Vascular-endothelial cadherin (CD144)- but not PECAM-1 (CD31)-based cell-to-cell contacts convey the maintenance of a quiescent endothelial monolayer

International Archives of Allergy and Immunology

Volumn 120, Issue 3, 1999, Pages 237-244

  Halama, Thomas ^a   Staffler, Günther ^b   Hoch, Susanne ^a   Stockinger, Hannes ^b   Wolff, Klaus ^a   Petzelbauer, Peter ^a  

^a Universitatsklinik fur Dermatologie   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Adherens junctions; Catenin; Endothelium; PECAM 1; VE cadherin

Indexed keywords

BETA CATENIN; CADHERIN; CD31 ANTIGEN; COMPLEMENTARY DNA; F ACTIN;

ARTICLE; CELL CONTACT; DNA TRANSFECTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MONOLAYER CULTURE; PRIORITY JOURNAL;

EID: 0032709607     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024273     Document Type: Article

References (27)

1. Schwartz SM, Liaw L: Growth control and morphogenesis in the development and pathology of arteries. J Cardiovasc Pharmacol 1993; 21(suppl. 1):S31-S49.
2. Breier G, Breviario F, Caveda L, Berthier R, Schnurch H, Gotsch U, Vestweber D, Risau W, Dejana E: Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system. Blood 1996;87:630-641.
3. Muller WA, Ratti CM, McDonnell SL, Cohn ZA: A human endothelial cell restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med 1989;170:399-414.
4. Caveda L, Martin PI, Navarro P, Breviario F, Corada M, Gulino D, Lampugnani MG, Dejana E: Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin). J Clin Invest 1996;98:886-893.
5. Navarro P, Caveda L, Breviario F, Mandoteanu I, Lampugnani MG, Dejana E: Catenin-dependent and -independent functions of vascular endothelial cadherin. J Biol Chem 1995;270:30965-30972.
6. Lampugnani MG, Corada M, Caveda L, Breviario F, Ayalon O, Geiger B, Dejana E: The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol 1995;129:203-217.
7. Kemler R: From cadherins to catenins: Cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet 1993;9:317-321.
8. Gumbiner BM: Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell 1996;84:345-357.
9. Breviario F, Caveda L, Corada M, I, MP, Navarro P, Golay J, Introna M, Gulino D, Lampugnani MG, Dejana E: Functional properties of human vascular endothelial cadherin (7B4/cadherin-5), an endothelium-specific cadherin. Arterioscler Thromb Vasc Biol 1995; 15:1229-1239.
10. Ayalon O, Sabanai H, Lampugnani MG, Dejana E, Geiger B: Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. J Cell Biol 1994;126:247-258.
11. Matsumura T, Wolff K, Petzelbauer P: Endothelial cell tube formation depends on cadherin-5 and CD31 interactions with filamentous actin. J Immunol 1997;158:3408-3416.
12. Muller WA, Weigl SA, Deng X, Phillips DM: PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 1993;178:449-460.
13. Allport JR, Ding H, Collins T, Gerritsen ME, Luscinskas FW: Endothelial-dependent mechanisms regulate leukocyte transmigration: A process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions. J Exp Med 1997;186:517-527.
14. Albelda SM, Muller WA, Buck CA, Newman PJ: Molecular and cellular properties of PECAM-1 (endoCAM/CD31): A novel vascular cell-cell adhesion molecule. J Cell Biol 1991;114:1059-1068.
15. DeLisser HM, Christofidou-Solomidou M, Streiter RM, Burdik MD, Robinson CS, Wexler RS, Kerr JS, Garlanda C, Mervin JR, Madri JA, Albelda SM: Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am J Pathol 1997;151:671-677.
16. Sheibani N, Newman PJ, Frazier WA: Thrombospondin-1, a natural inhibitor of angiogenesis, regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis. Mol Biol Cell 1997;8:1329-1341.
17. Bach TL, Barsigian C, Chalupowicz DG, Busler D, Yaen CH, Grant DS, Martinez J: VE-Cadherin mediates endothelial cell capillary tube formation in fibrin and collagen gels. Exp Cell Res 1998;238:324-334.
18. Vittet D, Buchou T, Schweitzer A, Dejana E, Huber P: Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc Natl Acad Sci USA 1997;94:6273-6278.
19. Duncan GS, Andrew DP, Takimoto H, Kauf man SA, Yoshida H, Spellberg J, de la Pompa JL, Elia A, Wakeham A, Karan Tamir B, Muller WA, Senaldi G, Zukowski MM, Mak TW: Genetic evidence for functional redundancy of platelet/endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol 1999;162:3022-3030.
20. Petzelbauer P, Bender JR, Wilson J, Pober JS: Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. J Immunol 1993;151:5062-5072.
21. Stockinger H, Gadd SJ, Eher R, Majdic O, Schreiber W, Kasinrerk W, Strass B, Schnabl E, Knapp W: Molecular characterization and functional analysis of the leukocyte surface protein CD31. J Immunol 1990;145:3889-3897.
22. Kitamura T, Onishi M, Kinoshita S, Shibuya A, Miyajima A, Nolan GP: Efficient screening of retroviral cDNA expression libraries. Proc Natl Acad Sci U S A 1995;92:9146-9150.
23. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
24. Petzelbauer P, Gröger M, Kunstfeld R, Petzelbauer E, Wolff K: Human delayed type hypersensitivity reaction in a SCID mouse engrafted with human T cells and autologous skin. J Invest Dermatol 1996;107:576-581.
25. Kubota Y, Kleinman HK, Martin GR, Lawley TJ: Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J Cell Biol 1988;107:1589-1598.
26. Fawcett J, Buckley C, Holness CL, Bird IN, Spragg JH, Saunders J, Harris A, Simmons DL: Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts. J Cell Biol 1995;128:1229-1241.
27. Orsulic S, Peifer M: An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling. J Cell Biol 1996;134:1283-1300.