메뉴 건너뛰기




Volumn 35, Issue 9, 1999, Pages 701-717

Perspectives in the treatment of Parkinson's disease: COMT inhibitors open up new treatment strategies

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; CATECHOL METHYLTRANSFERASE INHIBITOR; ENTACAPONE; LEVODOPA;

EID: 0032712818     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.1999.35.9.553216     Document Type: Review
Times cited : (2)

References (43)
  • 2
    • 0029690505 scopus 로고    scopus 로고
    • Effects of catechol-O-methyltransferase (COMT) inhibition on the pharmacokinetics of L-DOPA
    • Nutt, J.G. Effects of catechol-O-methyltransferase (COMT) inhibition on the pharmacokinetics of L-DOPA. Adv Neurol 1996, 69: 493-6.
    • (1996) Adv Neurol , vol.69 , pp. 493-496
    • Nutt, J.G.1
  • 3
    • 84951515357 scopus 로고
    • Clinical potential of catechol-O-methyltransferase (COMT) inhibitors as adjuvants in Parkinson's disease
    • Männisto, P.T. Clinical potential of catechol-O-methyltransferase (COMT) inhibitors as adjuvants in Parkinson's disease. CNS Drugs 1994, 1 (3): 172-9.
    • (1994) CNS Drugs , vol.1 , Issue.3 , pp. 172-179
    • Männisto, P.T.1
  • 4
    • 0027935135 scopus 로고
    • General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase
    • Kaakkola, S., Gordin, A., Männisto, P.T. General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase. Gen Pharmacol 1994, 25 (5): 813-24.
    • (1994) Gen Pharmacol , vol.25 , Issue.5 , pp. 813-824
    • Kaakkola, S.1    Gordin, A.2    Männisto, P.T.3
  • 5
    • 0024388924 scopus 로고
    • Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462
    • Schultz, E., Nissinen, E. Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462. Biochem Pharmacol 1989, 38 (22): 3953-6.
    • (1989) Biochem Pharmacol , vol.38 , Issue.22 , pp. 3953-3956
    • Schultz, E.1    Nissinen, E.2
  • 6
    • 0026570182 scopus 로고
    • Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat
    • Männisto, P.T., Tuomainen, P., Tuominen, R.K. Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. Br J Pharmacol 1992, 105 (3): 569-74.
    • (1992) Br J Pharmacol , vol.105 , Issue.3 , pp. 569-574
    • Männisto, P.T.1    Tuomainen, P.2    Tuominen, R.K.3
  • 7
    • 0028203007 scopus 로고
    • Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone
    • Keränen, T., Gordin, A., Karlsson, M. et al. Inhibition of soluble catechol-O-methyltransferase and single-dose pharmacokinetics after oral and intravenous administration of entacapone. Eur J Clin Pharmacol 1994, 46 (2): 151-7.
    • (1994) Eur J Clin Pharmacol , vol.46 , Issue.2 , pp. 151-157
    • Keränen, T.1    Gordin, A.2    Karlsson, M.3
  • 8
    • 0027844971 scopus 로고
    • Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog
    • Wikberg, T., Ottoila, P., Taskinen, J. Identification of major urinary metabolites of the catechol-O-methyltransferase inhibitor entacapone in the dog. Eur J Drug Metab Pharmacokinet 1993, 18 (4): 359-67.
    • (1993) Eur J Drug Metab Pharmacokinet , vol.18 , Issue.4 , pp. 359-367
    • Wikberg, T.1    Ottoila, P.2    Taskinen, J.3
  • 9
    • 0027417592 scopus 로고
    • Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans
    • Wikberg, T., Vuorela, A., Ottoila, P., Taskinen, J. Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans. Drug Metab Dispos 1993, 21 (1): 81-92.
