Detection of pre-S/S gene mutants in chronic hepatitis B carriers with concurrent hepatitis B surface antibody and hepatitis B surface antigen

Journal of Gastroenterology

Volumn 34, Issue 5, 1999, Pages 600-606

  Wang, Yuan Min ^a,b   Ng, Wee Chit ^a   Lo, Su Kong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b WESTMEAD HOSPITAL   (Australia)

Author keywords

Anti NBs; HBsAg; HBV carriers; Mutants; Polymerase chain reaction

Indexed keywords

HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; VIRUS DNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE MUTATION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOGENICITY; LIVER CELL CARCINOMA; MALE; MOLECULAR CLONING; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS CARRIER; VIRUS PARTICLE;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CARRIER STATE; DNA, VIRAL; FEMALE; HEPATITIS B ANTIBODIES; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POINT MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 0032748961     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005350050379     Document Type: Article

References (25)

1. Moriyama K, Nakajima E, Hohjoh H, Asayama R, Okochi K. Immunoselected hepatitis B virus mutant. Lancet 1991;337:125.
2. Raimondo G, Campo S, Smedile V, Rodino G, Sardo MA, Brancatelli S, et al. Hepatitis B virus variant, with a deletion in the preS2 and two translation stop codons in the precore regions, in a patient with hepatocellular carcinoma. J Hepatol 1991;13(Suppl 4):S74-7.
3. Carman WF, Zanetti AR, Karayiannis K, Waters J, Manzillo J, Tanzi E, et al. Vaccine-induced escape mutant of hepatitis B virus. Lancet 1990;336:325-9.
4. Shiels MT, Taswell HF, Czaja AJ, Nelson C, Swenke P. Frequency and significance of concurrent hepatitis B surface antigen and antibody in acute and chronic hepatitis B. Gastroenterology 1987;93:675-80.
5. Dienstag JL. Concurrent hepatitis B surface antigen and antibody and the clonal selection theory of antibody diversity. Gastroenterology 1987;93:899-904.
6. Wang YM, Ng WC, Kang JY, Yap I, Seet BL, Teo J, et al. Serological profiles of hepatitis B carrier patients in Singapore with special reference to the frequency and significance of concurrent presence of HBsAg and anti-HBs. Singapore Med J 1996;37:150-2.
7. Wang YJ, Lee SD, Wu JC, Lo KJ. Acute hepatitis B virus infection in a patient with anti-HBs. J Med Virol 1991;35:133-5.
8. Gerken G, Kremsdorf D, Capel F, Petit MA, Dauguet C, Manns MP, et al. Hepatitis B defective virus with rearrangements in the PreS gene during chronic infection. Virology 1991;183:555-65.
9. Tran A, Kremsdorf D, Capel F, Housset C, Dauguet C, Petit MA, et al. Emergence of and takeover by hepatitis B virus (HBV) with rearrangements in the Pre-S/S and Pre-C/C genes during chronic HBV infection. J Virol 1991;65:3566-74.
10. Minami M, Okanoue T, Nakajima E, Yasui K, Kagawa K, Kashima K. Significance of Pre-S region-defective hepatitis B virus that emerged during exacerbation of chronic type B hepatitis. Hepatology 1993;17:558-63.
11. Scotto J, Hadchouel M, Hery C, Yvart J, Tiollais P, Brechot C. Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: comparison with results for other viral markers. Hepatology 1983;3:279-84.
12. Harrison TJ, Bal V, Wheeler EG, Meacock TJ, Harrison JF, Zuckerman AJ. Hepatitis B virus DNA and e antigen in serum from blood donors in the United Kingdom positive for hepatitis B surface antigen. BMJ 1985;290:663-4.
13. Paterlini P, Gerken G, Nakajima E, Terre S, D'Errico A, Grigioni W, et al. Brechot C. Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen. N Engl J Med 1990;323:80-5.
14. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chainterminating inhibitors. Proc Natl Acad Sci USA. 1977;74:5463-7.
15. Pollicino T, Zanetti AR, Cacciola I, Pitit MA, Smedile A, Campo S, et al. Pre-S2 defective hepatitis B virus infection in patients with fulminant hepatitis. Hepatology 1997;26:495-9.
16. Zhang YY, Nordenfelt E, Hansson BG. Increasing heterogeneity of the "a" determinant of HBsAg found in the presumed late phase of chronic hepatitis B virus infection. Scand J Infect Dis 1996;28:9-15.
17. Pult I, Chouard T, Wieland S, Klenenz R, Yaniv M, Blum HE. A hepatitis B virus mutant with a new hepatocyte nuclear factor 1 binding site emerging in transplant-transmitted fulminant hepatitis B. Hepatology 1997;25:1507-15.
18. Fernholz D, Stemler M, Brunetto M, Bonino F, Will H. Replicating and virion secreting hepatitis B mutant virus unable to produce preS2 protein. J Hepatol 1991; 13 (Suppl 4):S102-4.
19. Santantonio T, Jung MC, Schneider R, Fernholz D, Milella M, Monno L, et al. Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy. Virology 1992;188:948-52.
20. Fernholz D, Galle PR, Stemler M, Brunetto MR, Bonino F, Will H. Infectious hepatitis B virus variant defective in pre-S2 protein expression in a chronic carrier. Virology 1993;194:137-48.
21. Melegari M, Bruno S, Wands JR. Properties of hepatitis B virus pre-S1 deletion mutants. Virology 1994;199:292-300.
22. Nakajima E, Minami M, Ochiya T, Kagawa K, Okanoue T. PreS1 deleted variants of hepatitis B virus in patients with chronic hepatitis. J Hepatol 1994;20:329-35.
23. Melegari M, Scaglioni PP, Wands J. Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. Hepatology 1998; 27:628-33.
24. Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumolo S, et al. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol 1994;68:2671-6.
25. Takayanagi M, Kakumu S, Ishikawa T, Higashi Y, Yoshioka K, Wakita T. Comparison of envelope and precore/core variants of hepatitis B virus (HBV) during chronic HBV infection. Virology 1993;196:138-45.