Hypomethylation of CpG sites and c-myc gene overexpression in hepatocellular carcinomas, but not hyperplastic nodules, induced by a choline-deficient L-amino acid-defined diet in rats

Japanese Journal of Cancer Research

Volumn 90, Issue 9, 1999, Pages 909-913

  Tsujiuchi, Toshifumi ^a   Tsutsumi, Masahiro ^a   Sasaki, Yasutaka ^a   Takahama, Makoto ^a   Konishi, Yoichi ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

c myc; Choline deficient L amino acid defined diet; DNA methylation; Hepatocarcinogenesis; Rat

Indexed keywords

AMINO ACID; BISULFITE; CHOLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GENETICS; CELL TRANSFORMATION; CONTROLLED STUDY; DIET; DNA METHYLATION; GENE OVEREXPRESSION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032735501     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1999.tb00834.x     Document Type: Article

References (26)

1. Zingg, J.-M. and Jones, P. A. Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation and carcinogenesis. Carcinogenesis, 18, 869-882 (1997).
2. Jones, P. A., Rideout, W. M., Shen, J. C., Spruck, C. H. and Tsai, Y. C. Methylation, mutation and cancer. Bioessays, 14, 22-26 (1992).
3. Laird, P. W. and Jaenisch, R. DNA methylation and cancer. Hum. Mol. Genet., 3, 1487-1495 (1994).
4. Jones, P. A. DNA methylation errors and cancer. Cancer Res., 56, 2463-2467 (1996).
5. Nakae, D., Yoshiji, H., Mizumoto, Y., Horiguchi, K., Shiraiwa, K., Tamura, K., Denda, A. and Konishi, Y. High incidence of hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats. Cancer Res., 52, 5042-5045 (1992).
6. Nakae, D., Mizumoto, Y., Yoshiji, H., Andoh, N., Horiguchi, K., Shiraiwa, K., Kobayashi, E., Endoh, T., Shimoji, N., Tamura, K., Tsujiuchi, T., Denda, A. and Konishi, Y. Different roles of 8-hydroxyguanine formation and 2-thiobarbituric acid-reacting substance generation in the early phase of liver carcinogenesis induced by a choline-deficient, L-amino acid-defined diet in rats. Jpn. J. Cancer Res., 85, 499-505 (1994).
7. Tsujiuchi, T., Kobayashi, E., Nakae, D., Mizumoto, Y., Andoh, N., Kitada, H., Ohashi, K., Fukuda, T., Kido, A., Tsutsumi, M., Denda, A. and Konishi, Y. Prevention by methionine of enhancement of hepatocarcinogenesis by coadministration of a choline-deficient L-amino acid-defined diet and ethionine in rats. Jpn. J. Cancer Res., 86, 1136-1142 (1995).
8. Farber, E. The step-by-step development of epithelial cancer: from phenotype to genotype. Adv. Cancer Res., 70, 21-48 (1988).
9. Tsujiuchi, T., Tsutsumi, M., Kido, A., Kobitsu, K., Takahama, M., Majima, T., Denda, A., Nakae, D. and Konishi, Y. Increased telomerase activity in hyperplastic nodules and hepatocellular carcinomas induced by a choline-deficient L-amino acid-defined diet in rats. Jpn. J. Cancer Res., 87, 1111-1115 (1996).
10. Tsujiuchi, T., Kido, A., Nakae, D., Takahama, M., Majima, T., Kobitsu, K., Okajima, E., Tsutsumi, M., Denda, A. and Konishi, Y. Infrequent Ki-ras and an absence of p53 mutations in hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats. Cancer Lett., 108, 137-141 (1996).
11. Cheah, M. S. C., Wallace, C. D. and Hoffman, R. M. Hypomethylation of DNA in human cancer cells: a site specific change in the c-myc oncogene. J. Natl. Cancer Inst., 73, 1057-1065 (1984).
12. Nambu, S., Inoue, K. and Sasaki, H. Site-specific hypomethylation of the c-myc oncogene in human hepatocellular carcinoma. Jpn. J. Cancer Res. (Gann), 78, 695-704 (1987).
13. Clark, S. J., Harrison, J., Paul, C. L. and Frommer, M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res., 22, 2990-2997 (1994).
14. INK-4a in primary rat lung tumors. Mol. Cell. Biol., 17, 1366-1374 (1997).
15. Squire, R. A. and Levitt, M. H. Report of a workshop on classification of specific hepatocellular lesions in rats. Cancer Res., 35, 3214-3223 (1975).
16. Jones, P. A. and Laird, P. W. Cancer epigenetics comes of age. Nat. Genet., 21, 163-167 (1999).
17. mCpG methylation. Gene, 195, 67-71 (1997).
18. Zapisek, W. F., Cronin, G. M., Lyn-Cook, B. D. and Poirier, L. A. The onset of oncogene hypomethylation in the livers of rats fed methyl-deficient, amino acid-defined diet. Carcinogenesis, 13, 1869-1872 (1992).
19. Wainfan, E. and Poirier, L. A. Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res., 52, 2071s-2077s (1992).
20. Dizik, M., Christman, J. K. and Wainfan, E. Alterations in expression and methylation of specific genes in livers of rats fed a cancer promoting methyl-deficient diet. Carcinogenesis, 7, 1307-1312 (1991).
21. Denda, A., Rao, P. M., Rajalakshmi, S. and Sarma, D. S. R. 5-Azacytidine potentiates initiation induced by carcinogenesis in rat liver. Carcinogenesis, 6, 145-146 (1985).
22. Rao, P. M., Antony, A., Rajalakshmi, S. and Sarma, D. S. R. Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver. Carcinogenesis, 10, 933-937 (1989).
23. Hartwell, L. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell, 71, 543-546 (1992).
24. Lengauer, C., Kinzler, K. W. and Vogelstein, B. DNA methylation and genetic instability in colorectal cancer cells. Proc. Natl. Acad. Sci. USA, 94, 2545-2550 (1997).
25. Thomas, J. H. Genomic imprinting proposed as a surveillance mechanism for chromosome loss. Proc. Natl. Acad. Sci. USA, 92, 480-482 (1995).
26. Becker, F. F., Fox, R. A., Klein, K. M. and Wolman, S. R. Chromosome patterns in rat hepatocytes during N-2-fluorenylacetamide carcinogenesis. J. Natl. Cancer Inst., 46, 1261-1269 (1971).