Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 274, Issue 3 43-3, 1998, Pages

  Lopez, John J ^a   Edelman, Elazer R ^b,c   Stamler, Alon ^a   Hibberd, Mark G ^a   Prasad, Pottumarthi ^a   Thomas, Kenneth A ^d   Disalvo, Jerry ^d   Caputo, Ronald P ^a   Carrozza, Joseph P ^a   Douglas, Pamela S ^a   Sellke, Frank W ^a   Simons, Michael ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Coronary flow; Growth factors; Myocardial function

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; ETHYLENE VINYL ACETATE COPOLYMER; MICROSPHERE;

ANGIOCARDIOGRAPHY; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECT; DRUG SCREENING; ECHOCARDIOGRAPHY; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE PACING; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SWINE;

EID: 20644464965     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.274.3.h930     Document Type: Article

References (48)

1. Baffour, R., J. Herman, J. L. Garb, S. W. Rhee, J. Kaufman, and P. Friedmann. Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: dose-response effect of basic fibroblast growth factor. J. Vasc. Surg. 16: 181-191, 1992.
2. Banai, S., M. T. Jaklitsch, W. Casscells, M. Shou, S. Shrivastav, R. Correa, S. E. Epstein, and E. F. Unger. Effects of acidic fibroblast growth factor on normal and ischemic myocardium. Circ. Res. 69: 76-85, 1991.
3. Banai, S., M. T. Jaklitsch, M. Shou, D. F. Lazarous, M. Scheinowitz, S. Biro, S. E. Epstein, and E. F. Unger. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 89: 2183-2189, 1994.
4. Battler, A., M. Scheinowitz, A. Bor, D. Hasdai, Z. Vered, E. Di Segni, N. Varda-Bloom, D. Nass, S. Engelberg, and M. Eldar. Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infarcted swine myocardium. J. Am. Coll. Cardiol. 22: 2001-2006, 1993.
5. Bjornsson, T. D., M. Dryjski, J. Tluczek, R. Mennie, J. Ronan, T. N. Mellin, and K. A. Thomas. Acidic fibroblast growth factor promotes vascular repair. Proc. Natl. Acad. Sci. USA 88: 8651-8655, 1991.
6. Blaber, M., J. DiSalvo, and K. A. Thomas. X-ray crystal structure of human acidic fibroblast growth factor. Biochemistry 35: 2086-2094, 1996.
7. Casscells, W., E. Speir, J. Sasse, M. Klagsbrun, P. Allen, M. Lee, B. Calvo, M. Chiba, L. Haggroth, and J. Folkman. Isolation, characterization, and localization of heparin-binding growth factors in the heart. J. Clin. Invest. 85: 433-441, 1990.
8. Copeland, R. A., H. Ji, A. J. Halfpenny, R. W. Williams, K. C. Thompson, W. K. Herber, K. A. Thomas, M. W. Bruner, J. A. Ryan, and D. Marquis-Omer. The structure of human acidic fibroblast growth factor and its interaction with heparin. Arch. Biochem. Biophys. 289: 53-61, 1991.
9. Cuevas, P., F. Carceller, S. Ortega, M. Zazo, I. Nieto, and G. Gimenez-Gallego. Hypotensive activity of fibroblast growth factor. Science 254: 1208-1210, 1991.
10. Edelman, E. R., D. H. Adams, and M. J. Karnovsky. Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury. Proc. Natl. Acad. Sci. USA 87: 3773-3777, 1990.
11. Edelman, E., M. Simons, M. Sirois, and R. Rosenberg. c-Myc in vasculoproliferative disease. Circ. Res. 76: 176-182, 1995.
12. Engelmann, G. L., C. A. Dionne, and M. C. Jaye. Acidic fibroblast growth factor and heart development. Role in myocyte proliferation and capillary angiogenesis. Circ. Res. 72: 7-19, 1993.
13. Fasol, R., B. Schumacher, K. Schlaudraff, K. H. Hauenstein, and R. Seitelberger. Experimental use of a modified fibrin glue to induce site-directed angiogenesis from the aorta to the heart. J. Thorac. Cardiovasc. Surg. 107: 1432-1439, 1994.
14. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1: 27-31, 1995.
15. Folkman, J., and Y. Shing. Angiogenesis. J. Biol. Chem. 267: 10931-10934, 1992.
16. Giordano, F. J., P. Ping, M. D. McKirnan, S. Nozaki, A. N. DeMaria, W. H. Dillmann, O. Mathieu-Costello, and H. K. Hammond. Intracoronary transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat. Med. 2: 534-539, 1996.
17. Harada, K., M. Friedman, J. J. Lopez, S. Y. Wang, J. Li, P. V. Prasad, J. D. Pearlman, E. R. Edelman, F. W. Sellke, and M. Simons. Vascular endothelial growth factor administration in chronic myocardial ischemia. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1791-H1802, 1996.
18. Harada, K., W. Grossman, M. Friedman, E. R. Edelman, P. V. Prasad, C. S. Keighley, W. J. Manning, F. W. Sellke, and M. Simons. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J. Clin. Invest. 94: 623-630, 1994.
19. Isner, J. M., A. Pieczek, R. Schainfeld, R. Blair, L. Haley, T. Asahara, K. Rosenfield, S. Razvi, K. Walsh, and J. F. Symes. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 348: 370-374, 1996.
20. Klagsbrun, M. Angiogenic factors: regulators of blood supply-side biology. FGF, endothelial cell growth factors and angiogenesis: a keystone symposium, Keystone, CO, USA, April 1-7, 1991. New. Biol. 3: 745-749, 1991.
21. Kowallik, P., R. Schulz, B. D. Guth, A. Schade, W. Paffhausen, R. Gross, and G. Heusch. Measurement of regional myocardial blood flow with multiple colored microspheres. Circulation 83: 974-982, 1991.
22. Lazarous, D. F., M. Scheinowitz, M. Shou, E. Hodge, S. Rajanayagam, S. Hunsberger, W. G. Robison, Jr., J. A. Stiber, R. Correa, and S. E. Epstein. Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart. Circulation 91: 145-153, 1995.
23. Linemeyer, D. L., J. G. Menke, L. J. Kelly, J. DiSalvo, D. Soderman, M. T. Schaeffer, S. Ortega, G. Gimenez-Gallego, and K. A. Thomas. Bisulfide bonds are neither required, present, nor compatible with full activity of human recombinant acidic fibroblast growth factor. Growth Factors 3: 287-298, 1990.
24. Lopez, J. J., E. R. Edelman, A. Stamler, M. G. Hibberd, P. Prasad, R. P. Caputo, J. C. Carrozza, P. S. Douglas, F. W. Sellke, and M. Simons. Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters. J. Pharmacol. Exp. Ther. 282: 385-390, 1997.
25. Mellin, T. N., R. J. Mennie, D. E. Cashen, J. J. Ronan, J. Capparella, M. L. James, J. DiSalvo, J. Frank, D. Linemeyer, and G. Gimenez-Gallego. Acidic fibroblast growth factor accelerates dermal wound healing. Growth Factors 7: 1-14, 1992.
26. Mima, T., H. Ueno, D. A. Fischman, L. T. Williams, and T. Mikawa. Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development. Proc. Natl. Acad. Sci. USA 92: 467-471, 1995.
27. Miyamoto, M., K. Naruo, C. Seko, S. Matsumoto, T. Kondo, and T. Kurokawa. Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. Mol. Cell. Biol. 13: 4251-4259, 1993.
28. Ornitz, D. M., J. Xu, J. S. Colvin, D. G. McEwen, C. A. MacArthur, F. Coulier, G. Gao, and M. Goldfarb. Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271: 15292-15297, 1996.
29. Ortega, S., M. T. Schaeffer, D. Soderman, J. DiSalvo, D. L. Linemeyer, G. Gimenez-Gallego, and K. A. Thomas. Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor. J. Biol. Chem. 266: 5842-5846, 1991.
30. Padua, R. R., R. Sethi, N. S. Dhalla, and E. Kardami. Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury. Mol. Cell. Biochem. 143: 129-135, 1995.
