Gamma-hydroxybutyric acid (GHB) in the treatment of alcohol withdrawal syndrome: A randomized comparative study versus benzodiazepine

Alcoholism: Clinical and Experimental Research

Volumn 23, Issue 10, 1999, Pages 1596-1604

  Addolorato, Giovanni ^a   Balducci, Giuseppe ^b   Capristo, Esmeralda ^a   Attilia, Maria L ^b   Taggi, Franco ^c   Gasbarrini, Giovanni ^a   Ceccanti, Mauro ^b  

^a CATHOLIC UNIVERSITY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Alcohol Withdrawal Syndrome; Anxiety; Benzodiazepine; Depression; Gamma Hydroxybutyric Acid (GHB)

Indexed keywords

4 HYDROXYBUTYRIC ACID; ALCOHOL; BENZODIAZEPINE; DIAZEPAM;

ADULT; AGITATION; ALCOHOL ABUSE; ALCOHOL WITHDRAWAL; ANXIETY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032747467     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1999.tb04049.x     Document Type: Article

References (64)

1. Addolorato G, Stefanini GF, Casella G, Marsigli L, Caputo F, Gasbarrini G (1995) Evaluation of the therapeutic efficacy of gamma-hydroxybutyric acid in the medium-term treatment of alcoholic outpatients. Preliminary data from an open multicentric study. Alcologia Eur J Alcohol Stud 7:233-236.
2. Addolorato G, Castelli E, Stefanini GF, Casella G, Caputo F, Marsigli L, Bernardi M, Gasbarrini G (1996) An open multicentric study evaluating 4-hydroxybutyric acid sodium salt in the medium-term treatment of 179 alcohol dependent subjects. Alcohol Alcohol 31:341-345.
3. Addolorato G, Capristo E, Stefanini GF, Gasbarrini G (1997a) Inflammatory bowel disease: A study of the association between anxiety and depression, physical morbidity, and nutritional status. Scand J Gastroenterol 32:1013-1021.
4. Addolorato G, Caputo F, Stefanini GF, Gasbarrini G (1997b) Gamma-hydroxybutyric acid in the treatment of alcohol dependence: Possible craving development for the drug. Addiction 92:1041-1042.
5. Addolorato G, Cibin M, Capristo E, Beghè, Gessa GL, Stefanini GF, Gasbarrini G. (1998a) Maintaining abstinence from alcohol by gamma-hydroxybutyric acid. Lancet 351:38.
6. Addolorato G, Cibin M, Caputo E, Gessa GL, Stefanini GF, Gasbarrini G. (1998b) Gamma-hydroxybutyric acid in the treatment of alcoholism: dosage fractioning utility in nonresponder alcoholic patients. Drug Alcohol Depend 53:7-10.
7. Addolorato G, Ancona C, Capristo E, Graziosetto R, Di Rienzo, Maurizi M, Gasbarrini G. (1999a) State and trait anxiety in women affected by allergic and vasomotor rhinitis. J Psychosom Res 46:283-289.
8. Addolorato G, Caputo F, Capristo E, Stefanini GF, Gasbarrini G (1999b) Gamma-hydroxybutyric acid: Efficacy, potential abuse and dependence in the treatment of alcohol addiction. Alcohol, in press.
9. Addolorato G, Capristo E, Gessa GL, Caputo F, Stefanini GF, Gasbarrini G. (1999c) Long-term administration of GHB does not affect muscular mass in alcoholics. Life Sci 65:191-196.
10. Addolorato G, Caputo F, Capristo E, Stefanini GF, Gasbarrini G. (1999d) A case of gamma-hydroxybutyric acid withdrawal syndrome during alcohol addiction treatment: Utility of diazepam administration. Clin Neuropharmacol 22:60-62.
11. Agabio R, Colombo G, Loche A, Lobina C, Pani ML, Reali R, Gessa GL (1998) Gamma-hydroxybutyric acid reducing effect on ethanol intake: Evidence in favour of a substitution mechanism. Alcohol Alcohol 33:1-10.
12. American Psychiatric Association. (1994) Diagnostic and Statistical Manual of Mental Disorders, ed IV. American Psychiatric Association, Washington, DC.
13. Buck KJ, Harris RA (1990) Benzodiazepine agonist and inverse agonist action on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol. J Pharmacol Exp Ther 253:713-719.
14. CDC (1997) Gamma hydroxybutyrate use. MMVR Morb Mortal Wkly Rep 46:281-283.
15. Chin MY, Kreutzer RA, Dyer JB (1992) Acute poisoning from gamma-hydroxybutyrate in California. West J Med 156:380-384.
