Opiate receptors in the periaqueductal gray mediate analgesic effect of nitrous oxide in rats

European Journal of Pharmacology

Volumn 336, Issue 2-3, 1997, Pages 137-141

  Fang, Fang ^a,b   Guo, Tian Zhi ^a,b   Davies, M Frances ^a,b   Maze, Mervyn ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

2 Adrenoceptor; Antinociception; Nitrous oxide (N2O); Opitate receptor; Periaqueductal gray

Indexed keywords

NALOXONE; NITROUS OXIDE; OPIATE ANTAGONIST; OPIATE RECEPTOR; YOHIMBINE;

ANALGESIA; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INHALATIONAL DRUG ADMINISTRATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; RAT; SPINAL CORD;

ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS, NON-NARCOTIC; ANIMALS; INJECTIONS, INTRAVENTRICULAR; MALE; MICROINJECTIONS; NALOXONE; NARCOTIC ANTAGONISTS; NITROUS OXIDE; PAIN THRESHOLD; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; YOHIMBINE;

EID: 0030695488     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01219-3     Document Type: Article

References (48)

1. Aimone L.D., Jones S.L., Gebhart G.F. Stimulation-produced descending inhibition from the periaqueductal gray and nucleus raphe magnus in the rat: Mediation by spinal monoamines but not opioids. Pain. 31:1987;123.
2. Akil H., Mayer D.J., Liebeskind J.C. Antagonism of stimulation produced analgesia by naloxone, a narcotic antagonist. Science. 191:1976;961.
3. Beitz A.J. The organization of afferent projections to the midbrain periaqueductal gray of the rat. Neuroscience. 7:1982;133.
4. Beitz A., Mullett M.A., Brandt N. The relationship of periaqueductal gray projections to bulbospinal neurons: A combined fluorogold-PHA-L analysis. Soc. Neurosci. Abstr. 14:1988;856.
5. Berkowitz B.A., Ngai S.H., Finck D.A. Nitrous oxide 'analgesia': Resemblance to opiate analgesia. Science. 194:1976;967.
6. Berkowitz B.A., Finck A.D., Ngai S.H. Nitrous oxide analgesia: Reversal by naloxone and development of tolerance. J. Pharmacol. Exp. Ther. 203:1977;539.
7. Berkowitz B.A., Finck A.D., Hynes M.D., Ngai S.H. Tolerance to nitrous oxide analgesia in rats and mice. Anesthesiology. 51:1979;309.
8. Byrum C.E., Guyenet P.G. Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J. Comp. Neurol. 261:1987;529.
9. Camarata P.J., Yaksh T.L. Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray. Brain Res. 336:1985;133.
10. Cameron A.A., Khan I.A., Westlund K.N., Willis W.D. The efferent projections of the periaqueductal gray in the rat: A phaseoleus vulgaris-leucoagglutin study. II. Descending projection. J. Comp. Neurol. 351:1995;585.
11. Chapman C.R., Benedetti C. Nitrous oxide effects on cerebral evoked potential to pain, partial reversal with a narcotic antagonist. Anesthesiology. 51:1979;135.
12. Chapman W.P., Arrowood J.G., Beecher H.K. The analgetic effects of low concentrations of nitrous oxide compared in man with morphine sulphate. J. Clin. Invest. 22:1943;871.
13. Clark F.M., Proudfit H.K. The projections of noradrenergic neurons in the A5 catecholamine cell group to the spinal cord in the rat: Anatomical evidence that A5 neurons modulate nociception. Brain Res. 616:1993;200.
14. Dundee J.W., Moore J. Alterations in response to somatic pain associated with anesthesia. IV: The effects of sub-anesthetic concentrations of inhalation agents. Br. J. Anesth. 32:1960;453.
15. Ennis M., Behbehani M., Shipley M.T., Van Bockstatele E.J., Aston-Jones G. Projections from the periaqueductal gray to the rostromedial pericoerulear region and nucleus locus coeruleus: Anatomical and physiological studies. J. Comp. Neurol. 306:1991;480.
16. Fang F., Marczynski T.J., Proudfit H.K. Projections from neurons in the ventrolateral periaqueductal gray to the spinally-projecting noradrenergic neurons in the A7 catecholamine cell group. Soc. Neurosci. Abstr. 21:1995;386.
17. Fardin V., Oliveras J.L., Besson J.M. A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal gray matter in the rat I. The production of behavioral side effects together with analgesia. Brain Res. 306:1984;105.
18. Fardin V., Oliveras J.L., Besson J.M. A reinvestigation of the analgesic effects induced by stimulation of the periaqueductal gray matter in the rat II. Different characteristics of the analgesia induced by ventral and dorsal PAG stimulation. Brain Res. 306:1984;125.
19. Finck A.D., Samaniego E., Ngai S.H. Nitrous oxide selectively releases Met-enkephalin and Met-enkephalin-Arg-Phe into canine third ventricular cerebrospinal fluid. Anesth. Analg. 80:1995;664.
20. Gebhart G.F., Toleikis J.R. An evaluation of stimulation produced analgesia in cat. Exp. Neurol. 62:1978;570.
21. Guo T.Z., Poree L., Golden W., Fujinaga M., Maze M. The antinociceptive response to nitrous oxide is mediated by supraspinal opiate alpha-2 adrenergic receptors in the rat. Anesthesiology. 85:1996;846.
