Retinoic acid receptor antagonist BMS453 inhibits the growth of normal and malignant breast cells without activating RAR-dependent gene expression

Breast Cancer Research and Treatment

Volumn 56, Issue 3, 1999, Pages 277-291

  Yang, L ^a   Munoz Medellin, D ^a   Kim, H T ^a   Ostrowski, J ^b   Reczek, P ^b   Brown, Powel H ^a,c  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Cell growth; Gene transcription; Normal and malignant breast cells; Retinoic acid; Retinoid receptor

Indexed keywords

BMS 453; ESTROGEN RECEPTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; BREAST CELL; BREAST EPITHELIUM; CANCER CELL; CELL GROWTH; CELL IMMORTALIZATION; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REPORTER GENE; TRANSACTIVATION;

EID: 0032720251     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1006219411078     Document Type: Article

References (60)

1. Roberts AB, Sporn MB: Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS (eds) The Retinoids. Academic Press, Orlando, FL, 1984, pp 443-520
2. Lotan R: Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells. Biochim Biophys Acta 605: 33-91, 1980
3. Harris CC, Sporn MB, Kaufman DG, Smith JM, Jackson FE, Saffiotti U: Histogenesis of squamous metaplasias in the hamster tracheal epithelium caused by vitamin A deficiency or benzo[a]pyrene-ferric oxide. J Natl Cancer Inst 48: 743, 1972
4. Moon RC, Grubbs CJ, Sporn MB: Inhibition of 7,12-dimethylbenz(a) anthracene-induced mammary carcinogenesis by retinyl acetate. Cancer Res 36: 2626-2630, 1976
5. Moon RC, Thomposon HJ, Becci PJ, Grubbs CJ, Gander RJ, Newton, DJ, Smith JM, Phillips SL, Henderson WR, Mullen LT, Brown CC, Sporn MB: N-(4-hydroxyphenyl) retinamide, a new retinoid for prevention of breast cancer in the rat. Cancer Res 39: 1339-1346, 1979
6. Nakajima M, Lotan D, Baig MM, Carralero RM, Wood WR, Hendrix MJC, Lotan R: Inhibition by retinoic acid of type IV collagenolysis and invasion through reconstituted basement membrane by metastatic rat mammary adenocarcinoma cells. Cancer Res 49: 1698-1706, 1989
7. Lacroix A, Lippman ME: Binding of retinoids to human breast cancer cell lines and their effects on cell growth. J Clin Invest 65: 586-590, 1980
8. Fontana JA, Hobbs PD, Dawson MI: Inhibition of mammary carcinoma growth by retinoidal benzoic acid derivatives. Exp Cell Biol 6: 254-263, 1988
9. Fanjul A, Dawson MI, Hobbs PD, Jong L, Cameron JF, Harlev E, Graupner G, Lu X-P, Pfahl M: A new class of retinoids with selective inhibition of AP-1 inhibits proliferation. Nature 372: 107-111,1994
10. Seewaldt V, Johnson BS, Parker MB, Collins SJ, Swisshelm K: Expression of retinoic acid receptor β mediates retinoic acid-induced growth arrest and apoptosis in breast cancer cells. Cell Growth and Differ 7: 1077-1088, 1995
11. Bollag W, Holdener EE: Retinoids in cancer prevention and therapy. Ann Oncol 3: 513-526, 1992
12. Evans RM: The steroid and thyroid hormone receptor superfamily. Science 240: 889-895, 1988
13. Gudas U: Retinoids, retinoid-response genes, cell differentiation and cancer. Cell Growth Differ 3: 655-662, 1992
14. Roman SD, Clarke CL, Hall RE, Alexander IE, Sutherland RL: Expression and regulation of retinoic acid receptors in human breast cancer cells. Cancer Res 52: 2236-2242, 1992
15. Swisshelm K, Ryan K, Lee X, Tsou HC, Beacocke M, Sager R: Down-regulation of retinoic acid receptor β in mammary carcinoma cell lines and its up-regulation in senescing normal mammary epithelial cells. Cell Growth Differ 5: 133-141, 1994
16. Zhao Z, Zhang Z-P, Soprano DR, Soprano, KJ: Effect of 9-cis-retinoic acid on growth and RXR expression in human breast cancer cells. Exp Cell Res 219: 555-561, 1995
17. Zhu W-Y, Jones CS, Kiss A, Matsukuma K, Amin S, De Luca LM: Retinoic acid inhibition of cell cycle progression in MCF7 human breast cancer cells. Exp Cell Res 234: 293-299, 1997
18. Marth C, Bock G, Daxenbichler, G: Effects of 4-hydroxyphenyiretinamide and retinoic acid on proliferation and cell cycle of cultured human breast cancer cells. J Natl Cancer Inst 75: 871-875, 1985