    • (1993) Drug Metab Dispos , vol.21 , Issue.1 , pp. 81-92
    • Wikberg, T.1    Vuorela, A.2    Ottoila, P.3    Taskinen, J.4
  • 10
    • 0028286186 scopus 로고
    • Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients
    • Nutt, J.G., Woodward, W.R., Beckner, R.M. et al. Effect of peripheral catechol-O-methyltransferase inhibition on the pharmacokinetics and pharmacodynamics of levodopa in parkinsonian patients. Neurology 1994, 44 (5): 913-9.
    • (1994) Neurology , vol.44 , Issue.5 , pp. 913-919
    • Nutt, J.G.1    Woodward, W.R.2    Beckner, R.M.3
  • 11
    • 0025669814 scopus 로고
    • Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat
    • Waldmeier, P.C., De, H.P., Maitre, L. Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat. J Neural Transm Suppl 1990, 32: 381-6.
    • (1990) J Neural Transm Suppl , vol.32 , pp. 381-386
    • Waldmeier, P.C.1    De, H.P.2    Maitre, L.3
  • 12
    • 0025657620 scopus 로고
    • Ro 40-7592: Inhibition of COMT in rat brain and extracerebral tissues
    • Zurcher, G., Colzi, A., Da, P.M. Ro 40-7592: Inhibition of COMT in rat brain and extracerebral tissues. J Neural Transm Suppl 1990, 32: 375-80.
    • (1990) J Neural Transm Suppl , vol.32 , pp. 375-380
    • Zurcher, G.1    Colzi, A.2    Da, P.M.3
  • 13
    • 0026671534 scopus 로고
    • Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone
    • Nissinen, E., Linden, I.B., Schultz, E., Pohto, P. Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone. Naunyn Schmied Arch Pharmacol 1992, 346 (3): 262-6.
    • (1992) Naunyn Schmied Arch Pharmacol , vol.346 , Issue.3 , pp. 262-266
    • Nissinen, E.1    Linden, I.B.2    Schultz, E.3    Pohto, P.4
  • 14
    • 0027223850 scopus 로고
    • Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa
    • Guttman, M., Leger, G., Reches, A. et al. Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa. Mov Disord 1993, 8 (3): 298-304.
    • (1993) Mov Disord , vol.8 , Issue.3 , pp. 298-304
    • Guttman, M.1    Leger, G.2    Reches, A.3
  • 15
    • 0028128512 scopus 로고
    • 18F]-6-L-fluorodopa metabolism: Implications for levodopa therapy of Parkinson's disease
    • 18F]-6-L-fluorodopa metabolism: Implications for levodopa therapy of Parkinson's disease. Neurology 1994, 44 (7): 1292-7.
    • (1994) Neurology , vol.44 , Issue.7 , pp. 1292-1297
    • Sawle, G.V.1    Burn, D.J.2    Morrrish, P.K.3
  • 16
    • 0030668631 scopus 로고    scopus 로고
    • Entacapone enhances levodopa-induced reversal of motor disability in MPTP-treated common marmosets
    • Smith, L.A., Gordin, A., Jenner, P., Marsden, C.D. Entacapone enhances levodopa-induced reversal of motor disability in MPTP-treated common marmosets. Mov Disord 1997, 12 (6): 935-45.
    • (1997) Mov Disord , vol.12 , Issue.6 , pp. 935-945
    • Smith, L.A.1    Gordin, A.2    Jenner, P.3    Marsden, C.D.4
  • 17
    • 0027436117 scopus 로고
    • The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise
    • Sundberg, S. et al. The effects of the COMT inhibitor entacapone on haemodynamics and peripheral catecholamine metabolism during exercise. Br J Clin Pharmacol 1993, 36: 451-6.
    • (1993) Br J Clin Pharmacol , vol.36 , pp. 451-456
    • Sundberg, S.1
  • 18
    • 0027514196 scopus 로고
    • The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers
    • Keränen, T., Gordin, A., Harjola, V.P. et al. The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers. Clin Neuropharmacol 1993, 16 (2): 145-56.
