Characterization of a dietary ethanol protocol for Cyp2e1 induction in the CD-1 mouse without evident hepatic toxicity or genotoxicity

International Journal of Toxicology

Volumn 18, Issue 5, 1999, Pages 327-335

  Daiker, Davis H ^a   Ward Jr , Jonathan B ^a   Schoenfeld, Heidi A ^b   Witz, Gisela ^b   Moslen, Mary Treinen ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

CD 1; Cyp2e1; DNA protein crosslink; Ethanol; Hprt mutant frequency; Immunotoxicity

Indexed keywords

ALCOHOL; CYTOCHROME P450;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; ENZYME ANALYSIS; ENZYME INDUCTION; ENZYME SUBSTRATE; FEMALE; GENE MUTATION; GENOTOXICITY; LIVER TOXICITY; MOUSE; NONHUMAN;

ANIMALIA; RODENTIA; TRIXIS;

EID: 0032700781     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/109158199225242     Document Type: Article

References (51)

1. Barnhill, J. G., D. A. Ciraulo, D. J. Greenblatt, M. A. Faggart, and J. S. Harmatz. 1991. Benzodiazapine response and receptor binding after chronic ethanol ingestion in a mouse model. J. Pharmacol. Exp. Ther. 258:812-819.
2. Bond, S. L., and S. M. Singh. 1990. Studies with DNA probes on the in vivo effect of ethanol on expression of the genes of alcohol metabolism. Alcohol Alcoholism 25:385-394.
3. Carlberg, I., and B. Mannervik. 1985. Glutathione reductase. Methods Enzymol. 113:484-485.
4. Condie, L. W., R. D. Laurie, T. Mills, M. Robinson, and J. P. Bercz. 1986. Effect of gavage vehicle on hepatotoxicity of carbon tetrachloride in CD-1 mice: Corn oil versus Tween-60 aqueous emulsion. Fundam. Appl. Toxicol. 7:199-206.
5. Crow, K. E., N. W. Cornell, and R. L. Voech. 1977. The rate of ethanol metabolism in isolated rat hepatocytes. Alcohol Clin. Exp. Res. 1:43-47.
6. Daiker, D. H., M. T. Moslen, J. B. Carr, and J. B. Ward Jr. 1996. Repeated oral benzene exposure alters enzymes involved in benzene metabolism. J. Toxicol. Environ. Health 48:439-451.
7. Dilger, K., J. Metzler, J. C. Bode, and U. Klotz. 1997. CYP2E1 activity in patients with alcoholic liver disease. J. Hepatol. 27:1009-1014.
8. Donnelly, P. J., R. M. Walker, and W. J. Racz. 1994. Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-included hepatotoxicity. Arch. Toxicol. 68:110-118.
9. Fang, J. L., and C. E. Vaca. 1997. Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers. Carcinogenesis 18:627-632.
10. Forkert, P. G., T. E. Massey, A. B. Jones, S. S. Park, H. V. Gelboin, and L. M. Anderson. 1991. Distribution of cytochrome CYP2E1 in murine liver after ethanol and acetone administration. Carcinogenesis 12:2259-2268.
11. Forkert, P. G., Z. M. Redza, S. Mangos, S. S. Park, and S. P. Tam. 1994. Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration. Drug Metab. Dispos. 22:248-253.
12. Ganousis, L. G., D. Goon, T. Zyglewska, K. K. Wu, and D. Ross. 1992. Cell-specific metabolism in mouse bone marrow stroma: Studies of activation and detoxification of benzene metabolities. Mol. Pharmacol. 42:1118-1125.
13. Center, M. B., and L. Recio. 1994. Absence of detectable P450 2E1 in bone marrow of B6C3F1 mice: Relevance to butadiene-induced bone marrow toxicity. Fundam. Appl. Toxicol. 22:469-473.
14. Habig, W. H., M. J. Pabst, and W. B. Jakoby. 1974. Glutathione-S-transferases: The first step in phenylmercapturic acid formation. J. Biol. Chem. 249:7130-7139.
15. Hung, H., J. Chuang, Y. Chien, H. Chern, C. Chiang, Y. Kuo, A. Hildesheim, and C. Chen. 1997. Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1: Environmental factors and risk of oral cancer. Cancer Epidem. Biomarker Prev. 6:901-905.
