메뉴 건너뛰기




Volumn 31, Issue 3, 1999, Pages 243-254

Analysis of the use of fortified medium in continuous culture of mammalian cells

Author keywords

Continuous culture; Growth inhibition; Osmolality; Perfusion culture

Indexed keywords

CELL CULTURE; CELL GROWTH; CONTINUOUS CULTURE; CULTURE MEDIUM; DRUG MANUFACTURE; GROWTH INHIBITION; MAMMAL CELL; MATHEMATICAL MODEL; NUTRIENT; OSMOLALITY; RECOMBINANT PROTEIN; SIMULATION; STOICHIOMETRY;

EID: 0032742185     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008026613975     Document Type: Article
Times cited : (8)

References (52)
  • 1
    • 0025514464 scopus 로고
    • Inclined sedimentation for selective retention of viable hybridomas in a continuous suspension bioreactor
    • Batt BC, Davis RH and Kompala DS (1990) Inclined sedimentation for selective retention of viable hybridomas in a continuous suspension bioreactor. Biotechnol Prog 6: 458-64.
    • (1990) Biotechnol Prog , vol.6 , pp. 458-464
    • Batt, B.C.1    Davis, R.H.2    Kompala, D.S.3
  • 4
    • 84988141839 scopus 로고
    • Kinetic Modelling of Hybridoma Cell Growth and Immunoglobulin Production in a Large-Scale Suspension Culture
    • Bree MA, Dhurjati P, Geoghegan RF, Jr. and Robnett B (1988) Kinetic Modelling of Hybridoma Cell Growth and Immunoglobulin Production in a Large-Scale Suspension Culture. Biotechnol Bioeng 32: 1067-1072.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 1067-1072
    • Bree, M.A.1    Dhurjati, P.2    Geoghegan R.F., Jr.3    Robnett, B.4
  • 5
    • 0028765767 scopus 로고
    • Enhancement of Monoclonal Antibody yield by Hybridoma fed-batch culture, resulting in extended maintenance of Viable Cell population
    • J.N. W
    • Bushell ME, Bell SL, Scott MF, Spier RE, J.N. W and Sanders PG (1994) Enhancement of Monoclonal Antibody yield by Hybridoma fed-batch culture, resulting in extended maintenance of Viable Cell population. Biotechnol Bioeng 44: 1099-1106.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 1099-1106
    • Bushell, M.E.1    Bell, S.L.2    Scott, M.F.3    Spier, R.E.4    Sanders, P.G.5
  • 7
    • 0026417346 scopus 로고
    • Long Term Perfusion Culture of Hybridoma: A "Grow or Die" Cell Cycle System
    • de la Broise D, Noiseux M, Lemieux R and Massie B (1991) Long Term Perfusion Culture of Hybridoma: a "Grow or Die" Cell Cycle System. Biotechnol Bioeng 38: 781-787.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 781-787
    • De La Broise, D.1    Noiseux, M.2    Lemieux, R.3    Massie, B.4
  • 8
    • 0345506897 scopus 로고
    • Practical matters in instrumentation for mammalian cell cultures
    • Thilly WJ (ed.) Butterworth, London
    • Fleischacker R (1986) Practical matters in instrumentation for mammalian cell cultures. In: Thilly WJ (ed.) Mammalian Cell Technology) Butterworth, London.
    • (1986) Mammalian Cell Technology
    • Fleischacker, R.1
  • 12
    • 0026416428 scopus 로고
    • Kinetic study of hybridoma cell growth in continuous culture. I. a model for non-producing cells
    • Frame KK and Hu W-S (1991) Kinetic study of hybridoma cell growth in continuous culture. I. A model for non-producing cells. Biotechnol Bioeng 37: 55-64.
    • (1991) Biotechnol Bioeng , vol.37 , pp. 55-64
    • Frame, K.K.1    Hu, W.-S.2
  • 13
    • 0025929438 scopus 로고
    • Bioreactor Control and Optimization
    • Ho CS and Wang DIC (ed.) Butterworth-Heinemann, Oxford
    • Glacken MW (1991) Bioreactor Control and Optimization. In: Ho CS and Wang DIC (ed.) Animal Cell Bioreactors (373-404) Butterworth-Heinemann, Oxford.
