Parathyroid hormone-related protein (PTHrP) and hypercalcaemia

European Journal of Cancer

Volumn 34, Issue 2, 1998, Pages 222-229

  Grill, V ^a   Rankin, W ^a   Martin, T J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; PARATHYROID HORMONE RELATED PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; HEMATOLOGIC DISEASE; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HUMORAL IMMUNITY; HYPERCALCEMIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS;

EID: 0032512915     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(97)10130-7     Document Type: Article

References (104)

1. 1. Zondek H, Petow H, Siebert W. Die bedeutung der calcium-bestimmung im blute fur die diagnose der niereninsuffizienz. Z Klin Med 1924, 99, 129-138.
2. 2. Mallory TB. Case records of the Massachusetts General Hospital (Case 27461). N Engl J Med 1941, 225, 789-791.
3. 3. Lafferty FW. Pseudohyperparathyroidism. Medicine 1966, 45, 247-260.
4. 4. Berson SA, Yalow RS. Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma. Science 1966, 154, 907-909.
5. 5. Mundy GR, Martin TJ. The hypercalcemia of malignancy: pathogenesis and management. Metabolism 1982, 31, 1247-1267.
6. 6. Riggs BL, Arnaud CD, Reynolds JC, Smith LH. Immunologic differentiation of primary hyperparathyroidism from hyperparathyroidism due to nonparathyroid cancer. J Clin Invest 1971, 50, 2079-2083.
7. 7. Powell D, Singer FR, Murray TM, Minkin C, Potts JT, Jr. Nonparathyroid humoral hypercalcemia in patients with neoplastic diseases. N Engl J Med 1973, 289, 176-181.
8. 8. Roof BS, Carpenter B, Fink DJ, Gordan GS. Some thoughts on the nature of ectopic parathyroid hormones. Am J Med 1971, 50, 686-691.
9. 9. Stewart AF, Horst R, Deftos LJ, Cadman EC, Lang R, Brodus AE. Biochemical evaluation of patients with calcium-association hypercalcemia. Evidence for humoral and nonhumoral groups. N Engl J Med 1980, 303, 1377-1383.
10. 10. Kukreja SC, Shemerdiak WP, Lad TE, Johnson PA. Elevated nephrogenous cyclic AMP with normal serum parathyroid hormone levels in patients with lung cancer. J Clin Endocrinol Metab 1980, 51, 167-169.
11. 11. Rude RK, Sharp CF, Jr, Fredericks RS, et al. Urinary and nephrogenous adenosine 3′,5′-monophosphate in the hypercalcemia of malignancy. J Clin Endocrinol Metab 1981, 52, 765-771.
12. 12. Stewart AF, Insogna KL, Goltzman D, Broadus AE. Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. Proc Natl Acad Sci USA 1983, 80, 1454-1458.
13. 13. Goltzman D, Stewart AF, Broadus AE. Malignancy-associated hypercalcemia: evaluation with a cytochemical bioassay for parathyroid hormone. J Clin Endocrinol Metab 1981, 53, 899-904.
14. 14. Rodan SB, Insogna KL, Vignery AM-C, et al. Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. J Clin Invest 1983, 72, 1511-1515.
15. 15. Simpson EL, Mundy GR, D'Souza SM, Ibbotson KJ, Bockman R, Jacobs JW. Absence of parathyroid hormone messenger RNA in nonparathyroid tumors associated with hypercalcemia. N Engl J Med 1983, 309, 325-330.
16. 16. Strewler GJ, Williams RD, Nissenson RA. Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. J Clin Invest 1983, 71, 769-774.
17. 17. Rosol TJ, Capen CC, Brooks CL. Bone and kidney adenylate cyclase-stimulating activity produced by a hypercalcemic canine adenocarcinoma line (CAC-8) maintained in nude mice. Cancer Res 1987, 47, 690-695.
18. 18. Moseley JM, Kubota M, Diefenbach-Jagger H, et al. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci USA 1987, 84, 5048-5052.
19. 19. Burtis WJ, Wu T, Bunch C, et al. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J Biol Chem 1987, 262, 7151-7156.
20. 20. Suva LJ, Winslow GA, Wettenhall REH, et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 1987, 237, 893-896.
21. 21. Mangin M, Webb AC, Dreyer BE, et al. Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci USA 1988, 85, 597-601.
