Hormones and lupus: Defective dehydroepiandrosterone activity induces impaired interleukin-2 activity of T lymphocytes in patients with systemic lupus erythematosus

Annales de Medecine Interne

Volumn 147, Issue 4, 1996, Pages 248-252

  Suzuki, Noboru ^a   Suzuki, Tomoko ^a   Sakane, Tsuyoshi ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

cytokine; dehydroepiandrosterone; lupus; sex hormones

Indexed keywords

CORTICOSTEROID; INTERLEUKIN 2; MESSENGER RNA; PRASTERONE; SEX HORMONE;

AUTOIMMUNITY; DRUG THERAPY; GENE EXPRESSION; HORMONE ACTION; HORMONE BLOOD LEVEL; HORMONE DEFICIENCY; HUMAN; LYMPHOCYTE FUNCTION; NONHUMAN; ORAL DRUG ADMINISTRATION; PATHOGENESIS; REVIEW; RNA TRANSCRIPTION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; VIRUS RECOMBINANT;

ANIMALS; DEHYDROEPIANDROSTERONE; HUMANS; INTERLEUKIN-2; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; T-LYMPHOCYTES;

EID: 0029789621     PISSN: 0003410X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (37)

1. WOODS VL Jr, ZVAIFLER NJ : Pathogenesis of systemic lupus erythematosis. In : WN KELLY, ED HARRIS, S RUDDY, CB SLEDGE, eds. Textbook of Rheumatology, 3rd edition, Vol 2. Philadelphia, PA : W.B. Saunders, 1989 : 1077-100.
2. TAN EM : Systemic lupus erythematosus : immunological aspects. In : D.J. MCCARTY, ed. Arthritis and allied conditions : a Textbook of Rheumatology. 11th edition. Philadelphia, PA : Lea & Febiger, 1989 : 1049-54.
3. FAUCI AS, STEINBERG AD, HAYNES BF, WHALEN G : Immunoregulatory aberrations in systemic lupus erythematosus. J Immunol 1978 ; 121 : 1473-9.
4. THEOFILOPOULOS AN, DIXON FJ : Murine models of systemic lupus erythematosus. Adv Immunol 1985 ; 37 : 269-390.
5. STEINBERG AD, KRIEG AM, GOURLEY MF, KLINMAN DM : Theoretical and experimental approaches to generalized autoimmunity. Immunol Rev 1990 ; 118 : 129-63.
6. HORWITZ DA : Systemic lupus erythematosus : generalized autoimmunity arising from disordered immune regulation. In . DJ MCCARTY, ed. Arthritis and allied conditions : a Textbook of Rheumatology. 12th edition. Philadelphia, PA : Lea & Febiger, 1993 : 1185-99.
7. JUNGERS P, NAHOUL K, PELISSIER C, DOUGADOS M, TRON F, BACH JF : Low plasma androgens in women with active or quiescent systemic lupus erythematosus. Arthritis Rheum 1982 ; 25 : 454-7.
8. LAHITA RG : Sex steroids and the rheumatic diseases. Arthritis Rheum 1985 ; 28 : 121-6.
9. LAHITA RG, BRADLOW HL, GINZLER E, PANG S, NEW M : Low plasma androgens in women with systemic lupus erythematosus. Arthritis Rheum 1987 ; 30 : 241-8.
10. JUNGERS PF, KUTTENN F, LIOTE C et al : Hormonal modulation in systemic lupus erythematosus. Preliminary clinical and hormonal results with cyproterone acetate. Arthritis Rheum 1985 ; 28 : 1243-50.
11. NAGARTHI H, SUZUKI N, SHIGEKI T et al : Constitutive expression of IL-6 receptors (IL-6R) of B lymphocytes from patients with systemic lupus erythematosus (SLE) and their roles on autoantibody production. Arthritis Rheum 1991 ; 34 : S162.
12. SUZUKI N, SAKANE T : Induction of excessive B cell proliferation and differentiation by an in vitro stimulus in culture in human systemic lupus erythematosus. J Clin Invest 1989 ; 83 : 937-44.
13. SUZUKI N, SAKANE T, ENGLEMAN EG : Anti-DNA antibody production by CD5+ and CD5- B cells of patients with systemic lupus erythematosus. J Clin Invest 1990 ; 85 : 238-47.
14. MURAKAWA Y, TAKADA S, UEDA Y, SUZUKI N, HOSHINO T, SAKANE T : Characterization of T lymphocyte subpopulations responsible for deficient intcrleukin 2 activity in patients with systemic lupus erythematosus. J Immunol 1985 ; 134 : 187-95.
15. LINKER-ISRAELI M, BAKKE AC, KITRIDOU RC, GENDLER S, GILLIS S, HORWITZ, DA : Defective production of interleukin I and interleukin 2 in patients with systemic lupus erythematosus (SLE). J Immunol 1983 ; 130 : 2651-5.
