Strong association, but incomplete correlation, between chloroquine resistance and allelic variation in the pfmdr-1 gene of Plasmodium falciparum isolates from India

Annals of Tropical Medicine and Parasitology

Volumn 93, Issue 7, 1999, Pages 679-684

  Bhattacharya, P R ^a   Pillai, C R ^a  

^a NATIONAL INSTITUTE OF MALARIA RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE;

ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; GENETIC VARIABILITY; INDIA; MALARIA CONTROL; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; POINT MUTATION;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0032752249     PISSN: 00034983     EISSN: None     Source Type: Journal    
DOI: 10.1080/00034983.1999.11813471     Document Type: Article

References (29)

1. AWAD-EL-KARIEM, F. M., MILES, M. A. & WARHURST, D. C. (1992). Chloroquine resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfwdr I gene thought to be associated with chloroquine resistance. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 587-589.
2. BARNES, D. A., FOOTE, S. J., GALATIS, D., KEMP, D. J. & COWMAN, A. F. (1992). Selection for high level chloroquine resistance results in deamplification of the pfmdr I gene and increased sensitivity to mefloquine in P. falciparum. EMBO Journal, 11, 3067-3075.
3. BASCO, L K., LE BRAS, J., RHOADES, Z. & WILSON, C. M. (1995). Analysis of pfmdr I and drug susceptibility in fresh isolates of Plasmodium falciparum from subsaharan Africa. Molecular and Biochemical Parasitology, 146, 225-229.
4. BHATTACHARYA, P. R. (1998). pfmdrI gene and chloroquine resistance: a reply. Transactions of the Royal Society of Tropical Medicine and Hygiene, 92, 123.
5. BHATTACHARYA, P. R., BISWAS, S. & KABILAN, L. (1997). Alleles of the Plasmodium falciparum pfmdr I gene appear not to be associated with chloroquine resistance in India. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 454-455.
6. COWMAN, A. F., GALATIS, D. & THOMPSON, J. K. (1994). Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr I gene and cross-resistance to halofantrine and quinine. Proceedings of the National Academy of Sciences of the United States of America, 91, 1143-1147.
7. COX-SINGH, J., SINGH, B., ALIAS, A. & ABDULLAH, M. S. (1995). Assessment of the association between three pfmdr I point mutations and chloroquine resistance in vitro of Malaysian Plasmodium falciparum isolates. Transactions of the Royal Society of Tropical Medicine and Hygiene, 89, 436-437.
8. FOLEY, M., RANFORD-CARTWRIGHT, C. L. & BABIKER, H. A. (1992). Rapid and simple method for isolating malaria DNA from fingerprick samples of blood. Molecular and Biochemical Parasitology, 53, 241-244.
9. FOOTE, S. J., THOMPSON, J. K., COWMAN, A. F. & KEMP, D. J. (1989). Amplification of the multi-drug resistance gene in some chloroquine-resistant isolates of Plasmodium falciparum. Cell, 57, 921-930.
10. FOOTE, S. J., KYLE., D. E., MARTIN, R. K, ODULA, A. M. J., FORSYTH, K, KEMP, D. J. & COWMAN, A. F. (1990). Several alleles of the multi drug resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature, 345, 255-258.
11. FREAN, J. (1998). pfmdrI gene and chloroquine resistance. Transactions of the Royal Society of Tropical Medicine and Hygiene, 92, 123.
12. FREAN, J. A., AWAD EL KARIEM, F. M., WARHURST, D. C. & MILES, M. A. (1992). Rapid detection of pfmdr I mutations in chloroquine resistant Plasmodium falciparum malaria by polymerase chain reaction analysis of blood spots. Transactions of the Royal Society of Tropical Medicine and Hygiene, 86, 29-30.
13. HARUKI, K., BRAY, G. P., STEPHEN, A. W., HOMMEL, M. & RITCHIE, G. Y. (1994). Chloroquine resistance of Plasmodium falciparum: further evidence for a lack of association with mutations of the pfmdr I gene. Transactions of the Royal Society of Tropical Medicine and Hygiene, 88, 694.
