Mechanisms of paraneoplastic syndromes in mice bearing a spontaneous lung adenocarcinoma

Tumor Biology

Volumn 20, Issue 6, 1999, Pages 304-311

  Parma, M ^b   Diament, M ^b   Garcia C ^b   Piccinni, E ^b   Mondelo, N ^b   Klein, Slobodanka ^a  

^a Instituto de Oncologia Angel H Roffo   (Argentina)

^b NONE

Author keywords

Hypercalcemia; Murine lung tumor; Paraneoplastic syndromes; pQCT; PTHrP

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE METASTASIS; CACHEXIA; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CYTOKINE RELEASE; HYPERCALCEMIA; LEUKOCYTOSIS; LUNG ADENOCARCINOMA; LUNG TUMOR; MOUSE; NONHUMAN; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; SUPERNATANT; TUMOR GROWTH;

EID: 0032748802     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1159/000030094     Document Type: Article

References (37)

1. Natanson L, Hall T: Paraneoplastic syndromes. Semin Oncol 1997;24: 265-268.
2. Garrett IR: Bone destruction in cancer. Semin Oncol 1993;20(suppl 2): 4-9.
3. Mundy GR, Guise TA: Hypercalcemia of malignancy. Am J Med 1997;103:134-145.
4. Grill V, Rankin W, Martin TJ: Parathryoid hormone-related protein (PTHrP) and hypercalcemia. Eur J Cancer 1998;34:222-229.
5. Firkin F, Schneider H, Grill V: Parathyroid hormone-related protein in hypercalcemia associated with hematological malignancy. Leuk Lymphoma 1998;29:499-506.
6. Tashjian AH Jr, Voelkel EF, Lazzaro M, Goad D, Bosma T, Levine L: Tumor necrosis factor alfa (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin-mediated mechanism. Endocrinoloy 1987;120:2029-2036.
7. Barengolts E, Lathon P, Lindh F, Kukreja S: Cytokines may be responsible for the inhibited bone formation in hypercalcemia of malignancy. J Bone Miner Res 1994; 9(suppl 1):73.
8. Mundy G: Myeloma bone disease. Eur J Cancer 1998;34:246-251.
9. Takahashi N, Udagawa N, Akatsu T, Tanaka H, Shionome M, Suda T: Role of colony-stimulating factors in osteoclast development. J Bone Miner Res 1991;6:977-985.
10. Amano H, Yamada S, Felix R: Colony stimulating factor-1 stimulates the fusion process in osteoclasts. J Bone Miner Res 1998;13:846-853.
11. Johnson R, Boyce B, Mundy G, Roodman G: Tumor producing human tumor necrosis factor induce hypercalcemia and osteoclastic bone resorption in nude mice. Endocrinology 1989;124:1424-1427.
12. Bertolini D, Nedwin G, Bringman T, Smith D, Mundy G: Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factor. Nature (Lord) 1986;319:516-518.
13. Canalis E: Effects of tumor necrosis factor on bone formation in vitro. Endocrinology 1987;121:1596-1604.
14. Pfelschifter J, Chenu C, Bird A, Mundy G, Roodman G: Interleukin-1 and tumor necrosis factor stimulate the formation of human osteoclast like cells in vitro. J Bone Miner Res 1989;4:113-118.
15. Uy H, Mundy G, Boyce B, Story B, Dunstan C, Yin J, Roodman G, Guise T: Tumor necrosis factor enhances parathyroid hormone-related protein-induced hypercalcemia and bone resorption without inhibiting bone formation in vivo. Cancer Res 1997;57:3194-3199.
16. Sato K, Fuji K, Kasono K, Ozawa M, Imamura K, Kanaji Y, Kurosawa H, Tsushima T, Shizume K: Parathyroid hormone-related protein, and interleukin-1α synergistically stimulate bone resorption in vitro, and increase the serum calcium concentration in mice in vivo. Endocrinology 1989;124:2172-2178.
17. Yoneda T, Nishimura R, Kato Y, Ohmae M, Takita M, Sakuda M: Frequency of the hypercalcemia-hyperleukocytosis syndrome in oral malignancies. Cancer 1991;68:617-622.
18. Peyrade F, Taillan B, Heudier P, Dujardin P: Association hypercalcémie-hyperleucocytose, un syndrome paranéoplastique original. Presse Méd 1998;27:658-660.
