Intercellular signaling during fruiting-body development of Myxococcus xanthus

Annual Review of Microbiology

Volumn 53, Issue , 1999, Pages 525-549

  Shimkets, Lawrence J ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Cell cell signaling; Fruiting body; Myxobacterium

Indexed keywords

ADAPTATION; BACTERIAL GROWTH; BACTERIUM MUTANT; CELL INTERACTION; CELL MOTILITY; GENETIC COMPLEMENTATION; LIFE CYCLE; MYXOCOCCALES; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SPOROGENESIS; STARVATION;

GENE EXPRESSION REGULATION, BACTERIAL; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; MOVEMENT; MYXOCOCCUS XANTHUS; SIGNAL TRANSDUCTION;

EID: 0032717993     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.micro.53.1.525     Document Type: Review

References (141)

1. Arnold JW, Shimkets LJ. 1988. Cell surface properties correlated with cohesion in Myxococcus xanthus. J. Bacteriol. 170:5771-77
2. Arnold JW, Shimkets LJ. 1988. Inhibition of cell-cell interactions in Myxococcus xanthus by Congo red. J. Bacteriol. 170:5765-70
3. Baker M. 1994. Myxococcus xanthus C-factor, a morphogenetic paracrin signal, is similar to Escherichia coli 3-oxoacyl-[acyl-carrier-protein] reductase and human 17β-hydroxysteroid dehydrogenase. Biochem. J. 301:311-12
4. Beale G. 1990, Self and nonself recognition in the ciliate protozoan Euplotes. Trends Genet. 6:137-139
5. Behmlander RM, Dworkin M. 1991. Extra-cellular fibrils and contact-mediated cell interactions in Myxococcus xanthus. J. Bacteriol. 173:7810-21
6. Behmlander RM, Dworkin M. 1994. Biochemical and structural analyses of the extracellular matrix fibrils of Myxococcus xanthus. J. Bacterial. 176:6295-303
7. Behmlander RM, Dworkin M. 1994. Integral proteins of the extracellular matrix fibrils of Myxococcus xanthus. J. Bacteriol. 176:6304-11
8. Bowden MG, Kaplan HB. 1998. The Myxococcus xanthus lipopolysaccharide O-antigen is required for social motility and multicellular development. Mol. Microbiol. 30:275-284
9. Bradley DE. 1980. A function of Pseudomonas aeruginosa PAO polar pili: twitching motility. Can. J. Microbiol. 26:146-54.
10. Brockman ER, Todd RL. 1974, Fruiting myxobacters as viewed with a scanning electron microscope. Int. J. Sys. Bacteriol. 24:118-24
11. Cashel M, Gentry DR, Hernandez VJ, Vinella D. 1996. The stringent response. In Escherichia coli and Salmonella: Cellular and Molecular Biology, ed. FC Neidhardt et al. Washington, DC: Am. Soc. Microbiol. pp. 1458-96
12. Chadwick-Furman N, Rinkevich B. 1994. A complex allorecognition system in a reef-building coral: delayed responses, reversals and nontransitive hierarchies. Coral Reefs 13:57-63
13. Chang B-Y, Dworkin M. 1994. Isolated fibrils rescue cohesion and development in the dsp mutant of Myxococcus xanthus. J. Bacterial. 176:7190-96
14. Cheng Y, Kaiser D. 1989. dsg, a gene required for cell-cell interaction early in Myxococcus development. J. Bacteriol. 171:3719-26
15. Cheng Y, Kalman LV, Kaiser D. 1994. The dsg gene of Myxococcus xanthus encodes a protein similar to translation initiation factor IF3. J. Bacteriol. 176:1427-33
16. Dana JR, Shimkets LJ. 1993. Regulation of cohesion-dependent cell interactions in Myxococcus xanthus. J. Bacteriol. 175:3636-47
17. Davis JM, Mayor J, Plamann L. 1995. A missense mutation in rpoD results in an A-signalling defect in Myxococcus xanthus. Mol. Microbiol. 18:943-52
18. Dessen A, Quemard A, Blanchard JS, Jacobs WR Jr., Sacchettini JC. 1995. Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. Science 267:1638-41
19. Downard J, Ramaswamy SV, Kil K-S. 1993. Identification of esg, a genetic locus involved in cell-cell signaling during Myxococcus xanthus development. J. Bacteriol. 175:7762-70
