Therapeutic angiogenesis in ischemic heart disease

Thrombosis and Haemostasis

Volumn 82, Issue 2, 1999, Pages 772-780

  Helisch, Armin ^a   Ware, J Anthony ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 5; GROWTH FACTOR; PLACENTAL GROWTH FACTOR 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANGIOGRAPHY; COLLATERAL CIRCULATION; CONFERENCE PAPER; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HISTOCHEMISTRY; HISTOLOGY; HUMAN; NONHUMAN; PERFUSION; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0032719667     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615910     Document Type: Conference Paper

References (78)

1. Schaper W, Piek JJ, Munoz-Chapuli R, Wolf C, Ito W. Collateral circulation of the heart. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:159-198.
2. Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674.
3. Folkman J. Clinical applications of research on angiogenesis. N Engl J Med. 1995;333:1757-1763.
4. Post M, Ware JA. Angiogenesis in Atherosclerosis and Restenosis. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:143-158.
5. Ware JA, Simons M. Angiogenesis in ischemic heart disease. Nat Med. 1997;3:158-164.
6. Ware JA. Cellular mechanisms of angiogenesis. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:30-59.
7. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM. Isolation of putative progenitor endothelial cells for angiogenesis. Science. 1997;275:964-967.
8. Simons M, Laham RJ. Therapeutic angiogenesis in myocardial ischemia. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:289-320.
9. O'Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997;88:277-285.
10. Westernacher D, Schaper W. A novel heart derived inhibitor of vascular cell proliferation. Purification and biological activity. J Mol Cell Cardiol. 1995;27:1535-1543.
11. Engleka KA, Maciag T. Molecular mechanisms of the fibroblast growth factor family. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:79-100.
12. Ferrara N, Gerber HP. The vascular endothelial growth factor family. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:101-127.
13. Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature. 1992; 359:843-845.
14. Bunn FH, Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev. 1996;70:839-885.
15. Takagi H, King GL, Ferrara N, Aiello LP. Hypoxia regulates vascular endothelial growth factor receptor KDR/Flk gene expression through adenosine A2 receptors in retinal capillary endothelial cells. Invest Ophthalmol Vis Sci. 1996;37:1311-1321.
16. Maltepe E, Schmidt JV, Baunoch D, Bradfeld CA, Simon MC. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature. 1997;386:403-407.
17. Stein I, Neeman M, Shweiki D, Itin A, Keshet E. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol Cell Biol. 1995;15:5363-5368.
18. 2 tension. Proc Natl Acad Sci U S A. 1995;92:5510-5514.
19. Levy AP, Levy NS, Wegner S, Goldberg M. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem. 1995;270:13333-13340.
20. Li J, Brown LF, Hibberd MG, Grossman JD, Morgan JP, Simons M. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol. 1996;270:H1803-H1811.
21. Li J, Hampton T, Morgan JP, Simons M. Stretch-induced VEGF expression in the heart. J Clin Invest. 1997;100:18-24.
22. Arras M, Ito WD, Scholz D, Winkler B, Schaper J, Schaper W. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest. 1998;101:40-50.
23. Coulier F, Pontarotti P, Roubin R, Hartung H, Goldfarb M, Birnbaum D. Of worms and men: an evolutionary perspective on the fibroblast growth factor (FGF) and FGF receptor families. J Mol Evol. 1997;44:43-56.
24. Yu C, English A, Edelman ER. Growth factor delivery strategies. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:238-257.
25. Cuevas P, Carceller F, Ortega S, Zazo M, Nieto I, Gimenez-Gallego G. Hypotensive activity of fibroblast growth factor. Science. 1991;254:1208-1210.
26. Sellke FW, Harrison DG. Coronary microcirculation and angiogenesis. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:258-288.
27. Ziche M, Morbidelli L, Choudhuri R, Zhang HT, Donnini S, Granger HJ, Bicknell R. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest. 1997;99:2625-2634.
