiarugi, V.P.3    Israel, M.A.4
  • 116
    • 0028143201 scopus 로고
    • Therapeutic effect of a retroviral wild-type p53 expression vector in an orthoptic lung cancer model
    • Fujiwara T et al. Therapeutic effect of a retroviral wild-type p53 expression vector in an orthoptic lung cancer model. J Natl Cancer Inst 1994; 86: 1458-1462.
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1458-1462
    • Fujiwara, T.1
  • 117
    • 0030969022 scopus 로고    scopus 로고
    • p53-mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy
    • Pirollo KF et al. p53-mediated sensitization of squamous cell carcinoma of the head and neck to radiotherapy. Oncogene 1997; 14: 1735-1746.
    • (1997) Oncogene , vol.14 , pp. 1735-1746
    • Pirollo, K.F.1
  • 118
    • 0031755588 scopus 로고    scopus 로고
    • Bystander effect in the adenovirus-mediated wild-type p53 gene therapy model of human squamous cell carcinoma of the head and neck
    • Frank DK, Frederick MJ, Liu T-J, dayman GL. Bystander effect in the adenovirus-mediated wild-type p53 gene therapy model of human squamous cell carcinoma of the head and neck. Clin Cancer Res 1998; 4: 2521-2527.
    • (1998) Clin Cancer Res , vol.4 , pp. 2521-2527
    • Frank, D.K.1    Frederick, M.J.2    Liu, T.-J.3    Dayman, G.L.4
  • 119
    • 0031749970 scopus 로고    scopus 로고
    • The expression of drug resistance gene products during the progression of human prostate cancer
    • Sullivan GF, Amenta PS, Villanueva JD, Alvarez CJ. The expression of drug resistance gene products during the progression of human prostate cancer. Clin Cancer Res 1998; 4: 1393-1403.
    • (1998) Clin Cancer Res , vol.4 , pp. 1393-1403
    • Sullivan, G.F.1    Amenta, P.S.2    Villanueva, J.D.3    Alvarez, C.J.4


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