Observational study in adult hypopituitary patients with untreated growth hormone deficiency (ODA study). Socio-economic impact and health status

European Journal of Endocrinology

Volumn 141, Issue 5, 1999, Pages 481-489

  Sanmartí, Anna ^a   Lucas, Anna ^a   Hawkins, Federico ^b   Webb, Susan M ^c   Ulied, Angels ^d  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^d I3 Research   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; FEMALE; FOLLOW UP; GROWTH HORMONE DEFICIENCY; HEALTH CARE COST; HEALTH STATUS; HUMAN; HYPOPITUITARISM; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; QUALITY OF LIFE; RISK FACTOR; SCORING SYSTEM; SOCIOECONOMICS;

EID: 0032750553     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1410481     Document Type: Article

References (40)

1. Cuneo RC, Salomon F, McGauley GA & Sönksen PH. The growth hormone deficiency syndrome in adults. Clinical Endocrinology 1992 37 387-397.
2. Jørgensen JOL, Pedersen SA, Thuesen L, Jørgensen J. Ingemann-Hansen T, Skakkebaek NE et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989 1 1221-1225.
3. Hoffman DM, O'Sullivan AJ, Freund J & Ho K. Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism. Journal of Clinical Endocrinology and Metabolism 1995 80 72-77.
4. De Boer H, Blok GJ & van der Veen VA. Clinical aspects of growth hormone deficiency in adults. Endocrine Reviews 1995 16 63-86.
5. Hoffman DM & Ho K. Growth hormone deficiency in adults. Endocrinologist 1997 7 233-237.
6. Carroll PV, Christ ER and the members of Growth Hormone Research Society Scientific Committee: Bengtsson B-A, Carlsson LM, Christiansen JS, Clemmons D, Hintz R, Ho K, Laron Z, Sizonenco P Sonksen PH, Tanaka T, & Thorner M. Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Journal of Clinical Endocrinology and Metabolism 1998 83 382-395.
7. Mårdh G, Lundin K, Borg G, Jonsson B & Lindberg A. Growth hormone replacement therapy in adult hypopituitary patients with growth hormone deficiency: combined data from 12 European placebo-controlled trials. Endocrinology and Metabolism 1994 (Suppl A) 43-49.
8. Burman P, Broman JE, Hetta J, Wiklund I, Erfurth EM, Hagg E et al. Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial. Journal of Clinical Endocrinology and Metabolism 1995 80 3585-3590.
9. Cuneo RC, Judd S, Wallace JD, Perry-Keene D, Burger H, Lim-Tio S et al. The Australian multicenter trial of growth hormone (GH) treatment in GH-deficient adults. Journal of Clinical Endocrinology and Metabolism 1998 83 107-116.
10. Johansson G, Rosen T, Bosaeus L, Sjostrom L & Bengtsson B-A. Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult onset GH deficiency. Journal of Clinical Endocrinology and Metabolism 1996 81 2865-2873.
11. Jørgensen JOL, Thuesen L, Muller J, Ovesen P, Skakkebaek NE & Christiansen JS. Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance. European Journal of Endocrinology 1994 130 224-228.
12. Attanasio AF, Lamberts SWJ, Matranga AMC, Birkett MA. Bates PC, Valk NK et al. Adult growth hormone-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. Journal of Clinical Endocrinology and Metabolism 1997 82 82-88.
13. Cuneo RC, Salomon F, Watts GF, Hesp R & Sonksen PH. Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism: Clinical and Experimental 1993 42 1519-1523.
14. De Boer H, Blok GJ, Voerman HJ, Philips M & Schouten JA. Serum lipid levels in growth hormone-deficient men. Metabolism: Clinical and Experimental 1994 43 199-203.
15. Ehrnborg C, Rosén T, Roijen LV, McDonnell J, Rutten FFH & Bengtsson BA. Cost of illness study of adult hypopituitary patients. 79th Annual Endocrine Society Meeting. Minneapolis 1997 Poster P03-100.
16. Doward LC. The development of the AGHDA: a measure to assess quality of life of adults with growth hormone deficiency. Quality of Life Research 1995 4 420-421.
