Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice

Toxicology and Applied Pharmacology

Volumn 141, Issue 2, 1996, Pages 584-594

  Bookstaff, Robert C ^a   Murphy, Vincent A ^a   Skare, Julie A ^a   Minnema, Daniel ^b   Sanzgiri, Uma ^c   Parkinson, Andrew ^c  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b UK   (United States)

^c UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYLAMINE; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; FEMALE; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; THYROID HORMONE BLOOD LEVEL;

EID: 0030461326     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0325     Document Type: Article

References (39)

1. Budroe, J. D., Shaddock, J. G., and Casciano, D. A. (1984). A study of the potential genotoxicity of methapyrilene and related antihistamines using the hepatocyte/DNA repair assay. Mutat. Res. 135, 131-137.
2. Burke, M. D., and Maer, R. T. (1974). Ethoxyresorufin: Direct fluorimetric assay of microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 2, 583-588.
3. Capen, C. C. (1992). Pathophysiology of chemical injury of the thyroid gland. Toxicol. Lett. 64/65, 381-388.
4. Carriere, V., Goasduff, T., Ratanasavanh, D., Morel, F., Gautier, J.-C., Guillouzo, A., Beaune, P., and Berthou, F. (1993). Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone. Chem. Res. Toxicol. 6, 852-857.
5. Casciano, D. A., Schol, H. M., Shaddock, J. G., and Feuers, R. J. (1986). Failure of methapyrilene and selected analogous to induce mutations in the Chinese hamster ovary mutagenesis assay system. Environ. Mutagen. 8(Suppl. 6), 16.
6. Curran, P. G., and DeGroot, L. J. (1991). The effect of hepatic enzyme-inducing drugs on thyroid hormones and the thyroid gland. Endocrine Rev. 12, 135-150.
7. De Sandro, V., Catinot, R., Kriszt, W., Cordier, A., and Richert, L. (1992). Male rat hepatic UDP-glucuronosyltransferase activity toward thyroxine. Activation and induction properties - Relation with thyroxine plasma disappearance rate. Biochem. Pharmacol. 43, 1563-1569.
8. Diwan, B. A., Palmer, A. E., Ohshima, M., and Rice, J. M. (1985). N-Nitroso-N-methylurea initiation in multiple tissues for organ-specific tumor promotion in rats by phenobarbital. J. Natl. Cancer Inst. 75, 1099-1105.
9. 125I-labeled thyroxine glucuronide by reverse-phase high-performance liquid chromatography using on-line radiochemical detection to determine UDP-glucuronosyltransferase activity. J. Chromatogr. 566, 415-426.
10. Dutton, D. R., and Parkinson, A. (1989). Reduction of 7-alkoxyresorufins by NADPH-cytochrome P450 reductase and its differential effects on their O-dealkylation by rat liver microsomal cytochrome P459. Arch. Biochem. Biophys. 268, 617-629.
11. Gibson, G. G., Orton, T. C., and Tamburini, P. P. (1982). Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanois acid (lauric acid). Biochem. J. 203, 161-168.
12. Giera, D. D., and van Lier, R. B. (1991). A convenient method for the determination of hepatic lauric acid ω̄oxidation based on solvent partition. Fundam. Appl. Toxicol. 16, 348-355.
13. Grasso, P., Sharratt, M., and Cohen, A. J. (1991). Role of persistent, non-genotoxic tissue damage in rodent cancer and relevance to humans. Annu. Rev. Pharmacol. Toxicol. 31, 253-287.
14. Grossman, S. J., DeLuca, J. G., Zimboni, R. J., Kleenan, K. P., Patrick, D. H., Herold, E. G., van Zwieten, M. J., and Zacchei, A. G. (1992). Enantioselective induction of peroxisomal proliferation in CD-1 mice by leukotriene antagonists. Toxicol. Appl. Pharmacol. 116, 217-224.
15. Guengerich, F. P. (1989). Analysis and characterization of enzymes. In Principles and Methods of Toxicology, 2nd edition (A. W. Hayes, Ed.), pp. 777-814. Raven Press, New York.
16. Hiasa, Y., Kitahori, Y., Ohshima, M., Fujita, T., Yuasa, T., Konishi, N., and Miyashiro, A. (1982). Promoting effects of phenobarbital and barbital on development of thyroid tumors in rats treated with N-bis (2-hydroxypropyl) nitrosamine. Carcinogenesis 3, 1187-1190.
