Genetic variants of dopamine receptor D4 and psychopathology

Schizophrenia Bulletin

Volumn 25, Issue 3, 1999, Pages 609-618

  Serretti, Alessandro ^a   Macciardi, Fabio ^a   Catalano, Marco ^a   Bellodi, Laura ^a   Smeraldi, Enrico ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

DRD4; Mood disorders; Psychiatric genetics; Psychopathology; Schizophrenia

Indexed keywords

DOPAMINE 4 RECEPTOR;

ADULT; ARTICLE; DELUSION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; PRIORITY JOURNAL; RECEPTOR DENSITY; SCORING SYSTEM; SYMPTOMATOLOGY;

EID: 0032713388     PISSN: 05867614     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.schbul.a033405     Document Type: Article

References (62)

1. American Psychiatric Association. DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders. 3rd ed., revised. Washington, DC: The Association, 1987.
2. American Psychiatric Association. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: The Association, 1994.
3. Asghari, V.; Sanyal, S.; Buchwaldt, S.; Paterson, A.; Jovanovic, V.; and Van Tol, H. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. Journal of Neurochemistry, 65(3):1157-1165, 1995.
4. Bellivier, F.; Laplanche, J.; Schurhoff, F.; Feingold, J.; Feline, A.; Jouvent, R.; Launay, J.; and Leboyer, M. Apolipoprotein E gene polymorphism in early and late onset bipolar patients. Neuroscience Letters, 233:45-48, 1997.
5. Benjamin, J.; Li, L.; Patterson, C.; Greenberg, B.; Murphy, D.; and Hamer, D. Population and familial association between the D4 dopamine receptor and measures of novelty seeking. Nature Genetics, 12:81-84, 1996.
6. Calabrese, J.; Kimmel, S.; Woyshville, M.; Rapport, D.; Faust, C.; Thompson, P.; and Meltzer, H. Clozapine for treatment-refractory mania. American Journal of Psychiatry, 153(6):759-764, 1996.
7. Cannon, T., and Marco, E. Structural brain abnormalities as indicators of vulnerability to schizophrenia. Schizophrenia Bulletin, 20:89-102, 1994.
8. Carey, G. Genetic association study in psychiatry: Analytical evaluation and a recommendation. American Journal of Medical Genetics, 54:311-317, 1994.
9. Catalano, M.; Nobile, M.; Novelli, E.; Nothen, M.; and Smeraldi, E. Distribution of novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biological Psychiatry, 34:459-464, 1993.
10. Cichon, S.; Nothen, M.; Catalano, M.; DiBella, D.; Maier, W.; Lichtermann, D.; Minges, J.; Albus, M.; Borrmann, M.; Franzek, E.; Stober, G.; Weigelt, B.; Korner, J.; Rietshel, M.; and Propping, P. Identification of two novel polymorphisms and a rare deletion variant in the human dopamine D4 receptor gene. Psychiatric Genetics, 5:97-103, 1995.
11. Claridge, G. Single indicator of risk for schizophrenia: Probable fact or likely myth? Schizophrenia Bulletin, 20:151-168, 1994.
12. Cloninger, C. Turning point in the design of linkage studies of schizophrenia. American Journal of Medical Genetics, 54:83-92, 1994.
13. Cloninger, C.; Adolfsson, R.; and Svrakic, N. Mapping genes for human personality. Nature Genetics, 12:3-4, 1996.
14. Csernansky, J., and Newcomer, J. Are there neurochemical indicators of risk for schizophrenia? Schizophrenia Bulletin, 20:75-88, 1994.
15. Dixon, W. BMDP Statistical Software Manual. Berkeley, CA: University of California Press, 1990.
16. Ebstein, R.P., and Belmaker, R.H. Saga of an adventure gene: Novelty seeking, substance abuse and the dopamine D4 receptor (D4DR) exon III repeat polymorphism. Molecular Psychiatry, 2(5):381-384, 1997.
17. Ebstein, R.; Novick, O.; Umansky, R.; Priel, B.; Osher, Y.; Blaine, D.; Bennett, E.; Nemanov, L.; Kats, M.; and Belmaker, R.H. Dopamine D4 receptor (D4DR) exon ni polymorphism associated with the human personality trait of novelty seeking. Nature Genetics, 12:78-80, 1996.
18. Elliott, J. Peripheral markers in anxiety and depression. Molecular Aspects of Medicine, 13(3):173-190, 1992.
19. Ginsburg, B.; Werick, T.; Escobar, J.; and Kugelmass, S. Molecular genetics of psychopathologies: A search for simple answers to complex problems. Behavior Genetics, 26(3):325-333, 1996.
20. Gottesman, I. Human genetics-twins-en route to QTLS for cognition. Science, 276(5318):1522-1523, 1997.
