Effects of 3-n-butylphthalide on production of vasoactive substances by cerebral and aortic endothelial cells

Acta Pharmacologica Sinica

Volumn 20, Issue 10, 1999, Pages 929-933

  Xu, Hao Liang ^a   Feng, Yi Pu ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

6 ketoprostaglandin F1 alpha; Aorta; Butylphthalides; Cerebral cortex; Cultured cells; Endothelin 1; Epoprostenol; Nitric oxide; Tumor necrosis factor

Indexed keywords

3 BUTYLPHTHALIDE; 6 OXOPROSTAGLANDIN F1 ALPHA; ENDOTHELIN 1; NITRIC OXIDE; NITRITE; PHTHALIDE DERIVATIVE; PROSTACYCLIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASOACTIVE AGENT;

ANIMAL CELL; AORTA; ARTICLE; BRAIN BLOOD VESSEL; CATTLE; CELL CULTURE; CONTROLLED STUDY; DRUG RESEARCH; ENDOTHELIUM CELL; NONHUMAN; RADIOIMMUNOASSAY; SPECTROMETRY;

6-KETOPROSTAGLANDIN F1 ALPHA; ANIMALS; ANIMALS, NEWBORN; AORTA; BENZOFURANS; CATTLE; CELLS, CULTURED; CEREBRAL CORTEX; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; STEREOISOMERISM;

EID: 0032705115     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Murohara T, Horowitz JR, Silver M, Tsurumi Y, Chen DF, Sullivan A, et al. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. Circulation 1998; 97: 99-107.
2. Liu XG, Feng YP. Protective effect of dl-3-n-butylphthalide on ischemic neurological damage and abnormal behavior in rats subjected to focal ischemia. Acta Pharm Sin 1995; 30: 896-903.
3. Lin JF, Feng YP. Effect of dl-3-n-butylphthalide on delayed neuronal damage after focal cerebral ischemia and intrasynaptosomes calcium in rats. Acta Pharm Sin 1996; 31: 166-70.
4. Yan CH, Feng YP, Zhang JT. Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats. Acta Pharmacol Sin 1998; 19: 117-20.
5. Xu HL, Feng YP. Effects of 3-n-butylphthalide on pial arterioles in focal cerebral ischemia rats. Acta Pharm Sin 1999; 34: in press.
6. Yan CH, Feng YP. Effects of d-3-n-butylphthalide and l-3-n-butylphthalide on extracellular NO level and intracellular cGMP level in primary cultured rat cortical neurons. Acta Pharm Sin 1998; 33: 418-23.
7. 1α in rat brain during focal cerebral ischemia and reperfusion. Acta Pharmacol Sin 1997; 18: 505-8.
8. Ichikata N, Naora K, Hirano H, Hashimoto M, Masumura S, Iwamoto K. Isolation and primary culture of rat cerebral microvascular endothelial cells for studing drug transport in vitro. J Pharmacol Toxicol Methods 1996; 36: 45-52.
9. Carmer E, Carmer G, Carmer M. Effects of TNF(on the production of vasoactive substances by cerebral endothelial and smooth muscle cells in culture. J Cereb Blood Flow Metab 1995; 15: 920-28.
10. Trautmann OD, Federici C, Creminon C, Chaverot NF, Roux F, Claire M, et al. Nitric oxide and endothelin secretion by brain microvessel endothelial cells: regulation by cyclicnucleotides. J Cell Physiol 1992; 155: 104-10.