-
2
-
-
0029690505
-
Effects of catechol-O-methyltransferase (COMT) inhibition on the pharmacokinetics of L-DOPA
-
Nutt, J.G. Effects of catechol-O-methyltransferase (COMT) inhibition on the pharmacokinetics of L-DOPA. Adv Neurol 1996, 69: 493-6.
-
(1996)
Adv Neurol
, vol.69
, pp. 493-496
-
-
Nutt, J.G.1
-
3
-
-
84951515357
-
Clinical potential of catechol-O-methyltransferase (COMT) inhibitors as adjuvants in Parkinson's disease
-
Männisto, P.T. Clinical potential of catechol-O-methyltransferase (COMT) inhibitors as adjuvants in Parkinson's disease. CNS Drugs 1994, 1 (3): 172-9.
-
(1994)
CNS Drugs
, vol.1
, Issue.3
, pp. 172-179
-
-
Männisto, P.T.1
-
4
-
-
0027935135
-
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase
-
Kaakkola, S., Gordin, A., Männisto, P.T. General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase. Gen Pharmacol 1994, 25 (5): 813-24.
-
(1994)
Gen Pharmacol
, vol.25
, Issue.5
, pp. 813-824
-
-
Kaakkola, S.1
Gordin, A.2
Männisto, P.T.3
-
5
-
-
0024388924
-
Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462
-
Schultz, E., Nissinen, E. Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462. Biochem Pharmacol 1989, 38 (22): 3953-6.
-
(1989)
Biochem Pharmacol
, vol.38
, Issue.22
, pp. 3953-3956
-
-
Schultz, E.1
Nissinen, E.2
-
6
-
-
0026570182
-
Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat
-
Männisto, P.T., Tuomainen, P., Tuominen, R.K. Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. Br J Pharmacol 1992, 105 (3): 569-74.
-
(1992)
Br J Pharmacol
, vol.105
, Issue.3
, pp. 569-574
-
-
Männisto, P.T.1
Tuomainen, P.2
Tuominen, R.K.3
-
7
-
-
0028203007
-
Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone
-
Keränen, T., Gordin, A., Karlsson, M. et al. Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone. Eur J Clin Pharmacol 1994, 46 (2): 151-7.
-
(1994)
Eur J Clin Pharmacol
, vol.46
, Issue.2
, pp. 151-157
-
-
Keränen, T.1
Gordin, A.2
Karlsson, M.3
-
8
-
-
0027844971
-
Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog
-
Wikberg, T., Ottoila, P., Taskinen, J. Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog. Eur J Drug Metab Pharmacokinet 1993, 18 (4): 359-67.
-
(1993)
Eur J Drug Metab Pharmacokinet
, vol.18
, Issue.4
, pp. 359-367
-
-
Wikberg, T.1
Ottoila, P.2
Taskinen, J.3
-
9
-
-
0027417592
-
Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans
-
Wikberg, T., Vuorela, A., Ottoila, P., Taskinen, J. Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans. Drug Metab Dispos 1993, 21 (1): 81-92.
-
(1993)
Drug Metab Dispos
, vol.21
, Issue.1
, pp. 81-92
-
-
Wikberg, T.1
Vuorela, A.2
Ottoila, P.3
Taskinen, J.4
-
10
-
-
0028286186
-
Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients
-
Nutt, J.G., Woodward, W.R., Beckner, R.M. et al. Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. Neurology 1994, 44 (5): 913-9.
-
(1994)
Neurology
, vol.44
, Issue.5
, pp. 913-919
-
-
Nutt, J.G.1
Woodward, W.R.2
Beckner, R.M.3
-
11
-
-
0025669814
-
Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat
-
Waldmeier, P.C., De, H.P., Maitre, L. Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat. J Neural Transm Suppl 1990, 32: 381-6.
-
(1990)
J Neural Transm Suppl
, vol.32
, pp. 381-386
-
-
Waldmeier, P.C.1
De, H.P.2
Maitre, L.3
-
12
-
-
0025657620
-
Ro 40-7592: Inhibition of COMT in rat brain and extracerebral tissues
-
Zurcher, G., Colzi, A., Da, P.M. Ro 40-7592: Inhibition of COMT in rat brain and extracerebral tissues. J Neural Transm Suppl 1990, 32: 375-80.
-
(1990)
J Neural Transm Suppl
, vol.32
, pp. 375-380
-
-
Zurcher, G.1
Colzi, A.2
Da, P.M.3
-
13
-
-
0026671534
-
Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone
-
Nissinen, E., Linden, I.B., Schultz, E., Pohto, P. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone. Naunyn Schmied Arch Pharmacol 1992, 346 (3): 262-6.