16. Colombo G, Agabio R, Lobina C, Reali R, Fadda F, Gessa GL (1995a) Symmetrical generalization between the discriminative stimulus effects of gamma-hydroxybutyric acid and ethanol: Occurrence within narrow dose ranges. Physiol Behav 57:105-111.
17. Colombo G, Agabio R, Lobina C, Reali R, Fadda F, Gessa GL (1995b) Cross tolerance to ethanol and -hydroxybutyric acid. Eur J Pharmacol 273:235-238.
18. Colombo G, Agabio R, Diaz G, Reali R, Gessa GL (1998) Gamma-hydroxybutyric acid (GHB) intake in ethanol-preferring (sP) and -nonpreferring (sNP) rats. Physiol Behav 64:197-202.
19. Di Bello MG, Gambassi F, Mugnai L, Masini E, Mannaioni PF (1995) Gamma-hydroxybutyric acid induced suppression and prevention of alcohol withdrawal syndrome and relief of craving in alcohol dependent patients. Alcologia Eur J Alcohol Stud 7:9-16.
20. Doherty JD, Hattox SE, Snead OC, Roth RH (1978) Identification of endogenous gamma-hydroxybutyrate in human and bovine brain and its regional distribution in human, guinea-pig, and rhesus monkey brain. J Pharmacol Exp Ther 207:130-139.
21. Dyer J, Kreutzer RA, Quattrone A (1990) Multistate outbreak of poisonings associated with illicit use of gamma-hydroxybutyrate. Morb Mortal Wkly Rep 39:861-863.
22. Dyer J (1991) Gamma-hydroxybutyrate: A health food product producing coma and seizure-like activity. Am J Emerg Med 9:321-324.
23. Fadda F, Argiolas A, Melis MR, DeMontis G, Gessa GL (1983) Suppression of voluntary ethanol consumption in rats by gamma-butyrolactone. Life Sci 32:1471-1477.
24. Fadda F, Mosca E, Meloni R, Gessa GL (1985) Suppression by progabide of ethanol withdrawal syndrome in rats. Eur J Pharmacol 109:321-325.
25. Fadda F, Mosca E, Colombo G, Gessa GL (1989) Suppression by gamma-hydroxy-butyric acid of ethanol withdrawal syndrome in rats. Alcohol Alcohol 24:447-451.
26. Frau M, Colombo G, Marchese G, Stefanini E, Gessa GL (1995) Different affinity of cortical GHB binding site in sardinian alcohol-preferring (sP) and -nonpreferring (sNP) rats. Alcohol Alcohol 30:133-137.
27. Frye GD, McCown TJ, Breese GR (1983) Differential sensitivity of ethanol withdrawal signs in the rat to -aminobutyric acid (GABA) mimetics: Blockade of audiogenic seizures but not forelimb tremors. J Pharmacol Exp Ther 226:720-725.
28. Gallimberti L, Canton G, Gentile N, Ferri M, Cibin M, Ferrara SD, Fadda F, Gessa GL (1989) Gamma-hydroxybutyric acid for the treatment of alcohol withdrawal syndrome. Lancet 2:787-789.
29. Gallimberti L, Ferri M, Ferrara SD, Fadda, Gessa GL (1992) Gamma-hydroxybutyric acid in the treatment of alcohol dependence: A double blind study. Alcohol Clin Exp Res 16:673-676.
30. Gessa GL, Vargiu L, Crabai F, Boero GC, Caboni F, Camba R (1966) Selective increase of brain dopamine induced by gamma-hydroxybutyrate. Life Sci 5:1921-1930.
31. Gessa GL, Crabai F, Vargiu, L, Spano PF (1968) Selective increase of brain dopamine induced by gamma-hydroxybutyrate: Study of the mechanism of action. J Neurochem 15:377-381.
32. Gessa GL, Agabio R, Carai M, Lobina C, Pani M, Reali R, Colombo G (1999) Mechanism of the anti-alcohol effect of gamma-hydroxybutyric acid (GHB). Alcohol, in press.
33. Goldstein DB (1973) Alcohol withdrawal reactions in mice: Effects of drugs that modify neurotrasmission. J Pharmacol Exp Ther 186:1-9.
34. B binding that is blocked by valproate and ethosuximide. J Pharmacol Exp Ther 281:753-760.
35. Janis GC, Devaud LL, Mitsuyama H, Morrow AL (1998) Effect of chronic ethanol consumption and withdrawal on the neuroactive steroid 3-hydroxy-5-pregnan-20-one in male and female rats. Alcohol Clin Exp Res 22:2055-2061.
36. Kolin A, Brezina A, Mamelak M, Pandula E (1993) Cardioprotective action of sodium gamma-hydroxybutyrate (GHB) against isoproterenol induced myocardial damage. Int J Exp Pathol 74:275-281.
37. Lejoyeux M, Solomon J, Adès J (1998) Benzodiazepine treatment for alcohol-dependent patients. Alcohol Alcohol 33:563-575.