20. Downard J, Toal D. 1995. Branched chain fatty acids: the case for a novel form of cell-cell signaling during Myxococcus xanthus development. Mol. Microbiol. 16:171-75
21. Dworkin M. 1962. Nutritional requirements for vegetative growth of Myxococcus xanthus. J. Bacteriol. 84:250-57
22. Dworkin M. 1963. Nutritional regulation of morphogenesis in Myxococcus xanthus. J. Bacteriol. 86:67-72
23. Dworkin M. 1996. Recent advances in the social and developmental biology of the myxobacteria. Microbiol. Rev. 60:70-102
24. Dworkin M, Kaiser D, eds. 1993. Myxobacteria II. Washington DC: Am. Soc. Microbiol.
25. Ellehauge E, Nørregaard-Madsen M, Søgaard-Andersen L. 1998. The FruA signal transduction protein provides a check-point for the temporal co-ordination of intercellular signals in Myxococc. xanthus development. Mol. Microbiol. 30:807-817
26. Erwin D, Valentine J, Jablonski D. 1997. The origin of animal body plans. Am. Sci. 85:126-37.
27. Fink JM, Zissler JF. 1989. Characterization of lipopolysaccharide from Myxococcus xanthus by use of monoclonal antibodies. J. Bacteriol. 171:2028-32
28. Fraser TH, Julius DJ, Rich A. 1979. Determination of aminoacylation isomeric specificity using tRNA terminating in 3′-amino-3′-deoxyadenosine and 2′-amino-2′-deoxyadenosine. Methods Enzymol. LIX:272-82.
29. Gaal T, Bartlett MS, Ross W, Turnbough CL Jr, Gourse RL. 1997. Transcription regulation by initiating NTP concentration: rRNA synthesis in bacteria. Science 278:2092-97
30. Geng Y, Yang Z, Downard J, Zusman D, Shi W. 1998. Methylation of FrzCD defines a discrete step in the developmental program of Myxococcus xanthus. J. Bacteriol. 180:5765-68
31. Ghosh D, Pletnev VZ, Zhu DW, Wawrkak Z, Pangborn WL, et al. 1995. Structure of human estrogenic 17β-hydroxysteroid dehydrogenase at 2.20 A resolution. Structure 3:503-13
32. Ghosh D, Wawrzak Z, Weeks CM, Duax WL, Erman M. 1994. The refined three-dimensional structure of 3α, 20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short chain dehydrogenases. Structure 2:629-40
33. Ghosh D, Weeks CM, Grochulski P, Duax WL, Erman M, et al. 1991. Three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase: a member of the short-chain dehydrogenase family. Proc. Natl. Acad. Sci. USA 88:10064-68
34. Gill RE, Bornemann MC. 1988. Identification and characterization of the Myxococcus xanthus bsgA gene product. J. Bacteriol. 170:5289-97
35. Gill RE, Karlok M, Benton D. 1993. Myxococcus xanthus encodes an ATP-dependent protease which is required for developmental gene transcription trod intercellular signaling. J. Bacteriol. 175:4538-44
36. Guo D, Bowden MG, Pershad R, Kaplan HB. 1996. The Myxococcus xanthus rfbABC operon encodes an ATP-binding cassette transporter homolog required for O-antigen biosynthesis and multicellular development. J. Bacteriol. 178:1631-39
37. Hagen DC, Bretscher AP, Kaiser D. 1978. Synergism between morphogenetic mutants of Myxococcus xanthus. Dev. Biol. 64:284-96
38. Hagen TJ, Shimkets LJ. 1990. Nucleotide sequence and transcriptional products of the csg locus of Myxococcus xanthus. J. Bacteriol. 172:15-23
39. Harris BZ, Kaiser D, Singer M. 1998. The guanosine nucleotide (p)ppGpp initiates development and A-factor production in Myxococcus xanthus. Genes Dev. 12:1022-35
40. Hartzell PL. 1997. Complementation of sporulation and motility defects in a prokaryote by a eukaryotic GTPase. Proc. Natl. Acad. Sci. USA 94:9881-86
41. Hartzell P, Kaiser D. 1991. Function of MglA, a 22-kilodalton protein essential for gliding in Myxococcus xanthus. J. Bacteriol. 173:7615-24
42. Hartzell PL, Youderian P. 1995. Genetics of gliding motility and development in Myxococcus xanthus. Arch. Microbiol. 164:309-23
43. 70 mediate; ppGpp-dependent function in vivo. J. Mol. Biol. 252:536-49.
