Kaposi's sarcoma-associated herpesvirus and sexual transmission of cancer risk

Current Opinion in Oncology

Volumn 11, Issue 6, 1999, Pages 508-515

  Martin, Jeffrey N ^a   Osmond, Dennis H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AFRICA; CANCER RISK; DISEASE ASSOCIATION; EUROPE; HOMOSEXUALITY; HUMAN; HUMAN HERPESVIRUS 8; KAPOSI SARCOMA; KIDNEY ALLOGRAFT; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEXUALLY TRANSMITTED DISEASE; UNITED STATES;

HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HUMANS; RISK FACTORS; SARCOMA, KAPOSI; SEXUAL BEHAVIOR; SEXUALLY TRANSMITTED DISEASES, VIRAL;

EID: 0032719270     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001622-199911000-00013     Document Type: Review

References (68)

1. 1 Beral V, Peterman TA, Berkelman RL, Jaffe HW: Kaposi's sarcoma among persons with AIDS: a sexually transmitted infection? Lancet 1990, 335:123-128.
2. 2 Drew WL, Conant MA, Miner RC, Huang ES, Ziegler JL, Groundwater JR, et al.: Cytomegalovirus and Kaposi's sarcoma in young homosexual men. Lancet 1982, 2:125-127.
3. 3 Wang RY, Shih JW, Weiss SH, Grandinetti T, Pierce PF, Lange M, et al.: Mycoplasma penetrans infection in male homosexuals with AIDS: high seroprevalence and association with Kaposi's sarcoma. Clin Infect Dis 1993, 17:724-729.
4. 4 Hunag YO, Li JJ, Rush MG, Poiesz BJ, Nicolaides A, Jacobson M, et al.: HPV-16-related DNA sequences in Kaposi's sarcoma, Lancet 1992, 339:515-518.
5. 5 Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS: Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994, 266:1865-1869.
6. 6 Hill AB: The environment and disease: Association or causation? Proc R Soc Med 1965, 58:295-300.
7. 7 Whitby D, Howard MR, Tenant-Flowers M, Brink NS, Copas A, Boshoff C, et al.: Detection of Kaposi sarcoma associated herpesvirus in peripheral blood HIV-infected individuals and progression to Kaposi's sarcoma. Lancet 1995, 346:799-802.
8. 8 Moore PS, Kingsley LA, Holmberg SD, Spira T, Gupta P, Hoover DR, et al.: Kaposi's sarcoma-associated herpesvirus infection prior to onset of Kaposi's sarcoma. AIDS 1996, 10:175-180.
9. 9 Lefrere JJ, Meyohas MC, Mariotti M, Meynard JL, Thauvin M, Frottier J: Detection of human herpesvirus 8 DNA sequences before the appearance of Kaposi's sarcoma in human imnmunodeficiency virus (HIV)-positive subjects with a known date of HIV seroconversion. J Infect Dis 1996, 174:283-287.
10. 10 Gao SJ, Kingsley L, Hoover DR, Spira TJ, Rinaldo CR, Saah A, et al.: Seroconversion to antibodies against Kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of Kaposi's sarcoma. N Engl J Med 1996, 335:233-241.
11. 11 Martin JN, Ganem DE, Osmond DH, Page-Shafer K, Macrae D, Kedes DH: Sexual transmission and natural history of human herpesvirus 8 infection. N Engl J Med 1998, 338:948-954. Population-based study in San Francisco that demonstrated that KSHV infection preceded and is associated with KS independent of degree of sexual exposure and immunocompromise. Provides evidence that KSHV is sexually transmitted among homosexual men by demonstrating that seroprevalent KSHV infection was associated with a history of sexually transmitted diseases and linearly associated with a number of male sexual intercourse partners.
