Prostaglandins mediate bradykinin-induced reduction of exhaled nitric oxide in asthma

European Respiratory Journal

Volumn 14, Issue 5, 1999, Pages 1023-1027

  Kharitonov, S A ^a   Sapienza, M M ^a   Chung, K F ^a,b   Barnes, P J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Airway inflammation asthma; Bradykinin exhaled nitric oxide; Prostaglandins

Indexed keywords

ACETYLSALICYLIC ACID; BRADYKININ; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR;

ADULT; ARTICLE; ASTHMA; BRONCHOSPASM; BRONCHUS REACTIVITY; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032743808     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.99.14510239     Document Type: Article

References (32)

1. Barnes PJ, Belvisi MG. Nitric oxide and lung disease. Thorax 1993; 48: 1034-1043.
2. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med 1994; 149: 538-551.
3. Gustafsson LE, Leone AM, Persson MG, Wilklund NP, Moncada S. Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commun 1991; 181: 852-857.
4. Kharitonov SA, Yates DH, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet 1994; 343: 133-135.
5. Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993; 6: 1368-1370.
6. Hamid Q, Springall DR, Riveros-Moreno V, et al. Induction of nitric oxide synthase in asthma. Lancet 1993; 342: 1510-1513.
7. Kobzik L, Bredt DS, Lowenstein CJ, et al. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 1993; 9: 371-377.
8. Barnes PJ. Bradykinin and asthma. Thorax 1992; 47: 979-983.
9. Fuller RW, Dixon CMS, Cuss FMC, Barnes PJ. Bradykinin-induced bronchoconstriction in humans mode of action. Am Rev Respir Dis 1987; 135: 176-180.
10. Polosa R, Holgate ST. Comparative airway responses to inhaled bradykinin, kallidin and [des Arg9]-bradyikinin in normal and asthmatic airways. Am Rev Respir Dis 1990; 142: 1367-1371.
11. Bramley AM, Samhoun MN, Piper PJ. The role of epithelium in modulating the responses of guinea-pig trachea induced by bradykinin in vitro. Br J Pharmacol 1990; 99: 762-766.
12. Ricciardolo FLM, Geppetti P, Mistretta A, et al. Randomised double-blind placebo-controlled study of the effect of inhibition on nitric oxide synthesis in bradykinin-induced asthma. Lancet 1996; 348: 374-377.
13. 2α, reduce exhaled nitric oxide in normal and asthmatic subjects irrespective of airway calibre changes. Am J Respir Crit Care Med 1998; 158: 1374-1378.
14. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995; 151: 1894-1899.
15. Kharitonov SA, Chung FK, Evans DJ, O'Connor BJ, Barnes PJ. The elevated level of exhaled nitric oxide in asthmatic patients is mainly derived from the lower respiratory tract. Am J Respir Crit Care Med 1996; 153: 1773-1780.
16. Kharitonov SA, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements, recommendations. Eur Respir J 1997; 10: 1683-1693.
17. 2 on allergen-induced asthma. Am Rev Respir Dis 1993; 148: 87-90.
18. 2 release by canine tracheal epithelium. Am J Physiol 1985; 248: F48-F55.
19. Lerner UH, Modeer T. Bradykinin B1 and B2 receptor agonists synergistically potentiate interleukin-1-induced prostaglandin biosynthesis in human gingival fibroblasts. Inflammation 1991; 15: 427-436.
20. 2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Nati Acad Sci USA 1994; 91: 12168-12172.
21. 2 release by intact cells expressing cyclo-oxygenase-2: evidence for a "two-component" model. J Pharmacol Exp Ther 1999; 288: 1101-1106.
22. Yates DH, Kharitonov SA, Thomas PS, Barnes PJ. Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. Am J Respir Crit Care Med 1996; 154: 247-250.
23. Hogman M, Frostell CG, Hedenstrom H, Hedenstierna G. Inhalation of nitric oxide modulates adult human bronchial tone. Am J Respir Crit Care Med 1993; 148: 1474-1478.
24. Charan NB, Johnson SR, Lakshminarayan S, Thompson WH, Carvalho P. Nitric oxide and beta-adrenergic agonist-induced bronchial arterial vasodilation. J Appl Physiol 1997; 82: 686-692.
25. Carvalho P, Johnson SR, Charan NB. Non-cAMP-mediated bronchial arterial vasodilation in response to inhaled beta-agonists. J Appl Physiol 1998; 84: 215-221.
26. Widdicombe J. The tracheobronchial vasculature: a possible role in asthma. Microcirculation 1996; 3: 129-141.
27. de Gouw H, Hendriks J, Woltman AM, Twiss IM, Sterk PJ. Exhaled nitric oxide (NO) is reduced shortly after bronchoconstriction to direct and indirect stimuli in asthma. Am J Respir Crit Care Med 1998; 158: 315-319.
28. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995; 151: 1894-1899.
29. de Gouw H, Grunberg K, Schot R, Kroes AC, Dick EC, Sterk PJ. Relationship between exhaled nitric oxide and airway hyperresponsiveness following experimental rhinovirus infection in asthmatic subjects. Eur Respir J 1998; 11: 126-132.
30. Finney MJ, Anderson SD, Black JL. Terfenadine modifies airway narrowing induced by the inhalation of non-isotonic aerosols in subjects with asthma. Am Rev Respir Dis 1990; 141: 1151-1157.
31. Rodwell LT, Anderson SD, Scale JP. Inhaled clemastine, an H1 antihistamine inhibits airway narrowing caused by aerosols of nonisotonic saline. Eur Respir J 1991; 4: 1126-1134.
32. Barnes PJ, Liew FY. Nitric oxide and asthmatic inflammation. Immunology Today 1995; 16: 128-130.