Iodine-123 labelled PE2I for dopamine transporter imaging: Influence of age in healthy subjects

European Journal of Nuclear Medicine

Volumn 26, Issue 11, 1999, Pages 1486-1488

  Kuikka, Jyrki T ^a,b   Tupala, Erkki ^a   Bergström, Kim A ^a   Hiltunen, Jukka ^c   Tiihonen, Jari ^b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c MAP Medical Technologies Oy   (Finland)

Author keywords

Age; Dopamine transporter; Human brain; Single photon emission tomography; Striatum

Indexed keywords

DOPAMINE TRANSPORTER; IODINE 123; N (3 IODOPROP 2 ENYL) 2BETA CARBOMETHOXY 3BETA (4' METHYLPHENYL)NORTROPANE; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ARTICLE; BRAIN TOMOGRAPHY; DRUG DISTRIBUTION; HUMAN; HUMAN EXPERIMENT; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; MALE; PHOTON EMISSION TOMOGRAPHY; SCINTILLATION CAMERA;

ADULT; AGE FACTORS; AGED; BRAIN; CARRIER PROTEINS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; IODINE RADIOISOTOPES; LIGANDS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; NORTROPANES; PARKINSON DISEASE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0032743314     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590050483     Document Type: Article

References (10)

1. Emond P, Garreau L, Chalon S, et al. Synthesis and ligand binding of nortropane derivates: N-substituted-2β-carbomethoxy-3β-(-4-iodophenyl)nortropane and N-(3-iodopro-2E-enyl)-2β-carbomethoxy-3β-(3′,4*-disubstitu ted phenyl)nortropane. New high affinity and selective compounds for the dopamine transporter. J Med Chem 1997; 40: 1366-1372.
2. Kuikka JT, Baulieu JL, Hiltunen J, et al. Pharmacokinetics and dosimetry of iodine-123 labelled PE2I in humans, a radioligand for dopamine transporter imaging. Eur J Nucl Med 1998; 25: 531-534.
3. 125I]PE2I. Neuroimage 1999; 9: 108-116.
4. Kuikka JT, Tiihonen J, Bergström KA, et al. Imaging of serotonin and dopamine transporters in the living human brain. Eur J Nucl Med 1995; 22: 346-350.
5. Volkow ND, Ding YS, Fowler JS, et al. Dopamine transporters decrease with age. J Nucl Med 1996; 37: 554-559.
6. 99mTc]TRODAT-1 binding to dopamine transporters in nonhuman primates using single-photon emission tomography. Eur J Nucl Med 1999; 26: 518-526.
7. Logan J, Fowler JS, Volkow ND, et al. Graphical analysis of reversible binding from time activity measurements. J Cereb Blood Flow Metab 1990; 10: 740-747.
8. Lammertsmaa AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage 1996; 4: 153-158.
9. Kung HF, Kim HJ, Kung MP, et al. Imaging of dopamine transporter in humans with technetium-99 m TRODAT-1. Eur J Nucl Med 1996; 23: 1527-1530.
10. Kuikka JT, Bergström KA, Ahonen A, et al. Comparison of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)nortropane for imaging of the dopamine transporter in the living human brain. Eur J Nucl Med 1995; 22: 356-360.