12. 12 Renwich N, Halaby T, Weverling GJ, Dukers NHTM, Simpson G, Coutinho RA, et al: Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi's sarcoma. AIDS 1998, 12:2481-2488. Longitudinal analysis from the Amsterdam Cohort that showed that among HIV-infected homosexual men, KSHV infection temporally preceded and was associated with the development of KS independent of CD4 lymphocyte count and the HIV plasma viral load. Those who seroconvert for KSHV after HIV seroconversion are at highest risk for KS.
13. 13 O'Brien T, Kedes D, Ganem D, Macrae D, Goedert J: Concurrent epidemics of HHV-8 and HIV-1 in homosexual men. 6th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, 1999. In HIV-infected homosexual men from the United States, KSHV infection temporally preceded and was associated with KS independent of CD4 lymphocyte count and plasma HIV RNA level.
14. 14 Beral V, Bull D, Darby S, Weller I, Carne C, Beecham M, Jaffe H: Risk of Kaposi's sarcoma and sexual practices associated with faecal contact in homosexaul or bisexual men with AIDS. Lancet 1992, 339:632-635.
15. 15 Miller G, Rigsby MO, Heston L, Grogan E, Sun R, Metroka C, et al.: Antibodies to butyrate-inducible antigens of Kaposi's sarcoma-associated herpesvirus in patients with HIV-1 infection. N Engl J Med 1996, 334:1292-1297.
16. 16 Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D: The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection on KS risk gorups and evidence for sexual transmission. Nat Med 1996, 2:918-924.
17. 17 Gao SJ, Kingsley L, Li M, Zheng W, Parravicini C, Ziegler J, et al.: KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma. Nat Med 1996, 2:925-928.
18. 18 Simpson GR, Schulz TF, Whitby D, Cook PM, Boshoff C, Rainbow L, et al.: Prevalence of Kaposi's sarcoma associated herpesvirus infection by antibodies to recombinant capsid protein and latent antigen. Lancet 1996, 348:1133-1138.
19. 19 Lennette ET, Blackbourn DJ, Levy JA: Antibodies to human herpesvirus type 8 in the general population and in Kaposi's sarcoma patients. Lancet 1996, 348:858-861.
20. 20 Gompels UA, Kasolo FC: HHV-8 serology and Kaposi's sarcoma. Lancet 1996, 348:1587-1588.
21. 21 Fredericks DN, Relman DA: Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Clin Microbiol Rev 1996, 9:18-33.
22. 22 Moore PS, Chang Y: Kaposi's sarcoma (KS), KS-associated herpesvirus, and the criteria for causality in the age of molecular biology. Am J Epidemiol 1998, 147:217-221. Interesting discussion from the discoverers of KSHV about what criteria should be used to judge its causal role in KS. Provides pertinent advice to both epidemologists and basic scientists for evaluating each other's work.
23. 23 Mellors JW, Rinaldo CR, Jr., Gupta P, White RM, Todd JA, Kingsley LA: Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996, 272:1167-1170.
24. 24 Rothman KJ, Greenland S: Causation and causal inference. In: Modern epidemiology. Philadelphia, PA: Lippincott-Raven, 1998:7-28.
25. 25 Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM: Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995, 332:1186-1191.
26. 26 Soulier J, Grollet L, Oksenhendler E, Cacoub P, Cazals-Hatem D, Babinet P, et al.: Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease. Blood 1995, 86:1276-1280.
27. 27 Kedes DH, Ganem D: Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs. Implications for potential therapy. J Clin Invest 1997, 99:2082-2086.
28. 28 Medveczky MM, Horvath E, Lund T, Medvexzky PG: In vitro antiviral drug sensitivity of the Kaposi's sarcoma-associated herpesvirus. AIDS 1997, 11:1327-1332.
29. 29 Martin DF, Kuppermann BD, Wolitz RA, Palestine AG, Li H, Robinson CA: Oral ganciclovir for patients with cytomegalovirus retinis treated with a ganciclovir implant. Roche Ganciclovir Study Group. N Engl J Med 1999, 340:1063-1070.
