Induction of hepatic xenobiotic metabolizing enzymes in female Fischer- 344 rats following repeated inhalation exposure to decamethylcyclopentasiloxane (D5)

Toxicological Sciences

Volumn 50, Issue 1, 1999, Pages 10-19

  McKim J M , Jr ^a   Choudhuri, S ^a   Wilga, P C ^a   Madan, A ^a   Burns Naas, L A ^a   Gallavan, R H ^a   Mast, R W ^a   Naas, D J ^a   Parkinson, A ^a   Meeks, R G ^a  

^a PFIZER INC   (United States)

Author keywords

Cytochrome P450 inhalation exposure; Decamethylcyclopentasiloxane (D5); Hepatic enzymes; Rat

Indexed keywords

4 NITROPHENOL; CYTOCHROME P450; CYTOCHROME P450 3A; CYTOCHROME P450 4A; DECAMETHYLCYCLOPENTASILOXANE; EPOXIDE HYDROLASE; ETHOXYRESORUFIN DEETHYLASE; GLUCURONOSYLTRANSFERASE; LAURIC ACID; PENTOXYRESORUFIN DEALKYLASE; PHENACETIN O DEETHYLASE; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; SILICONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; EXPOSURE; FEMALE; LIVER SIZE; NONHUMAN; PROTEIN EXPRESSION; RAT;

ADMINISTRATION, INHALATION; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; LIVER; MICROSOMES, LIVER; RATS; RATS, INBRED F344; SILOXANES; TIME FACTORS;

ANIMALIA;

EID: 0032764718     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/50.1.10     Document Type: Article

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