    • (1993) Clin Neuropharmacol , vol.16 , Issue.2 , pp. 145-156
    • Keränen, T.1    Gordin, A.2    Harjola, V.P.3
  • 19
    • 0028046134 scopus 로고
    • COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise
    • Illi, A., Sundberg, S., Koulu, M., Scheinin, M., Heinavaara, S., Gordin, A. COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise. Int J Clin Pharmacol Ther 1994, 32 (11): 582-8.
    • (1994) Int J Clin Pharmacol Ther , vol.32 , Issue.11 , pp. 582-588
    • Illi, A.1    Sundberg, S.2    Koulu, M.3    Scheinin, M.4    Heinavaara, S.5    Gordin, A.6
  • 20
    • 0027478136 scopus 로고
    • The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition
    • Sundberg, S., Scheinin, M., Ojala-Karlsson, P., Akkila, J., Gordin, A. The effects of the COMT inhibitor nitecapone for one week on exercise haemodynamics and catecholamine disposition. Eur J Clin Pharmacol 1993, 44 (3): 287-90.
    • (1993) Eur J Clin Pharmacol , vol.44 , Issue.3 , pp. 287-290
    • Sundberg, S.1    Scheinin, M.2    Ojala-Karlsson, P.3    Akkila, J.4    Gordin, A.5
  • 21
    • 0028891614 scopus 로고
    • Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers
    • Ahtila, S., Kaakkola, S., Gordin, A. et al. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics and metabolism of levodopa after administration of controlled-release levodopa-carbidopa in volunteers. Clin Neuropharmacol 1995, 18 (1): 46-57.
    • (1995) Clin Neuropharmacol , vol.18 , Issue.1 , pp. 46-57
    • Ahtila, S.1    Kaakkola, S.2    Gordin, A.3
  • 22
    • 0029785290 scopus 로고    scopus 로고
    • Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: Effect of the plasma 3-O-methyldopa fraction on data analysis
    • Ishikawa, T., Dhawan, V., Chaly, T. et al. Fluorodopa positron emission tomography with an inhibitor of catechol-O-methyltransferase: Effect of the plasma 3-O-methyldopa fraction on data analysis. J Cereb Blood Flow Metab 1996, 16 (5): 854-63.
    • (1996) J Cereb Blood Flow Metab , vol.16 , Issue.5 , pp. 854-863
    • Ishikawa, T.1    Dhawan, V.2    Chaly, T.3
  • 23
    • 0029895288 scopus 로고    scopus 로고
    • A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease
    • Ruottinen, H.M., Rinne, U.K. A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease. Clin Neuropharmacol 1996, 19 (4): 283-96.
    • (1996) Clin Neuropharmacol , vol.19 , Issue.4 , pp. 283-296
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 24
    • 0030476572 scopus 로고    scopus 로고
    • Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: Lack of interactions
    • Illi, A., Sundberg, S., Ojala-Karlsson, P., Scheinin, M., Gordin, A. Simultaneous inhibition of catecholamine-O-methylation by entacapone and neuronal uptake by imipramine: Lack of interactions. Eur J Clin Pharmacol 1996, 51 (3-4): 273-6.
    • (1996) Eur J Clin Pharmacol , vol.51 , Issue.3-4 , pp. 273-276
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3    Scheinin, M.4    Gordin, A.5
  • 25
    • 0029881150 scopus 로고    scopus 로고
    • Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on hemodynamics and catecholamine metabolism in healthy volunteers
    • Illi, A., Sundberg, S., Ojala-Karlsson, P., Scheinin, M., Gordin, A. Simultaneous inhibition of catechol-O-methyltransferase and monoamine oxidase A: Effects on hemodynamics and catecholamine metabolism in healthy volunteers. Clin Pharmacol Ther 1996, 59 (4): 450-7.