22. 22. Thiede MA, Strewler GJ, Nissenson RA, Rosenblatt M, Rodan GA. Human renal carcinoma expresses two messages encoding a parathyroid hormone-like peptide: evidence for the alternative splicing of a single copy gene. Proc Natl Acad Sci USA 1988, 85, 4605-4609.
23. 23. Abou-Samra A-B, Uneno S, Jueppner H, et al. Non-homologous sequences of parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells. Endocrinology 1989, 125, 2215-2217.
24. 24. Jüppner H, Abou-Samra A-B, Freeman M, et al. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 1991, 254, 1024-1026.
25. 25. Moseley JM, Gillespie MT. Parathyroid hormone-related protein. Crit Rev Clin Lab Sci 1995, 32, 299-343.
26. 26. Yates AJP, Gutierrez GE, Smolens P, et al. Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents. J Clin Invest 1988, 81, 932-938.
27. 27. Horiuchi N, Caulfield MP, Fisher JE, et al. Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro. Science 1987, 238, 1566-1568.
28. 28. Sato K, Yamakawa Y, Shizume K, et al. Passive immunization with anti-parathyroid hormone-related protein monoclonal antibody markedly prolongs survival time of hypercalcemic nude mice bearing transplanted human PTHrP-producing tumors. J Bone Min Research 1993, 8, 849-860.
29. 29. Kukreja SC, Shevrin DH, Wimbiscus SA, et al. Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy-associated hypercalcemia due to human tumors. J Clin Invest 1988, 82, 1798-1802.
30. 30. Kukreja SC, Rosol TJ, Wimbiscus SA, et al. Tumor resection and antibodies to parathyroid hormone-related protein cause similar changes in bone histomorphometry in hypercalcemia of cancer. Endocrinology 1990, 127, 305-310.
31. 31. Budayr AA, Nissenson RA, Klein RF, et al. Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia. Ann Intern Med 1989, 111, 807-812.
32. 32. Henderson JE, Shustik C, Kremer R, Rabbani SA, Hendy GN, Goltzman D. Circulating concentrations of parathyroid hormone-like peptide in malignancy and in hyperparathyroidism. J Bone Min Research 1990, 5, 105-113.
33. 33. Kao PC, Klee GG, Taylor RL, Heath H. Parathyroid hormone-related peptide in plasma of patients with hypercalcemia and malignant lesions. Mayo Clin Proc 1990, 65, 1399-1407.
34. 34. Grill V, Ho P, Body JJ, et al. Parathyroid hormone-related protein: elevated levels in both humoral hypercalcemia of malignancy and hypercalcemia complicating metastatic breast cancer. J Clin Endocrinol Metab 1991, 73, 1309-1315.
35. 35. Burtis WJ, Brady TG, Orloff JJ, et al. Immunochemical characterisation of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. N Engl J Med 1990, 322, 1106-1112.
36. 36. Pandian MR, Morgan CH, Carlton E, Segre GV. Modified immunoradiometric assay of parathyroid hormone-related protein: clinical application in the differential diagnosis of hypercalcemia. Clin Chem 1992, 38, 282-288.
37. 37. Fraser WD, Robinson J, Lawton R, et al. Clinical and laboratory studies of a new immunoradiometric assay of parathyroid hormone-related protein. Clin Chem 1993, 39, 414-419.
38. 38. Ikeda K, Ohno H, Hane M, et al. Development of a sensitive two-site immunoradiometric assay for parathyroid hormone-related peptide: evidence for elevated levels in plasma from patients with adult T-cell leukemia/lymphoma and B-cell lymphoma. J Clin Endocrinol Metab 1994, 79, 1322-1327.
39. 39. Ikeda K, Weir EC, Mangin M, et al. Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas. Mol Endocrinol 1988, 2, 1230-1236.
40. 40. Danks JA, Ebeling PR, Hayman JA, et al. Immunohistochemical localization of parathyroid hormone-related protein in parathyroid adenoma andhyperplasia. J Pathol 1990, 161, 27-33.
41. 41. Kasahara T, Tsuchiya M, Adachi R, Horikawa S, Tanaka S, Tachibana S. Development of a C-terminal-region-specific radioimmunoassay of parathyroid hormone-related protein. Biomed Res 1992, 13, 155-161.
42. 42. Bundred NJ, Ratcliffe WA, Walker RA, Coley S, Morrison JM, Ratcliffe JG. Parathyroid hormone related protein and hypercalcaemia in breast cancer. Br Med J 1991, 303, 1506-1509.