21. Heun, R., and Maier, W. The distinction of bipolar II disorder from bipolar I and recurrent unipolar depression: Results of a controlled family study. Acta Psychiatrica Scandinavica, 87(4):279-284, 1993.
22. Jonsson, E.G.; Nothen, M.M.; Gustavsson, J.P.; Neidt, H.; Brene, S.; Tylec, A.; Propping, P.; and Sedvall, G.C. Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. American Journal of Psychiatry, 154(5):697-699, 1997.
23. Kahn, R., and Davis, K. New developments in dopamine and schizophrenia. In: Bloom, F., and Kupfer, D., eds. Psychopharmacology: The Fourth Generation of Progress. New York, NY: Raven Press, 1995. pp. 1193-1203.
24. Koyama, T., and Yamashita, I. Biological markers of depression: WHO multi-center studies and future perspective. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 16(6):791-796, 1992.
25. Lahiri, D., and Nurnberger, J.J. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acid Research, 19:5444, 1991.
26. LaHoste, G.; Swanson, J.; Wigal, S.; Glabe, C.; Wigal, T.; King, N.; and Kennedy, J. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Molecular Psychiatry, 1:121-124, 1996.
27. Levinson, D. Pragmatics and statistics in psychiatric genet-ics. American Journal of Medical Genetics, 74:220-222, 1997.
28. Lim, L.; Gurling, H.; Curtis, D.; Brynjolfsson, J.; Petursson, H.; and Gill, M. Linkage between tyrosine hydroxylase gene and affective disorder cannot be excluded in two of six pedigrees. American Journal of Medical Genetics, 48(4):223-238, 1993.
29. Lim, L.; Nothen, M.; Korner, J.; Rietschel, M.; Castle, D.; Hunt, N.; Propping, P.; Murray, R.; and Gill, M. No evidence of association between dopamine D4 receptor variants and bipolar affective disorder. American Journal of Medical Genetics, 54:259-263, 1994.
30. Macciardi, F.; Petronis, A.; Van Tol, H.; Marino, C.; Cavallini, M.; Smeraldi, E.; and Kennedy, J. Analysis of the D4 dopamine receptor gene variant in an Italian schizophrenia kindred. Archives of General Psychiatry, 51:288-293, 1994.
31. Maier, W.; Lichtermann, D.; Minges, J.; Hallmayer, J.; Heun, R.; Benkert, O.; and Levinson, D. Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study. Archives of General Psychiatry, 50(11):871-883, 1993.
32. Maier, W.; Lichtermann, D.; Minges, J.; Heun, R.; Hallmayer, J.; and Benkert, O. Schizoaffective disorder and affective disorders with mood-incongruent psychotic features: Keep separate or combine? Evidence from a family study. American Journal of Psychiatry, 149(12):1666-1673, 1992.
33. Manki, H.; Kanba, S.; Muramatsu, T.; Higuchi, S.; Suzuki, E.; Matsushita, S.; Ono, Y.; Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders. Journal of Affective Disorders, 40:7-13, 1996.
34. Marder, S. Management of treatment-resistant patients with schizophrenia. Journal of Clinical Psychiatry, 57(suppl. 11):26-30, 1996.
35. Matsumoto, M.; Hidaka, K.; Tada, S.; Tasaki, Y.; and Yamaguchi, T. Full-length cDNA cloning and distribution of human dopamine D4 receptor. Brain Research. Molecular Brain Research, 29(1): 157-162, 1995.
36. McGuffin, P.; Farmer, A.; and Harvey, I. A polydiagnostic application of operational criteria in studies of psychotic illness: Development and reliability of the OPCRIT system. Archives of General Psychiatry, 48:764-770, 1991.
37. Murray, A.; Hyde, T.; Knable, M.; Herman, M.; Bigelow, L.; Carter, J.; Weinberger, D.; and Kleinman, J. Distribution of putative D4 dopamine receptors in post-mortem striatum from patients with schizophrenia. Journal of Neuroscience, 15(3):2186-2191, 1995.
38. Nothen, M.; Cichon, S.; Hemmer, S.; Hebebrand, J.; Remschmidt, H.; Lehmkuhl, G.; Poustka, F.; Schmidt, M.; Catalano, M.; Fimmers, R.; Korner, J.; Rietschel, M.; and Propping, P. Human dopamine D4 receptor gene: Frequent occurrence of a null allele and observation of homozygosity. Human Molecular Genetics, 3(12):2207-2212, 1994.
39. Ono, Y.; Manki, H.; Yoshimura, K.; Muramatsu, T.; Mizushima, H.; Higuchi, S.; Yagi, G.; Kanba, S.; and Asai, M. Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. American Journal of Medical Genetics, 74(5):501-503, 1997.
40. Petronis, A.; Macciardi, F.; Athanassiades, A.; Paterson, A.; Verga, M.; Meltzer, H.; Cola, P.; Buchanan, J.; Van Tol, H.; and Kennedy, J. Association study between the dopamine D4 receptor gene and schizophrenia. American Journal of Medical Genetics, 60(5):452-455, 1995.