    • (1991) Animal Cell Bioreactors , pp. 373-404
    • Glacken, M.W.1
  • 14
    • 0024278869 scopus 로고
    • Mathematical descriptions of hybridoma culture kinetics: I. Initial metabolic rates
    • Glacken MW, Adema E and Sinskey AJ (1988) Mathematical descriptions of hybridoma culture kinetics: I. Initial metabolic rates. Biotechnol Bioeng 32: 491-506.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 491-506
    • Glacken, M.W.1    Adema, E.2    Sinskey, A.J.3
  • 15
    • 0022787791 scopus 로고
    • Reduction of waste product excretion via nutrient control: Possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells
    • Glacken MW, Fleischaker RJ and Sinskey AJ (1986) Reduction of waste product excretion via nutrient control: Possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells. Biotechnol Bioeng 28: 1376-1389.
    • (1986) Biotechnol Bioeng , vol.28 , pp. 1376-1389
    • Glacken, M.W.1    Fleischaker, R.J.2    Sinskey, A.J.3
  • 16
    • 0025580537 scopus 로고
    • Monitoring and control of animal cell bioreactors: Biochemical engineering considerations
    • Hu WS and Oberg MG (1990) Monitoring and control of animal cell bioreactors: biochemical engineering considerations. [Review]. Bioprocess Technology 10: 451-81.
    • (1990) Bioprocess Technology , vol.10 , pp. 451-481
    • Hu, W.S.1    Oberg, M.G.2
  • 17
    • 0026845470 scopus 로고
    • Mammalian cell culture processes
    • Hu WS and Piret JM (1992) Mammalian cell culture processes. [Review] [44 refs]. Curr Opin Biotechnol 3: 110-4.
    • (1992) Curr Opin Biotechnol , vol.3 , pp. 110-114
    • Hu, W.S.1    Piret, J.M.2
  • 18
    • 0026137003 scopus 로고
    • Animal cell bioreactors. Recent advances and challenges to scale-up
    • Hu W-S and Peshwa MV (1991) Animal cell bioreactors. Recent advances and challenges to scale-up. Can J Chem Eng 69: 409-420.
    • (1991) Can J Chem Eng , vol.69 , pp. 409-420
    • Hu, W.-S.1    Peshwa, M.V.2
  • 22
    • 10144250933 scopus 로고    scopus 로고
    • Monitoring and Control of the Physiological State of Cell Cultures
    • Konstantinov KB (1996) Monitoring and Control Of the Physiological State Of Cell Cultures. Biotechnol Bioeng 52: 271-289.
    • (1996) Biotechnol Bioeng , vol.52 , pp. 271-289
    • Konstantinov, K.B.1
  • 23
    • 0025860534 scopus 로고
    • Physiologically motivated strategies for control of the fed-batch cultivation of recombinant Escherichia coli for phenylalanine production
    • Konstantinov KB, Nishio N, Seki T and Yoshida T (1991) Physiologically motivated strategies for control of the fed-batch cultivation of recombinant Escherichia coli for phenylalanine production. J Ferm Bioeng: 350-355.
    • (1991) J Ferm Bioeng , pp. 350-355
    • Konstantinov, K.B.1    Nishio, N.2    Seki, T.3    Yoshida, T.4
  • 25
    • 0030038110 scopus 로고    scopus 로고
    • Control of Long-Term Perfusion Chinese Hamster Ovary Cell Glucose Auxostat
    • Konstantinov KB, Tsai YS, Moles D and Matanguihan R (1996) Control Of Long-Term Perfusion Chinese Hamster Ovary Cell Glucose Auxostat. Biotechnol Prog 12: 100-109.
    • (1996) Biotechnol Prog , vol.12 , pp. 100-109
    • Konstantinov, K.B.1    Tsai, Y.S.2    Moles, D.3    Matanguihan, R.4
  • 26
    • 0028765274 scopus 로고
    • Growth Characteristics in Fed-Batch Culture of Hybridoma Cells with Control of Glucose and Glutamine Concentrations
    • Kurokawa H, Park YS, Iijima S and Kobayashi T (1994) Growth Characteristics in Fed-Batch Culture of Hybridoma Cells with Control of Glucose and Glutamine Concentrations. Biotechnol Bioeng 44: 95-103.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 95-103
    • Kurokawa, H.1    Park, Y.S.2    Iijima, S.3    Kobayashi, T.4
  • 27
    • 0027295683 scopus 로고
    • Kinetic study of Hybridoma Metabolism and Antibody production in Continuous Culture using Serum-free media
    • Kurokawa H, Tatsuya O, Kamihira M, Park YS, Iijima S and Kobayashi T (1993) Kinetic study of Hybridoma Metabolism and Antibody production in Continuous Culture using Serum-free media. J Perm Bioeng 76: 128-133.
