Localization of the human 64kD autoantigen D1 to myofibrils in a subset of extraocular muscle fibers

Current Eye Research

Volumn 19, Issue 4, 1999, Pages 313-322

  Conley, C A ^a,b   Fowler, V M ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NASA AMES RESEARCH CENTER   (United States)

Author keywords

64kDa autoantigen D1; Extraocular muscles; Slow myosin; Thyroid associated orbitopathy; Tropomodulin

Indexed keywords

AUTOANTIGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; EXTRAOCULAR MUSCLE; GENE EXPRESSION SYSTEM; IMMUNOFLUORESCENCE; MUSCLE FIBRIL; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; WESTERN BLOTTING;

EID: 0032719930     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1076/ceyr.19.4.313.5304     Document Type: Article

References (36)

1. Weetman AP. Eyeing up Graves' ophthalmopathy. Mol Cell Endocrin. 1997;126:113-116.
2. Heufelder AE. Pathogenesis of Graves' ophthalmopathy: recent controversies and progress. Eur J Endocrin. 1995;132:532-541.
3. Kendler DL. Immunologic mechanisms in Graves' orbitopathy. BC Med J 1994;36:814-816.
4. Weetman AP, McGregor AM. Autoimmune thyroid disease: further developments in our understanding. Endocrine Rev. 1994;15:788-830.
5. Wall JR, Bernard N, Boucher A, Salvi M, Zhang ZG, Kennerdell J, Tyutyunikov A, Genovese C. Pathogenesis of thyroid-associated ophthalmopathy: an autoimmune disorder of the eye muscle associated with Graves' hyperthyroidism and Hashimoto's thyroiditis. Clin Immunol Immunopath. 1993;68:1-8.
6. Kubota S, Gunji K, Ackrell BAC, Cochran B, Stolarski C, Wengrowicz S, Kennerdell JS, Hiromatsu Y, Wall JR. The 64-kilodalton eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune-mediated damage to the eye muscle in patients with Graves' hyperthyroidism. J Clin Endocrin Met. 1998;83:443-447.
7. Dong Q, Ludgate M, Vassart G. Cloning and sequencing of a novel 64-kDa autoantigen recognized by patients with autoimmune thyroid disease. J Clin Endocrin Met. 1991;72:1375-1381.
8. Conley CA, Fowler VM. A new family of actin filament pointed end capping proteins. (Abstract). Mol Biol Cell. 1996;7 (suppl.):379A.
9. Sung LA, Fan YS, Lin CC. Gene assignment, expression, and homology of human tropomodulin. Genomics. 1996;34:92-96.
10. Kromminga A, Hagel C, Arndt R, Schuppert F. Serological reactivity of recombinant 1D autoantigen and its expression in human thyroid and eye muscle tissue: a possible autoantigenic link in Graves' patients. J Clin Endocrin Met. 1998;83:2817-2823.
11. Zhang Z-G, Wall JR, Bernard NF. Tissue distribution and quantitation of a gene expressing a 64-kDa antigen associated with thyroid-associated ophthalmopathy. Clin Immunol Immunopath. 1996;80:236-244.
12. Ross PV, Koenig RJ, Arscott P, Ludgate M, Waier M, Nelson CC, Kaplan MM, Baker JR. Tissue specificity and serologic reactivity of an autoantigen associated with autoimmune thyroid disease. J Clin Endocrin Met. 1993;77:433-438.
13. Kiljanski J, Stolarski C, Barsouk A, Nebes V, Wall JR. Failure to demonstrate cell-mediated immunity to orbital tissue antigens and epitopic fragments of a 64 kDa protein in the majority of patients with thyroid-assoicated ophthalmopathy. J Endocrin Invest. 1996;19:284-292.
14. Zhang Z-G, Wall JR, Bernard NF. Identification of antigenic epitopes of 1D antigen recognized by antibodies in the serum of patients with thyroid-associated ophthalmopathy. Clin Immunol Immunopath. 1995;77:193-200.
15. Wall JR, Triller H, Boucher A, Bernard NF, Salvi M, Ludgate M. Antibodies reactive with an intracellular epitope of a recombinant 64kDa thyroid and eye muscle protein in patients with thyroid autoimmunity and ophthalmopathy. J Endocrin Invest. 1993;16:863-868.
