Inhibition of prolylendopeptidase does not affect γ-secretase processing of amyloid precursor protein in a human neuroblastoma cell line

Neuroscience Letters

Volumn 277, Issue 1, 1999, Pages 33-36

  Johnston, Janet A ^a   Jensen, Malene ^b   Lannfelt, Lars ^b   Walker, Brian ^a   Williams, Carvell H ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

secretase; A ; Alzheimer's disease; Amyloid precursor protein; EC 3.4.21.26; Neuroblastoma; Prolylendopeptidase

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PROLYL ENDOPEPTIDASE;

ALZHEIMER DISEASE; ARTICLE; CELL VIABILITY; CYTOTOXICITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACIDS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BRAIN NEOPLASMS; ENDOPEPTIDASES; FLUORENES; HUMANS; NEUROBLASTOMA; OLIGOPEPTIDES; TUMOR CELLS, CULTURED;

EID: 0032735374     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00834-4     Document Type: Article

References (14)

1. Checler F. Processing of the β-amyloid precursor protein and its regulation in Alzheimer's disease. J. Neurochem. 65:1995;1431-1444.
2. Citron M., Vigo-Pelfrey C., Teplow D.B., Miller C., Schenk D., Johnston J., Winblad B., Venizelos N., Lannfelt L., Selkoe D.J. Excessive production of amyloid β-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer's disease mutation. Proc. Natl. Acad. Sci. USA. 91:1994;11993-11997.
3. Dyrks T., Dyrks E., Mönning U., Urmoneit B., Turner J., Beyreuther K. Generation of βA4 from the amyloid protein precursor and fragments thereof. FEBS Lett. 335:1993;89-93.
4. Gervais F.G., Xu D.G., Robertson G.S., Vaillancourt J.P., Zhu Y.X., Huang J.Q., LeBlanc A., Smith D., Rigby M., Shearman M.S., Clarke F.E., Zheng H., VanDerPloeg L.H.T., Ruffolo S.C., Thornberry N.A., Xanthoudakis S., Zamboni R.J., Roy S., Nicholson D.W. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation. Cell. 97:1999;395-406.
5. Ida N., Hartmann T., Pantel J., Schröder J., Zerfass R., Förstl H., Sandbrink R., Masters C.L., Beyreuther K. Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive western blot assay. J. Biol. Chem. 271:1996;22908-22914.
6. Ishiura S., Tsukahara T., Tabira T., Shimizu T., Arahata K., Sugita H. Identification of a putative amyloid A4-generating enzyme as a prolylendopeptidase. FEBS Lett. 260:1990;131-134.
7. Jensen M., Schröder J., Blomberg M., Engvall B., Pantel J., Ida N., Basun H., Wahlund L.-O., Werle E., Jauss M., Beyreuther K., Lannfelt L., Hartmann T. Cerebrospinal fluid Aβ42 is increased early in sporadic Alzheimer's disease and declines with disease progression. Ann. Neurol. 45:1999;504-511.
8. Johnston J.A., Cowburn R.F., Norgren S., Wiehager B., Venizelos N., Winblad B., Vigo-Pelfrey C., Schenk D., Lannfelt L., O'Neill C. Increased β-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation. FEBS Lett. 354:1994;274-278.
9. Kato A., Fukunari A., Sakai Y., Nakajima T. Prevention of amyloid-like deposition by a selective prolyl endopeptidase inhibitor. Y-29794, in senescence-accelerated mouse. J. Pharmacol. Exp. Ther. 283:1997;328-335.
10. Katsube N., Sunaga K., Aishita H., Chuang D.-M., Ishitani R. ONO-1603, a potential antidementia drug, delays age-induced apoptosis and suppresses overexpression of glyceraldehyde-3-phosphate dehydrogenase in cultured central nervous system neurons. J. Pharmacol. Exp. Ther. 288:1999;6-13.
11. Li J.R., Wilk E., Wilk S. Inhibition of prolyloligopeptidase by Fmoc-aminoacylpyrrolidine-2-nitriles. J. Neurochem. 66:1996;2105-2112.
12. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2:1996;864-870.
13. Shinoda M., Toide K., Ohsawa I., Kohsaka S. Specific inhibitor for prolyl endopeptidase suppresses the generation of amyloid β protein in NG 108-15 cells. Biochem. Biophys. Res. Commun. 235:1997;641-645.
14. Wang R., Sweeney D., Gandy S.E., Sisodia S.S. The profile of soluble amyloid β protein in cultured cell media. Detection and quantification of amyloid β protein and variants by immunoprecipitation-mass spectrometry. J. Biol. Chem. 271:1996;31894-31902.