A non-cytotoxic herpes simplex virus vector which expresses Cre recombinase directs efficient site specific recombination

Virus Research

Volumn 65, Issue 1, 1999, Pages 11-20

  Rinaldi, Angela ^a   Marshall, Ker R ^a   Preston, Chris M ^a  

^a INSTITUTE OF VIROLOGY   (United Kingdom)

Author keywords

Expression of Cre recombinase; HSV 1 vector; Site specific recombination

Indexed keywords

RECOMBINASE; VIRUS ENZYME; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BACTERIOPHAGE P1; CELL LINE; CELL STRAIN BHK; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; GENE SEQUENCE; GENOME; HERPES SIMPLEX VIRUS; HERPES SIMPLEX VIRUS 1; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL GANGLION; TISSUE CULTURE; VERO CELL; VIRUS GENOME; VIRUS INFECTION; VIRUS MUTANT; VIRUS RECOMBINANT; VIRUS RECOMBINATION;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CRICETINAE; GENETIC VECTORS; HERPESVIRUS 1, HUMAN; INTEGRASES; MICE; MICE, INBRED BALB C; MUTATION; NEURONS, AFFERENT; RECOMBINATION, GENETIC; VERO CELLS; VIRAL PROTEINS;

HERPES; HUMAN HERPESVIRUS 1;

EID: 0032729126     PISSN: 01681702     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-1702(99)00102-1     Document Type: Conference Paper

References (40)

