vanA and vanB incorporate into an endemic ampicillin-resistant vancomycin-sensitive Enterococcus faecium strain: Effect on interpretation of clonality

Journal of Clinical Microbiology

Volumn 37, Issue 12, 1999, Pages 3934-3939

  Suppola, Juhana P ^a   Kolho, Elina ^b   Salmenlinna, Saara ^c   Tarkka, Eveliina ^b   Vuopio Varkila, Jaana ^c   Vaara, Martti ^a,b,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; ENTEROCOCCUS FAECIUM; FINLAND; GENE LOCATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; STRAIN DIFFERENCE;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECIUM; POSIBACTERIA;

EID: 0032723039     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/jcm.37.12.3934-3939.1999     Document Type: Article

References (27)

1. Bonten, M. J., M. K. Hayden, C. Nathan, T. W. Rice, and R. A. Weinstein. 1998. Stability of vancomycin-resistant enterococcal genotypes isolated from long-term-colonized patients. J. Infect. Dis. 177:378-382.
2. Boyce, J. M., S. M. Opal, J. W. Chow, M. J. Zervos, G. Patter-Bynoe, C. B. Sherman, R. L. C. Romulo, S. Fortna, and A. A. Medeiros. 1994. Outbreak of multidrug-resistant Enterococcus faecium with transferable vanB class vancomycin resistance. J. Clin. Microbiol. 32:1148-1153.
3. Dahl, K. H., G. S. Simonsen, O. Olsvik, and A. Sundsfjord. 1999. Heterogeneity in the vanB gene cluster of genomically diverse clinical strains of vancomycin-resistant enterococci. Antimicrob. Agents Chemother. 43:1105- 1110.
4. Dunne, W. M., Jr., and W. Wang. 1997. Clonal dissemination and colony morphotype variation of vancomycin resistant Enterococcus faecium isolates in metropolitan Detroit, Michigan. J. Clin. Microbiol. 35:388-392.
5. Dutka-Malen, S., R. Leclercq, V. Coutant, J. Duval, and P. Courvalin. 1990. Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in gram-positive bacteria. Antimicrob. Agents Chemother. 34:1875- 1879.
6. Dutka-Malen, S., S. Evers, and P. Courvalin. 1995. Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR. J. Clin. Microbiol. 33:24-27.
7. Facklam, R. R., and M. D. Collins. 1989. Identification of Enterococcus species isolated from human infection by a conventional test scheme. J. Clin. Microbiol. 27:731-734.
8. Handwerger, S., B. Raucher, D. Altarac, J. Monka, S. Marchione, K. V. Singh, B. E. Murray, J. Wolff, and B. Walters. 1993. Nosocomial outbreak due to Enterococcus faecium highly resistant to vancomycin, penicillin, and gentamycin. Clin. Infect. Dis. 16:750-755.
9. Kapala, M. M., B. M. Willey, F. Arce, G. Large, A. McGeer, and D. E. Low. 1998. In vitro evidence of an outbreak due to conjugative transfer of vanA genes into a hospital's endemic vancomycin-susceptible enterococci (VSE), abstr. H-141, p. 355. In Program and abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
10. Leclercq, R., S. Dutka-Malen, J. Duval, and P. Courvalin. 1992. Vancomycin resistance gene vanC is specific to Enterococcus gallinarum. Antimicrob. Agents Chemother. 36:2005-2008.
11. Moreno, F., P. Grota, C. Crisp, K. Magnon, G. P. Melcher, J. H. Jorgensen, and J. E. Patterson. 1995. Clinical and molecular epidemiology of vancomycin resistant Enterococcus faecium during its emergence in a city in southern Texas. Clin. Infect. Dis. 21:1234-1237.
12. Murray, B. E., K. V. Singh, J. D. Heath, B. R. Sharma, and G. M. Weinstock. 1990. Comparison of genomic DNAs of different enterococcal isolates using restriction endonucleases with infrequent recognition sites. J. Clin. Microbiol. 28:2059-2063.
13. National Committee for Clinical Laboratory Standards. 1999. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing. NCCLS document M100-S9. National Committee for Clinical Laboratory Standards, Wayne, Pa.
14. Navarro, F., and P. Courvalin. 1994. Analysis of genes encoding D-alanine: D-alanine ligase-related enzymes in Enterococcus casseliflavus and Enterococcus flavescens. Antimicrob. Agents Chemother. 38:1788-1793.
15. Patel, R., J. R. Uhl, P. Kohner, M. K. Hopkins, and F. R. Cockerill III. 1997. Multiplex PCR detection of vanA, vanB, vanC-1, and van C2/3 genes in enterococci. J. Clin. Microbiol. 35:703-707.
16. Patel, R., J. R. Uhl, and P. Kohner. 1998. DNA sequence variation within vanA, vanB, vanC-1, and vanC-213 genes of clinical Enterococcus isolates. Antimicrob. Agents Chemother. 42:202-205.
17. Pegues, D. A., C. F. Pegues, P. L. Hibberd, D. S. Ford, and D. C. Hooper. 1997. Emergence and dissemination of a highly vancomycin-resistant vanA strain of Enterococcus faecium at a large teaching hospital. J. Clin. Microbiol. 35:1565-1570.
18. Perlada, D. E., G. Smulian, and M. T. Cushion. 1997. Epidemiology and antibiotic susceptibility of enterococci in Cincinnati, Ohio: a prospective citywide survey. J. Clin. Microbiol. 35:2342-2347.
19. Pitcher, D. G., N. A. Saunders, and R. J. Owen. 1989. Rapid extraction of bacterial genomic DNA with guanidium thiocyanate. Lett. Appl. Microbiol. 8:151-156.
20. Quintillani, R., Jr., S. Evers, and P. Courvalin. 1993. The vanB gene confers various levels of self-transferable resistance to vancomycin in enterococci. J. Infect. Dis. 167:1220-1223.
21. Schoonmaker, D. J., L. H. Bopp, A. L. Baltch, R. P. Smith, M. E. Rafferty, and M. George. 1998. Genetic analysis of multiple vancomycin-resistant Enterococcus isolates obtained serially from two long-term patients. J. Clin. Microbiol. 36:2105-2108.
22. Suppola, J. P., L. Volin, V. V. Valtonen, and M. Vaara. 1996. Overgrowth of Enterococcus faecium in the feces of patients with hematologic malignancies. Clin. Infect. Dis. 23:694-697.
23. Swenson, J. M., M. J. Ferraro, D. F. Sahm, P. Charache, the National Committee for Clinical Laboratory Standards Working Group on Enterococci, and F. C. Tenover. 1992. New vancomycin disk diffusion breakpoints for enterococci. J. Clin. Microbiol. 30:2525-2528.
24. Tenover, F. C., R. D. Arbeit, R. V. Goering, P. A. Michelsen, B. E. Murray, and D. H. Persing. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
25. Woodford, N., D. Morrison, B. Cookson, and R. S. Georges. 1993. Comparison of high-level gentamicin-resistant Enterococcus faecium isolates from different continents. Antimicrob. Agents Chemother. 37:681-684.
26. Woodford, N., D. Morrison, A. P. Johnson, A. C. Bateman, J. G. M. Hastings, S. J. Elliott, and B. Cookson. 1995. Plasmid-mediated vanB glycopeptide resistance in enterococci. Microb. Drug Resist. 1:235-239.
27. Woodford, N., P. R. Chadwick, D. Morrison, and B. D. Cookson. 1997. Strains of glycopeptide-resistant Enterococcus faecium can alter their van genotypes during an outbreak. J. Clin. Microbiol. 35:2966-2968.