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Regulation of the immune response by sex hormones: In vivo effects of estradiol and testosterone on pokeweed mitogen-induced B-cell differentiation
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Sthoeger ZM, Chiorazzi N, Lahita RG: Regulation of the immune response by sex hormones: in vivo effects of estradiol and testosterone on pokeweed mitogen-induced B-cell differentiation. J Immunol 1988, 141:91
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Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus-analyses of strain, gender, and age effects
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McMurray RW, Hoffman RW, Nelson W, Walker SE: Cytokine mRNA expression in the B/W mouse model of systemic lupus erythematosus-analyses of strain, gender, and age effects. Clin Immunol Immunopathol 1997, 84:260-268
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Does DHEAS restore immune competence in aged animals through its capacity to function as a natural modulator of peroxisome activities?
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Edited by Bellino FL, Daynes RD, Hornsby PJ, Lavren DH, Nestler JE. New York: New York Academy of Sciences
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Spencer NFL, Poynter ME, Hennebold JD, Mu HH, Daynes RA: Does DHEAS restore immune competence in aged animals through its capacity to function as a natural modulator of peroxisome activities? In Dehydroepiandrosterone (DHEA) and Aging, 1st ed. Edited by Bellino FL, Daynes RD, Hornsby PJ, Lavren DH, Nestler JE. New York: New York Academy of Sciences; 1996:200-216
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Spencer, N.F.L.1
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0031106207
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Estrogen decreases in vitro apoptosis of peripheral blood mononuclear cells from women with normal menstrual cycles and decreases TNF-alpha production in SLE but not in normal cultures
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Evans MJ, Maclaughlin S, Marvin RD, Abdou NI: Estrogen decreases in vitro apoptosis of peripheral blood mononuclear cells from women with normal menstrual cycles and decreases TNF-alpha production in SLE but not in normal cultures. Clin Immunol Immunopathol 1997, 82:258-262
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Evans, M.J.1
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Possible underlying mechanisms of sexual dimorphism in the immune response, fact and hypothesis
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Gaillard RC, Spinedi E: Sex and stress steroids interactions and the immune system: evidence for a neuroendocrine-immunological sexual dimorphism. Domestic Animal Endocrinology 1998, 15:345-352
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Tesar V, Masek Z, Rychlik I, Merta M, Bart, Stejskalova A, Zabka J, et al.: Cytokines and adhesion molecules in renal vasculitis and lupus nephritis. Nephrol Dial Transplant 1998, 13:1662-1667
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Gender differences in autoimmune diseases: Estrogen increases calcineurin expression in systemic lupus erythematosus
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Rider V, Foster RT, Evans M, Suenaga R, Abdou NI: Gender differences in autoimmune diseases: estrogen increases calcineurin expression in systemic lupus erythematosus. Clin Immunol Immunopathol 1998, 891:171-180. A recent paper detailing the increase of mRNA in lupus T cells as a result of estrogen stimulation. This is likely to be quite important as an example of the manner in which estrogen acts on cells from diseased patients and to offer clues to pathogenesis
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Clin Immunol Immunopathol
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Rider, V.1
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A gender gap in autoimmunity
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Whiteacre C, Reingold SC, O'Looney PA, and Task Force on Multiple Sclerosis and Autoimmunity: A gender gap in autoimmunity. Science 1999, 283:1277-1278. The most recent discussion of sex differences of immune function. The model used is multiple sclerosis that can be compared to SLE. The most interesting aspect of this discussion is the TH1 and TH2 paradigms and their relation to sex hormones
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Science
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Whiteacre, C.1
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Androgens accelerate thymocyte apoptosis
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Olsen NJ, Viselli SM, Pan J, Kovacs WJ: Androgens Accelerate Thymocyte Apoptosis. Endocrinology 1998, 139:748-752. This is the definitive paper on androgen-induced programmed cell death
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Endocrinology
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Olsen, N.J.1
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Peripheral blood T cells and monocytes and B cell lines derived from patients with systemic lupus erythematosus express estrogen receptor transcripts similar to those of normal cells
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Suenaga R, Evans MJ, Mitamura K, Rider V, Abdou NI: Peripheral blood T cells and monocytes and B cell lines derived from patients with systemic lupus erythematosus express estrogen receptor transcripts similar to those of normal cells. J Rheumatol 1998, 25:2305-1312
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Increased oxidation of testosterone in systemic lupus erythematosus
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Lahita RG, Bradlow HL, Kunkel HG, Fishman J: Increased oxidation of testosterone in systemic lupus erythematosus. Arthritis Rheumatol 1983, 26:1517-1521
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Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol
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Lahita RG, Bradlow HL, Ginzler E, Pang S, New M: Low plasma androgens in women with systemic lupus erythematosus. Arthritis Rheumatol 1987, 30:241-248
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Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's syndrome
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Bizzarro A, Valentini G, Di Martino G, Daponte A, De Bellis A, Iacono G: Influence of testosterone therapy on clinical and immunological features of autoimmune diseases associated with Klinefelter's syndrome. J Clin Endocrinol Metab 1987, 64:32-36
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Walker SE, Mcmurray R, Houri JM, Allen SH, Keisler D, Sharp GC: Effects of Prolactin in stimulating disease activity in systemic lupus erythematosus. Ann N Y Acad Sci 1998, 840:762-772. Prolactin, thought to be a cytokine in itself, is given in this paper as a separate factor in the cause of SLE. This laboratory is probably the most experienced in the world dealing with prolactin-induced SLE
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Derksen RH: Dehydroepiandrosterone (DHEA) and systemic lupus erythematosus. Sem Arthritis Rheum 1998, 27:335-347
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Kammer G, Tsokos G: Emerging Concepts of the molecular basis for estrogen effects on T lymphocytes in systemic lupus erythematosus. Clin Immunol Immunopathol 1998, 89:192-195. A spirited discussion of what is and is not known about the molecular aspects of sex steroids and the immune system in the disease SLE. This is essential reading for anyone interested in the effects of gender on the immune system.
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Kammer, G.1
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