28. Vincenti V, Cassano C, Rocchi M, Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation. 1996;93:1493-1495.
29. Keyt BA, Berleau LT, Nguyen HV, Chen H, Heinsohn H, Vandlen R, Ferrara N. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem. 1996;271:7788-7795.
30. Asahara T, Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Isner JM. A novel function of VEGF: mobilization of bone marrow derived endothelial progenitor cells. Circulation. 1998;98 (Suppl. 1):1-605.
31. Kalka C, Takahashi T, Masuda H, Pieczek A, Asahara T. Intramuscular VEGF gene transfer mobilizes endothelial cell progenitor cells in human subjects. Circulation. 1998;98 (Suppl. 1):1-1685.
32. Achen MG, Jeltsch M, Kukk E, Makinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc Natl Acad Sci USA. 1998;95:548-553.
33. Witzenbichler B, Asahara T, Murohara T, Silver M, Spyridopoulos I, Magner M, Principe N, Kearney M, Hu JS, Isner JM. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. Am J Pathol. 1998;153:381-394.
34. Cao Y, Linden P, Shima D, Browne F, Folkman J. In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J Clin Invest. 1996;98:2507-2511.
35. Kurz H, Wilting J, Sandau K, Christ B. Automated evaluation of angiogenic effects mediated by VEGF and PlGF homo- and heterodimers. Microvasc Res. 1998;55:92-102.
36. Ziehe M, Maglione D, Ribatti D, Morbidelli L, Lago CT, Battisti M, Paoletti I, Barra A, Tucci M, Parise G, Vincenti V, Granger HJ, Viglietto G, Persico MG. Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic. Lab Invest. 1997;76:517-531.
37. Mezaros JG, Brunton LL, Bloor CM. Animal models of angiogenesis in cardiovascular tissues. In: Ware JA, Simons M, eds. Angiogenesis and Cardiovascular Disease. New York: Oxford University Press, 1999:213-237.
38. Michael LH, Entman ML, Hartley CJ, Youker KA, Zhu J, Hall SR, Hawkins HK, Berens K, Ballantyne CM. Myocardial ischemia and reperfusion: a murine model. Am J Physiol. 1995;269:H2147-H2154.
39. Couffinhal T, Silver M, Zheng LP, Kearney M, Witzenbichler B, Isner JM. Mouse model of angiogenesis. Am J Pathol. 1998;152:1667-1679.
40. Sanborn TA, Tarazona N, Deutsch E, Lee L, Hackett N, 0El-Sawy T, Crystal RG. Percutaneous endocardial gene therapy: in vivo gene transfer and expression. J Am Coll Cardiol. 1999;33 (Suppl A):262a.
41. Arras M, Mollnau H, Strasser R, Wenz R, Ito WD, Schaper J, Schaper W. The delivery of angiogenic factors to the heart by microsphere therapy. Nat Biotechnol. 1998;16:159-162.
42. Banai S, Jaklitsch MT, Casscells W, Shou M, Shrivastav S, Correa R, Epstein SE, Unger EF. Effects of acidic fibroblast growth factor on normal and ischemic myocardium. Circ Res. 1991;69:76-85.
43. Unger EF, Shou M, Sheffield CD, Hodge E, Jaye M, Epstein SE. Extracardiac to coronary anastomoses support regional left ventricular function in dogs. Am J Physiol. 1993;264:H1567-H1574.
44. Unger EF, Banai S, Shou M, Jaklitsch M, Hodge E, Correa R, Jaye M, Epstein SE. A model to assess interventions to improve collateral blood flow: continuous administration of agents into the left coronary artery in dogs. Cardiovasc Res. 1993;27:785-791.
45. Schlaudraff K, Schumacher B, von Specht BU, Seitelberger R, Schlosser V, Fasol R. Growth of "new" coronary vascular structures by angiogenetic growth factors. Eur J Cardiothorac Surg. 1993; 7:637-643.
46. Ortega S, Schaeffer MT, Soderman D, DiSalvo J, Linemeyer DL, Gimenez-Gallego G, Thomas KA. Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor. J Biol Chem. 1991;266:5842-5846.
47. Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Thomas KA, DiSalvo J, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. Am J Physiol. 1998;274:H930-H936.
48. Yanagisawa-Miwa A, Uchida Y, Nakamura F, Tomaru T, Kido H, Kamijo T, Sugimoto T, Kaji K, Utsuyama M, Kurashima C, et al. Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor. Science. 1992;257:1401-1403.
49. Uchida Y, Yanagisawa-Miwa A, Nakamura F, Yamada K, Tomaru T, Kimura K, Morita T. Angiogenic therapy of acute myocardial infarction by intrapericardial injection of basic fibroblast growth factor and heparin sulfate: an experimental study. Am Heart J. 1995;130:1182-1188.
50. Padua RR, Sethi R, Dhalla NS, Kardami E. Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury. Mol Cell Biochem. 1995;143:129-135.
51. Huang Z, Chen K, Huang PL, Finklestein SP, Moskowitz MA. bFgf ameliorates focal ischemic injury by blood flow-independent mechanisms in eNos mutant mice. Am J Physiol. 1997;272:H1401-H1405.
52. Battler A, Scheinowitz M, Bor A, Hasdai D, Vered Z, Di Segni E, Varda-Bloom N, Nass D, Engelberg S, Eldar M, et al. Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infarcted swine myocardium. J Am Coll Cardiol. 1993;22:2001-2006.
53. Unger EF, Banai S, Shou M, Lazarous DF, Jaklitsch MT, Scheinowitz M, Correa R, Klingbeil C, Epstein SE. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model. Am J Physiol. 1994;266:H1588-H1595.
54. Lazarous DF, Scheinowitz M, Shou M, Hodge E, Rajanayagam S, Hunsberger S, Robison WG, Jr., Stiber JA, Correa R, Epstein SE, et al. Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart. Circulation. 1995;91:145-153.
55. Harada K, Grossman W, Friedman M, Edelman ER, Prasad PV, Keighley CS, Manning WJ, Sellke FW, Simons M. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J Clin Invest. 1994;94:623-630.
56. Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters. J Pharmacol Exp Ther. 1997;282:385-390.
57. Baffour R, Berman J, Garb JL, Rhee SW, Kaufman J, Friedmann P. Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: dose-response effect of basic fibroblast growth factor. J Vasc Surg. 1992;16:181-191.
58. Pu LQ, Sniderman AD, Brassard R, Lachapelle KJ, Graham AM, Lisbona R, Symes JF. Enhanced revascularization of the ischemic limb by angiogenic therapy. Circulation. 1993;88:208-215.
59. Pu LQ, Sniderman AD, Arekat Z, Graham AM, Brassard R, Symes JF. Angiogenic growth factor and revascularization of the ischemic limb: evaluation in a rabbit model. J Surg Res. 1993;54:575-583.
60. Giordano FJ, Ping P, McKirnan MD, Nozaki S, DeMaria AN, Dillmann WH, Mathieu-Costello O, Hammond HK. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med. 1996;2:534-539.
61. Takeshita S, Pu LQ, Stein LA, Sniderman AD, Bunting S, Ferrara N, Isner JM, Symes JF. Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia. Circulation. 1994;90:II 228-234.
62. Takeshita S, Zheng LP, Brogi E, Kearney M, Pu LQ, Bunting S, Ferrara N, Symes JF, Isner JM. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J Clin Invest. 1994;93:662-670.
63. Bauters C, Asahara T, Zheng LP, Takeshita S, Bunting S, Ferrara N, Syrmes JF, Isner JM. Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor. J Vasc Surg. 1995;21:314-324.
64. Takeshita S, Tsurumi Y, Couffinahl T, Asahara T, Bauters C, Symes J, Ferrara N, Isner JM. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Lab Invest. 1996;75:487-501.
65. Banai S, Jaklitsch MT, Shou M, Lazarous DF, Scheinowitz M, Biro S, Epstein SE, Unger EF. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation. 1994;89:2183-2189.
