Emergence and dissemination of a highly vancomycin-resistant vanA strain of Enterococcus faecium at a large teaching hospital

Journal of Clinical Microbiology

Volumn 35, Issue 6, 1997, Pages 1565-1570

  Pegues, David A ^a,b,c   Pegues, Clare F ^a,c   Hibberd, Patricia L ^a,b   Ford, Dale S ^a   Hooper, David C ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; ENTEROCOCCUS FAECALIS; HOSPITAL INFECTION; HOSPITALIZATION; NONHUMAN; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; STREPTOCOCCUS;

EID: 0031009445     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/jcm.35.6.1565-1570.1997     Document Type: Article

References (24)

1. Boyce, J. M., L. A. Mermel, M. J. Zervos, L. B. Rice, G. Potter-Bynoe, C. Giorgio, and A. A. Medeiros. 1995. Controlling vancomycin-resistant enterococci. Infect. Control Hosp. Epidemiol. 16:634-637.
2. Centers for Disease Control and Prevention. 1993. Nosocomial enterococci resistant to vancomycin - United States, 1989-1993. Morbid. Mortal. Weekly Rep. 42:597-599.
3. Centers for Disease Control and Prevention. 1995. Recommendation for presenting the spread of vancomycin resistance: recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). Morbid. Mortal. Weekly Rep. 44:1-12.
4. Chow, J. W., A. Kuritza, D. M. Shlaes, M. Green, D. F. Sahm, and M. J. Zervos. 1993. Clonal spread of vancomycin-resistant Enterococcus faecium between patients in three hospitals in two states. J. Clin. Microbiol. 31:1609-1611.
5. Clark, N. C., R. C. Cooksey, B. C. Hill, J. M. Swenson, and F. C. Tenover. 1993. Characterization of glycopeptide-resistant enterococci from U.S. hospitals. Antimicrob. Agents Chemother. 37:2311-2317.
6. Dean, A. G., J. A. Dean, J. A. Burton, and R. C. Dicker. 1994. EpiInfo. version 6: a wordprocessing, database, and statistics program for epidemiology for public health on IBM-compatible microcomputers. Centers for Disease Control and Prevention, Atlanta, Ga.
7. Donabedian, S. M., J. W. Chow, J. M. Boyce, R. E. McCabe, S. M. Markowitz, P. E. Coudron, A. Kuritza, C. L. Pierson, and M. J. Zervos. 1992. Molecular typing of ampicillin-resistant, non-β-lactamase-producing Enterococcus faecium isolates from diverse geographic areas. J. Clin. Microbiol. 30:2757-2761.
8. Dutka-Malen, S., C. Molinas, M. Arthur, and P. Courvalin. 1990. The VanA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes. Mol. Gen. Genet. 224:364-372.
9. Edmond, M. B., R. N. Jones, M. A. Pfaller, S. E. Wallace, R. P. Wenzel, and SCOPE Consortium Hospitals. 1996. Multicenter surveillance for nosocomial enterococcal bacteremia: a comparison of vancomycin-sensitive vs. vancomycin-resistant cases. Infect. Control Hosp. Epidemiol. 17(Suppl. 2):18. (Abstract 14).
10. Edmond, M. B., J. F. Ober, D. L. Weinbaum, M. A. Pfaller, T. Hwang, M. D. Sanford, and R. P. Wenzel. 1995. Vancomycin-resistant Enterococcus faecium bacteremia: risk factors for infection. Clin. Infect. Dis. 20:1126-1133.
11. Evers, S., D. F. Sahm, and P. Courvalin. 1993. The vanB gene of vancomycin-resistant Enterococcus faecalis V583 is structurally related to genes encoding D-Ala:D-Ala ligases and glycopeptide-resistance proteins VanA and VanC. Gene 124:143-144.
12. Faklam, R. R., and M. D. Collins. 1989. Identification of Enterococcus species isolated from human infections by a conventional test scheme. J. Clin. Microbiol. 27:731-734.
13. Fridkin, S., and D. C. Hooper. Unpublished data.
14. Garner, J. S., W. R. Jarvis, T. G. Emori, T. G. Horan, and J. M. Hughes. 1988. CDC definitions for nosocomial infections. 1988. Am. J. Infect. Control 16:128-140.
15. Gaynes, R., J. Edwards, and the National Nosocomial Infection Surveillance System. 1996. Nosocomial vancomycin resistant enterococci (VRE) in the United States. 1989-1995: the first 1000 isolates. Infect. Control Hosp. Epidemiol. 17(Suppl. 2):18. (Abstract 13).
16. Gold, H. S., S. Unal, E. Cercenado, C. Thauvin-Eliopoulos, G. M. Eliopoulos, C. B. Wennersten, and R. C. Moellering, Jr. 1993. A gene conferring resistance to vancomycin but not teicoplanin in isolates of Enterococcus faecalis and Enterococcus faecium demonstrates homology with vanB, vanA, and vanC genes of enterococci. Antimicrob. Agents Chemother. 37:1604-1609.
17. Livornese, L. L., Jr., S. Dias, C. Samel, B. Romanowski, S. Taylor, P. May, P. Pitsakis, G. Woods, D. Kaye, M. E. Levison, et al. 1992. Hospital-acquired infection with vancomycin-resistant Enterococcus faecium transmitted by electronic thermometers. Ann. Intern. Med. 117:112-116.
18. Moreno, F., P. Grota, C. Crisp, K. Magnon, G. P. Melcher, J. H. Jorgensen, and J. E. Patterson. 1995. Clinical and molecular epidemiology of vancomycin-resistant Enterococcus faecium during its emergence in a city in southern Texas. Clin. Infect. Dis. 21:1234-1237.
19. Morris, J. G., Jr., D. K. Shay, J. N. Hebden, R. J. McCarter, Jr., B. E. Perdue, W. Jarvis, J. A. Johnson, T. C. Dowling, L. B. Polish, and R. S. Schwalbe. 1995. Enterococci resistant to multiple antimicrobial agents, including vancomycin. Establishment of endemicity in a university medical center. Ann. Intern. Med. 123:250-259.
20. National Committee for Clinical Laboratory Standards. 1993. Performance standards for antimicrobial disk susceptibility tests for bacteria that grow aerobically, 3rd ed. Approved standard. Abstract. National Committee for Clinical Laboratory Standards, Villanova, Pa.
21. Ruoff, K. L., L. de la Maza, M. Murtagh, J. D. Spargo, and M. J. Ferraro. 1990. Species identities of enterococci isolated from clinical specimens. J. Clin. Microbiol. 28:435-437.
22. Shlaes, D. M., A. Bouvet, C. Devine, J. H. Shlaes, S. Al-Obeid, and R. Williamson. 1989. Inducible, transferable resistance to vancomycin in Enterococcus faecalis A256. Antimicrob. Agents Chemother. 33:198-203.
23. Tenover, F. C., R. D. Arbeit, R. V. Goering, P. A. Mickelsen, B. E. Murray, D. H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
24. Wells, C. L., B. A. Juni, S. B. Cameron, K. R. Mason, D. L. Dunn, P. Ferrieri, and F. S. Rhame. 1995. Stool carriage, clinical isolation, and mortality during an outbreak of vancomycin-resistant enterococci in hospitalized medical and/or surgical patients. Clin. Infect. Dis. 21:45-50.