17. Holmes SJ, McKenna SP, Doward LC, Hunt SM & Shalet S. Development of a questionnaire to assess the quality of life of adults with growth hormone deficiency. Endocrinology and Metabolism 1995 2 63-67.
18. McKenna SR & Doward LC. Quality-of-life assessment of adults with growth hormone deficiency. PharmacoEconomics 1994 6 434-441.
19. Realidad social en España. Capítulo 7. Centro de Investigación sobre la Realidad Social (CIRES). Bilbao 1994. Monografía encuesta de salud española. Fundación Banco Bilbao-Vizcaya.
20. Drummond M. Cost-of-illness studies. A major headache? PharmacoEconomics 1992 2 1-4.
21. Kotsanos JG & Zeckel M. Dollars and sense: learning the health economics language to survive. Endocrinologist 1997 7 267-270.
22. Gisbert R, Brosa M, Figueras M, Mindan E & Rovira J. 1997 El coste de la enfermedad en Espana. El coste de las enfermedades cardiovasculares. Monografia MSD, Madrid.
23. Kobelt G, Eberhardt K, Jönsson L & Jönson B. Economic consequences of the progression of rheumatoid arthritis in Sweden. Arthritis and Rheumatism 1999 42 347-355.
24. Hoffman C, Rice D & Sung HY. Persons with chronic conditions: their prevalence and costs. JAMA 1996 276 1473-1479.
25. Granada ML, Murillo J, Llopis MP, Lucas A, Salinas I, Cuatrecases G et al. Diagnostic efficiency of serum IGF-I, IGFBP-3 and urinary GH (UGH). Measurements in the diagnosis of adult growth hormone deficiency (GHD). Importance of appropriate reference population. IV European Congress of Endocrinology. Seville 1998 1 1-124.
26. Badia X, Lucas A, Sanmartí A, Roset M & Ulied A on behalf of the collaborative group. One-year follow-up of quality of life in adults with untreated growth hormone deficiency. Clinical Endocrinology 1998 49 765-771.
27. Lamberts WJS, Walk NR & Bineverts A. The use of growth hormone in adults: a changing scene. Clinical Endocrinology 1992 37 111-115.
28. Rosén T & Bengtsson B-A. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990 336 285-288.
29. Rosén T, Edén S, Larson G, Wilhelmsen L & Bengtsson B-A. Cardiovascular risk factors in adults with growth hormone deficiency. Acta Endocrinologica 1993 129 195-200.
30. Instituto Nacional de Estadistica (INE). 1993 Tablas de mortalidad española, pp 134-149. Madrid.
31. Aranceta J, Pérez C, Serra L, Ribas L, Quiles J, Vioque J et al. Prevalencia de la obesidad en España: estudio SEEDO'97. Medicina Clinica 1998 111 441-445.
32. a De. Barcelona 1993, 60-80.
33. Tresserras R & Pardell H. Prevalencia e importancia sanitaria de la Hipertensión Arterial. Anales de Medicina Interna 1990 7 (Suppl 3) 1-6.
34. Rosén T, Wirén L, Wilhelmsen L, Wiklund I & Bengtsson B-A. Decreased psychological well-being in adult patients with growth hormone deficiency. Clinical Endocrinology 1994 40 111-116.
35. McGauley GA, Cuneo RC, Salomon F & Sönksen PH. Psychological well-being before and after growth hormone treatment in adults with growth hormone deficiency. Hormone Research 1990 33 52-54.
36. Wirén L, Bengtson B-A & Johannsson G. Beneficial effects of long-term GH replacement therapy on quality of life in adults with GH deficiency. Clinical Endocrinology 1998 48 613-620.
37. Almqvist O, Thoren M, Sääf M & Eriksson O. Effects of growth hormone substitution on mental performance in adults with growth hormone deficiency: a pilot study. Psychoneuroendocrinology 1986 11 347-352.
38. Wallymahmed ME, Foy P, Shaw D, Hutcheon R, Edwards RHT & MacFarlane IA. Quality of life, body composition and muscle strength in adult growth hormone deficiency: the influence of growth hormone replacement therapy for up to 3 years. Clinical Endocrinology 1997 47 439-446.
39. Rikken B, van Busschbach J, le Cessie S, Manten W, Spermon T, Grobbee R et al. Impaired social status of growth hormone-deficient adults as compared with controls with short or normal stature. Clinical Endocrinology 1995 43 205-211.
40. Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure. The Sixth Report (JNC VI). Archives of Internal Medicine 1997 157 2413-2439.