30. 30 IARC Working Group: Kaposi's sarcoma herpesvirus/human herpesvirus 8. IARC Monogr Eval Carcinog Risks Hum 1997, 70:375-492.
31. 31 Rezza G, Lennette ET, Giuliani M, Pezzotti P, Caprilli F, Monini P, et al.: Prevalence and determinants of anti-lytic and anti-latent antibodies to human herpesvirus-8 among Italian individuals at risk of sexually and parenterally transmitted infections. Intl J Cancer 1998, 77:361-365.
32. 32 Sosa C, Klaskala W, Chandran B, Soto R, Sieczkowsi L, Wu MH, et al.: Human herpesvirus 8 as a potential sexually transmitted agent in Honduras. J Infect Dis 1998, 178:547-551.
33. 33 Whitby D, Smith N, Ariyoshi K, Bourboulia D, Sabin C, de Ruiter A, et al.: Serologic evidence for different routes of transmission of HHV-8 in different populations. Second National AIDS Malignancy Conference, Bethesda, Maryland, 1998.
34. 34 Melbye M, Cook PM, Hjalgrim H, Begtrup K, Simpson GR, Biggar RJ, et al.: Risk factors for Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) seropositivity in a cohort of homosexual men, 1981-1996. Intl J Cancer 1998, 77:543-548. First published report evaluating specific sexual practices associated with KSHV infection. Receptive anal intercourse was associated with seroprevalent, but not seroincident, KSHV infection.
35. 35 Jacobson LP, jenkins F, Springer G, Munoz A, Shah K, Armenian H: Behaviors associated with HHV-8 infection: Results from the Multicenter AIDS Cohort Study (MACS). First Annual Meeting on Kaposi's sarcoma-associated Herpesvirus (KSHV) and Related Agents. Santa Cruz, California, 1998.
36. 36 Blackbourn DJ, Osmond D, Levy JA, Lennette ET: Increased human herpesvirus 8 seroprevalence in young homosexual men who have multiple sex contacts with different sex partners. J Infect Dis 1999.
37. 37 Pauk J, Krone M, Chandran B, Koelle D, Wald A, Corey L, Celum C: Risk factors for human herpesvirus-8 seroprevalence in a cohort of HIV seronegative MSM. 6th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, 1999.
38. 38 Goudsmit J, Renwick N, Dukers NHTM, Coutinho RA, Heisterkamp S, Schultz T, et al.: Recent epidemic of primary HHV8 infections among homosexual men: evidence of oral-genital transmission. 6th Conference on Retroviruses and Opportunistic Infections. Chicago, Illinois, 1999.
39. 39 Sitas F, Carrara H, Beral V, Newton R, Patel M, Ruff P, et al.: Association between HHV8, HIV, cancer and selected risk factors in South Africa. Second National AIDS Malignancy Conference. Bethesda, Maryland, 1998.
40. 40 Jacobson LP, Munoz A, Fox R, Phair JP, Dudley J, Obrams GI, et al.: Incidence of Kaposi's sarcoma in a cohort of homosexual men infected with the human immunodeficiency virus type 1. The Multicenter AIDS Cohort Study Group. J Acquir Immune Defic Syndr 1990, 3(suppl1):S24-S31.
41. 41 Grulich AE, Kaldor JM, Hendry O, Luo K, Bodworh NJ, Cooper DA: Risk of Kaposi's sarcoma and oroanal sexual contact. Am J Epidemiol 1997, 145:673-679.
42. 42 Archibald CP, Scheeler MT, Craib KJ, Le TN, Douglas B, Willoughby B, O'Shaughnessy M: Risk factors for Kaposi's sarcoma in the Vancouver Lymphadenopathy-AIDS Study. J Acquir Immune Defic Syndr 1990, 3(suppl1):S18-S23.