16. James, S. J., S. M. Enger, W. J. Peterson, and T. Makinodan. 1990. Immune potentiation after fractionated exposure to very low doses of ionizing radiation and/or caloric restriction in autoimmune-prone and normal C57B1/6 mice. Clin, Immunol. Immunopathol. 55:427-437.
17. Jerrells, T., W. Smith, and M. J. Eckardt. 1990. Murine model of ethanol-induced immunosuppression. Alcohol Clin. Exp. Res. 14:546-550.
18. Klotz, U., and E. Ammon. 1998. Clinical and toxicological consequences of the inductive potential of ethanol. Eur. J. Clin. Pharmacol. 54:7-12.
19. Koop, D. 1986. Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P-450 isozyme 3α. Mol. Pharmacol. 29:399-404.
20. Koop, D. R., E. T. Morgan, G. E. Tarr, and M. J. Coon. 1982. Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J. Biol Chem. 257:8472-8480.
21. Laemmli, U. K. 1970. Cleavage of structural proteins during assembly of the head bacteriophage T4. Nature 227:680-685.
22. Lawrence, R. A., and R. F. Burke. 1976. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71:952-958.
23. Lieber, C. S. 1995. Medical disorders of alcoholism. N. Engl. J. Med. 333:1058-1065.
24. Lieber, C. S., and L. M. DeCarli. 1989. Liquid diet technique of ethanol administration: 1989 update. Alcohol Alcoholism 24:197-211.
25. Lindahl, R., and S. Evces. 1984. Comparative subcellular distribution of aldehyde dehydrogenase in rat, mouse and rabbit liver. Biochem. Pharmacol. 33:3383-3389.
26. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein determination with the Folin Phenol reagent. J. Biol. Chem. 193:265-275.
27. Monahan, C. M., E. L. Padgett, K. L. Biber, K. M. Moscatello, F. L. Johnston, and R. M. Wolcott. 1997. Dose response to ethanol-containing liquid diets for use in a murine model for studies of biological effects due to ethanol consumption. Alcohol Clin. Exp. Res. 21:1092-1099.
28. Nakajima, T., R. S. Wang, E. Elovaara, S. S. Park, H. V. Gelboin, and H. Vainio. 1993. Cytochrome P450-related differences between rats and mice in the metabolism of benzene, toluene and trichloroethylene in liver microsomes. Biochem. Pharmacol. 45:1079-1085.
29. National Institutes of Health. 1995. Guide for the care and use of laboratory animals. NIH Publication 86-23. Bethesda, MD: U.S. Department of Health and Human Service.
30. Ohkawa, H., N. Ohishi, and K. Yagi. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351-358.
31. O'Shea, D., S. N. Davis, R. B. Kim, and G. R. Wilkinson. 1994. Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: A putative probe of CYP-2E1 activity. Clin. Pharmacol. Ther. 56:359-367.
32. Porter, T. D., S. C. Khani, and M. J. Coon. 1989. Induction and tissue-specific expression of rabbit cytochrome P450IIE1 and IIE2 genes. Mol. Pharmacol. 36:61-65.
33. Prochaska, H. J., and A. B. Santamaria. 1988. Direct measurement of NAD(P)H: quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers. Anal. Biochem. 169:328-336.
34. Raucy, J. L., C. Gerald, and S. P. Carpenter. 1995. Use of lymphocytes for assessing ethanol-mediated alterations in the expression of hepatic cytochrome P4502E1. Alcohol. Clin. Exp. Res. 19:1369-1375.
35. Raucy, J. L., E. D. Schultz, M. R. Wester, S. Arora, D. E. Johnston, J. L. Omdahl, and S. P. Carpenter. 1997. Human lymphocyte cytochrome P450 2E1, a putative marker for alcohol-mediated changes in hepatic chlorzoxazone activity. Drug. Metab. Dispos. 25:1429-1435.