44. Hildebrandt K, Eastman D, Dworkin M. 1997. ADP-ribosylation by the extracellular fibrils of Myxococcus xanthus. Mol. Microbiol. 23:231-35
45. Hodgkin J, Kaiser D. 1977. Cell-to-cell stimulation of movement in nonmotile mutants of Myxococcus. Proc. Natl. Acad. Sci. USA 74:2938-42
46. Hodgkin J, Kaiser D. 1979. Genetics of gliding motility in Myxococcus xanthus (Myxobacterales): genes controlling movement of single cells. Mol. Gen. Genet. 171:167-76
47. Hodgkin J, Kaiser D. 1979. Genetics of gliding motility in Myxococcus xanthus (Myxobacterales): two gene systems control movement. Mol. Gen. Genet. 171:177-91
48. Jelsbak L, Søgaard-Andersen L. 1999. The cell surface-associated intercellular C-signal induces behavioral changes in individual Myxococcus xanthus cells during fruiting body morphogenesis, Proc. Natl. Acad. Sci. USA 96:5031-503
49. Kaiser D. 1979. Social gliding is correlated with the presence of pili in Myxococcus xanthus. Proc. Natl. Acad. Sci. USA 76:5952-56
50. Kaiser D. 1993. Roland Thaxter's legacy and the origins of multicellular development. Genetics 135:249-54
51. Kaiser D. 1996. Bacteria also vote. Science 272:1598-99
52. Kalman LV, Cheng YL, Kaiser D. 1994. The Myxococcus xanthus dsg gene product performs functions of translation initiation factor IF3 in vivo. J. Bacteriol. 176:1434-42
53. Kaplan H, Kuspa A, Kaiser D. 1991. Suppressors that permit A-signal-independent developmental gene expression in Myxococcus xanthus. J. Bacteriol. 173:1460-70
54. Kaplan HB, Plamann L. 1996. A Myxococcus xanthus cell density-sensing system required for multicellular development. FEMS Microbiol. Lett. 139:89-95