    • (1993) J Perm Bioeng , vol.76 , pp. 128-133
    • Kurokawa, H.1    Tatsuya, O.2    Kamihira, M.3    Park, Y.S.4    Iijima, S.5    Kobayashi, T.6
  • 28
    • 0028121775 scopus 로고
    • High cell density culture of mammalian cells with dynamic perfusion based on on-line oxygen uptake rate measurements
    • Kyung Y-S, Peshwa MV, Gryte DM and W-S. H (1994) High cell density culture of mammalian cells with dynamic perfusion based on on-line oxygen uptake rate measurements. Cytotechnology 14: 183-190.
    • (1994) Cytotechnology , vol.14 , pp. 183-190
    • Kyung, Y.-S.1    Peshwa, M.V.2    Gryte, D.M.3    W-S, H.4
  • 31
    • 0023079190 scopus 로고
    • Invasive infrared sensor for the determination of the cell number in a continuous fermentation of hybridomas
    • Merten OW, Palfi GE, Staheli J and Steiner J (1987) Invasive infrared sensor for the determination of the cell number in a continuous fermentation of hybridomas. Dev Biol Standard 66: 357-360.
    • (1987) Dev Biol Standard , vol.66 , pp. 357-360
    • Merten, O.W.1    Palfi, G.E.2    Staheli, J.3    Steiner, J.4
  • 32
    • 84988106827 scopus 로고
    • A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration , dilution rate, and pH
    • Miller WM, Wilke CR and Blanch HW (1988) A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration , dilution rate, and pH. Biotechnol Bioeng 32: 947-965.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 947-965
    • Miller, W.M.1    Wilke, C.R.2    Blanch, H.W.3
  • 33
    • 0025929115 scopus 로고
    • Continuous cell culture
    • Ho CS and Wang DIC (ed.) Butterworth-Heinemann, Oxford
    • Nicholson ML, Hampson BS, Pugh GG and Ho CS (1991) Continuous cell culture. In: Ho CS and Wang DIC (ed.) Animal Cell Bioreactors (269-303) Butterworth-Heinemann, Oxford.
    • (1991) Animal Cell Bioreactors , pp. 269-303
    • Nicholson, M.L.1    Hampson, B.S.2    Pugh, G.G.3    Ho, C.S.4
  • 34
    • 0029078345 scopus 로고
    • Intracellular responses of productive hybridomas subjected to high osmotic pressure
    • Oh SKW, Chua FKF and Choo ABH (1995) Intracellular responses of productive hybridomas subjected to high osmotic pressure. Biotechnol Bioeng 46: 525-535.
    • (1995) Biotechnol Bioeng , vol.46 , pp. 525-535
    • Oh, S.K.W.1    Chua, F.K.F.2    Choo, A.B.H.3
  • 35
    • 0028486197 scopus 로고
    • Hyperosmotic hybridoma cell cultures: Increased monoclonal antibody production with addition of glycine betaine
    • Oyaas K, Ellingsen TE, Dyrset N and Levine DW (1994) Hyperosmotic hybridoma cell cultures: increased monoclonal antibody production with addition of glycine betaine. Biotechnol Bioeng 44: 991-998.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 991-998
    • Oyaas, K.1    Ellingsen, T.E.2    Dyrset, N.3    Levine, D.W.4
  • 36
    • 0026147822 scopus 로고
    • Effect of Medium Osmolarity on Hybridoma Growth, Metabolism, and Antibody Production
    • Ozturk SS and Palsson BO (1991) Effect of Medium Osmolarity on Hybridoma Growth, Metabolism, and Antibody Production. Biotechnol Bioeng 37: 989-993.