16. TAKADA S, UEDA Y, SUZUKI N et al : Abnormalities in autologous mixed lymphocyte reaction-activated immunologic precesses in systemic lupus erythematosus and their possible correction by interleukin 2. Eur J Immunol 1985 ; 15 : 262-7.
17. GUTIERREZ-RAMOS JC, ANDREU JL, REVILLA Y, VINUELAL E, MARTINEZ AC : Recovery from autoimmunity of MRL/1pr mice after infection with an interleukin-2/vaccinia recombinant virus. Nature 1990 ; 346 : 271-4.
18. SMITH KA : Interleukin-2 : inception, impact, and implications. Science 1988 ; 240 : 1169-76
19. SCHORLE H, HOLTSCHKE T, HUNIG T, SCHIMPL A, HORAK I : Development and function of T cells in mice rendered interleukin-2 deficient by gene targetting. Nature 1991 ; 352 : 621-4.
20. SADLACK B, MERZ H, SCHORLE H, SCHIMPL A, FELLER AC, HORAK I : Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993 ; 75 : 253-61.
21. TALAL N, DAUPHINEE MJ, WOFSY D: Interleukin-2 deficiency, genes, and systemic lupus erythematosus. Arthritis Rheum 1982 ; 25 : 838-42.
22. SAKANE T, MURAKAWA Y, SUZUKI N et al : Familial occurrence of impaired interleukin-2 activity and increased peripheral blood B cells actively secreting immunoglobulins in systemic lupus erythematosus. Am J Med 1989 ; 86 : 385-90.
23. NIESCHLAG E, LORIAUX DL, RUDER HJ, ZUCKER IR, KIRSCHNER MA, LIPSETT MB : The secretion of dehydroepiandrosterone and dehydroepiandrosterone sulfate in man. J Endocrinol 1973 ; 57 : 123-34.
24. LOUCKS AB, HORVATH SM : Exercise-induced stress responses of amenorrheic and eumenorrheic runners. J Clin Emiocrinol Metab 1984 ; 59 : 1109-20.
25. AAKVAAG A, FYLLING P : A method for the simultaneous determination of progesterone, androstenedione, testosterone and dehydroepiandrosterone sulfate in biological fluids. Acta Endocrinol 1968 ; 57 : 447-56.
26. MILEWICH L, GARCIA RL, GERRITY LW : Steroid sulfatase and 17β-hydroxysteroid oxidoreductase activities in mouse tissues. J Steroid Biochem 1984 ; 21 : 529-38.
27. DAYNES RA, ARANEO BA, DOWALL TA, HUANG K, DUDLEY D : Regulation of murine lymphokine production in vivo : III the lymphoid tissue microenvironment exerts regulatory influences over T helper cell function. J Exp Med 1990 ; 171 : 979-96.
28. LUCAS JA, AHMED SA, CASEY ML, MCDONALD PC : Prevention of autoantibody formation and prolonged survival in New Zealand Black/New Zealand White F1 mice fed dehydroepiandrosterone. J Clin Invest 1985 ; 75 : 2091-3.
29. VAN VOLLENHOVEN RF, MCDEVITT HO : Studies of treatment of nephritis in NZB/NZW mice with dehydroepiandrosterone. Arthritis Rheum 1992 ; 35 : S207.
30. SUZUKI T, SUZUKI N, DAYNES RA, ENGLEMAN EG : Dehydroepiandrosterone enhances IL-2 production and cytotoxic effector function of human T cells. Clin Immunol Immunopathol 1991 ; 61 : 202-11.
31. CUTOLO M, BALLEARI E, GIUSTI M, INTRA E, ACCARDO S : Androgen replacement therapy in male patients with rheumatoid arthritis. Arthritis Rheum 1991 ; 34 : 1-5.
32. HEDMAN M, NILSSON E, DE LA TORRE B : Low blood and synovial fluid levels of sulpho-conjugated steroids in rheumatoid arthritis. Clin Exp Rheumatol 1992 ; 10 : 25-30.
33. MURAKAWA Y, SAKANE T : Deficient phytohemagglutinin-induced mterleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate. Arthritis Rheum 1988 ; 31 : 826-33.
34. SMITH KA : Lowest dose interleukin-2 immunotherapy. Blood 1993 ; 81 : 1414-23.
35. TEPPLER H, KAPLAN G, SMITH KA, MONTANA AL, MEYN P, COHN ZA : Prolonged immunostimulatory effect of lowdose polyethylene glycol interleukin 2 in patients with human immunodeficiency virus type 1 infection. J Exp Med 1993 ; 177 : 483-92.
36. VAN VOLLENHOVEN RF, ENGLEMAN EG, MCGUIRE JL : An open study of dehydroepiandrosterone in systemic lupus erythematosus. Arthritis Rheum 1994 ; 37 : 1305-10.
37. VAN VOLLENHOVEN RF, ENGLEMAN EG, MCGUIRE JL : Dehydroepiandrosterone (DHEA) in systemic lupus erythematosus : results of a double-blinded, placebo-controlled, randomized clinical trial. Arthritis Rheum 1995 ; 38 : 1826-31.