1. Akagi K., Sandig V., Vooijs M., Van der Valk M., Giovanni M., Strauss M., Berns A. Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res. 25:1997;1766-1773.
2. Andersen J.K., Garber D.A., Meaney C.A., Breakefield X.O. Gene transfer into mammalian central nervous system using herpes virus vectors: extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter. Hum. Gene Ther. 3:1992;487-499.
3. Anton M., Graham F.L. Site-specific recombination mediated by an adenovirus vector expressing the cre recombinase protein: a molecular switch for control of gene expression. J. Virol. 69:1995;4600-4606.
4. Bergemann J., Kuhlcke K., Fehse B., Ratz I., Ostertag W., Lother H. Excision of specific DNA-sequences from integrated retroviral vectors via site-specific recombination. Nucleic Acids Res. 23:1995;4451-4456.
5. Bloom D.C., Maidment N.T., Tan A., Dissette V.B., Feldman L.T., Stevens J.G. Long-term expression of a reporter gene from latent herpes simplex virus in the rat hippocampus. Mol. Brain Res. 31:1995;48-60.
6. Brooks A.I., Muhkerjee B., Panahian N., Cory-Slechta D., Federoff H.J. Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nature Biotechnol. 15:1997;57-62.
7. Campbell M.E.M., Palfreyman J.W., Preston C.M. Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription. J. Mol. Biol. 180:1984;1-19.
8. Choulika A., Guyot V., Nicholas J-F. Transfer of single gene-containing long terminal repeats into the genome of mammalian cells by a retroviral vector carrying the cre gene and the loxP site. J. Virol. 70:1996;1792-1798.
9. Ecob-Prince M.S., Preston C.M., Rixon F.J., Hassan K., Kennedy P.G.E. Neurons containing latency-associated transcripts are numerous and widespread in dorsal root ganglia following footpad inoculation of mice with herpes simplex virus type 1 mutant in1814. J. Gen. Virol. 74(1993):1993;985-994.
10. Everett R.D. Transactivation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity. EMBO J. 3:1984;3135-3141.
11. Everett R.D. The regulation of transcription of viral and cellular genes by herpesvirus immediate-early gene products. Anticancer Res. 7:1987;589-604.
12. Gage P.J., Sauer B., Levine M., Glorioso J.G. A cell-free recombination system for site-specific integration of multigenic shuttle plasmids into the herpes simplex virus type 1 genome. J. Virol. 66:1992;5509-5515.
13. Glorioso J.C., DeLuca N.A., Fink D.J. Development and application of herpes simplex virus vectors for human gene therapy. Annu. Rev. Microbiol. 49:1995;675-710.
14. Jamieson D.R.S., Robinson L.H., Daksis J.I., Nicholl M.J., Preston C.M. Quiescent viral genomes in human fibroblasts after infection with herpes simplex virus Vmw65 mutants. J. Gen. Virol. 76:1995;1417-1431.
15. Johnson P.A., Wang M.J., Friedmann T. Improved cell survival by the reduction of immediate-early gene expression in replication-defective mutants of herpes simplex virus type 1 but not by mutation of the virion host shutoff function. J. Virol. 68:1994;6347-6362.
16. Kanegae Y., Lee G., Sato Y., Tanaka M., Nakai M., Sakaki T., Sugano S., Saito I. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res. 23:1995;3816-3821.
17. Kanegae Y., Takamori K., Sato Y., Lee G., Nakai M., Saito I. Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase. Gene. 181:1996;207-212.
18. McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D., Perry L.J., Scott J.E., Taylor P. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. 69:1988;1531-1574.
19. Nicholl M.J., Preston C.M. Inhibition of herpes simplex virus type 1 immediate-early gene expression by alpha interferon is not VP16 specific. J. Virol. 70:1996;6336-6339.
20. O'Hare P. The virion transactivator of herpes simplex virus. Semin. Virol. 4:1993;145-155.
21. Preston C.M. Control of herpes simplex virus type 1 mRNA synthesis in cells infected with wild type virus or the temperature sensitive mutant tsK. J. Virol. 29:1979;275-284.
22. Preston C.M., Mabbs R., Nicholl M.J. Construction and characterization of herpes simplex virus type 1 mutants with conditional defects in immediate early gene expression. Virology. 229:1997;228-239.
23. Preston C.M., Nicholl M.J. Repression of gene expression upon infection of cells with herpes simplex virus type 1 mutants impaired for immediate early protein synthesis. J. Virol. 71:1997;7807-7813.
24. Preston C.M., Rinaldi A., Nicholl M.J. Herpes simplex virus type 1 immediate early gene expression is stimulated by inhibition of protein synthesis. J. Gen. Virol. 79:1998;117-124.
25. Sacks W.R., Schaffer P.A. Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in culture. J. Virol. 61:1987;829-839.
26. Samaniego L.A., Neiderhiser L., DeLuca N.A. Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins. J. Virol. 72:1998;3307-3320.
27. Samaniego L.A., Wu N., DeLuca N.A. The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27. J. Virol. 71:1997;4614-4625.
28. Sandri-Goldin R.M., Mendoza G.E. A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing. Genes Dev. 6:1992;848-863.
29. Sauer B., Henderson N. Site-specific DNA recombination in mammalian cells by the cre recombinase of bacteriophage P1. Proc. Natl. Acad. Sci. USA. 85:1988;5166-5170.
30. Sauer B., Henderson N. Targeted insertion of exogenous DNA into the eukaryotic genome by the Cre recombinase. New Biol. 2:1990;441-449.
31. Sauer B., Whealy M., Robbins A., Enquist L. Site-specific insertion of DNA into a pseudorabies virus vector. Proc. Natl. Acad. Sci. USA. 84:1987;9108-9112.
32. Sawtell N.M. Comprehensive quantification of herpes simplex virus latency at the single-cell level. J. Virol. 71:1997;5423-5431.
33. Schwenk F., Baron U., Rahewski K. A cre-transgenic mouse strain for the ubiquitous deletion of loxp-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23:1995;5080-5081.
34. Sederati F., Izumi K.M., Wagner E.K., Stevens J.G. Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome. Virology. 192:1993;687-691.
35. Stevens J.G., Wagner E.K., Devi-Rao G.B., Cook M.L., Feldman L. RNA complementary to a herpesvirus alpha gene mRNA is predominant in latently infected neurons. Science. 235:1987;1056-1059.
36. Stow N.D., Stow E.C. Isolation and characterisation of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw110. J. Gen. Virol. 67:1986;2571-2585.
37. Wang P., Anton M., Graham F.L., Baccetti S. High frequency recombination between loxP sites in human chromosomes mediated by an adenovirus vector expressing Cre recombinase. Somatic Cell Mol. Genet. 21:1995;429-441.
38. Westerman K.A., Leboulch P. Reversible immortalization of mammalian cells mediated by retroviral transfer and site-specific recombination. Proc. Natl. Acad. Sci. USA. 93:1996;8971-8976.
39. Wilkie N.M., Clements J.B., Boll W., Mantei N., Lonsdale D., Weissman C. Hybrid plasmids containing an active thymidine kinase gene of herpes simplex virus. Nucleic Acids Res. 7:1979;859-877.
40. Wu N., Watkins S.C., Schaffer P.A., DeLuca N.A. Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. J. Virol. 70:1996;6358-6369.