14. KROGSTAD, D. J., GLUZMAN, I. Y., KYLE, D. E., ODULA, A. M., MARTIN, S. K., MILHOUS, W. K. & SCHLESINGER, P. H. (1987). Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance. Science, 238, 1283-1285.
15. LE BRAS, J., DELORON, P., RICOUR, A., ANDRIEU, B., SAVEL, J. & COULAND, J. P. (1983). Plasmodium falciparum: drug sensitivity in vitro of isolates before and after adaptation to continuous culture. Experimental Parasitology, 56, 9-14.
16. PEEL, S. A., BRIGHT, P., YOUNT, B., HANDY, J. & BARIC, R. S. (1994). A strong association between mefloquine and halofantrine resistance and amplification, overexpression and mutation in the P-glycoprotein gene homolog (pfmdr) ofPlasmodium falciparum in vítro. American Journal of Tropical Medicine and Hygiene, 51, 648-658.
17. POLOGE, L. G. & RAVETCH, J. V. (1986). A chromosome rearrangement in Plasmodium falciparum histidine-rich protein gene is associated with the knobless phenotype. Nature, 322, 474-477.
18. RIECKMANN, K. H., MCNAMARA, J. V., FRISHER, H., STOCKERT, T. A., CARSON, P. E. & POWELL, R. D. (1968). Effects of chloroquine, quinine and cycloguanil upon the maturations of asexual erythrocytic forms of two strains of Plasmodium falciparum in vitro. American Journal of Tropical Medicine and Hygiene, 17, 661-671.
19. RIECKMANN, K., CAMPBELL, H. G. H., SAX. L. & MREMA, J. E. (1978). Drug sensitivity of Plasmodium falciparum: an in vitro microtechnique. Lancet, i, 22-23.
20. RUBIO, J. P. & COWMAN, A. F. (1994). Plasmodium falciparum: the Pfmdr 2 protein is not overexpressed in chloroquine-resistant isolates of the malaria parasite. Experimental Parasitology, 79, 137-147.
21. SAIKI, R. K., GELFAND, D. H., STOFFEL, S., SCHARB, S. J., HIGUCHI, R., HORN, G. T., MULLIS, K. B. & ERLICH, H. A. (1988). Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science, 239, 487-491.
22. SU, X., KIRKMAN, L. A., FUJIOKA, H. & WELLEMS, T. E. (1997). Complex polymorphisms in an 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa. Cell, 91, 593-603.
23. USHA DEVI, C., PILLAI, C. R., ADAK, T., SHARMA, V. P. & DWIVEDI, S. C. (1996). In vitro sensitivity of Indian isolates of Plasmodium falciparum to antimalarials. Journal of Parasitic Diseases, 20, 177-180.
24. VON SEIDLEIN, L., DURAISINGH, M. T., DRAKELEY, C. J., BAILEY, R., GREENWOOD, B. M. & PINDER, M. (1997). Polymorphism of the pfmdr-I gene and chloroquine resistance in Plasmodium falciparum in the Gambia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 91, 450-453.
25. WELLEMS, T. E., PANTON, L. J., GLUZMAN, I. Y. P., ROSARIO, V. E., GWADZ, R. W., WALKER-JONATH, A. & KROGSTAD, D. J. (1990). Chloroquine resistance not linked to mdr-like genes in Plasmodium falciparum cross. Nature, 345, 253-255.
26. WILSON, C. M., SERRANO, A. F., WASLEY, A., BOGENSCHUTZ, M. P., SHANKAR, A. H. & WIRTH, D. F. (1989). Amplification of a gene related to mammalian mdr genes in drug resistant Plasmodium falciparum. Science, 244, 1184-1186.
27. WILSON, C. M., VOLKMAN, S. K., THAITHONG, S., MARTIN, R. K., KYLE, D. E., MILHOUSE, W. K. & WIRTH, D. F. (1993). Amplification of pfmdr-I associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Molecular and Biochemical Parasitology, 57, 151-160.
28. WORLD HEALTH ORGANIZATION (1990). In Vitro Micro-test (Mark II) for the Assessment of the Response of Plasmodium falciparum to Chloroquine, Mefloquine, Quinine, Sulfadoxine/ pyrimethamine and Amodi aquine. Document MAP/87.2. Geneva: WHO.
29. ZALLS, M. G., WILSON, C. M., CRAIG, M. W., ZHANG, Y. & WIRTH, D. F. (1993). Characterization of the pfmdr-2 gene for Plasmodium falciparum. Molecular and Biochemical Parasitology, 62, 83-92.