16. Zhang Z-G, Dong A, Rodien P, Alcade L, Bernard N, Boucher A, Salvi M, Arthurs B, Vassart GM, Ludgate M, Wall JR. Antibodies in the serum of patients with autoimmune thyroid disorders react with a recombinant 98 amino acid fragment of a full-length 64 kDa eye muscle membrane protein which is also expressed in the thyroid. Autoimmunity. 1992;13:151-157.
17. Arnold K, Tandon N, McIntosh RS, Elisei R, Ludgate M, Weetman AP. T-cell responses to orbital antigens in thyroid-associated ophthalmopathy. Clin Exp Immunol. 1994;96:329-334.
18. Bernard NF, Nygen TN, Tyutyunicov A, Stolarski C, Scalise D, Genovese C, Hayes MB, Ludgate M, Wall JR. Antibodies against 1D, a recombinant 64-kDa membrane protein, are associated with ophthalmopathy in patients with thyroid autoimmunity. Clin Immun Immunopath. 1994;70:225-233.
19. Fowler VM. Regulation of actin filament length in erythrocytes and striated muscle. Curr Op Cell Bio. 1996;8:86-96.
20. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
21. Fowler VM, Adam EJH. Spectrin redistributes to the cytosol and is phosphorylated during mitosis in cultured cells. J Cell Biol. 1992;119:1559-1572.
22. Fowler VM. Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actin. J Cell Biol. 1990; 111:471-482.
23. Ursitti JA, Fowler VM. Immunolocalization of tropomodulin, tropomyosin, and actin in spread human erythrocyte skeletons. J Cell Sci. 1994;107:1633-1639.
24. Towbin H, Gordon J, Staehelin T. Electrophoretic transfer of proteins from poly-acrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci. 1979;76:4350-4354.
25. Li X, Larsson L. Contractility and myosin isoform compositions of skeletal muscles and muscle cells from rats treated with thyroid hormone for 0, 4, and 8 weeks. J Mus Res Cell Mot. 1997;18:333-344.
26. Heufelder AE, Goellner JR, Wenzel BE, Bahn RS. Immunohistochemical detection and localization of a 72-kilodalton heat shock protein in autoimmune thyroid disease. J Clin Endocrin Met. 1992;74:724-731.
27. Hiromatsu Y, Tanaka K, Ishisaka N, Kamachi J, Kuroki T, Hoshino T, Inoue Y, Wall JR Nonaka K. Human histocompatibility leukocyte antigen-DR and heat shock protein-70 expression in eye muscle tissue in thyroid-associated ophthalmopathy. J Clin Endocrin Met. 1995;80:685-691.
28. Petrof BJ. The molecular basis of activity-induced muscle injury in Duchenne muscular dystrophy. Mol Cell Biochem. 1998;179:111-123.
29. Kurki P. Cytoskeletal antibodies. In Autoimmune Hepatitis, M.Nishioka, G.Toda, and M.Zeniya, eds. Elsevier Science Publishers. 1994:185-198.
30. Littlefield R and Fowler VM. Defining actin filament length in striated muscle: rulers and caps or dynamic stability? Annu Rev Cell Dev Biol. 1998;14:487-525.
31. Karpati G, Carpenter S, Prescott S. Small-caliber skeletal muscle fibers do not suffer necrosis in mdx mouse dystrophy. Muscle Nerve. 1988;11:795-803.
32. Porter JD, Rafael JA, Ragusa RJ, Bruckner JK, Trickett JI, Davies KE. The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin. J Cell Sci. 1998;111:1801-1811.
33. Fowler VM, Conley CA. Tropomodulin. in Guidebook to the Cytoskeletal and Motor Proteins, 2nd ed. (in press).
34. Almenar-Queralt A, Gregorio CC, Fowler VM. Tropomodulin assembles early in myofibrillogenesis in chick skeletal muscle: evidence that thin filaments rearrange to form striated myofibrils. J Cell Sci. 1999;112: 1111-1123
35. Fowler VM. Capping actin filament growth: Tropomodulin in muscle and nonmuscle cells. 50th Annual Meeting and Symposium of the Society of General Physiologists: Cytoskeletal Regulation of Membrane Function 1997; 52:79-89.
36. Spencer RF, Porter JD. Structural organization of the extrocular muscles. In Buttner-Ennever JA. Neuroanatomy of the oculomotor system. New York: Elsevier Science Pub. Co; 1988;chap 2.