19. Diament M, García C, Stillitani I, Muñiz Saavedra V, Manzur T, Vauthay L, Klein S: Spontaneous murine lung adenocarcinoma (P07): A new experimental model to study paraneoplastic syndromes of lung cancer. Int J Mol Med 1998;2:45-50.
20. Niemeyer G: New noninvasive pQCT devices to determine bone structure. J Jpn Soc Bone Morphom 1997;7:97-105.
21. Oshawa N, Ueyama K, Morita M, Kondo Y: Heterotransplantation of human functioning tumours to nude mice; in Nomura T, Oshawa N, Tamaoki T, Fujirawa K (eds): Proceedings of the Second International Workshop on Nude Mice. Tokyo, University of Tokyo Press, 1977, pp 395-405.
22. Saito K, Kuratomi Y, Yamamoto K, Saito T, Kuzuya T, Yoshida S, Moriyama S, Takahashi A: Primary squamous cell carcinoma of the thyroid associated with marked leukocytosis and hypercalcemia. Cancer 1981;48:2080-2083.
23. De la Mata J, Uy H, Guise T, Story B, Boyce F, Mundy G, Roodman G: Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest 1995;95:2846-2852.
24. Guise T, Yoneda T, Yates A, Mundy G: The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-α enhance hypercalcemia in vivo and bone resorption in vitro. J Clin Endocrinol Metab 1993;77:40-45.
25. Teitelbaum S, Tondravi M, Ross F: Osteoclasts, macrophages, and the molecular mechanisms of bone resorption. J Leukoc Biol 1997;61: 381-388.
26. Tanaka R, Okada M, Kajimura N, Gyotoku M, Nagasaki K, Ekimoto H, Yamaguchi K: Triple paraneoplastic syndrome of hypercalcemia, leukocytosis and cachexia in two human tumor xenografts in nude mice. Jpn J Clin Oncol 1996;26:88-94.
27. Insogna K, Stewart A, Vigney A, Weir E, Namnum P, Baron R, Kirkwood J, Deftos L, Broadus A: Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy. Endocrinology 1984;114: 888-896.
28. Stewart A, Horst R, Deftos L, Cadman E, Lang R, Broadus A: Biochemical evaluation of patients with cancer-associated hypercalcemia: Evidence for humoral and nonhumoral groups. N Engl J Med 1980; 303:1377-1383.
29. Torres R, De La Piedra C, Rapado A: Osteocalcin and bone remodeling in Paget's disease of bone, primary hyperparathryroidism, hypercalcemia of malignancy and involutional osteoporosis. Scand J Clin Lab Invest 1989;49:279-285.
30. Kitazawa R, Imai Y, Fukases M, Fujita T: Effects of continuous infusion of parathyroid hormone and parathyroid hormone-related peptide on rat bone in vivo: Comparative study by histomorphometry. J Bone Miner Res 1991;12:157-166.
31. Rosol T, Capen C, Horst R: Effects of infusions of human parathyroid hormone-related protein (1-40) in nude mice: Histomorphometric and biochemical investigations. J Bone Miner Res 1988;3:699-706.
32. Nicoletti G, De Giovanni C, Lollini P, Bagnara G, Scotlandi K, Landuzzi L, Del Re B, Zauli G, Prodi G, Nanni P: In vivo and in vitro production of haematopoietic colony stimulating activity by murine cell lines of different origin: A frequent finding. Eur J Cancer Clin Oncol 1988;25:1281-1286.
33. Diament M, Fontanals A, D'Elia I, Klein S: Producción de GM-CSF por tumores con distinta capacidad metastásica. Acta Physiol Pharmacol Ther Latinoam 1997;47:48.
34. Tisdale M: Biology of cachexia. J Natl Cancer Inst 1997;89:1763-1773.
35. Socher S, Martinez D, Craig J: Tumor necrosis factor not detectable in patients with clinical cancer cachexia. J Natl Cancer Inst 1988;80:595-598.
36. Puccio M, Nathanson L: The cancer cachexia syndrome. Semin Oncol 1997;24:277-287.
37. Parma M, García C, Diament M, Klein S, Peluffo V, Piccinni E, Mondelo N: Effect of olpadronate (OPD) on the hypercalcemia induced by a murine lung adenocarcinoma (P07). Bone 1998;22:50S.