-
(1992)
Naunyn Schmied Arch Pharmacol
, vol.346
, Issue.3
, pp. 262-266
-
-
Nissinen, E.1
Linden, I.B.2
Schultz, E.3
Pohto, P.4
-
14
-
-
0027223850
-
Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa
-
Guttman, M., Leger, G., Reches, A. et al. Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa. Mov Disord 1993, 8 (3): 298-304.
-
(1993)
Mov Disord
, vol.8
, Issue.3
, pp. 298-304
-
-
Guttman, M.1
Leger, G.2
Reches, A.3
-
15
-
-
0028128512
-
18F]-6-L-fluorodopa metabolism: Implications for levodopa therapy of Parkinson's disease
-
18F]-6-L-fluorodopa metabolism: Implications for levodopa therapy of Parkinson's disease. Neurology 1994, 44 (7): 1292-7.
-
(1994)
Neurology
, vol.44
, Issue.7
, pp. 1292-1297
-
-
Sawle, G.V.1
Burn, D.J.2
Morrrish, P.K.3
-
16
-
-
0030668631
-
Entacapone enhances levodopa-induced reversal of motor disability in MPTP-treated common marmosets
-
Smith, L.A., Gordin, A., Jenner, P., Marsden, C.D. Entacapone enhances levodopa-induced reversal of motor disability in MPTP-treated common marmosets. Mov Disord 1997, 12 (6): 935-45.
-
(1997)
Mov Disord
, vol.12
, Issue.6
, pp. 935-945
-
-
Smith, L.A.1
Gordin, A.2
Jenner, P.3
Marsden, C.D.4
-
17
-
-
0027436117
-
The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise
-
Sundberg, S. et al. The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise. Br J Clin Pharmacol 1993, 36: 451-6.
-
(1993)
Br J Clin Pharmacol
, vol.36
, pp. 451-456
-
-
Sundberg, S.1
-
18
-
-
0027514196
-
The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers
-
Keränen, T., Gordin, A., Harjola, V.P. et al. The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers. Clin Neuropharmacol 1993, 16 (2): 145-56.
-
(1993)
Clin Neuropharmacol
, vol.16
, Issue.2
, pp. 145-156
-
-
Keränen, T.1
Gordin, A.2
Harjola, V.P.3
-
19
-
-
0028046134
-
COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise
-
Illi, A., Sundberg, S., Koulu, M., Scheinin, M., Heinavaara, S., Gordin, A. COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise. Int J Clin Pharmacol Ther 1994, 32 (11): 582-8.
-
(1994)
Int J Clin Pharmacol Ther
, vol.32
, Issue.11
, pp. 582-588
-
-
Illi, A.1
Sundberg, S.2
Koulu, M.3
Scheinin, M.4
Heinavaara, S.5
Gordin, A.6
-
20
-
-
0027478136
-
The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition
-
Sundberg, S., Scheinin, M., Ojala-Karlsson, P., Akkila, J., Gordin, A. The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition. Eur J Clin Pharmacol 1993, 44 (3): 287-90.
-
(1993)
Eur J Clin Pharmacol
, vol.44
, Issue.3
, pp. 287-290
-
-
Sundberg, S.1
Scheinin, M.2
Ojala-Karlsson, P.3
Akkila, J.4
Gordin, A.5
-
21
-
-
0028891614
-
Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers
-
Ahtila, S., Kaakkola, S., Gordin, A. et al. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers. Clin Neuropharmacol 1995, 18 (1): 46-57.
-
(1995)
Clin Neuropharmacol
, vol.18
, Issue.1
, pp. 46-57
-
-
Ahtila, S.1
Kaakkola, S.2
Gordin, A.3
-
22
-
-
0029785290
-
Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: Effect of the plasma 3-O-methyldopa fraction on data analysis
-
Ishikawa, T., Dhawan, V., Chaly, T. et al. Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: Effect of the plasma 3-O-methyldopa fraction on data analysis. J Cereb Blood Flow Metab 1996, 16 (5): 854-63.
-
(1996)
J Cereb Blood Flow Metab
, vol.16
, Issue.5
, pp. 854-863
-
-
Ishikawa, T.1
Dhawan, V.2
Chaly, T.3
-
23
-
-
0029895288
-
A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease
-
Ruottinen, H.M., Rinne, U.K. A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease. Clin Neuropharmacol 1996, 19 (4): 283-96.