    • (1991) Biotechnol Bioeng , vol.37 , pp. 989-993
    • Ozturk, S.S.1    Palsson, B.O.2
  • 37
    • 0031554631 scopus 로고    scopus 로고
    • Simultaneous measurement of glucose and glutamine in insect cell culture media by near infrared spectroscopy
    • M. R, J. ZX, A. AM and W. MD
    • Riley MR, M. R, J. ZX, A. AM and W. MD (1997) Simultaneous measurement of glucose and glutamine in insect cell culture media by near infrared spectroscopy. Biotechnol Bioeng 55: 11-15.
    • (1997) Biotechnol Bioeng , vol.55 , pp. 11-15
    • Riley, M.R.1
  • 38
    • 0025008342 scopus 로고
    • Kinetics of Growth and Antibody Production by a Hybridoma Cell Line in a Perfusion Culture
    • Seamans TC and Hu W-S (1990) Kinetics of Growth and Antibody Production by a Hybridoma Cell Line in a Perfusion Culture. J Perm Bioeng 70: 241-245.
    • (1990) J Perm Bioeng , vol.70 , pp. 241-245
    • Seamans, T.C.1    Hu, W.-S.2
  • 39
    • 0030015158 scopus 로고    scopus 로고
    • Large-Scale Perfusion Culture Process for Suspended Mammalian That Uses a Centrifuge with Multiple Settling Zones
    • Takamatsu H, Hamamoto K, Ishimaru K, Yokoyama S and Tokashiki M (1996) Large-Scale Perfusion Culture Process For Suspended Mammalian That Uses a Centrifuge With Multiple Settling Zones. Appl Microbiol Biotechnol 45: 454-457.
    • (1996) Appl Microbiol Biotechnol , vol.45 , pp. 454-457
    • Takamatsu, H.1    Hamamoto, K.2    Ishimaru, K.3    Yokoyama, S.4    Tokashiki, M.5
  • 40
    • 0024847585 scopus 로고
    • High Cell Density Perfusion Culture of Mouse-Human Hybridomas
    • Takazawa Y and Tokashiki M (1989) High Cell Density Perfusion Culture of Mouse-Human Hybridomas. Appl Microbiol Biotechnol 32: 280-284.
    • (1989) Appl Microbiol Biotechnol , vol.32 , pp. 280-284
    • Takazawa, Y.1    Tokashiki, M.2
  • 41
    • 0025428552 scopus 로고
    • High density culture of hybridoma cells using a perfusion culture vessel with an external centrifuge
    • Tokashiki M, Arai T, Hamamoto K and Ishimaru K (1990) High density culture of hybridoma cells using a perfusion culture vessel with an external centrifuge. Cytotechnology 3: 239-44.
    • (1990) Cytotechnology , vol.3 , pp. 239-244
    • Tokashiki, M.1    Arai, T.2    Hamamoto, K.3    Ishimaru, K.4
  • 42
    • 0026918455 scopus 로고
    • Fluctuations in Continuous Mammalian Cell Bioreactors with Retention
    • Vits H and Hu W-S (1992) Fluctuations in Continuous Mammalian Cell Bioreactors with Retention. Biotechnol Prog 8: 397-403.
    • (1992) Biotechnol Prog , vol.8 , pp. 397-403
    • Vits, H.1    Hu, W.-S.2
  • 43
    • 0345506888 scopus 로고
    • High Cell Density Perfusion Culture of Hybridoma Cells for Production of Monoclonal Antibodies in the Celligen Packed Bed Reactor
    • Wang G, Zhang W, Jacklin C, Eppstein L and Freedman D, (ed.) Kluwer Academic Publishers, Dordrecht
    • Wang G, Zhang W, Jacklin C, Eppstein L and Freedman D (1993) High Cell Density Perfusion Culture of Hybridoma Cells for Production of Monoclonal Antibodies in the Celligen Packed Bed Reactor. In: Wang G, Zhang W, Jacklin C, Eppstein L and Freedman D, (ed.) Animal Cell Technology: Basic and Applied Aspects. (463-469) Kluwer Academic Publishers, Dordrecht.
    • (1993) Animal Cell Technology: Basic and Applied Aspects , pp. 463-469
    • Wang, G.1    Zhang, W.2    Jacklin, C.3    Eppstein, L.4    Freedman, D.5
  • 44
    • 0031105335 scopus 로고    scopus 로고
    • Integrated Approaches to the Design of Media and Feeding Strategies for Fed-batch Cultures of Animal Cells
    • Xie L and Wang DI (1997) Integrated Approaches to the Design of Media and Feeding Strategies for Fed-batch Cultures of Animal Cells. Trends Biotechnol 15: 109-13.