    • (1996) Clin Pharmacol Ther , vol.59 , Issue.4 , pp. 450-457
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3    Scheinin, M.4    Gordin, A.5
  • 26
    • 0029160593 scopus 로고
    • The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine
    • Illi, A., Sundberg, S., Ojala-Karlsson, P., Korhonen, P., Scheinin, M., Gordin, A. The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine. Clin Pharmacol Ther 1995, 58 (2): 221-7.
    • (1995) Clin Pharmacol Ther , vol.58 , Issue.2 , pp. 221-227
    • Illi, A.1    Sundberg, S.2    Ojala-Karlsson, P.3    Korhonen, P.4    Scheinin, M.5    Gordin, A.6
  • 27
    • 0027445460 scopus 로고
    • Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease
    • Myllylä, V.V., Sotaniemi, K.A., Illi, A., Suominen, K., Keränen, T. Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease. Eur J Clin Pharmacol 1993, 45 (5): 419-23.
    • (1993) Eur J Clin Pharmacol , vol.45 , Issue.5 , pp. 419-423
    • Myllylä, V.V.1    Sotaniemi, K.A.2    Illi, A.3    Suominen, K.4    Keränen, T.5
  • 28
    • 0029417246 scopus 로고
    • 18F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease
    • 18F]fluorodopa utilization after COMT inhibition with entacapone studied with PET in advanced Parkinson's disease. J Neural Transm Park Dis Dement Sect 1995, 10 (2-3): 91-106.
    • (1995) J Neural Transm Park Dis Dement Sect , vol.10 , Issue.2-3 , pp. 91-106
    • Ruottinen, H.M.1    Rinne, J.O.2    Ruotsalainen, U.H.3
  • 29
    • 84878700593 scopus 로고    scopus 로고
    • 18F]fluorodopa (FDOPA) accumulation after entacapone administration
    • 18F]fluorodopa (FDOPA) accumulation after entacapone administration. Neurology 1997, 48 (3): A186.
    • (1997) Neurology , vol.48 , Issue.3
    • Ruottinen, H.M.1
  • 30
    • 0009623785 scopus 로고    scopus 로고
    • Prolonged FDOPA PET imaging after peripheral COMT inhibition
    • Ruottinen, H.M. et al. Prolonged FDOPA PET imaging after peripheral COMT inhibition. J Cereb Blood Flow Metab 1997, 17 (Suppl. 1): S737.
    • (1997) J Cereb Blood Flow Metab , vol.17 , Issue.SUPPL. 1
    • Ruottinen, H.M.1
  • 31
    • 0028078890 scopus 로고
    • Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients
    • Kaakkola, S., Teravainen, H., Ahtila, S., Rita, H., Gordin, A. Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients. Neurology 1994, 44 (1): 77-80.
    • (1994) Neurology , vol.44 , Issue.1 , pp. 77-80
    • Kaakkola, S.1    Teravainen, H.2    Ahtila, S.3    Rita, H.4    Gordin, A.5
  • 32
    • 85005235624 scopus 로고
    • Entacapone in combination with standard or controlled-release levodopa/carbidopa: A clinical and pharmacokinetic study in patients with Parkinson's disease
    • Kaakkola, S. et al. Entacapone in combination with standard or controlled-release levodopa/carbidopa: A clinical and pharmacokinetic study in patients with Parkinson's disease. Eur J Neurol 1995, 2: 341-7.
    • (1995) Eur J Neurol , vol.2 , pp. 341-347
    • Kaakkola, S.1
  • 33
    • 0029881772 scopus 로고    scopus 로고
    • Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients
    • Ruottinen, H.M., Rinne, U.K. Effect of one month's treatment with peripherally acting catechol-O-methyltransferase inhibitor, entacapone, on pharmacokinetics and motor response to levodopa in advanced parkinsonian patients. Clin Neuropharmacol 1996, 19 (3): 222-33.
    • (1996) Clin Neuropharmacol , vol.19 , Issue.3 , pp. 222-233
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 34
    • 0030042649 scopus 로고    scopus 로고
    • Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations
    • Ruottinen, H.M., Rinne, U.K. Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations. J Neurol Neurosurg Psychiatry 1996, 60 (1): 36-40.
