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0009562389
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note
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In the case of phenyl n-propyl sulfide, extended reactions in the presence of the engineered yeast strain gave only a low yield of the corresponding (R)-sulfoxide in 25% ee. Neither ethyl thiophenylacetate nor methyl β-(thiophenyl)ethyl ether afforded any sulfoxide products, even after extended reaction times. Moreover, when the racemic sulfoxides derived from these thioethers were incubated with the yeast strain, all traces of the sulfoxides disappeared within 78 h. We did not investigate the fates of these materials further.
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42
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36349008454
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C. C. R. Allen, D. R. Boyd, H. Dalton, N. D. Sharma, S. A. Haughey, R. A. S. McMordie, B. T. McMurray, G. N. Sheldrake and K. Sproule, J. Chem. Soc., Chem. Commun., 1995, 119.
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43
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0009610623
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Details of this construction are provided as Supplementary Material
-
Details of this construction are provided as Supplementary Material.
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44
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0023958999
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46
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0009629355
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note
-
Using racemic sulfoxide 5a and purified cyclohexanone monooxygenase, Colonna and co-workers estimated an enantioselectivity value of 12 for the oxidation of 5a to 7a.
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