A new single-injury model of balloon angioplasty in cholesterol-fed rabbits: Beneficial effect of hirudin and comparison with double-injury model

Laboratory Investigation

Volumn 77, Issue 1, 1997, Pages 109-116

  Barry, William L ^a   Wiegman, Peter J ^a   Gimple, Lawrence W ^a   Gertz, S David ^b   Powers, Eric R ^a   Owens, Gary K ^a   Sarembock, Ian J ^a,c  

^a UNIVERSITY OF VIRGINIA   (United States)

^b HEBREW UNIVERSITY   (Israel)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; HIRUDIN; THROMBIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; MALE; MORPHOMETRICS; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RABBIT; RESTENOSIS;

ANGIOPLASTY, BALLOON; ANIMALS; CELL DIVISION; CHOLESTEROL, DIETARY; CORONARY DISEASE; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FIBRINOLYTIC AGENTS; HIRUDINS; MALE; MODELS, BIOLOGICAL; RABBITS;

EID: 0030791910     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Gertz SD, Gimple LW, Ragosta M, Roberts WC, Haber HL, Powers ER, Perez LS, and Sarembock IJ (1993). Response of femoral arteries of cholesterol-fed rabbits to balloon angioplasty with or without laser: Emphasis on the distribution of foam cells. Exp Mol Pathol 59:225-243.
2. Jorgenson L, Grothe AG, Groves HM, Kinlough-Rathbone RL, Richardson M, and Mustard JF (1988a). Distribution of cellular responses in rabbit aortae following one and two injuries with a balloon catheter. Br J Exp Pathol 69:351-365.
3. Jorgenson L, Grothe AG, Groves HM, Kinlough-Rathbone RL, Richardson M, and Mustard JF (1988b). Sequence of cellular responses in rabbit aortas following one and two injuries with a balloon catheter. Br J Exp Pathol 69:473-486.
4. Kakuta T, Currier JW, Haudenschild CC, Ryan TJ, and Faxon DP (1994). Differences in compensating vessel enlargement, not intimal formation, account for restenosis after angioplasty in the hypercholesterolemic rabbit model. Circulation 89: 2809-2815.
5. Lefer AM and Ma XL (1993). Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium. Arterioscler Thromb 13:771-776.
6. Leveen RF, Wolf GL, and Villanueva TG (1982). New rabbit atherosclerosis model for the investigation of transluminal angioplasty. Invest Radiol 17:470-475.
7. Levine GN, Kearney JFJ, and Vita JA (1995). Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. N Engl J Med 332:512-521.
8. Movat H (1955). Demonstration of all connective tissue elements in a single section. Arch Pathol Lab Med 60:289-295.
9. Muller DW, Gordon D, Topol EJ, Levy RJ, and Golomb G (1996). Sustained-release local hirulog therapy decreases early thrombosis but not neointimal thickening after arterial stenting. Am Heart J 131:211-218.
10. Panteghini M and Pagani F (1993). Pre-analytical, analytical and biological sources of variation of lipoprotein(a). Eur J Clin Chem Clin Biochem 31:23-28.
11. Post MJ, Borst C, and Kuntz RE (1994). The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty: A study in the normal rabbit and the hypercholesterolemic Yucatan minipig. Circulation 89:2816-2821.
12. Ragosta M, Barry WL, Gimple LW, Gertz SD, McCoy KW, Stouffer GA, McNamara CA, Powers ER, Owens GK, and Sarembock IJ (1996). Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits. Circulation 93:1194-1200.
13. Richardson M, Kinlough-Rathbone RL, Groves HM, Jorgenson L, Mustard JF, and Moore S (1984). Ultrastructural changes in re-endothelialized and non-endothelialized rabbit aortic neo-intima following re-injury with a balloon catheter. Br J Exp Path 65:597-611.
14. Sarembock IJ, Gertz SD, Gimple LW, Owen RM, Powers ER, and Roberts WC (1991). Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation 84:232-243.
15. Sarembock IJ, LaVeau PJ, Sigal SL, Timms I, Sussman J, Haudenschild C, and Ezekowitz MD (1989). Influence of inflation pressure and balloon size on the development of intimal hyperplasia after balloon angioplasty: A study in the atherosclerotic rabbit. Circulation 80:1029-1040.
16. Scott NA, Cipolla GD, Ross CE, Dunn B, Martin FH, Simonet L, and Wilcox JN (1996). Identification of a potential role for the adventitia in vascular lesion formation after balloon overstretch injury of porcine coronary arteries. Circulation 93:2178-2187.
17. Thome LM, Gimple LW, Ragosta M, Gertz SD, McNamara CA, Powers ER, and Sarembock IJ (1995). Early plus delayed hirudin infusion reduces restenosis in the atherosclerotic rabbit more than early administration alone (abstract). Circulation 92(Suppl):1-382.
18. Unterberg C, Sandrock D, Nebendahl K, and Buchwald AB (1995). Reduced acute thrombus formation results in decreased neointimal proliferation after coronary angioplasty. J Am Coll Cardiol 26:1747-1754.
19. Wilensky RL, March KL, Gradus-Pizlo I, Sandusky G, Fineberg N, and Hathaway DR (1995). Vascular injury, repair, and restenosis after percutaneous transluminal angioplasty in the atherosclerotic rabbit. Circulation 92:2995-3005.