22. Hosobuchi Y., Adams J.E., Linchitz R. Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. Science. 197:1977;183.
23. Hodges B.L., Gagnon M.J., Gillepie T.R., Breneisen J.R., O'Leary D.F., Hara S., Quock R.M. Antagonism of nitrous oxide antinociception in the rat hot plate test by site-specific μ and ε opioid receptor blockade. J. Pharmacol. Exp. Ther. 269(2):1994;596-600.
24. Jensen T.S., Yaksh T.L. Spinal monoamine and opiate systems partially mediate the antinociceptive effects produced by glutamate at brainstem sites. Brain Res. 321:1984;287.
25. Kendig J.J., Savola M.K.T., Woodley S.J., Maze M. Alpha-2 adrenoceptors inhibit a nociceptive response in neonatal rat spinal cord. Eur. J. Pharmacol. 192:1991;293.
26. Lawrence D., Livingston A. Opiate-like analgesic activity in general anaesthetics. Br. J. Pharmacol. 73:1981;435.
27. Lovick T.A. Integrated activity of cardiovascular and pain regulatory systems: Role in adaptive behavioural response. Prog. Neurobiol. 40:1993;631.
28. Mayer D.J., Liebeskind J.C. Pain produced by focal electrical stimulation of the brain: An anatomical and behavioral analysis. Brain Res. 68:1974;73.
29. Ohara A., Zhang P., Mashimo T., Kamibayashi T., Takada K., Mammoto T., Yamatodani A., Yoshiya I. Myocardinal effects of xenon and nitrous oxide during halothane anesthesia in dogs. Anesthesiology. 79A:1993;613.
30. Ossipov M., Gebhart G.F. Absence of antinociceptive effect of alpha-2 agonists microinjected in the periaqueductal gray of the rat. Brain Res. 289:1983;354.
31. Parbrook G.D., Ree S., Robertson G.S. Comparison of a 25% nitrous oxide and oxygen mixture with morphine. Br. Med. J. 2:1964;480.
32. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates, 2nd ed. Academic Press, Sydney, Australia.
33. Pang I.H., Vasko M.R. Effect of depletion of spinal cord norepinephrine on morphine-induced antinociception. Brain Res. 371:1986;171.
34. Peng Y.B., Lin Q., Willis W.D. Involvement of alpha-2 adrenoceptors in the periaqueductal gray-induced inhibition of dorsal horn cell activity in rats. J. Pharmacol. Exp. Ther. 278:1996;125.
35. Quock R.M., Graczak L.M. Influence of narcotic antagonistic drugs upon nitrous oxide analgesia in mice. Brain Res. 440:1988;35.
36. Quock R.M., Kouchich F.J., Tseng L.F. Does nitrous oxide induce release of brain opioid peptides? Pharmacology. 30:1985;95.
37. Richardson D.E., Akil H. Pain reduction by electrical brain stimulation in man. II. Chronic self administration in the periaqueductal gray matter. J. Neurosurg. 47:1977;184.
38. Roizen M.F., Koblin D.D., Johnson B.H., Eger E.I. II, Bainton C.R. Mechanism of age-related and nitrous oxide-associated anesthetic sensitivity: The role of brain catecholamines. Anesthesiology. 69:1988;716.
39. Sagen J., Proudfit H.K. Evidence for pain modulation by pre- and postsynaptic noradrenergic receptors in the medulla oblongata. Brain Res. 331:1985;285.
40. Sandkuhler J., Gebhart G.F. Relative contribution of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat. Brain Res. 305:1984;77.
41. Unnerstall J.R., Kopajtic T.A., Kuhar M.J. Distribution of alpha-2 agonist binding sites in the rat and human central nervous system: Analysis of some functional, anatomic correlates of the pharmacological effects of clonidine and related adrenergic agents. Brain Res. 319:1984;69.
42. Weiner, N., 1985. Atropine, scopolamine and related antimuscarinic drugs. In: Gilman, A.G., Goodman, L.S., Rall T.W., Murad, F. (Eds.), Goodman and Gilman's The Pharmacological Basis of Therapeutics. Macmillan, New York, p. 130.
43. Westlund K.N., Bowker R.M., Ziegler M.G., Coulter J.D. Origins and terminations of descending noradrenergic projections to the spinal cord of monkey. Brain Res. 292:1984;1.
44. Yang J.C., Clark W.C., Ngai S.H. Antagonism of nitrous oxide analgesia by naloxone in man. Anesthesiology. 52:1980;414.
45. Young, W.S., Kuhar, M.J., 1981. Anatomical mapping of clonidine (alpha-2 noradrenergic) receptors in rat brain, relationship to function. In: Lal, H., Fielding, S. (Eds.), Psychopharmacology of Clonidine. Alan R. Liss, New York, p. 41.
46. Zuniga J.R., Joseph S.A., Knigge K.M. The effects of nitrous oxide on the central endogenous pro-opiomelanocortin system in the rat. Brain Res. 420:1987;57.
47. Zuniga J.R., Joseph S.A., Knigge K.M. The effects of nitrous oxide on the secretory activity of pro-opiomelanocortin peptides from the basal hypothalamic cells attached to cytodex beads in a superfusion in vitro system. Brain Res. 420:1987;66.
48. Zuniga J., Joseph S., Knigge K. Nitrous oxide analgesia: Partial antagonism by naloxone and total reversal after periaqueductal gray lesions in the rat. Eur. J. Pharmacol. 142:1987;51.