Tumor necrosis factor enhances parathyroid hormone-related protein- induced hypercalcemia and bone resorption without inhibiting: Bone formation in vivo

Cancer Research

Volumn 57, Issue 15, 1997, Pages 3194-3199

  Uy, Harry L ^a,b   Mundy, Gregory R ^b   Boyce, Brendan F ^a   Story, Beryl M ^a   Dunstan, Colin R ^c   Yin, Juan Juan ^a   Roodman, G David ^a,b   Guise, Theresa A ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PARATHYROID HORMONE RELATED PROTEIN; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE METABOLISM; CALCIUM HOMEOSTASIS; CHO CELL; HYPERCALCEMIA; MALE; MORPHOMETRICS; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; BONE RESORPTION; CALCIFICATION, PHYSIOLOGIC; CALCIUM; CHO CELLS; CRICETINAE; HUMANS; HYPERCALCEMIA; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, FLUORESCENCE; OSTEOCLASTS; PARATHYROID HORMONE-RELATED PROTEIN; PROTEINS; SKULL; SPINE; TIME FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030843582     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Yates, A. J. P., Gutierrez, G. E., Smolens, P., Travis, P. S., Katz, M. S., Aufdemorte, T. B., Boyce, B. F., Hymer, T. K., Poser, J. W., and Mundy, G. R. Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption, and bone metabolism in vivo and in vitro in rodents. J. Clin. Invest., 81: 932-938, 1988.
2. Stewart, A. F., and Broadus, A. E. Clinical Review 16. Parathyroid hormone-related proteins: coming of age in the 1990s. J. Clin. Endocrinol. Metab., 91: 1410-1414, 1990.
3. Yoneda, T., Alsina, M. A., Chavez, J. B., Bonewald, L., Nishimura, R., and Mundy, G. R. Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice. J. Clin. Invest., 87: 977-985, 1991.
4. Sabatini, M., Chavez, J., Mundy, G. R., and Bonewald, L. F. Stimulation of tumor necrosis factor release from monocytic cells by the A375 human melanoma via granulocyte-macrophage colony-stimulating factor. Cancer Res., 50: 2673-2678, 1990.
5. Sato, K., Fujii, Y., Kasono, K., Tsushima, T., and Shizume, K. Production of interleukin-1α and a parathyroid hormone-like factor by a squamous cell carcinoma of the esophagus (EC-GI) derived from a patient with hypercalcemia. J. Clin. Endocrinol. Metab., 67: 592-601, 1988.
6. Sato, K., Fujii, Y., Ono, M., Nomura, H., and Shizume, K. Production of interleukin 1α-like factor and colony-stimulating factor by a squamous cell carcinoma of the thyroid (T3 M-5) derived from a patient with hypercalcemia and leukocytosis. Cancer Res., 47: 6474-6480, 1987.
7. Nowak, R. A., Morrison, N. E., Goad, D. L., Gaffney, E. V., and Tashjian, A. H., Jr. Squamous cell carcinomas often produce more than a single bone resorption-stimulating factor: role of interleukin-1α. Endocrinology, 127: 3061-3069, 1990.
8. Weissglas, M., Schamhart, D., Lowik, C., Papapoulos, S., Vos, P., and Kurth, K-H. Hypercalcemia, and cosecretion of interleukin-6, and parathyroid hormone related peptide by a human renal cell carcinoma implanted into nude mice. J. Urol., 153: 854-857, 1995.
9. Nagata, N., Akatsu, T., Kugai, N., Yasutomo, Y., Kinoshita, T., Kosano, H., Shimauchi, T., Takatani, O., and Ueyama, Y. The tumor cells (FA-6) established from a pancreatic cancer associated with humoral hypercalcemia of malignancy: a simultaneous production of parathyroid hormone-like activity and transforming growth factor activity. Endocrinol. Jpn., 36: 75-85, 1989.
10. Nagata, N., Yasutomo, Y., Kugai, N., Matsuura, Y., Akatsu, T., Sugiyama, K., Kinoshita, T., Takatani, O., Mamiya, Y., Yamaguchi, K., and Abe, K. Parathyroid hormone-related protein, and transforming growth factor activities in an extract from a breast cancer associated with humoral hypercalcemia of malignancy. Jpn. J. Clin. Oncol., 19: 353-359, 1989.
11. Sato, K., Fujii, K., Kasono, K., Ozawa, M., Imamura, H., Kanaji, Y., Kurosawa, H., Tsushima, T., and Shizume, K. Parathyroid hormone-related protein, and interleukin-1α synergistically stimulate bone resorption in vitro, and increase the serum calcium concentration in mice in vivo. Endocrinology, 124: 2172-2178, 1989.
12. De la Mata, J., Uy, H. L., Guise, T. A., Story, B., Boyce, B. F., Mundy, G. R., and Roodman, G. D. Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J. Clin. Invest., 95: 2846-2852, 1995.