43. 43 Lifson AR, Darrow WW, Hessol NA, PM OM, Barnhart JL, Jaffe HW, Rutherford GW: Kaposi's sarcoma in a cohort of homosexual and bisexual men. Epidemiology and analysis for cofactors. Am J Epidemiol 1990, 131:221-231.
44. 44 Page-Bodkin K, Tappero J, Samuel M, Winkelstein W: Kaposi's sarcoma and faecal-oral exposure [letter]. Lancet 1992, 339:1490.
45. 45 Elford J, Tindall B, Sharkey T: Kaposi's sarcoma and insertive rimming [letter]. Lancet 1992, 339:938.
46. 46 Martin JN, Osmond DH, Ganem DE, Lam PK, Page-Shafer K, MacRae D, Kedes DH: A population-based study of specific sexual practice risk factors for acquisition of human herpesvirus 8 infection, 12th World AIDS Conference. Geneva, Switzerland, 1998.
47. 47 Grulich A, Olsen S, Hendry O, Luo K, Cooper D, Zheng W, et al.: Route of transmission of Kaposi's sarcoma-associated herpesvirus. First national AIDS Malignancy Conference. Bethesda, Maryland, 1997.
48. 48 Rabkin CS, Schulz TF, Whitby D, Lennette ET, Magpantay LI, Chatlynne L, Biggar RJ: Interassay correlation of human herpesvirus 8 serologic tests. HHV-8 Interlaboratory Collaborative Group. J Infect Dis 1998, 178:304-309. Sentinel interassay comparison that documents the suboptimal correlation among current serologic tests, especially in non-KS patients. Excellent discussion that emphasizes the usefulness of current assays for comparative epidemiologic work but their lack of utility in accurately estimating absolute seroprevalence in any one group or individual.
49. 49 LaDuca JR, Love JL, Abbott LZ, Dube S, Freidman-Kien AE, Poiesz BJ: Detection of human herpesvirus 8 DNA sequences in tissues and bodily fluids. J Infect Dis 1998, 178:1610-1615.
50. 50 Lin JC, Lin SC, Mar EC, Pellett PE, Stamey FR, Stewart JA, Spira TJ: Is Kaposi's sarcoma-associated herpesvirus detectable in semen of HIV-infected homosexual men? Lancet 1995, 346:1601-1602.
51. 51 Monini O, de Lellis L, Fabris M, Rigolin F, Cassai E: Kaposi's sarcoma-associated herpesvirus DNA sequences in prostate tissue and human semen. N Engl J Med 1996, 334:1168-1172.
52. 52 Lin JC, Lin SC, Mar EC, Pellett PE, Stamey FR, Stewart JA, Spira TJ: Retraction: Is Kaposi's sarcoma-associated herpesvirus in semen of HIV-infected homosexual men?[retraction of Lin JC, Lin SC, Mar EC, Pellett PE, Stamey FR, Stewart JA, Spira TJ. In: Lancet 1995 Dec 16;346(8990):1601-1602]. Lancet 1998, 351:1365. This retraction of a previously high estimate of KSHV prevalence in seminal fluid,along with work from Seattle, forms the basis of the emerging consensus that KSHV can be present in semen, but such an occurrence is uncommon.
53. 53 Gupta P, Singh MK, Rinaldo C, Ding M, Farzadegan H, Saah A, et al.: Detection of Kaposi's sarcoma herpesvirus DNA in semen of homosexual men with Kaposi's sarcoma [letter]. AIDS 1996, 10:1596-1598.
54. 54 Diamond C, Huang ML, Kedes DH, Speck C, Rankin GW Jr., Ganem D, et al.: Absence of detectable human herpesvirus 8 in the semen of human immunodeficiency virus-infected men without Kaposi's sarcoma. J Infect Dis 1997, 176:775-777.
55. 55 Howard MR, Whitby D, Bahadur G, Suggett F, Boshoff C, Tenant-Flowers M, et al.: Detection of human herpesvirus 8 DNA in semen from HIV-infected individuals but not healthy semen donors. AIDS 1997, 11:F15-F19.