36. Roberts, B. J., S. E. Shoaf, K. S. Jeong, and B. J. Song. 1994. Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: Evidence that CYP2E1 possesses a rapid phase halflife of 6 hours or less. Biochem. Biophys. Res. Commun. 205:1064-1071.
37. Schnier, G. G., C. L. Laethem, and D. R. Koop. 1989. Identification and induction of cytochromes P450, P450IIE1 and P450IA1 in rabbit bone marrow. J. Pharmacol. Exp. Ther. 251:790-796.
38. Scott, J. E., P. G. Forkert, M. Oulton, M. G. Rasmusson, S. Temple, M. O. Fraser, and S. Whitefield. 1988. Pulmonary toxicity of trichloroethylene: Induction of changes in surfactant phospholipids and phospholipase A2 activity in the mouse lung. Exp. Mol. Pathol. 49:141-150.
39. 1 mice exposed to N-ethyl-N-nitrosurea. Proc. Natl. Acad. Sci. U.S.A. 89:7866-7870.
40. Soh, Y, H. M. Rhee, D. H. Sohn, and B. J. Song. 1996. Immunological detection of CYP2E1 in fresh rat lymphocytes and its pretranslational induction by fasting. Biochem. Biophys. Res. Commun. 227:541-546.
41. Subrahmanyam, V. V., A. Sadler, E. Suba, and D. Ross. 1989. Stimulation of the in vitro bioactivation of hydroquinone by phenol in bone marrow cells. Drug Metab. Dispos. 17:348-350.
42. Tassaneeyakul, W., M. E. Veronese, D. J. Birkett, F. J. Gonzales, and J. O. Miners. 1993. Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques. Biochem. Pharmacol. 46:1975-1981.
43. Tales, A. D., F. J. van Dam, C. M. van Teylingen, F. A. de Zwart, and A. H. Zwinderman. 1998. Comparison of induction of hprt mutations by 1,3-butadiene and/or its metabolites 1,2-diepoxybutene and 1,2,3,4-diepoxybutane in lymphocytes from spleen of adult male mice and rats in vivo. Mutat. Res. 397:21-36.
44. Tietze, F. 1969. Enzymatic method for the quantitative determination of nanogram amounts of total and oxidized glutathione. Anal. Biochem. 27:502-515.
45. Tsutsumi, M., J.-S. Wang, S. Takase, and A. Takada. 1994. Hepatic messenger RNA contents of cytochrome P4502E1 in patients with different P4502E1 genotypes. Alcohol. Clin. Exp. Res. 29:29-32.
46. Uematsu, F., H. Kikuchi, M. Motomiya, T. Abe, I. Sagami, T. Ohmachi, A. Wakui, R. Kanamaru, and M. Watanable. 1991. Association between restriction fragment length polymorphism of the human cytochrome P4502E1 gene and susceptibility to lung cancer. Jpn. J. Cancer. Res. 82:254-256.
47. Ward, J. B., Jr., M. M. Ammenheuser, V. M. Ramanujam, D. L. Morris, E. B. Whorton Jr., and M. S. Legator. 1992. The mutagenic effects of low-level sub-acute inhalation exposure to benzene in CD-1 mice. Mutat. Res. 268:49-57.
48. Weltman, M. C., G. C. Farrell, P. Hall, M. Ingelman-Sundberg, and C. Liddle. 1998. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis. Hepatology 27:128-133.
49. Yu, M. W., A. Gladex-Yarborough, S. Chiamprasert, R. M. Santella, Y. F. Liaw, and C. J. Chen. 1995. Cytochrome P-450 2E1 and glutathione-S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoama. Gastroenterology 109:1266-1273.
50. Zhitkovich, A., and M. Costa. 1992. A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo. Carcinogenesis 13:1485-1489.
51. Zisman, D. A., R. M. Stricter, S. L. Kunkel, W. C. Tsai, J. M. Wilkowski, K. A. Bucknell, and T. J. Standiford. 1998. Ethanol feeding impairs innate immunity and alters the expression of Th1-and Th2-phenotype cytokines in murine Klebsiella pneumonia. Alcohol Clin. Exp. Res. 22:621-627.