Neuropeptide Y gene expression in lines of mice subjected to long-term divergent selection on fat content

Journal of Molecular Endocrinology

Volumn 23, Issue 1, 1999, Pages 77-83

  Boswell, T ^a   Nicholson, M A ^b   Bunger L ^c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b AMGEN INC   (United States)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE Y;

ARTICLE; BODY FAT; BODY MASS; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION;

ADIPOSE TISSUE; ANIMALS; BODY COMPOSITION; BODY WEIGHT; FEMALE; GENE EXPRESSION; LEPTIN; MALE; MICE; MICE, INBRED CBA; MICE, INBRED STRAINS; NEUROPEPTIDE Y; OBESITY; PROTEINS; RNA, MESSENGER; SELECTION (GENETICS); TIME FACTORS; VARIATION (GENETICS);

EID: 0032768528     PISSN: 09525041     EISSN: None     Source Type: Journal    
DOI: 10.1677/jme.0.0230077     Document Type: Article

References (38)

1. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E & Flier JS 1996 Role of leptin in the neuroendocrine response to fasting. Nature 382 250-252.
2. Bünger L & Hill WG 1997 Effects of leptin administration on long-term selected fat mice. Genetical Research 69 215-225.
3. Bünger L & Hill WG 1999 Inbred lines derived from long-term divergent selection on fat content and body weight. Mammalian Genome (In Press).
4. Bünger L, Wallace H, Bishop JO, Hastings IM & Hill WG 1998a Effects of thyroid hormone deficiency on mice selected for increased and decreased body weight and fatness. Genetical Research 72 39-53.
5. Bünger L, Nicholson M & Hill WG 1998b Leptin levels in lines of mice developed by long-term divergent selection on fat content. Genetical Research 73 37-44.
6. Billington CJ, Briggs JE, Harker S, Grace M & Levine AS 1994 Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism. American Journal of Physiology 266 R1765-R1770.
7. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL & Considine RV 1996 Leptin: the tale of an obesity gene. Diabetes 45 1455-1462.
8. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI & Morgenstern JP 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84 491-495.
9. Chua SC Jr, Brown AW, Kim J, Hennessey KL, Leibel RL & Hirsch J 1991a Food deprivation and hypothalamic neuropeptide gene expression: effects of strain background and the diabetes mutation. Molecular Brain Research 11 291-299.
10. Chua SC Jr, Leibel RL & Hirsch J 1991b Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland. Molecular Brain Research 9 95-101.
11. Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu S-M, Tartaglia L & Leibel RL 1996 Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271 994-996.
12. Clark JT, Kalra PS, Crowley WR & Kalra SP 1984 Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115 427-429.
13. Da Silva BA, Bjørbaek C, Uotani S & Flier JS 1998 Functional properties of leptin receptor isoforms containing the Gln-Pro extracellular domain mutation of the fatty rat. Endocrinology 139 3681-3690.
14. Doolittle DP, Davisson MT, Guidi JN & Green MC 1996 Catalog of mutant genes and polymorphic loci. In Genetic Variants and Strains of the Laboratory Mouse, edn 3, pp 17-854. Eds MF Lyon, S Rastan & SDM Brown. Oxford: Oxford University Press.
15. Friedman JM & Halaas JL 1998 Leptin and the regulation of body weight in mammals. Nature 395 763-770.
16. Gilmour AR, Thompson R, Cullis BR & Welham SJ 1997 ASREML Manual. New South Wales, Australia: Department of Agriculture.
17. Hastings IM & Hill WG 1989 A note on the effect of different selection criteria on carcass composition in mice. Animal Production 48 229-233.
18. Hastings IM, Yang J & Hill WG 1991 Analysis of lines of mice selected on fat content. 4. Correlated responses in growth and reproduction. Genetical Research 58 253-259.
19. Higuchi H, Yang H-YT & Sabol S 1988 Rat neuropeptide Y precursor gene expression. Journal of Biological Chemistry 263 6288-6295.
20. Hollopeter G, Erickson JC & Palmiter RD 1998 Role of neuropeptide Y in diet-, chemical- and genetic-induced obesity of mice. International Journal of Obesity 22 506-512.
21. Hotta K, Gustafson TA, Ortmeyer HK, Bodkin NL, Nicolson MA & Hansen BC 1996 Regulation of obese (ob) mRNA and plasma leptin levels in rhesus monkeys. Effects of insulin, body weight, and non-insulin-dependent diabetes mellitus. Journal of Biological Chemistry 271 25327-25331.
22. Kalra SP, Dube MG, Sahu A, Phelps CP & Kalra PS 1991 Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proceedings of the National Academy of Sciences of the USA 88 10931-10935.
23. Kesterson RA, Huszar D, Lynch CA, Simerly RB & Cone RD 1997 Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the Agouti obesity syndrome. Molecular Endocrinology 11 630-637.
24. Kotz CM, Briggs JE, Pomonis JD, Grace MK, Levine AS & Billington CJ 1998 Neural site of leptin influence on neuropeptide Y signaling pathways altering feeding and uncoupling protein. American Journal of Physiology 275 R478-R484.
25. Lee G-H, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI & Friedman JM 1996 Abnormal splicing of the leptin receptor in diabetic mice. Nature 379 632-635.
26. Mantzoros CS, Frederich RC, Qu D, Lowell BB, Maratos-Flier E & Flier JS 1998 Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes 47 230-238.
27. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Morgan PJ & Trayhurn P 1996 Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. Journal of Neuroendocrinology 8 733-735.
28. Palmiter RD, Erickson JC, Hollopeter G, Baraban SC & Schwartz MW 1998 Life without neuropeptide Y. Recent Progress in Hormone Research 53 163-199.
29. Sanacora G, Kershaw M, Finkelsteiri JA & White JD 1990 Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology 127 730-737.
30. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ & Weigle DS 1996 Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45 531-535.
31. Schwartz MW, Erickson JC, Baskin DG & Palmiter RD 1998 Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology 139 2629-2635.
32. Sharp GL, Hill WG & Robertson A 1984 Effects of selection on growth, body composition and food intake in mice. 1. Responses in selected traits. Genetical Research 43 75-92.
33. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Hoffmann J, Hsiung HM, Kriauciunas A, MacKellar W, Rosteck PR Jr, Schoner B, Smith D, Tinsley FC, Zhang XY & Heiman M 1995 The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377 530-532.
34. White JD & Kershaw M 1990 Increased hypothalamic neuropeptide Y expression following food deprivation. Molecular and Cellular Neurosciences 1 41-48.
35. Wilding JPH, Gilbey SG, Mannan M, Aslam N, Ghatei MA & Bloom SR 1992 Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats. Journal of Endocrinology 132 299-304.
36. Wilding JPH, Gilbey SG, Bailey CJ, Batt RAL, Williams G, Ghatei MA & Bloom SR 1993 Increased neuropeptide Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology 132 1939-1944.
37. Williams G, Shellard L, Lewis DE, McKibbin PE, McCarthy HD, Koeslag DG & Russell JC 1992 Hypothalamic neuropeptide Y disturbances in the obese (cp/cp) JCR:LA corpulent rat. Peptides 13 537-540.
38. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372 425-432.