17. Hill, R. N., Erdreich, L. S., Paynter, O. E., Roberts, P. A., Rosenthal, S. L., and Wilkinson, C. F. (1989). Thyroid follicular cell carcinogenesis. Fundam. Appl. Toxicol. 12, 629-697.
18. International Agency for Research on Cancer. (1985). Interpretation of negative epidemiological evidence for carcinogenicity. Proceedings of a symposium held in Oxford 4-6 July, 1983 (N. Wald and R. Doll, Eds.), pp. 151-160. IARC Scientific Publications No. 65.
19. Jackson, C., and Sheldon, W. (1993). Two-year toxicity study of doxylamine succinate in the B6C3F1 mice. J. Am. Coll. Toxicol. 12, 311-231.
20. Kelley, M., Womack, J., and Safe, S. (1990). Effects of cytochrome P-450 monooxygenase inducers on mouse hepatic microsomal metabolism of testosterone and alkoxyresorufins. Biochem. Pharmacol. 39, 1991-1998.
21. Lubet, R. A., Mayer, R. T., Cameron, J. W., Nims, R. W., Burke, M. D., Wolff, T., and Guengerich, F. P. (1985). Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophys. 238, 43-48.
22. Lubet, R. A., Nims, R. W., Ward, J. M., Rice, J. M., and Diwan, B. A. (1989). Induction of cytochrome P450b and its relationship to liver tumor promotion. J. Am. Coll. Toxicol. 8, 259-268.
23. Lubet, R. A., Syi, J.-L., Nelson, J. O., and Nims, R. W. (1990). Induction of hepatic cytochrome P-450 mediated alkoxyresorufin O-dealkylase activities in different species by prototype P-450 inducers. Chem. Biol. Interactions 75, 325-339.
24. McClain, R. M. (1989). The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implications for thyroid gland neoplasia. Toxicol Pathol. 17, 294-306.
25. McClain, R. M. (1992). Thyroid gland neoplasia: Non-genotoxic mechanisms. Toxicol. Lett. 64/65, 397-408.
26. McClain, R. M., Levin, A., Posch, R., and Downing, J. (1989). The effect of phenobarbital on the metabolism and excretion of thyroxine in rats. Toxicol. Appl. Pharmacol. 99, 216-228.
27. McKenzie, J. M., and Williamson, A. (1966). Experience with a bio-assay of the long-acting thyroid stimulator. J. Clin. Endocrinol. Metab. 26, 518-526.
28. Muller, L., Korte, A., and Madle, S. (1989). Mutagenicity testing of doxylamine succinate, an antinauseant drug. Toxicol. Lett. 49, 79-86.
29. Omura, T., and Sato, R. (1964). The carbon monoxide-binding pigment of liver microsomes. Evidence for its hemeprotein nature. J. Biol. Chem. 239, 2379-2385.
30. Orton, T. C., and Parker, G. L. (1982). The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid. Drug. Metab. Dispos. 10, 110-115.
31. Parkinson, A., Clement, R. P., Casciano, C. N., and Cayen, M. N. (1992). Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice. Biochem. Pharmacol. 43, 2169-2180.
32. Peter, R., Bocker, R., Beaune, P. H., Iwasaki, M., Guengerich, F. P., and Yang, C. S. (1990). Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1. Chem. Res Toxicol. 3, 566-573.
33. Romano, M. C., Straub, K. M., Yodis, L. A. P., Eckardt, R. D., and Newton, J. F. (1988). Determination of microsomal lauric acid hydroxylase activity by HPLC with flow-through radiochemical quantitation. Anal. Biochem. 170, 83-93.
34. Sonderfan, A. J., Arlotto, M. P., Dutton, D. R., McMillen, S. M., and Parkinson, A. (1987). Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P450. Arch. Biochem. Biophys. 255, 27-41.
35. Sonderfan, A. J., and Parkinson, A. (1988). Inhibition of steroid 5α-reductase and its effects on testosterone hydroxylation by rat liver microsomal cytochrome P-450. Biochem. Biophys. 265, 208-218.
36. Tsuda, H., Fukushima, S., Imaida, K., Kurata, Y., and Ito, N. (1983). Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea. Cancer Res. 43, 3292-3296.
37. Williams, G. M. (1990). Epigenetic mechanisms of liver tumor promotion. In Mouse Liver Carcinogenesis: Mechanisms and Species Comparisons (D. E. Stevenson et al., Eds.), pp. 131-145. Liss, New York.
38. 19 steroids by five highly purified and rconstituted rat hepatic cytochrome P-450 isozymes. J. Biol. Chem. 258, 8839-8847.
39. Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. (1987). Salmonella mutagenicity tests III. Results from the testing of 255 chemicals. Environ. Mutagen. 9(Suppl. 9), 1-110.