43. 43. Danks JA, Ebeling PR, Hayman J, et al. Parathyroid hormone-related protein: immunohistochemical localization in cancers and in normal skin. J Bone Min Research 1989, 4, 273-278.
44. 44. Brandt DW, Burton DW, Gazdar AF, Oie HE, Deftos LJ. All major lung cancer cell types produce parathyroid hormone-like protein: heterogeneity assessed by high performance liquid chromatography. Endocrinology 1991, 129, 2466-2470.
45. 45. Davidson LA, Black M, Carey FA, Logue F, McNicol AM. Lung tumours immunoreactive for parathyroid hormone related peptide: analysis of serum calcium levels and tumour type. J Pathol 1996, 178, 398-401.
46. 46. Antonioli Corboz V, Cecchini MG, Felix R, Fleisch H, van der Pluijm G, Löwik CWGM. Effect of macrophage colony-stimulating factor on in vitro osteoclast generation and bone resorption. Endocrinology 1992, 130, 437-442.
47. 47. Gowen M, Mundy GR. Actions of recombinant interleukin 1, interleukin 2, and interferon-γ on bone resorption in vitro. J Immunol 1986, 136, 2478-2482.
48. 48. Tashjian AH, Jr, Voelkel EF, Lazzaro M, Goad D, Bosma T, Levine L. Tumor necrosis factor-α (cachectin) stimulates bone resorption in mouse calvaria via a prostaglandin-mediated mechanism. Endocrinology 1987, 120, 2029-2036.
49. 49. Gowen M, Wood DD, Ihrie EJ, McGuire MKB, Russell RGG. An interleukin 1 like factor stimulates bone resorption in vitro. Nature 1983, 306, 378-380.
50. 50. Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 1986, 319, 516-518.
51. 51. Ibbotson KJ, Harrod J, Gowen M, et al. Human recombinant transforming growth factor a stimulates bone resorption and inhibits formation in vitro. Proc Natl Acad Sci USA 1986, 83, 2228-2232.
52. 52. Tashjian AH, Jr, Voelkel EF, Lazzaro M, et al. α and β human transforming growth factors stimulate prostaglandin production and bone resorption in cultured mouse calvaria. Proc Natl Acad Ssi USA 1985, 82, 4535-4538.
53. 53. Garrett IR, Durie BGM, Nedwin GE, et al. Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. N Engl J Med 1987, 317, 526-532.
54. 54. Kondo Y, Sato K, Ohkawa H, et al. Association of hypercalcemia with tumors producing colony-stimulating factor(s). Cancer Res 1983, 43, 2368-2374.
55. 55. Tashjian AH, Jr, Voelkel EF, Lloyd W, Derynck R, Winkler ME, Levine L. Actions of growth factors on plasma calcium. Epidermal growth factor and human transforming growth factor-alpha cause elevation of plasma calcium in mice. J Clin Invest 1986, 78, 1405-1409.
56. 56. Sabatini M, Boy ce BF, Aufdemorte T, Bonewald L, Mundy GR. Infusions of recombinant human interleukins 1α and 1β cause hypercalcemia in normal mice. Proc Natl Acad Sci USA 1988, 85, 5235-5239.
57. 57. Niesvizky R, Siegal DS, Busquets X, et al. Hypercalcemia and increased serum interleukin-6 levels induced by all-trans retinoic acid in patients with multiple myeloma. Br J Haematol 1995, 89, 217-218.
58. 58. Yoneda T, Nishimura R, Kato I, Ohmae M, Takita M, Sakuda M. Frequency of the hypercalcemia-leukocytosis syndrome in oral malignancies. Cancer 1991, 68, 617-622.
59. 59. Yoneda T, Nakai M, Moriyama K, et al. Neutralizing antibodies to human interleukin 6 reverse hypercalcemia associated with a human squamous carcinoma. Cancer Res 1993, 53, 737-740.
60. 60. Ralston SH, Fogelman I, Gardner MD, Boyle IT. Relative contribution of humoral and metastatic factors to the pathogenesis of hypercalcemia of malignancy. Br Med J 1984, 288, 1405-1408.
61. 61. Coleman RE, Rubens RD. The clinical course of bone metastases from breast cancer. Br J Cancer 1987, 55, 61-66.
62. 62. Southby J, Kissin MW, Danks JA, et al. Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer. Cancer Res 1990, 50, 7710-7716.