38. Li J, Stokes SA, Woeckener A (1998) A tale of novel intoxication: A review of the effects of gamma-hydroxybutyric acid with recommendations for management. Ann Emerg Med 31:729-736.
39. Louagie HK, Verstraete AG, De Soete CJ, Baetens DG, Calle P (1997) A sudden awakening from a near coma after combined intake of gamma-hydroxybutyric acid (GHB) and ethanol. J Toxicol Clin Toxicol 35:591-594.
40. Luby S, Jones J, Zalewski A (1992) GHB use in South Carolina. Am J Pub Health 82:128.
41. Magruder KM, Norquist GS, Feil MB, Kopans B, Jacobs D (1995) Who comes to a voluntary depression screening program? Am J Psychiatry 152:1615-1622.
42. A receptor gene expression. Mol Pharmacol 42:415-422.
43. Mayo-Smith MF (1997) Pharmacological management of alcohol withdrawal: A meta-analysis and evidence-based practice guideline: American Society of Addiction Medicine Working Group on Pharmacological Management of Alcohol Withdrawal. JAMA 278:144-151.
44. McLennan FM, Parry JWL (1983) Gammahydroxybutyrate. Anaesthesia 38:589-599.
45. - uptake in cerebral cortical synaptoneurosomes. J Pharmacol Exp Ther 246:158-164.
46. Morton A, Laird LK, Crane DF, Partovi N, Frye LH (1994) A prediction model for identifying alcohol withdrawal seizures. Am J Drug Alcohol Abuse 20:75-86.
47. Nelson T, Kaufman EE, Kline J, Sokoloff L (1981) The extraneuronal distribution of gamma-hydroxybutyrate. J Neurochem 37:1345-1348.
48. Nimmerrichter A, Beckmann E, Gazsó E, Mader R, Marx B, Plech A, Puchinger H, Saletu M, Lesch OM (1997) Double blind controlled trial of GHB in two dosage and clormethiazole in the treatment of alcohol withdrawal syndrome (abstract). Alcohol Clin Exp Res 21 (Suppl):32A.
49. O'Connor PG, Schottenfeld RS (1998) Patients with alcohol problems. N Engl J Med 338:592-602.
50. Pieninkeroinen IP, Telakivi TM, Hillbom ME (1992) Outcome in subjects with alcohol-provoked seizures. Alcohol Clin Exp Res 16:955-959.
51. Poldrugo F, Addolorato G (1999) The role of gamma-hydroxybutyric acid (GHB) in the treatment of alcoholism: From animal to clinical studies. Alcohol Alcohol 34:15-24.
52. Ross HE (1993) Benzodiazepine use and anxiolytic abuse and dependence in treated alcoholics. Addiction 88:209-218.
53. Saitz R, Mayo-Smith MF, Roberts MS, Redmond HA, Bernard DR, Calkins DR (1994) Individualized treatment for alcohol withdrawal: A randomized double-blind controlled trial. JAMA 272:519-523.
54. A and NMDA receptor function in the rat brain Alcohol Clin Exp Res 17:115-123.
55. Schuckit MA (1995) Alcoholism acute treatment, in Drug and alcohol abuse. A clinical guide to diagnosis and treatment. IV ed. (MA Schuckit ed), pp 97-117, Plenum Medical Book Co, New York-London.
56. Snead OC (1977) Gamma-hydroxybutyrate. Life Sci 20:1935-1944.
57. Snead OC, Moreley BJ (1981) Ontogeny of gamma-hydroxybutyric acid. Regional concentration in developing rat, monkey and human brain. Brain Res 227:579-589.
58. Spielberg CD, Gorsuch RL, Lushene RE (1983) Manual for the State-Trait Anxiety Inventory. Consulting Psychologist Press; Paolo Alto (CA).
59. Sullivan JT, Sykora K, Schneiderman J, Naranjo CA (1989) Assessment of alcohol withdrawal: The revised Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar). Br J Addict 84:1353-1357.
60. Thomas G, Bonner S, Gascoigne A (1997) Coma induced by abuse of gamma-hydroxybutyrate (GHB or liquid ecstasy): A case report. BMJ 314:35-36.
61. Tunnicliff G (1997) Site of action of Gamma-hydroxybutyrate (GHB) -a neuroactive drug with abuse potential. J Toxicol Clin Toxicol 35:581-590.
62. Ueki Y (1992) Effects of gamma-hydroxybutyrate on monoamine metabolism and protein synthesis after transient global cerebral ischemia. No Shinkei Geka 20:937-946.
63. Vayer P, Mandel M, Maitre M (1987) Gamma-hydroxybutyrate, a possible neurotransmitter. Life Sci 41:1547-1557.
64. Zung WW, Richards CB, Short MJ (1965) A self-rating depression scale in outpatient clinic. Further validation of SDS. Arch Gen Psychiatry 13:508-515.