19. Breitman TR, Selonick SE, Collins SJ: Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Pro Natl Acad Sci USA 77: 2936-2940, 1980
20. Toma S, Isnard L, Raffo P, Dastoli G, De Francisci E, Riccardi L, Palumbo R, Bollag W: Effects of all-trans-retinoic acid and 13-cis retinoic acid on breast-cancer cell lines: growth inhibition and apoptosis induction. Int J Cancer 70: 619-627, 1997
21. Agarwa N, Mehta K: Possible involvement of Bcl-2 pathway in retinoid X receptor alpha-induced apoptosis of HL-60 cells. Biochem Biophys Res Comm 230: 251-253, 1997
22. Nagy L, Thomazy VA, Shipley GL, Fesus L, Lamph W, Heyman RA, Chandraratna RAS, Davis PJA: Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. Mol Cell Biol 15: 3540-3551, 1995
23. Mehta K, McQueen T, Neamati N, Collins S, Andreeff M: Activation of retinoid receptors RAR alpha and RXR alpha induces differentiation and apoptosis, respectively, in HL-60 cells. Cell Growth Differ 7: 179-186, 1996
24. Martin JL, Coverley JA, Pattison ST, Baxter RC: Insulin-like growth factor binding protein-3 production by MCF-7 breast cancer cells: stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol. Endocrinology 136: 1219-1226, 1995
25. Oh Y, Gucev Z, Ng L, Muller HL, Rosenfeld RG: Antiproliferative actions of insulin-like growth binding protein (IGFBP-3) in human breast cancer cells. Prog Growth Factor Res 6: 503-512, 1995
26. Kojima S, Rifkin DB: Mechanism of retinoid-induced activation of latent transforming growth factor-β in bovine endothelial cells. J Cell Physiol 155: 323-332, 1993
27. Lee HY, Walsh GL, Dawson MI, Hong WK, Kurie JM: All-trans-retonoic acid inhibits Jun N-terminal kinase-dependent signaling pathways. J Biol Chem 273: 7066-7071, 1998
28. Nicholson RC, Mader S, Nagpal S, Leid M, Rochette-Egly C, Chambon P: Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site. EMBO J 9: 4443-4454, 1990
29. Pfahl M: Nuclear receptor/AP-1 interaction. Endocrine Rev 14: 651-658, 1993
30. Yang-Yen H-F, Zhang X-K, Graupner G, Tzukerman M, Sakamoto B, Karin M, Pfahl M: Antagonism between retinoic acid receptors and AP-1: Implications for tumor promotion and inflammation. The New Biologist 3: 1206-1219, 1991
31. Schule R, Rangarajan P, Yang N, Kliewer S, Ransone L, Bolado J, Verma IM, Evans RM: Retinoic acid is a negative regulator of AP-1-responsive genes. Proc Natl Acad Sci USA 88: 6092-6096, 1991
32. Yang L, Kim H-T, Munoz-Medellin D, Reddy P, Brown PH: Induction of retinoid resistance in breast cancer cells by overexpression of cJun. Cancer Res 57: 4652-4661, 1997
33. Kamei Y, Xu L, Heinzel T, Torchia J, Kurokawa R, Gloss B, Lin S-C, Heyman RA, Rose DW, Glass CK, Rosenfeld MG: A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 85: 403-414, 1996
34. Chakravarti D, LaMorte VJ, Nelson MC, Nakajima T, Schulman IG, Juguilon H, Montminy M, Evans RM: Role of CBP/P300 in nuclear receptor signaling. Nature 383: 99-103, 1996
35. Chen TK, Smith LM, Gebhardt DK, Birrer MJ, Brown PH: Activation and inhibition of the AP1 complex in human breast cancer cells. Mol Carcinogen 15: 215-226, 1996
36. Smith LM, Birrer MJ, Stampfer MR, Brown PH: Breast cancer cells have lower mammalian activating protein 1 transcription factor activity than normal mammarian epithelial cells. Cancer Res 57: 3046-3054, 1997
37. van der Burg B, Slager-Davidov R, van der Leede BM, de Laat SW, van der Saag PT: Differential regulation of AP1 activity by retinoic acid in hormone-dependent and -independent breast cancer cells. Mol Cell Endocrinol 112: 143-152, 1995
38. Schadlow VC, Barzilai N, Deutsch PJ: Regulation of gene expression in PC12 cells via an activator of dual second messengers: pituitary adenylate cyclase activating polypeptide. Mol Biol Cell 3: 941-951, 1992
39. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Naar AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG: RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67: 1251-1266, 1991
40. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ: Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochem 18: 5294-5299, 1979