55. Kearns DB, Shimkets LJ. 1998. Chemotaxis in a gliding bacterium. Proc. Natl. Acad. Sci. USA 95:11957-11962.
56. Kim S, Kaiser D. 1991. C-Factor has distinct aggregation and sporulation thresholds during Myxococcus development. J. Bacteriol. 173:1722-28
57. Kim SK, Kaiser D. 1990. C-factor: a cell-cell signaling protein required for fruiting body morphogenesis of M. xanthus. Cell 61:19-26
58. Kim SK, Kaiser D. 1990. Cell alignment required in differentiation of M. xanthus. Science 249:926-28
59. Kim SK, Kaiser D. 1990. Cell motility is required for the transmission of C-factor, an intercellular signal that coordinates fruiting body morphogenesis of Myxococcus xanthus. Genes Dev. 4:896-905
60. Kim SK, Kaiser D. 1990. Purification and properties of Myxococcus xanthus C-factor, an intercellular signalling protein. Proc. Natl. Acad. Sci. USA 87:3635-39
61. Kroos L, Kaiser D. 1984, Construction of Tn5 lac, a transposon that fuses lacZ expression to exogenous promoters, and its introduction into Myxococcus xanthus. Proc. Natl. Acad. Sci. USA 81:5816-20
62. Kroos L, Kaiser D. 1987. Expression of many developmentally regulated genes in Myxococcus depends on a sequence of cell interactions. Genes Dev. 1:840-54
63. Kuspa A, Kroos L, Kaiser D. 1986. Intercellular signaling is required for developmental gene expression in Myxococcus xanthus. Dev. Biol. 117:267-76
64. Kuspa A, Plamann L, Kaiser D. 1992a. Identification of heat-stable A-factor from Myxococcus xanthus. J. Bacteriol. 174:3319-26
65. Kuspa A, Plamann L, Kaiser D. 1992b. A-Signalling and the cell density requirement for Myxococcus xanthus development. J. Bacteriol. 174:7360-69
66. LaRossa R, Kuner J, Hagan D, Manoil C, Kaiser D. 1983. Developmental cell interactions of Myxococcus xanthus: Analysis of mutants. J. Bacteriol. 153:1394-1404
67. Lauc BE, Gill RE, 1995. Using a phase-locked mutant of Myxococcus xanthus to study the role of phase variation in development. J. Bacteriol. 177:4089-96
68. +-containing protein. Genes Der 9:2964-73
69. Lee K, Shimkets LJ. 1994. Cloning and characterization of the socA locus which restores development to Myxococcus xanthus C-signaling mutants. J. Bacteriol. 176:2200-9
70. Lee K, Shimkets LJ. 1996. Suppression of a signaling defect during Myxococcus xanthus development. J. Bacteriol. 178:977-84
71. Li S, Lee B, Shimkets LJ. 1992. csgA expression entrains Myxococcus xanthus development. Genes Dev. 6:401-10
72. Li SF, Shimkets LJ. 1993. Effect of dsp mutations on the cell-to-cell transmission of CsgA in Myxococcus xanthus. J. Bacteriol. 175:3648-52
73. Li Y, Plamann L. 1996, Purification and in vitro phosphorylation of Myxococcus xanthus AsgA protein. J. Bacteriol. 178:289-92
74. Manoil C, Kaiser D. 1980. Accumulation of guanosine tetraphosphate and guanosine pentaphosphate in Myxococcus xanthus during starvation and myxospore formation. J. Bacteriol. 141:297-304
75. Manoil C, Kaiser D. 1980. Guanosine pentaphosphate and guanosine tetraphosphate accumulation and induction of Myxococcus xanthus fruiting body development. J. Bacteriol. 141:305-15
76. McBride MJ, Kohler T, Zusman DR. 1992. Methylation of FrzCD, a methyl-accepting taxis protein of Myxococcus xanthus, is correlated with factors affecting cell behavior. J. Bacterial. 174:4246-57
77. McBride MJ, Weinberg RA, Zusman DR. 1989. "Frizzy" aggregation genes of the gliding bacterium Myxococcus xanthus show sequence similarities to the chemotaxis genes of enteric bacteria. Proc. Natl. Acad. Sci. USA 86:424-28