-
(1996)
Clin Neuropharmacol
, vol.19
, Issue.4
, pp. 283-296
-
-
Ruottinen, H.M.1
Rinne, U.K.2
-
24
-
-
0030476572
-
Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: Lack of interactions
-
Illi, A., Sundberg, S., Ojala-Karlsson, P., Scheinin, M., Gordin, A. Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: Lack of interactions. Eur J Clin Pharmacol 1996, 51 (3-4): 273-6.
-
(1996)
Eur J Clin Pharmacol
, vol.51
, Issue.3-4
, pp. 273-276
-
-
Illi, A.1
Sundberg, S.2
Ojala-Karlsson, P.3
Scheinin, M.4
Gordin, A.5
-
25
-
-
0029881150
-
Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on hemodynamics and catecholamine metabolism in healthy volunteers
-
Illi, A., Sundberg, S., Ojala-Karlsson, P., Scheinin, M., Gordin, A. Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on hemodynamics and catecholamine metabolism in healthy volunteers. Clin Pharmacol Ther 1996, 59 (4): 450-7.
-
(1996)
Clin Pharmacol Ther
, vol.59
, Issue.4
, pp. 450-457
-
-
Illi, A.1
Sundberg, S.2
Ojala-Karlsson, P.3
Scheinin, M.4
Gordin, A.5
-
26
-
-
0029160593
-
The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine
-
Illi, A., Sundberg, S., Ojala-Karlsson, P., Korhonen, P., Scheinin, M., Gordin, A. The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine. Clin Pharmacol Ther 1995, 58 (2): 221-7.
-
(1995)
Clin Pharmacol Ther
, vol.58
, Issue.2
, pp. 221-227
-
-
Illi, A.1
Sundberg, S.2
Ojala-Karlsson, P.3
Korhonen, P.4
Scheinin, M.5
Gordin, A.6
-
27
-
-
0027445460
-
Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease
-
Myllylä, V.V., Sotaniemi, K.A., Illi, A., Suominen, K., Keränen, T. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease. Eur J Clin Pharmacol 1993, 45 (5): 419-23.
-
(1993)
Eur J Clin Pharmacol
, vol.45
, Issue.5
, pp. 419-423
-
-
Myllylä, V.V.1
Sotaniemi, K.A.2
Illi, A.3
Suominen, K.4
Keränen, T.5
-
28
-
-
0029417246
-
18F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease
-
18F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease. J Neural Transm Park Dis Dement Sect 1995, 10 (2-3): 91-106.
-
(1995)
J Neural Transm Park Dis Dement Sect
, vol.10
, Issue.2-3
, pp. 91-106
-
-
Ruottinen, H.M.1
Rinne, J.O.2
Ruotsalainen, U.H.3
-
29
-
-
84878700593
-
18F]fluorodopa (FDOPA) accumulation after entacapone administration
-
18F]fluorodopa (FDOPA) accumulation after entacapone administration. Neurology 1997, 48 (3): A186.
-
(1997)
Neurology
, vol.48
, Issue.3
-
-
Ruottinen, H.M.1
-
30
-
-
0009623785
-
Prolonged FDOPA PET imaging after peripheral COMT inhibition
-
Ruottinen, H.M. et al. Prolonged FDOPA PET imaging after peripheral COMT inhibition. J Cereb Blood Flow Metab 1997, 17 (Suppl. 1): S737.
-
(1997)
J Cereb Blood Flow Metab
, vol.17
, Issue.SUPPL. 1
-
-
Ruottinen, H.M.1
-
31
-
-
0028078890
-
Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients
-
Kaakkola, S., Teravainen, H., Ahtila, S., Rita, H., Gordin, A. Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients. Neurology 1994, 44 (1): 77-80.
-
(1994)
Neurology
, vol.44
, Issue.1
, pp. 77-80
-
-
Kaakkola, S.1
Teravainen, H.2
Ahtila, S.3
Rita, H.4
Gordin, A.5
-
32
-
-
85005235624
-
Entacapone in combination with standard or controlled-release levodopa/carbidopa: A clinical and pharmacokinetic study in patients with Parkinson's disease
-
Kaakkola, S. et al. Entacapone in combination with standard or controlled-release levodopa/carbidopa: A clinical and pharmacokinetic study in patients with Parkinson's disease. Eur J Neurol 1995, 2: 341-7.