41. Szabo E, Preis LH, Brown PH, Birrer MJ: The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation. Cell Growth Differ 2: 475-482, 1991
42. Feinberg AP, Vogelstein B: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132: 6-13, 1983
43. Yang F, Fredrichs WE, Cupples RL, Bonifacio ML, Sanford JA, Horton WA, Bowman BH: Human ceruloplasmin. Tissue-specific expression of transcripts produced by alternative splicing. J Biol Chem 265: 10780-10785, 1990
44. Chen J-Y, Penco S, Ostrowski J, Balague P, Pon M, Starett J, Reezek P, Chambon P, Gronemeyer H: RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation. EMBO J 14: 1187-1197, 1995
45. Bulens F, Ibanez-Tallon, van Acker P, De Vriese A, Nelles L. Belayew A, Collen D: Retinoic acid induction of human tissue-type plasminogen activator gene expression via a direct repeat element (DR5) located at -7 kilobases. J Biol Chem 270: 7167-7175, 1995
46. Yuspa SH, Ben T, Steinert P: Retinoic acid induces transglutaminase activity but inhibits cornification of cultured epidermal cells. J Biol Chem 257: 9906-9908, 1982
47. Davies PJA, Murtaugh MP, Moore WT, Johnson GS, Lucas D: Retinoic acid-induced expression of tissue transglutaminase in human promyelocytic leukemia (HL-60) cells. J Biol Chem 260: 5166-5174, 1985
48. Vollberg TM Sr, Nervi C, George MD, Eujimoto W, Krust A, Jetten AM: Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation. Mol Endocrinol 6: 667-676, 1992
49. Jetten AM, Nervi C, Vollberg TM: Control of squamous differentiation in tracheobronchial and epidermal epithelial cells: role of retinoids. J Natl Cancer Inst Monogr 13: 93-100, 1992
50. Lee H-Y, Dawson MI, Walsh GL, Nesbitt JC, Eckert RL, Fuchs E, Hong WK, Lotan R, Kurie JM: Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells. Cell Growth Differ 7: 997-1004, 1996
51. Fanjul AN, Piedrafita FJ, AL-Shamma H, Pfahl M: Apoptosis induction and potent antiestrogen receptor-negative breast cancer activity in vivo by a retinoid antagonist. Cancer Res 58: 4607-4610, 1998
52. Toma S, Isnard L, Raffo L, Riccardi L, Dastoli G, Apfel C, LeMotte P, Bollag W: RARα antagonist RO 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines. Int J Cancer 78: 86-94, 1998
53. Liu Y, Lee M-O, Wang H-G, Li Y, Hashimoto Y, Klaus M, Reed JC, Zhang X-K: Retinoic acid receptor β mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells. Mol Cell Biol 16: 1138-1149, 1996
54. Seewaldt VL, Kim J-H, Caldwell LE, Johnson BS, Swisshem K, Collins SJ: All-trans-retinoic acid mediates G1 arrest but not apoptosis or normal human mammary epithelial cells. Cell Growth Differ 8: 631-641, 1997
55. van der Burg B, van der Leede BM, Kwakkenbos-Isbrucker L, Salverda S, de Laat SW, van der Saag PT: Retinoic acid resistance of estradiol-independent breast cancer cells coincides with diminished retinoic acid receptor function. Mol Cell Endocrinol 91: 149-157, 1993
56. Fitzgerald P, Teng M, Chandraratna RAS, Heyman RA, Allegretto EA: Retinoic acid receptor alpha expression correlates with retinoid-induced growth inhibition of human breast cancer cells regardless of estrogen receptor status. Cancer Res 57: 2642-2650, 1997
57. Sheikh MS, Shao Z-M, Li X-S, Dawson M, Jetten AM, Wu S, Conley BA, Garcia M, Rochefort H, Fontana JA: Retinoid-resistant estrogen receptor-negative human breast carcinoma cells transfected with retinoic acid receptor-α acquire sensitivity to growth inhibition by retinoids. J Biol Chem: 269: 21440-21447, 1994
58. Chambon P: A decade of molecular biology of retinoic acid receptors. FASEB J 10: 940-954, 1996
59. Caelles C, Gonzalez-Sancho JM, Munoz A: Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev 11: 3351-3364, 1997
60. Han GR, Dohi DF, Lee HY, Rajah R, Walsh GL, Hong WK, Cohen P, Kuric JM: All-trans-retinoic acid increases transforming growth factor-beta2 and insulin-like growth factor binding protein-3 expression through a retinoic acid receptor-alpha-dependent signaling pathway. J Biol Chem 272: 13711-13716, 1997