78. McBride MJ, Zusman DR. 1993. FrzCD, a methyl-accepting taxis protein from Myxococcus xanthus, shows modulated methylation during fruiting body formation. J. Bacteriol. 175:4936-40
79. McCleary W, McBride M, Zusman D. 1990. Developmental sensory transduction in M. xanthus involves methylation and demethylation of FrzCD. J. Bacteriol. 172:4877-87
80. McCleary W, Zusman D. 1990. FrzE of M. xanthus is homologous to both CheA and CheY of Salmonella typhimurium. Proc. Natl. Acad. Sci. USA 87:5898-902
81. McCleary W, Zusman D. 1990. Purification and characterization of the M. xanthus FrzE protein shows that it has autophosphorylation activity. J. Bacteriol. 172:6661-68
82. McClure BA, Haring V, Ebert PR, Anderson MA, Simpson RJ, et al. 1989. Style self-incompatibility gene products of Nicotina alata are ribonucleases. Nature 342:955-57
83. McVittie A, Messik F, Zahler SA. 1962. Developmental biology of Myxococcus. J. Bacteriol. 84:546-1
84. Neidle E, Hartnett C, Ornston LN, Bairoch A, Rekik M, Harayama S. 1992. Cisdiol dehydrogenases encoded by the TOL pWWO plasmid xylL gene and the Acinetobacter calcoaceticus chromosomal bend gene are members of the short-chain alcohol dehydrogenase superfamily. Eur. J. Biochem. 204:113-20
85. O'Connor K, Zusman D. 1991. Analysis of Myxococcus xanthus cell types by two-dimensional polyacrylamide gel electrophoresis. J. Bacteriol. 173:3334-41
86. O'Connor K, Zusman D. 1991. Behavior of peripheral rods and their role in the life cycle of Myxococcus xanthus. J. Bacteriol. 173:3342-55
87. O'Connor K, Zusman D. 1991. Development in Myxococcus xanthus involves differentiation into two cell types, peripheral rods and spores. J. Bacteriol. 173:3318-33
88. O'Connor KA, Zusman DR. 1988. Reexamination of the role of autolysis in the development of Myxococcus xanthus. J. Bacteriol. 170:4103-12
89. Ogawa M, Fujitani S, Mao X, Inouye S, Komano T. 1996. FruA, a putative transcription factor essential for the development of Myxococcus xanthus. Mol. Microbiol. 22:757-67
90. Panasenko SM. 1983. Protein and lipid methylation by methionine and S-adenosylmethionine in Myxococcus xanthus. Can. J. Microbiol. 29:1224-28
91. Panasenko SM, Jann B, Jann K. 1989. Novel change in the carbohydrate portion of Myxococcus xanthus lipopolysaccharide during development. J. Bacteriol. 171:1835-40
92. Persson B, Krook M, Jornvall H. 1991. Characteristics of short-chain alcohol dehydrogenases and related enzymes. Eur. J. Biochem. 200:537-43
93. Plamann L, Davis JM, Cantwell B, Mayor J. 1994. Evidence that asgB encodes a DNA-binding protein essential for growth and development of Myxococcus xanthus. J. Bacteriol. 176:2013-20
94. Plamann L, Kaplan HB. 1999. Cell-density signaling during early development in Myxococcus xanthus. In Cell-cell signaling in bacteria, eds, GM Dunny, SC Winans. Washington DC: American Society for Microbiology Press pp 67-82
95. Plamann L, Kuspa A, Kaiser D. 1992. Proteins that rescue A-signal-defective mutants of Myxococcus xanthus. J. Bacteriol. 174:3311-18
96. Plamann L, Li Y, Cantwell B, Mayor J. 1995. The Myxococcus xanthus asgA gene encodes a novel signal transduction protein required for multicellular development. J. Bacteriol. 177:2014-20
97. Rafferty JB, Simon JW, Baldock C, Artymiuk PJ, Stuitje AR, et al. 1995. Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl acyl carrier protein reductase. Structure 3:927-38