    • (1997) Trends Biotechnol , vol.15 , pp. 109-113
    • Xie, L.1    Wang, D.I.2
  • 45
    • 0028436847 scopus 로고
    • Fed-batch cultivation of animal cells using different medium design concepts and feeding strategies
    • Xie L and Wang DIC (1994) Fed-batch cultivation of animal cells using different medium design concepts and feeding strategies. Biotechnol Bioeng 43: 1175-1189.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 1175-1189
    • Xie, L.1    Wang, D.I.C.2
  • 46
    • 9444286985 scopus 로고    scopus 로고
    • High Cell Density and High Monoclonal Antibody Production through Medium Design and Rational Control in a Bioreactor
    • Xie LZ and Wang DIC (1996) High Cell Density and High Monoclonal Antibody Production through Medium Design and Rational Control In a Bioreactor. Biotechnol Bioeng 51: 725-729.
    • (1996) Biotechnol Bioeng , vol.51 , pp. 725-729
    • Xie, L.Z.1    Wang, D.I.C.2
  • 47
    • 0345075354 scopus 로고
    • Kinetics of Cell Metabolism and Antibody Production in High Concentration Perfusion Cultures
    • Zhang S, A. H-C and Spier RE, (ed.) Kluwer Academic Publishers, Dordrecht
    • Zhang S, Handa-Corrigan A and Spier RE (1993) Kinetics of Cell Metabolism and Antibody Production in High Concentration Perfusion Cultures. In: Zhang S, A. H-C and Spier RE, (ed.) Animal Cell Technology: Basic and Applied Aspects. (309-324.) Kluwer Academic Publishers, Dordrecht.
    • (1993) Animal Cell Technology: Basic and Applied Aspects , pp. 309-324
    • Zhang, S.1    Handa-Corrigan, A.2    Spier, R.E.3
  • 48
    • 0028279711 scopus 로고
    • Computer-aided on-line monitoring of physiological variables in suspended cell cultures of Perilla frutescens in a bioreactor
    • Zhong J-J, Konstantinov KB and Yoshida T (1994) Computer-aided on-line monitoring of physiological variables in suspended cell cultures of Perilla frutescens in a bioreactor. J Ferm Bioeng 77: 445-447.
    • (1994) J Ferm Bioeng , vol.77 , pp. 445-447
    • Zhong, J.-J.1    Konstantinov, K.B.2    Yoshida, T.3
  • 49
    • 0028454939 scopus 로고
    • On-line characterization of a hybridoma cell culture process
    • Zhou W and Hu W-S (1994) On-line characterization of a hybridoma cell culture process. Biotechnol Bioeng 44: 170-177.
    • (1994) Biotechnol Bioeng , vol.44 , pp. 170-177
    • Zhou, W.1    Hu, W.-S.2
  • 50
    • 0029329096 scopus 로고
    • Effect of insulin on a serum-free hybridoma culture
    • Zhou W and Hu W-S (1995) Effect of insulin on a serum-free hybridoma culture. Biotechnol Bioeng 47: 181-185.
    • (1995) Biotechnol Bioeng , vol.47 , pp. 181-185
    • Zhou, W.1    Hu, W.-S.2
  • 51
    • 0029059493 scopus 로고
    • High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding
    • Zhou WC, Rehm J and Hu WS (1995) High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding. Biotechnol Bioeng 46: 579-587.
    • (1995) Biotechnol Bioeng , vol.46 , pp. 579-587
    • Zhou, W.C.1    Rehm, J.2    Hu, W.S.3
  • 52
    • 0030916886 scopus 로고    scopus 로고
    • Alteration of mammalian cell metabolism by dynamic nutrient feeding
    • Zhou W-C, Rehm J, Europa A and Hu W-S (1997) Alteration of mammalian cell metabolism by dynamic nutrient feeding. Cytotechnology 24: 99-108.
    • (1997) Cytotechnology , vol.24 , pp. 99-108
    • Zhou, W.-C.1    Rehm, J.2    Europa, A.3    Hu, W.-S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.