31. Parker, T. G., S. E. Packer, and M. D. Schneider. Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes. J. Clin. Invest. 85: 507-514, 1990.
32. Sasaki, H., H. Hoshi, Y. M. Hong, T. Suzuki, T. Kato, H. Sasaki, M. Saito, H. Youki, K. Karube, and S. Konno. Purification of acidic fibroblast growth factor from bovine heart and its localization in the cardiac myocytes. J. Biol. Chem. 264: 17606-17612, 1989.
33. Schlaudraff, K., B. Schumacher, B. U. Specht, R. Seitelberger, V. Schlosser, and R. Fasol. Growth of new coronary vascular structures by angiogenic growth factors. Eur. J. Cardiothorac. Surg. 7: 637-641, 1993.
34. Sellke, F. W., J. Li, A. Stamler, J. J. Lopez, K. A. Thomas, and M. Simons. Angiogenesis induced by acidic fibroblast growth factor as an alternative method of revascularization for chronic myocardial ischemia. Surgery 120: 182-188, 1996.
35. Sellke, F. W., S. Y. Wang, M. Friedman, K. Harada, E. R. Edelman, W. Grossman, and M. Simons. Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1303-H1311, 1994.
36. Sellke, F. W., S. Y. Wang, A. Stamler, J. J. Lopez, J. Li, J. Li, and M. Simons. Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H713-H720, 1996.
37. Shreeniwas, R., S. Ogawa, F. Cozzolino, G. Torcia, N. Braunstein, C. Butura, J. Brett, H. B. Lieberman, M. B. Furie, and J. Joseph-Silverstein. Macrovascular and microvascular endothelium during long-term hypoxia: alterations in cell growth, monolayer permeability, and cell surface coagulant properties. J. Cell. Physiol. 146: 8-17, 1991.
38. Simons, M., and J. A. Ware. Food for starving hearts. Nat. Med. 2: 519-520, 1996.
39. Smallwood, P. M., I. Munoz-Sanjuan, P. Tong, J. P. Macke, S. H. Hendry, D. J. Gilbert, N. G. Copeland, N. A. Jenkins, and J. Nathans. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc. Natl. Acad. Sci. USA 93: 9850-9857, 1996.
40. Stamm, R. B., B. A. Carabello, D. L. Mayers, and R. P. Martin. Two-dimensional echocardiographic measurement of left ventricular ejection fraction: prospective analysis of what constitutes an adequate determination. Am. Heart J. 104: 136-144, 1982.
41. Takeshita, S., L. P. Zheng, E. Brogi, M. Kearney, L. Q. Pu, S. Bunting, N. Ferrara, J. F. Symes, and J. M. Isner. Therapeutic angiogenesis. A single intraarterial bolus of vascular ehdothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J. Clin. Invest. 93: 662-670, 1994.
42. Thomas, K. A. Biochemistry and molecular biology of fibroblast growth factors. In: Neurotropic Factors, edited by J. H. Fallon and S. E. Loughlin. Orlando, FL: Academic, 1992, p. 285-312.
43. Thomas, K. A. Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem. 271: 603-606, 1996.
44. Unger, E. F., S. Banai, M. Shou, D. F. Lazarous, M. T. Jaklitsch, M. Scheinowitz, R. Correa, C. Klingbeil, and S. E. Epstein. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1588-H1595, 1994.
45. Volkin, D. B., P. K. Tsai, J. M. Dabora, J. O. Gress, C. J. Burke, R. J. Linhardt, and C. R. Middaugh. Physical stabilization of acidic fibroblast growth factor by polyanions. Arch. Biochem. Biophys. 300: 30-41, 1993.
46. Ware, J. A., and M. Simons. Angiogenesis in ischemic heart disease. Nat. Med. 3: 158-164, 1997.
47. Weiner, H. L., and J. L. Swain. Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix. Proc. Natl. Acad. Sci. USA 86: 2683-2687, 1989.
48. Yamasaki, M., A. Miyake, S. Tagashira, and N. Itoh. Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family. J. Biol. Chem. 271: 15918-15021, 1996.