56. 56 Huang YQ, Li JJ, Poiesz BJ, Kaplan MH, Friendman-Kien AE: Detection of the herpesvirus-like DNA sequences in matched specimens of semen and blood from patients with AIDS-related Kaposi's sarcoma by polymerase chain reaction in situ hybridization. Am J Pathol 1997, 150:147-153.
57. 57 Koelle DM, Huang ML, Chandran B, Vieira J, Piepkorn M, Corey L: Frequent detection of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in saliva of human immunodeficiency virus-infected men: clinical and Immunologic correlates. J Infect Dis 1997, 176:94-102.
58. 58 Viviano E, Vitale F, Ajello F, Perna AM, Villafrate MR, Bonura F, et al.: Human herpesvirus type 8 DNA sequences in biological samples of HIV-positive and negative individuals in Sicily. AIDS 1997, 11:607-612.
59. 59 Vieira J, Huang ML, Koelle DM, Corey L: Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma. J Virol 1997, 71:7083-7087.
60. 60 Boldogh I, Szaniszlo P, Bresnahan WA, Flaitz CM, Nichols MC, Albrecht T: Kaposi's sarcoma herpesvirus-like DNA sequences in the saliva of individuals infected with human immunodeficiency virus. Clin Infect Dis 1996, 23:406-407.
61. 61 Thomas JA, Brookes LA, McGowan I, Weller I, Crawford DH: HHV8 DNA in normal gastrointestinal mucosa from HIV seropositive people [letter]. Lancet 1996, 347:1337-1338.
62. 62 Regamey M, Tamm M, Wernli M, Witschi A, Theil G, Cathomas G, Erb P: Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. N Engl J Med, 339:1358-1363. Careful study documenting KSHV transmission through renal allografts-not only documents seroconversion after renal transplant, but excludes possible transmission via blood products in some cases and finds that seroconverters are more likely to have seropositive donors than are nonseroconverters.
63. 63 Blackbourn DJ, Ambroziak J, Lennette E, Adams M, Ramachandran B, Levy JA: Infectious human herpesvirus 8 in a healthy North American blod donor. Lancet 1997, 349:609-611.
64. 64 Marcelin AG, Apetrei C, Dupin N, Bossi P, Descamps D, Simon F, Calvez V: Parenteral transmission of Kaposi's sarcoma-associated herpesvirus [letter]. AIDS 1998, 12:2351.
65. 65 Bourboulia D, Whitby D, Boshoff C, Newton R, Beral V, Carrara H, et al.: Serologic evidence for mother-to-child transmission of Kaposi sarcoma-associated herpesvirus infection [letter]. JAMA 1998, 280:31-32.
66. 66 Angeloni A, Heston L, Uccini S, Sirianni MC, Cottoni F, Masala MV, et al.: High prevalence of antibodies to human herpesvirus 8 in relatives of patients with classic Kaposi's sarcoma from Sardinia. J Infect Dis 1998, 177:1715-1718. Elegant study from Sardinia that documents a role for nonsexual horizontal and/or vertical transmission in KSHV endemic areas. Family members of KS patients were more likely to be KSHV seropositive than nonfamily member controls.
67. 67 Mayama S, Cuevas LE, Sheldon J, Omar OH, Smith DH, Okong P, et al.: Prevalence and transmission of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in Ugandan children and adolescents. Int J Cancer 1998, 77:817-820. Demonstrated nonsexual horizontal transmission in Africa by showing an age-dependent increase in KSHV seropositivity prior to puberty.
68. 68 Andreoni M, El-Sawaf G, Rezza G, Ensoli B, Nicastri E, Ventura L, et al.: High seroprevalence of antibodies to human herpesvirus-8 in Egyptian children: evidence on nonsexual transmission. J Natl Cancer Inst 199, 91:465-469.