63. 63. Henderson MA, Danks JA, Powell GW, et al. Immunohistochemical detection of parathyroid hormone related protein in the primary tumours of hypercalcaemic breast cancer patients. Breast 1995, 4, 112-116.
64. 64. Kissin MW, Henderson MA, Danks JA, Hayman JA, Bennett RC, Martin TJ. Parathyroid hormone related protein in breast cancers of widely varying prognosis. Eur J Surg Oncol 1993, 19, 134-142.
65. 65. Powell GJ, Southby J, Danks JA, et al. Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res 1991, 51, 3059-3061.
66. 66. Vargas SJ, Gillespie MT, Powell GJ, et al. Localization of parathyroid hormone-related protein mRNA in breast cancer and metastatic lesions by in situ hybridization. J Bone Min Research 1992, 7, 971-979.
67. 67. Guise TA, Yin JJ, Taylor SD, et al. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest 1996, 98, 1544-1549.
68. 68. Franks LM. Etiology, epidemiology and pathology of prostate cancer. Cancer 1973, 32, 1092-1095.
69. 69. Suzuki T, Shimizu T, Kurokawa K, Jimbo H, Sato J, Yamanaka H. Pattern of prostate metastasis to the vertebral column. Prostate 1994, 25, 141-146.
70. 70. Smith DC, Tueker JA, Trump DL. Hypercalcemia and neuroendocrine carcinoma of the prostate: a report of three cases and a review of the literature. J Clin Oncol 1992, 10, 499-505.
71. 71. Iwamura M, di Sant'Agnese PA, Wu G, et al. Immunohistochemical localization of parathyroid hormone-related protein in human prostate cancer. Cancer Res 1993, 53, 1724-1726.
72. 72. Cramer SD, Peehl DM, Edgar MG, Wong ST, Deftos LJ, Feldman D. Parathyroid hormone-related protein (PTHrP) is an epidermal growth factor-regulated secretory product of human prostatic epithelial cells. Prostate 1996, 29, 20-29.
73. 73. Iwamura M, Wu G, Abrahamsson P-A, di Sant'Agnese PA, Cockett ATK, Deftos LJ. Parathyroid hormone-related protein is expressed by prostatic neuroendocrine cells. Urology 1994, 43, 667-674.
74. 74. Iwamura M, Abrahamsson P-A, Schoen S, Cockett ATK, Deftos LJ. Immunoreactive parathyroid hormone-related protein is present in human seminal plasma and is of prostate origin. J Androl 1994, 15, 410-414.
75. 75. Iwamura M, Abrahamsson P-A, Foss KA, Wu G, Cockett ATK, Deftos LJ. Parathyroid hormone related protein: a potential autocrine growth regulator in human prostate cancer cell lines. Urology 1994, 43, 675-679.
76. 76. Iwamura M, Gershagen S, Lapets O, et al. Immunohistochemical localization of parathyroid hormone-related protein in prostatic intraepithelial neoplasia. Hum Pathol 1995, 26, 797-801.
77. 77. Firkin F, Seymour JF, Watson AM, Grill V, Martin TJ. Parathyroid hormone-related protein in hypercalcaemia associated with haematological malignancy. Br J Haematol 1996, 94, 486-492.
78. 78. Breslau NA, McGuire JL, Zerwekh JE, Frenkel EP, Pak CYC. Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma. Ann Intern Med 1984, 100, 1-7.
79. 79. Rosenthal N, Insogna KL, Godsall JW, Smaldone L, Waldron JA, Stewart AF. Elevations in circulating 1,25-dihydroxyvitamin D in three patients with lymphoma-associated hypercalcemia. J Clin Endocrinol Metab 1985, 60, 29-33.
80. 80. Fukumoto S, Matsumoto T, Ikeda K, et al. Clinical evaluation of calcium metabolism in adult T-cell leukemia/lymphoma. Arch Intern Med 1988, 148, 921-925.
81. 81. Watanabe T, Yamaguchi K, Takatsuki K, Osame M, Yoshida M. Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be transactivated by HTLV-1 tax gene. J Exp Med 1990, 172, 759-765.
82. 82. Ejima E, Rosenblatt JD, Massari M, et al. Cell-type-specific transactivation of the parathyroid hormone-related protein gene by the human T-cell leukemia virus type I (HTLV-I) tax and HTLV-II tax proteins. Blood 1993, 81, 1017-1024.