98. Reichenbach H, Dworkin M. 1992. The Myxobacteria. In The Prokaryotes, eds. HGTA Balows, M Dworkin, W Harder, K-H Schleifer. A Handbook on the Biology of Bacteria: Ecophysiology, Isolation, Identification, Applications. New York: Springer-Verlag. pp. 3416-87
99. Rhie HG, Shimkets LJ. 1989. Developmental bypass supression of Myxococcus xanthus csgA mutations. J. Bacteriol. 171:3268-76
100. Rhie H, Shimkets L. 1991. Low-temperature induction of M. xanthus developmental gene expression in wild-type and csgA suppressor cells. J. Bacteriol. 173:2206-11
101. Rodriguez-Soto JP, Kaiser D. 1997. Identification and localization of the Tgl protein, which is required for Myxococcus xanthus social motility. J. Bacteriol. 179:4372-81
102. Rodriguez-Soto JP, Kaiser D. 1997. The tgl gene: social motility and stimulation in Myxococcus xanthus. J. Bacteriol. 179:4361-71
103. Sager B, Kaiser D. 1994. Intercellular C-signaling and the traveling waves of Myxococcus. Genes Dev. 8:2793-804
104. Shi W, Kohler T, Zusman DR. 1993. Chemotaxis plays a role in the social behavior of Myxococcus xanthus. Mol. Microbiol. 9:601-11
105. Shi W, Kohler T, Zusman DR. 1994. Isolation and characterization of Myxococcus xanthus mutants which are defective in sensing negative stimuli. J. Bacteriol. 176:696-701
106. Shi W, Zusman DR. 1994. Sensory adaptation during negative chemotaxis in Myxococcus xanthus. J. Bacteriol. 176:1517-20
107. Shimkets L, Seale TW. 1975. Fruiting-body formation and myxospore differentiation and germination in Myxococcus xanthus viewed by scanning electron microscopy. J. Bacteriol. 121:711-20
108. Shimkets LJ. 1986. Correlation of energy-dependent cell cohesion with social motility in Myxococcus xanthus. J. Bacteriol. 166:837-41
109. Shimkets LJ. 1986. Role of cell cohesion in Myxococcus xanthus fruiting body formation. J. Bacteriol. 166:842-48
110. Shimkets LJ. 1993. The myxobacterial genome. In Myxobacteria II, ed. M Dworkin, D Kaiser. Washington DC: Am. Soc. Microbiol. pp. 85-107
111. Shimkets LJ. 1996. Myxococcus coadhesion and role in the life cycle. In Bacterial Adhesion: Molecular and Ecological Diversity, ed. M Fletcher. New York: Wiley-Liss, pp. 333-47
112. Shimkets LJ. 1997a. Myxococcus xanthus DK1622. In Bacterial Genomes: Physical Structure and Analysis, ed. FJ de Bruijn, JR Lupski, GM Weinstock. New York: Chapman & Hall. pp. 695-701.
113. Shimkets, LJ. 1997b. Structure and sizes of genomes of the Archaca and Bacteria. See Shimkets 1997a, pp. 5-11
114. Shimkets LJ, Dworkin M. 1997. Myxobacterial multicellularity. In Bacteria as Multicellular Organisms, eds. JA Shapiro, M Dworkin. New York: Oxford Univ. Press. pp. 220-44
115. Shimkets LJ, Kaiser D. 1982. Murein components rescue developmental sporulation of Myxococcus xanthus. J. Bacteriol. 152:462-70
116. Shimkets LJ, Kaiser D. 1999. Cell contact-dependent C-signaling in Myxococcus xanthus. In cell-cell signaling in bacteria, eds. GM Dunny, SC Winans, Washington DC: American Society for Microbiology Press. pp 83-97
117. Shimkets LJ, Rafiee H. 1990. CsgA, an extracellular protein essential for Myxococcus xanthus development. J. Bacteriol. 172:5299-306
118. Singer M, Kaiser D. 1995. Ectopic production of guanosine penta- and tetraphosphate can initiate early developmental gene expression in Myxococcus xanthus. Genes Dev. 9:1633-44
119. Smith D, Dworkin M. 1994. Territorial interactions between two Myxococcus species. J. Bacteriol. 176:1201-5
