The 64-kilodalton eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: The corresponding serum antibodies are good markers of an immune-mediated damage to the eye muscle in patients with Graves' hyperthyroidism

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 2, 1998, Pages 443-447

  Kubota, S ^e   Gunji, K ^e   Ackrell, B A C ^a   Cochran, B ^a   Stolarski, C ^e   Wengrowicz, S ^b   Kennerdell, J S ^e   Hiromatsu, Y ^c   Wall, J ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC ANTIBODY; FLAVOPROTEIN; MEMBRANE PROTEIN; SUCCINATE DEHYDROGENASE;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRAOCULAR MUSCLE; EYE DISEASE; FEMALE; GRAVES DISEASE; HUMAN; HYPERTHYROIDISM; IMMUNE MEDIATED INJURY; IMMUNOBLOTTING; MALE; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION;

ADULT; AGED; AMINO ACID SEQUENCE; ANIMALS; AUTOANTIBODIES; BLOTTING, WESTERN; CATTLE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EYE DISEASES; FEMALE; GRAVES DISEASE; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; SUCCINATE DEHYDROGENASE; SWINE;

BOVINAE; SUIDAE;

EID: 0031765309     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.2.443     Document Type: Article

References (37)

1. Burch H, Wartofsky L. 1993 Graves' ophthalmopathy: current concepts regarding pathogenesis and management. Endocr Rev. 14:747-793.
2. Weetman AF. 1991 Thyroid-associated eye disease: pathophysiology. Lancet. 338:25-28.
3. Wall JR, Boucher BA, Salvi M, et al. 1993 Pathogenesis of thyroid associated ophthalmopathy: an autoimmune disorder of the eye muscle associated with Graves' hyperthyroidism and Hashimoto's thyroiditis. Clin lmmunol Immunopathol. 68:1-8.
4. Bahn RS. 1995 The fibroblast is the target cell in the connective tissue manifestations of Graves' disease. Int Arch Allergy Immunol. 106:213-218.
5. Heufelder AE. 1995 Involvement of the orbital fibroblast and TSH receptor in the pathogenesis of Graves' ophthalmopathy. Thyroid. 5:331-340.
6. Feliciello A, Porcellini A, Ciullo I, Bonavolonta G, Awedimento EV, Fenzi G. 1993 Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue. Lancet. 342:337-338.
7. Endo T, Ohta K, Haraguchi K, Onaya T. 1995 Cloning, and functional expression of a thyrotropin receptor cDNA from fat cells. J Biol Chem. 270:10833-10837.
8. Dutton CM, Natt N, Bahn RS. Liquid hybridization analysis of TSH receptor mRNA in cultured fibroblasts from patients with Graves' ophthalmopathy (Abstract 54). Proc of the 69th Annual Meet of the Am Thyroid Assoc. 1996.
9. Kiljanski J, Nebes V, Wall JR. 1995 The ocular muscle cell is a target of the immune system in endocrine ophthalmopathy-Pro. Int Arch Allergy Immunol. 106:204-212.
10. Hiromatsu Y, Sato M, Tanaka K, et al. 1993 Significance of anti-eye muscle antibody in patients with thyroid-associated ophthalmopathy by quantitative Western blot. Autoimmunity. 14:1-8.
11. Chang TC, Chang TJ, Huang YS, Hua KM, Su RJ, Kao SCS. 1992 Identification of autoantigen recognized by autoimmune ophthalmopathy sera with immunoblotting correlated with orbital computed tomography. Clin Immunol Immunopathol. 65:161-166.
12. Campbell RJ. 1989 Immunology of Graves' ophthalmopathy: retrobulbar histology, histochemistry. Acta Endocrinol (Copenh). 121(Suppl 2):9-16.
13. Riley FC. 1972 Orbital pathology in Graves' disease. Mayo Clinic Proc. 47:975-979.
14. Salvi M, Miller A, Wall JR. 1988 Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid-associated ophthalmopathy. FEBS Lett. 232:135-139.
15. Salvi M, Bernard N, Miller A, Zhang ZG, Gardini E, Wall JR. 1991 Prevalence of antibodies reactive with a 64 kDa eye muscle membrane antigen in thyroid-associated ophthalmopathy. Thyroid. 1:207-213.
16. Miller A, Arthurs B, Boucher A, et al. 1992 Significance of antibodies reactive with a 64 kDa eye muscle membrane antigen in patients with thyroid autoimmunity. Thyroid. 2:197-202.
17. Wall JR, Barsouk A, Stolareki C, et al. 1966 Serum eye muscle and TSH receptor antibodies predicted the development of ophthalmopathy in a euthyroid subject with a family history of autoimmunity. Thyroid. 6:353-358.
