Overexpression of dominant negative mutant hepatocyte nuclear factor (HNF)-1α inhibits arginine-induced insulin secretion in MIN6 cells

Diabetologia

Volumn 42, Issue 7, 1999, Pages 887-891

  Tanizawa, Y ^a,b   Ohta, Y ^a   Nomiyama, J ^a   Matsuda, K ^a   Tanabe, K ^a   Inoue, H ^a   Matsutani, A ^a   Okuya, S ^a   Oka, Y ^a  

^a YAMAGUCHI UNIVERSITY   (Japan)

^b YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Arginine; Dominant negative effect; Hepatocyte nuclear factor 1 ; MIN6 cells; MODY; Recombinant adenovirus

Indexed keywords

ALPHA 1 ANTITRYPSIN; ARGININE; CARRIER PROTEIN; GLUCOSE; HOMOARGININE; INSULIN; LEUCINE; NUCLEAR FACTOR I; PHENYLALANINE 4 MONOOXYGENASE; POTASSIUM CHLORIDE;

ADENOVIRUS; ALLELE; ANIMAL CELL; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULINOMA; MATURITY ONSET DIABETES MELLITUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR CELL LINE;

ANIMALS; ARGININE; DNA-BINDING PROTEINS; GENE EXPRESSION; HEPATOCYTE NUCLEAR FACTOR 1; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HEPATOCYTE NUCLEAR FACTOR 1-BETA; HUMANS; INSULIN; MUTATION; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0032765354     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051242     Document Type: Article

References (19)

1. 1. Yamagata K, Oda N, Kaisaki PJ et al. (1996) Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3). Nature 384: 455-458
2. 2. Yamagata K, Furuta H, Oda N et al. (1996) Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1). Nature 384: 458-460
3. 3. Tronche F, Yaniv M (1992) HNF1, a homeoprotein member of the hepatic transcription regulatory network. BioEssays 14: 579-587
4. 4. Byrne MM, Sturis J, Fajans SS et al. (1995) Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20. Diabetes 44: 699-704
5. 5. Byrne MM, Sturis J, Menzel S et al. (1996) Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes 45: 1503-1510
6. 6. Hansen T, Eiberg H, Rouard M et al. (1997) Novel MODY3 mutations in the hepatocyte nuclear factor-1α gene. Evidence for a hyperexcitability of pancreatic β-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation. Diabetes 46: 726-730
7. 7. Herman WH, Fajans SS, Smith MJ, Polonsky KS, Bell GI, Halter JB (1997) Diminished insulin and glucagon secretory response to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4α/MODY1 gene. Diabetes 46: 1749-1754
8. 8. Yamagata K, Yang Q, Yamamoto K et al. (1998) Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1α is dominant negative. Diabetes 47: 1231-1235
9. 9. Closs EI, Albritton LM, Kim JW, Cunningham JM (1993) Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver. J Biol Chem 268: 7538-7544
10. 10. Miyake S, Makimura M, Kanegae Y et al. (1996) Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome Proc Natl Acad Sci USA 93: 1320-1324
11. 11. Ishihara H, Nakazaki M, Kanagae Y et al. (1996) Effect of mitochondrial and/or cytosolic glycerol 3-phosphate dehydrogenase overexpression on glucose-stimulated insulin secretion from MIN6 and HIT cells. Diabetes 45: 1238-1244
12. 12. Pontoglio M, Barra J, Hadchouel M et al. (1996) Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell 84: 575-585
13. 13. Smith PA, Sakura H, Coles B, Gummerson N, Proks P, Ashcroft FM (1997) Electrogenic arginine transport mediated stimulus-secretion coupling in mouse pancreatic β-cells. J Physiol (Lond) 499: 625-635
14. 14. Emens LA, Landes DW, Moss LG (1992) Hepatocyte nuclear factor 1α is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. Proc Natl Acad Sci USA 89: 7300-7304
15. 15. Takeda J, Kayano T, Fukomoto H, Bell GI (1993) Organization of the human GLUT2 (pancreatic beta-cell and hepatocyte) glucose transporter gene. Diabetes 42: 773-777
16. 16. Schmidt HH, Warner TD, Ishii K, Sheng H, Murad F (1992) Insulin secretion from pancreatic beta-cells caused by L-arginine derived nitrogen oxides. Science 255: 721-723
17. 17. Jones PM, Persaud SJ, Bjaaland T, Pearson JD, Howell SL (1992) Nitric oxide is not involved in the initiation of insulin secretion from rat islets of Langerhans. Diabetologia 35: 1020-1027
18. 18. Charles S, Tamagawa T, Henquin JC (1982) A single mechanism for the stimulation of insulin release and Rb efflux from rat islets by cationic amino acids. Biochem J 208: 301-308
19. 19. Pontoglio M, Sreenan S, Roe M et al. (1998) Defective insulin secretion in hepatocyte nuclear factor 1α-deficient mice. J Clin Invest 101: 2215-2222