β-Carotene produces sustained remissions in patients with oral leukoplakia. Results of a multicenter prospective trial

Archives of Otolaryngology - Head and Neck Surgery

Volumn 125, Issue 12, 1999, Pages 1305-1310

  Garewal, Harinder ^a,c,g   Katz, R V ^d   Meyskens, F ^e   Pitcock, J ^e   Morse, D ^d   Friedman, S ^a,c   Peng, Y ^a   Pendrys, D G ^d   Mayne, S ^f   Alberts, D ^a   Kiersch, T ^b   Graver, E ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c S Arizona Vet' Aff Hlthcare S   (United States)

^d UNIVERSITY OF CONNECTICUT   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Section of Hematology Oncology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CAROTENE; PLACEBO;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER REGRESSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; HUMAN; LEUKOPLAKIA; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRECANCER; RANDOMIZED CONTROLLED TRIAL; TUMOR BIOPSY;

EID: 0032764956     PISSN: 08864470     EISSN: None     Source Type: Journal    
DOI: 10.1001/archotol.125.12.1305     Document Type: Article

References (27)

1. Garewal HS, Meyskens FL, Killen D, et al. Response of oral leukoplakia to beta-carotene. J Clin Oncol. 1990;8:1715-1720.
2. Garewal H. Antioxidants in oral cancer prevention. Am J Clin Nutr. 1995;62 14105-14165.
3. Toma S, Micheletti A, Giacchero A, et al. Selenium therapy in patients with precancerous and malignant oral cavity lesions: preliminary results. Cancer Detect Prev. 1991;15:491-494.
4. Kaugars G, Silverman S. The use of 13-cis-retinoic acid in the treatment of oral leukoplakia: short-term observations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:264-265.
5. Krishnaswamy K, Prasad MPR, Krishna TP, Annapurna VV, Reddy GA. A case study of nutrient intervention of oral precancerous lesions in India. Oral Oncol. 1995;31B:41-48.
6. Stich HF, Rosin MP, Hornby AP. Remission of oral leukoplakias and micronuclei in tobacco/betel quid chewers treated with beta-carotene and with beta-carotene plus vitamin A. Int J Cancer. 1988;42:195-199.
7. Kaugars GE, Silverman S, Lovas JGL, et al. A clinical trial of antioxidant supplements in the treatment of oral leukoplakia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1994;78:462-468.
8. Stich HF, Hornby AP, Dunn BP. A pilot beta-carotene intervention trial with Inuits using smokeless tobacco. Int J Cancer 1985;36:321-327.
9. Malaker K, Anderson BJ, Beecroft WA, Hodson DI. Management of oral mucosal dysplasia with beta-carotene retinoic acid: a pilot cross-over study. Cancer Detect Prev. 1991;15:335-340.
10. Zaridze D, Evstifeeva T, Boyle P. Chemoprevention of oral leukoplakia and chronic esophagitis in an area of high incidence of oral and esophageal cancer. Ann Epidemiol. 1993;3:225-234.
11. Peng YS, Peng YM. Simultaneous liquid chromatographic determination of carotenoids, retinoids, and tocopherols in human buccal mucosal cells. Cancer Epidemiol Biomarkers Prev. 1992;1:375-382.
12. Block G, Hartman AM, Dresser CM, Carroll MD, Gannon J, Gardner L. A databased approach to diet questionnaire design and testing. Am J Epidemiol. 1986; 124:453-469.
13. Ritenbaugh CR, Peng YM, Aickin MA, Graver E, Branch M, Alberts DS. New carotenoid values for foods improve relationship of food frequency questionnaire intake estimates to plasma levels. Cancer Epidemiol Biomarkers Prev. 1996;5: 907-912.
14. Krutchkoff DJ, Eisenberg E, Anderson C. Dysplasia of oral mucosa: a unified approach to proper evaluation. Mod Pathol. 1991;4:115-119.
15. Lippman SM, Batsakis JG, Toth B, et al. Comparison of low-dose isotretinoin with beta-carotene to prevent oral carcinogenesis. N Engl J Med. 1993;328:15-20.
16. Garewal HS, Schantz S. Emerging role of beta-carotene and antioxidant nutrients in oral cancer prevention. Arch Otolaryngol Head Neck Surg. 1995;121:141-146.
17. Stich HF, Stich W, Rosin MP, Vallejera DM. Use of the micronucleus test to monitor the effect of vitamin A, beta-carotene and canthaxanthin on the buccal mucosa of betel nut/tobacco chewers. Int J Cancer. 1990;34:745-750.
18. Garewal HS, Ramsey L, Kaugars G, Boyle J. Clinical experience with the micronucleus assay. J Cell Biochem Suppl. 1993;17F:206-212.
19. Xu MJ, Plezia PM, Alberts DS, et al. Reduction in plasma or skin alpha-tocopherol concentration with long-term oral administration of beta-carotene in humans and mice. J Natl Cancer Inst. 1992;84:1559-1565.
20. Nirenberg DW, Dain BJ, Mott LA, Baron JA, Greenberg ER. Effects of four years of oral supplementation with β-carotene on serum concentrations of retinol, tocopherol and five carotenoids. Am J Clin Nutr. 1997;66:315-319.
21. Goodman GE, Metch BJ, Omenn GS. The effect of long-term β-carotene and vitamin A administration on serum concentrations of α-tocopherol. Cancer Epidemiol Biomarkers Prev. 1994;3:429-432.
22. McClarty JW. An intervention trial in high-risk asbestos-exposed persons. In: Newell GR, Hong WK, eds. The Biology and Prevention of Aerodigestive Tract Cancer. New York, NY: Plenum Press Inc; 1992:141-149.
23. Willett WC, Stampfer MJ, Underwood BA, Taylor JO, Hennekens CH. Vitamins A, E and carotene: effects of supplementation on their plasma levels. Am J Clin Nutr. 1983;38:559-566.
24. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study Group. The effect of vitamin E and beta-carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330:1029-1035.
25. Omenn GS, Goodman G, Thornquist MD, et al. Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:1150-1155.
26. Stephens NG, Parsons A, Schofield PM, et al. Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet. 1996;347:781-786.
27. Clark LC, Combs GF, Turnbull BW, et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. JAMA. 1996;276: 1957-1963.