41. Risch, N. Linkage strategies for genetically complex traits: I. Multilocus models. American Journal of Medical Genetics, 46:222-228, 1990.
42. Risch, N., and Botstein, D. A manic depressive history. Nature Genetics, 12:351-353, 1996.
43. Sander, T.; Harms, H.; Dufeu, P.; Kuhn, S.; Rommelspacher, H.; and Schmidt, L.G. Dopamine D4 receptor exon III alleles and variation of novelty seeking in alcoholics. American Journal of Medical Genetics, 74(5):483-487, 1997.
44. Seeman, P.; Guan, H.; and Van Tol, H. Dopamine D4 receptors elevated in schizophrenia. Nature, 365:441-445, 1993.
45. Seeman, P.; Ulpian, C.; Chouinard, G.; Van Tol, H.; Dwosh, H.; Lieberman, J.; Siminovitch, K.; Liu, I.; Waye, J.; Voruganti, P.; Hudson, C.; Serjeant, G.R.; Masibay, A.S.; and Seeman, M.V. Dopamine D4 receptor variant, D4GLYCINE194, in Africans, but not in Caucasians: No association with schizophrenia. American Journal of Medical Genetics, 54(4):384-390, 1994.
46. Serretti, A.; Macciardi, F.; and Smeraldi, E. Identification of symptomatologic patterns common to major psychoses: Proposal for a phenotype definition. American Journal of Medical Genetics (Neuropsychiatric Genetics), 67:393-400, 1996.
47. Serretti, A.; Lilli, R.; DiBella, D.; Bertelli, S.; Nobile, M.; Novelli, E.; Catalano, M.; and Smeraldi, E. Dopamine receptor D4 gene is not associated with major psychoses. American Journal of Medical Genetics, in press.
48. Shaikh, S.; Collier, D.; Kerwin, R.; Pilovsky, L.; Gill, M.; Xu, W.; and Thornton, A. Dopamine D4 receptor subtypes and response to clozapine. Lancet, 341:116, 1993.
49. Shaikh, S.; Gill, M.; Owen, M.; Asherson, P.; McGuffin, P.; Nanko, S.; Murray, R.; and Collier, D. Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia. American Journal of Medical Genetics, 54(1):8-11, 1994.
50. 3H]raclopride binding in post-mortem caudate nucleus of subjects with schizophrenia or major depression. Brain Research, 681(1-2):109-116, 1995.
51. Taylor, M. Are schizophrenia and affective disorder related? A selective literature review. American Journal of Psychiatry, 149(1):22-32, 1992.
52. Taylor, M.; Berenbaum, S.; Jampala, V.; and Cloninger, C. Are schizophrenia and affective disorder related? Preliminary data from a family study. American Journal of Psychiatry, 150(2):278-285, 1993.
53. Tsuang, M., and Faraone, S. The Genetics of Mood Disorders. Baltimore, MD: Johns Hopkins University Press, 1990.
54. Van Tol, H.; Bunzow, J.; Guan, H.; Sunahara, R.; Seeman, P.; Niznik, H.; and Civelli, O. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature, 350(6319):610-614, 1991.
55. Van Tol, H.; Caren, M.; Guan, H.; Ohara, K.; Bunzow, J.; Civelli, O.; Kennedy, J.; Seeman, P.; Niznik, H.; and Jovanovic, V. Multiple dopamine D4 receptor variants in the human population. Nature, 358:149-152, 1992.
56. Vandenbergh, D.J.; Zonderman, A.B.; Wang, J.; Uhl, G.R.; and Costa, P.T. Jr. No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants. Molecular Psychiatry, 2(5):417-419, 1997.
57. 18F]fluorodeoxyglucose (FDG). European Neuropsychopharmacology, 7(1):9-24, 1997.
58. Weisgraber, K.; Roses, A.; and Strittmatter, W. The role of apolipoprotein E in the nervous system. Current Opinion in Lipidology, 5(2):110-116, 1994.
59. Willner, P. Dopaminergic mechanisms in depression and mania. In: Bloom, F., and Kupfer, D., eds. Psychopharmacology: The Fourth Generation of Progress. New York, NY: Raven Press, 1995. pp. 921-931.
60. Winokur, G.; Coryell, W.; Endicott, J.; and Akiskal, H. Further distinctions between manic-depressive illness (bipolar disorder) and primary depressive disorder (unipolar depression). American Journal of Psychiatry, 150(8):1176-1181, 1993.
61. Winokur, G.; Coryell, W.; Keller, M.; Endicott, J.; and Leon, A. A family study of manic-depressive (bipolar I) disease: Is it a distinct illness separable from primary unipolar depression? Archives of General Psychiatry, 52(5):367-373, 1995.
62. Yaffe, K.; Cauley, J.; Sands, L.; and Browner, W. Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women. Archives of Neurology, 54(9):1110-1114, 1997.