83. 1 : evidence for the involvement of transcription factor ets1. J Virol 1993, 67, 6087-6095.
84. 84. Roodman GD. Osteoclast function in Paget's disease and multiple myeloma. Bone 1995, 17 (Suppl. 2), 57S-61S.
85. 85. Mundy GR, Raisz LG, Cooper RA, Schechter GP, Salmon SE. Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J Med 1974, 291, 1041-1046.
86. 86. Nakamura Y, Bando H, Shintani Y, Yokogoshi Y, Saito S. Serum parathyroid hormone-related protein concentrations in patients with hematologic malignancies or solid tumors. Acta Endocrinol 1992, 127, 324-330.
87. 87. Tamura K, Kubota K, Kurabayashi H, Take H, Shirakura T. Evidence for parathyroid hormone-related peptide as a cause of hypercalcemia in myeloma. Blood 1994, 8, 1692-1693.
88. 88. Kremer R, Shustik C, Tabak T, Papavasiliou V, Goltzman D. Parathyroid-hormone-related peptide in hematologic malignancies. Am J Med 1996, 100, 406-411.
89. 89. Suzuki A, Takahashi T, Okuno Y, et al. Production of parathyroid hormone-related protein by cultured human myeloma cells. Am J Hematol 1994, 45, 88-90.
90. 90. Gurney H, Kefford R, Stuart-Harris R. Renal phosphate threshold and response to pamidronate in humoral hypercalcaemia of malignancy. Lancet 1989, 2, 241-244.
91. 91. Gurney H, Grill V, Martin TJ. Parathyroid hormone-related protein and response to pamidronate in tumour-induced hypercalcaemia. Lancet 1993, 341, 1611-1613.
92. 92. Grill V, Hillary J, Ho PMW, et al. Parathyroid hormone-related protein: a possible endocrine function in lactation. Clin Endocrinol 1992, 37, 405-410.
93. 93. MacIsaac RJ, Heath JA, Rodda CP, et al. Role of the fetal parathyroid glands and parathyroid hormone-related protein in the regulation of placental transport of calcium, magnesium and inorganic phosphate. Reprod Fertil Dev 1991, 3, 447-4157.
94. 94. Ellis AG, Adam WR, Martin TJ. Comparison of the effects of parathyroid hormone (PTH) and recombinant PTH-related protein on bicarbonate excretion by the isolated perfused rat kidney. J Endocrinol 1990, 126, 403-408.
95. 95. Fenton AJ, Kemp BE, Kent GN, et al. A carboxyl-terminal peptide from the parathyroid hormone-related protein inhibits bone resorption by osteoclasts. Endocrinology 1991, 129, 1762-1768.
96. 96. Fenton AJ, Kemp BE, Hammonds RG, Jr, et al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology 1991, 129, 3424-3426.
97. 97. Sone T, Kohno H, Kikuchi H, et al. Human parathyroid hormone-related peptide-(107-111) does not inhibit bone resorption in neonatal mouse calvariae. Endocrinology 1992, 131, 2742-2746.
98. 98. Kaji H, Sugimoto T, Kanatani M, Fukase M, Chihara K. Carboxy-terminal peptides from parathyroid hormone-related protein stimulate osteoclast-like cell formation. Endocrinology 1995, 136, 842-848.
99. 99. Chan SDH, Strewler GJ, King KL, Nissenson RA. Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. Mol Endocrinol 1990, 4, 638-646.
100. 100. van de Stolpe A, Karperien M, Lowik CWGM, et al. Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation. J Cell Biol 1993, 120, 235-243.
101. 101. Lee K, Deeds JD, Segre GV. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats. Endocrinology 1995, 136, 453-463.
102. 102. Bruns ME, Ferguson JE, II, Bruns DE, et al. Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acid in human amnion and chorion-decidua: implications for secretion and function. Am J Obstet Gynecol 1995, 173, 739-746.
103. 103. Hellman P, Ridefelt P, Juhlin C, Akerstrom G, Rastad J, Gylfe E. Parathyroid-like regulation of parathyroid-hormone-related protein release and cytoplasmic calcium in cytotrophoblast cells of human placenta. Arch Biochem Biophys 1992, 293, 174-180.
104. 104. Bowden SJ, Emly JF, Hughes SV, et al. Parathyroid hormone-related protein in human term placenta and membranes. J Endocrinol 1994, 142, 217-224.