120. Smith D, Dworkin M. 1997. A mutation that affects fibril protein, development, cohesion and gene expression in Myxococcus xanthus. Microbiology 143:3683-92
121. Sogaard-Anderson L, Kaiser D. 1996, C-factor, a cell-surface-associated intercellular signaling protein, stimulates the cytoplasmic Frz signal transduction system in Myxococcus xanthus. Proc. Natl. Acad. Sci. USA 93:2625-79
122. Sogaard-Anderson L, Slack FJ, Kimsey H, Kaiser D. 1996. Intercellular C-signaling in Myxococcus xanthus involves a branched signal transduction pathway. Genes Dev. 10:740-54
123. Spudich JL. 1994. Protein-protein interaction converts a proton pump into a sensory receptor. 1994. Cell 79:747-50
124. Su Y, Varughese KI, Xuong NH, Bray TL, Roche DJ, Whiteley JM. 1993. The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from it rat homologue. J. Biol. Chem. 268:26836-41
125. Tanaka N, Nanaka T, Nakanishi M, Deyashiki Y, Hara A, Mitsui Y. 1996. Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain alcohol dehydrogenase/reductase family. Structure 4:33-45
126. Toal DR, Clifton SW, Roe BR, Downard J. 1995. The esg locus of Myxococcus xanthus encodes the E1α and E1β sub-units of a branched-chain keto acid dehydrogenase. Mol. Microbiol. 16:177-89
127. Varughese KI, Skinner MM, Whiteley JM, Matthews DA, Xuong NH. 1992. Crystal structure of rat liver dihydropteridine reductase. Proc. Natl. Acad. Sci USA 89:6080-84
128. 3-Lys-containing family of reductases and dehydrogenases. Proc. Natl. Acad. Sci. USA 91:5582-86
129. Wall D, Kaiser D. 1998. Alignment enhances the cell-to-cell transfer of pilus phenotype. Proc. Nat. Acad. Sci. USA 95:3054-58
130. Wall D, Wu SS, Kaiser D. 1998. Contact stimulation of Tgl and type IV pill in Myxococcus xanthus. J. Bacteriol. 180:759-61
131. Ward MJ, Mok KC, Zusman DR. 1998. Myxococcus xanthus displays Frz-dependent chemokinetic behavior during vegetative swarming. J. Bacteriol. 180:440-43
132. Ward MJ, Zusman DR. 1997. Regulation of directed motility in Myxococcus xanthus. Mol. Microbiol. 24:885-93
133. Whitchurch CB, Hobbs M, Livingston SP, Krishnapillai V, Mattick JS. 1991. Characterization of a Pseudomonas aeruginosa twitching motility gene and evidence for a specialised protein export system widespread in eubacteria. Gene 101:33-44
134. Wireman JW, Dworkin M. 1977. Developmentally induced autolysis during fruiting body formation by Myxococcus xanthus. J. Bacteriol. 129:796-802
135. Wu S, Kaiser D. 1996. Markerless deletions of pil genes in Myxococcus xanthus generated by counterselection with the Bacillus subtilis sacB gene. J. Bacteriol. 178:5817-21
136. Wu SS, Kaiser D. 1995. Genetic and functional evidence that Type IV pili are required for social gliding motility in Myxococcus xanthus. 18:547-58
137. Wu SS, Kaiser D. 1997. Regulation of expression of the pilA gene of Myxococcus xanthus. J. Bacteriol. 179:7748-58
138. Wu SS, Wu J, Kaiser D. 1997. The Myxococcus xanthus pilT locus is required for social gliding motility although pili are still produced. Mol. Microbiol. 23:109-21
139. Yang C, Kaplan HB. 1997. Myxococcus xanthus sasS encodes a sensor histidine kinase required for early developmental gene expression. J. Bacteriol. 179:7759-67
140. Yang Z, Geng Y, Xu D, Kaplan HB, Shi W. 1998. A new set of chemotaxis homologs is essential for Myxococcus xanthus social motility. Mol. Microbiol. In press 30:1123-1130
141. Youderian P. 1998. Bacterial motility: secretory secrets of gliding bacteria. Curr. Biol. 8:R408-R411