    • (1996) J Neurol Neurosurg Psychiatry , vol.60 , Issue.1 , pp. 36-40
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 35
    • 0028137620 scopus 로고
    • Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease
    • Merello, M., Lees, A.J., Webster, R., Bovingdon, M., Gordin, A. Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 1994, 57 (2): 186-9.
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , Issue.2 , pp. 186-189
    • Merello, M.1    Lees, A.J.2    Webster, R.3    Bovingdon, M.4    Gordin, A.5
  • 36
    • 0030778373 scopus 로고    scopus 로고
    • Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients
    • Parkinson Study Group
    • Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients. Parkinson Study Group. Ann Neurol 1997, 42 (5): 747-55.
    • (1997) Ann Neurol , vol.42 , Issue.5 , pp. 747-755
  • 37
    • 0031773064 scopus 로고    scopus 로고
    • Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations
    • Nomecomt Study Group
    • Rinne, U.K., Larsen, J.P., Siden, A., Worm-Petersen, J. Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations. Nomecomt Study Group. Neurology 1998, 51 (5): 1309-14.
    • (1998) Neurology , vol.51 , Issue.5 , pp. 1309-1314
    • Rinne, U.K.1    Larsen, J.P.2    Siden, A.3    Worm-Petersen, J.4
  • 38
    • 0029827782 scopus 로고    scopus 로고
    • COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers
    • Keränen, T., Gordin, A., Koula, M. et al. COMT inhibition by entacapone does not affect growth hormone or prolactin secretion in healthy volunteers. J Neural Transm Gen Sect 1996, 103 (6): 729-36.
    • (1996) J Neural Transm Gen Sect , vol.103 , Issue.6 , pp. 729-736
    • Keränen, T.1    Gordin, A.2    Koula, M.3
  • 39
    • 0031708101 scopus 로고    scopus 로고
    • COMT inhibition in the treatment of Parkinson's disease
    • Ruottinen, H.M., Rinne, U.K. COMT inhibition in the treatment of Parkinson's disease. J Neurol 1998, 245 (11, Suppl. 3): 25-34.
    • (1998) J Neurol , vol.245 , Issue.11 SUPPL. 3 , pp. 25-34
    • Ruottinen, H.M.1    Rinne, U.K.2
  • 40
    • 3943082124 scopus 로고    scopus 로고
    • Discovery of monoamine oxidase forms A and B
    • Squires, R.F. Discovery of monoamine oxidase forms A and B. Vopr Med Khim 1997, 43 (6): 433-9.
    • (1997) Vopr Med Khim , vol.43 , Issue.6 , pp. 433-439
    • Squires, R.F.1
  • 41
    • 0032914318 scopus 로고    scopus 로고
    • Monoamine oxidase: From genes to behavior
    • Shin, J.C., Chen, K., Ridd, M.J. Monoamine oxidase: From genes to behavior. Annu Rev Neurosci 1999, 22: 197-217.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 197-217
    • Shin, J.C.1    Chen, K.2    Ridd, M.J.3
  • 42
    • 0027354031 scopus 로고
    • MAO-B inhibitors in Parkinson's disease
    • Olanow, C.W. MAO-B inhibitors in Parkinson's disease. Adv Neurol 1993, 60: 666-71.
    • (1993) Adv Neurol , vol.60 , pp. 666-671
    • Olanow, C.W.1
  • 43
    • 0023023958 scopus 로고
    • Pharmacology of MAO B inhibitors: Mode of action of (-)-deprenyl in Parkinson's disease
    • Youdim, M.B. Pharmacology of MAO B inhibitors: Mode of action of (-)-deprenyl in Parkinson's disease. J Neural Transm Suppl 1986, 22: 91-105.
    • (1986) J Neural Transm Suppl , vol.22 , pp. 91-105
    • Youdim, M.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.