18. Dakovska L, Vulkova H, Kovatchena R, et al.. Anti-eye muscle antibodies in patients with thyroid-associated ophthalmopathy (TAO) [Abstract]. Proc of the Annual Balkan Congr of Endocrinol. 1995.
19. Wengrowicz S, Puig-Domingo M, Soldevila J, de Leiva A. Prevalences of antibodies reactive with pig eye muscle membrane antigens in patients with thyroid-associated ophthalmopathy (Abstract 27). Proc of the 11th Int Thyroid Congr. 1995; p. 514.
20. Wu Y-J, Clarke SEM, Shepherd P. Prevalence and significance of antibodies reactive with eye muscle membrane antigens in sera from patients with Graves' ophthalmopathy and other thyroid and non-thyroid disorders. Thyroid. In press.
21. Kadlubowski M, Irvine WJ, Rowland AC. 1986 The lack of specificity of ophthalmic immunoglobulins in Graves' disease. J Clin Endocrinol Metab. 63:990-999.
22. Ahmann A, Baker JR, Weetman AP, Wartofsky L, Nutman TB, Burman KD. 1987 Antibodies to porcine eye muscle in patients with Graves' ophthalmopathy: identification of serum immunoglobulins directed against unique determinants by immunoblotting and enzyme linked immunosorbent assay. J Clin Endocrinol Metab. 64:454-460.
23. Tandon N, Van SL, Arnold K, Metcalfe RA, Weetman AP. 1994 Immunoglobulin class and subdass distribution of eye muscle and fibroblast antibodies in patients with thyroid-associated ophthalmopathy. Clin Endocrinol (Oxf). 40:629-639.
24. Kubota S, Gunji K, Stolarski C, Kennerdell JS, Wall JR. Role of eye muscle antibody measurement in the diagnosis of thyroid-asociated ophthalmopathy: a laboratory update. Endocr Pract. In press.
25. Committees of the American, European, Asia-Oceania, and Latin America Thyroid Associations 1992 Classification of eye changes of Graves' disease. Thyroid. 2:235-236.
26. Laemmli UK. 1970 Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature. 227:680-681.
27. Davis KA, Hatefi Y. 1971 Succinate dehydrogenase. I. Purification, molecular properties, and substructure. Biochemistry. 10:2509-2516.
28. Baginsky ML, Hatefi Y. 1969 Reconstitution of succinate dehydrogenase-coenzyme Q reductase (complex II) and succinate oxidase activities by a highly purified, reactivated, succinate dehydrogenase. J Biol Chem. 244:5313-5319.
29. Merli A, Capaldi RA, Ackrell BAC, Kearney EB. 1979 Arrangement of complex 11 (succinateubiquinone reductase) in the mitochondrial inner membrane. Biochemistry. 18:1393-1400.
30. Kubota S, Gunji K, Ackrell BAC, et al. The 64 kDa eye muscle protein is the flavoprotein subunit of mitochondrial succinate dehydrogenase: the corresponding serum antibodies are good markers of an immune-mediated damage to the eye muscle in patients with Graves' hyperthyroidism. J Clin Endocrinol Metab. in press.
31. Nebes V, Sato M, Gunji K, et al. Molecular cloning and characterization of a 64 kDa eye muscle autoantigen associated with thyroid-associated ophthalmopathy (Abstract 197). Proc of the 69th Annual Meet of the Am Thyroid Assoc. 1996.
32. Morris A, Farnsworth L, Ackrell BAC, Turnbull DM, Birch-Machin MA. 1994 The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase. Biochim Biophys Acta. 1185:125-128.
33. Kita K, Oya H, Gennis RB, Ackrell BA, Kasahara M. 1990 Human complex II (succinate-ubiquinone oxidireductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria. Biochem Biophys Res Commun. 166:1091-1108.
34. Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M, Scheffler IE. 1995 Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase. Gene. 159:249-253.
35. Madaio MP, Yanase K, Foster MH, et al. 1997 Nuclear localization of autoantibodies. Novel insights into protein translocation and cellular function. Ann NY Acad Sci. 815:263-266.
36. Jackson MJ, Schaefer JA, Johnson MA, Morris A, Tumbull DM, Bindoff LA. 1995 Presentation and clinical investigation of mitochondrial respiratory chain disease. A study of 51 patients. Brain. 118:339-357.
37. Gunji K, Kubota S, Stolarski, C, Wall JR. Cloning and characterization of a novel thyroid and eye muscle shared autoantigen associated with the development of ophthalmopathy in patients with thyroid autoimmunity [Abstract]. Proc of the 70th Annual Meet of the Am Thyroid Assoc. 1997.