-
(1995)
Eur J Neurol
, vol.2
, pp. 341-347
-
-
Kaakkola, S.1
-
33
-
-
0029881772
-
Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients
-
Ruottinen, H.M., Rinne, U.K. Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients. Clin Neuropharmacol 1996, 19 (3): 222-33.
-
(1996)
Clin Neuropharmacol
, vol.19
, Issue.3
, pp. 222-233
-
-
Ruottinen, H.M.1
Rinne, U.K.2
-
34
-
-
0030042649
-
Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations
-
Ruottinen, H.M., Rinne, U.K. Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations. J Neurol Neurosurg Psychiatry 1996, 60 (1): 36-40.
-
(1996)
J Neurol Neurosurg Psychiatry
, vol.60
, Issue.1
, pp. 36-40
-
-
Ruottinen, H.M.1
Rinne, U.K.2
-
35
-
-
0028137620
-
Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease
-
Merello, M., Lees, A.J., Webster, R., Bovingdon, M., Gordin, A. Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 1994, 57 (2): 186-9.
-
(1994)
J Neurol Neurosurg Psychiatry
, vol.57
, Issue.2
, pp. 186-189
-
-
Merello, M.1
Lees, A.J.2
Webster, R.3
Bovingdon, M.4
Gordin, A.5
-
36
-
-
0030778373
-
Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients
-
Parkinson Study Group
-
Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients. Parkinson Study Group. Ann Neurol 1997, 42 (5): 747-55.
-
(1997)
Ann Neurol
, vol.42
, Issue.5
, pp. 747-755
-
-
-
37
-
-
0031773064
-
Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations
-
Nomecomt Study Group
-
Rinne, U.K., Larsen, J.P., Siden, A., Worm-Petersen, J. Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations. Nomecomt Study Group. Neurology 1998, 51 (5): 1309-14.
-
(1998)
Neurology
, vol.51
, Issue.5
, pp. 1309-1314
-
-
Rinne, U.K.1
Larsen, J.P.2
Siden, A.3
Worm-Petersen, J.4
-
38
-
-
0029827782
-
COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers
-
Keränen, T., Gordin, A., Koula, M. et al. COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers. J Neural Transm Gen Sect 1996, 103 (6): 729-36.
-
(1996)
J Neural Transm Gen Sect
, vol.103
, Issue.6
, pp. 729-736
-
-
Keränen, T.1
Gordin, A.2
Koula, M.3
-
39
-
-
0031708101
-
COMT inhibition in the treatment of Parkinson's disease
-
Ruottinen, H.M., Rinne, U.K. COMT inhibition in the treatment of Parkinson's disease. J Neurol 1998, 245 (11, Suppl. 3): 25-34.
-
(1998)
J Neurol
, vol.245
, Issue.11 SUPPL. 3
, pp. 25-34
-
-
Ruottinen, H.M.1
Rinne, U.K.2
-
40
-
-
3943082124
-
Discovery of monoamine oxidase forms A and B
-
Squires, R.F. Discovery of monoamine oxidase forms A and B. Vopr Med Khim 1997, 43 (6): 433-9.
-
(1997)
Vopr Med Khim
, vol.43
, Issue.6
, pp. 433-439
-
-
Squires, R.F.1
-
41
-
-
0032914318
-
Monoamine oxidase: From genes to behavior
-
Shin, J.C., Chen, K., Ridd, M.J. Monoamine oxidase: From genes to behavior. Annu Rev Neurosci 1999, 22: 197-217.
-
(1999)
Annu Rev Neurosci
, vol.22
, pp. 197-217
-
-
Shin, J.C.1
Chen, K.2
Ridd, M.J.3
-
42
-
-
0027354031
-
MAO-B inhibitors in Parkinson's disease
-
Olanow, C.W. MAO-B inhibitors in Parkinson's disease. Adv Neurol 1993, 60: 666-71.
-
(1993)
Adv Neurol
, vol.60
, pp. 666-671
-
-
Olanow, C.W.1
-
43
-
-
0023023958
-
Pharmacology of MAO B inhibitors: Mode of action of (-)-deprenyl in Parkinson's disease
-
Youdim, M.B. Pharmacology of MAO B inhibitors: Mode of action of (-)-deprenyl in Parkinson's disease. J Neural Transm Suppl 1986, 22: 91-105.
-
(1986)
J Neural Transm Suppl
, vol.22
, pp. 91-105
-
-
Youdim, M.B.1
|