66. Lazarous DF, Shou M, Scheinowitz M, Hodge E, Thirumurti V, Kitsiou AN, Stiber JA, Lobo AD, Hunsberger S, Guetta E, Epstein SE, Unger EF. Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. Circulation. 1996;94:1074-1082.
67. Harada K, Friedman M, Lopez JJ, Wang SY, Li J, Prasad PV, Pearlman JD, Edelman ER, Sellke FW, Simons M. Vascular endothelial growth factor administration in chronic myocardial ischemia. Am J Physiol. 1996;270:H1791-H1802.
68. Sayeed-Shah U, Mann MJ, Martin J, Grachev S, Reimold S, Laurence R, Dzau V, Cohn LH. Complete reversal of ischemic wall motion abnormalities by combined use of gene therapy with transmyocardial laser revascularization. J Thorac Cardiovasc Surg. 1998;116:763-769.
69. Nakamura S, Moriguchi A, Nakamura Y, Mastsushita H, Aoki M, Tomita N, Nakamura T. Therapeutic angiogenesis by a single intra-arterial injection of human hepatocyte growth factor (HGF) in rabbit ischemic hind limb model as "supplement cytokine therapy." Circulation. 1998;98 (Suppl. 1):1-268.
70. Shyu K-G, Vincent KA, Luo Y, Magner M, Tio RA, Jiang C, Akita GY, Isner JM, Gregory RJ. Naked DNA encoding an hypoxia-inducible factor 1α (HIF-1α)/VP16 hybrid transcription factor enhances angiogenesis in rabbit hindlimb ischemia: an alternate method for therapeutic angiogenesis utilizing a transcriptional regulatory system. Circulation. 1998;98 (Suppl 1):1-68.
71. Schumacher B, Pecher P, von Specht BU, Stegmann T. Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease. Circulation. 1998;97:645-650.
72. Sellke FW, Laham RJ, Edelman ER, Pearlman JD, Simons M. Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results. Ann Thorac Surg. 1998;65:1540-1544.
73. Laham RJ, Sellke FW, Ware JA, Pearlman JD, Edelman ER, Simons M. Results of a randomized, double-blind, placebo-controlled study of local perivascular basic fibroblast growth factor (bFGF) treatment in patients undergoing coronary artery bypass surgery. J Am Coll Cardiol. 1999;33 (Suppl A):383A-384a.
74. Laham RJ, Leimbach M, Chronos NA, Vansant JP, Pearlman JD, Pettigrew R, Guler H-P, Whitehouse MJ, Hung D, Baim DS, King III SB, Simons M. Intracoronary administration of recombinant fibroblast growth factor-2 (rFGF-2) in patients with severe coronary artery disease: results of phase I. J Am Coll Cardiol. 1999;33 (Suppl A):383a.
75. Losordo DW, Vale PR, Symes JF, Dunnington CH, Esakof DD, Maysky M, Ashare AB, Lathi K, Isner JM. Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation. 1998;98:2800-2804.
76. Vale PR, Losordo DW, Dunnington CH, Lathi K, Esakof DD, Symes JF, Isner JM. Direct intramyocardial injection of VEGF results in effective gene transfer for patients with chronic myocardial ischemia. J Am Coll Cardiol. 1999;33 (Suppl A):384a.
77. Rosengart TK, Patel SR, Lee LY, Sanborn TA, Hachamovitch R, Kligfield PD, Isom OW, Crystal RG. Safety of direct myocardial VEGF121 cDNA adenovirus-mediated angiogenesis gene therapy in conjunction with coronary bypass surgery. Circulation. 1998;98 (Suppl 1):1-321.
78. Henry TD, Annex BH, Azrin MA, McKendall GR, Willerson JT, Hendel RC, Giordano F, Klein R, Gibson M, Berman DS, Luce CA, McCluskey ER. Double blind, placebo controlled trial of recombinant human vascular endothelial growth factor - the VIVA trial. J Am Coll Cardiol. 1999;33 (Suppl.A):384a.