4-Chloro-o-phenylenediamine induces a dose-related increase in G:C>T:A transversions and one major DNA adduct in the liver of Big Blue® mice after 26 weeks in feed treatment

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 430, Issue 1, 1999, Pages 121-130

  Staedtler, Frank ^a   Crespo Perez, Jaime ^b   Sagelsdorff, Peter ^a   Steiner, Sandra ^c   Suter, Willi ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b CE Durviz Laboratory   (Spain)

^c Biosource Proteomics   (United States)

Author keywords

2 week or 26 week treatment; 4 Chloro o phenylenediamine (4 C o PDA); Big Blue ; DNA adduct; DNA sequencing; G:C>T:A transversions

Indexed keywords

PHENYLENEDIAMINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; DNA SEQUENCE; FEMALE; LIVER; MALE; MOUSE; MUTAGEN TESTING; MUTAGENICITY; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ADENINE; ANIMAL FEED; ANIMALS; CYTOSINE; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUANINE; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTAGENS; PHENYLENEDIAMINES; POINT MUTATION; THYMINE;

ANIMALIA; MUS MUSCULUS;

EID: 0032729550     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00185-2     Document Type: Article

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