M2 muscarinic receptor subtype in the feline medial pontine reticular formation modulates the amount of rapid eye movement sleep

Sleep

Volumn 22, Issue 7, 1999, Pages 835-847

  Baghdoyan, Helen A ^a,b   Lydic, R ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

4 DAMP; Bethanechol; Intracerebral microinjection; Methoctramine; Pons

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; BETHANECHOL; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BREATHING RATE; MOLECULAR CLONING; NONHUMAN; PONS RETICULAR FORMATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; REGULATORY MECHANISM; REM SLEEP; RESPIRATION DEPRESSION;

EID: 0032697379     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/22.7.835     Document Type: Article

References (42)

1. Baghdoyan HA. Cholinergic mechanisms regulating REM sleep. In: Schwartz WJ, ed. Sleep science: integrating basic research and clinical practice. Monographs in clinical neuroscience. Vol. 15. Basel: Karger, 1997:88-116.
2. Lydic R. Respiratory modulation by nonrespiratory neurons. In: Schwartz WJ, ed. Sleep science: integrating basic research and clinical practice. Monographs in clinical neuroscience. Vol. 15. Basel: Karger, 1997:117-42.
3. Imeri L, Bianchi S, Angeli P, Mancia M. Selective blockade of different brain stem muscarinic receptor subtypes: effects on the sleep-wake cycle. Brain Res 1994;636:68-72.
4. Lee LH, Friedman DB, Lydic R. Respiratory nuclei share synaptic connectivity with pontine reticular regions regulating REM sleep. Am J Physiol 1995;268:L251-L62.
5. Shiromani PJ, Fishbein W. Continuous pontine cholinergic microinfusion via mini-pump induces sustained alterations in rapid eye movement (REM) sleep. Pharmacol Biochem Behav 1986;25:1253-61.
6. Sitaram N, Moore A, Gillin J. Induction and resetting of REM sleep rhythm in normal man by arecoline: blockade by scopolamine. Sleep 1978;1:83-90.
7. Gillin JC, Sutton L, Ruiz C, et al. The cholinergic rapid eye movement induction test with arecoline in depression. Arch Gen Psychiatry 1991;48:264-70.
8. Buckley NJ. Molecular pharmacology of cloned muscarinic receptors. In: Nahorski SR, ed. Transmembrane signaling, intracellular messengers and implications for drug development. Chichester: John Wiley & Sons Ltd, 1990:11-30.
9. Jones SVP, Levey AI, Weiner DM, et al. Muscarinic acetylcholine receptors. In: Brann MR, ed. Molecular biology of G-protein-coupled receptors. Boston, MA: Birkhäuser, 1992:170-97.
10. Caulfield MP. Muscarinic receptors - characterization, coupling and function. Pharmacol Ther 1993;58:319-79.
11. Hulme EC, Birdsall NJM, Buckley NJ. Muscarinic receptor subtypes. Ann Rev Pharmacol Toxicol 1990;30:633-73.
12. Caulfield MP, Birdsall NJM. International union of pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacological Reviews 1998;50:279-90.
13. Zoltoski RK, Velazquez-Moctezuma J, Shiromani PJ, Gillin JC. The relative effects of selective M1 muscarinic antagonists on rapid eye movement sleep. Brain Res 1993;608:186-90.
14. Velazquez-Moctezuma J, Gillin JC, Shiromani PJ. Effect of specific M1 and M2 muscarinic receptor agonists on REM sleep generation. Brain Res 1989;503:128-31.
15. Velazquez-Moctezuma J, Shalauta M, Gillin JC, Shiromani PJ. Cholinergic antagonists and REM sleep generation. Brain Res 1991;543:175-9.
16. Sakai K, Onoe H. Critical role for M3 muscarinic receptors in paradoxical sleep generation in the cat. Eur J Neurosci 1997;9:415-23.
17. Baghdoyan HA, Mallios VJ, Duckrow RB, Mash DC. Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. NeuroReport 1994;5:1631-4.
18. Baghdoyan HA. Location and quantification of muscarinic receptor subtypes in rat pons: implications for REM sleep generation. Am J Physiol 1997;273:R896-R904.
19. Capece ML, Lydic R. Cyclic AMP and protein kinase A modulate cholinergic rapid eye movement sleep generation. Am J Physiol 1997;273:R1430-R40.
20. Shuman SL, Capece ML, Baghdoyan HA, Lydic R. Pertussis toxin-sensitive G proteins mediate carbachol induced REM sleep and respiratory depression. Am J Physiol 1995;269:R308-R17.
21. Capece ML, Baghdoyan HA, Lydic R. Carbachol-stimulated [35S]guanylyl 5′-(γ-thio)triphosphate binding in sleep-related brain stem nuclei of rat. J Neurosci 1998;18:3779-85.
22. Baghdoyan HA, Monaco AP, Rodrigo-Angulo ML, Assens F, McCarley RW, Hobson JA. Microinjection of neostigmine into the pontine reticular formation of cats enhances desynchronized sleep signs. J Pharmacol Exp Ther 1984;231:173-80.
23. Baghdoyan HA, Spotts JL, Snyder SG. Simultaneous pontine and basal forebrain microinjections of carbachol suppress REM sleep. J Neurosci 1993;13:229-42.
24. Leonard TO, Lydic R. Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate. J Neurosci 1997;17:774-85.
25. Berman AL. The brain stem of the cat. Madison, WI: University of Wisconsin Press, 1968.
26. Lydic R, Baghdoyan HA, Lorinc Z. Microdialysis of cat pons reveals enhanced acetylcholine release during state-dependent respiratory depression. Am J Physiol 1991;261:R766-R70.
27. Baghdoyan HA, Rodrigo-Angulo ML, McCarley RW, Hobson JA. Site-specific enhancement and suppression of desynchronized sleep signs following cholinergic stimulation of three brainstem regions. Brain Res 1984;306:39-52.
28. Hobson JA, Goldberg M, Vivaldi E, Riew D. Enhancement of desynchronized sleep signs after pontine microinjection of the muscarinic agonist bethanechol. Brain Res 1983;275:127-36.
29. Baghdoyan HA, Rodrigo-Angulo ML, McCarley RW, Hobson JA. A neuroanatomical gradient in the pontine tegmentum for the cholinoceptive induction of desynchronized sleep signs. Brain Res 1987;414:245-61.
30. Ursin R, Sterman MB. A Manual for Standardized Scoring of Sleep and Waking States in the Adult Cat. Los Angeles, CA: UCLA: Brain Information Services/Brain Research Institute, 1981.
31. Limbird LE. Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition. Boston, MA: Martinus Nijhoff Publishing, 1996.
32. Lydic R, Baghdoyan HA. Cholinoceptive pontine reticular mechanisms cause state-dependent respiratory changes in the cat. Neurosci Lett 1989;102:211-6.
33. Eglen RM, Watson N. Selective muscarinic receptor agonists and antagonists. Pharmacol Toxicol 1996;78:59-68.
34. Felder CC. Muscarinic acetylcholine receptors: signal transduction through multiple effectors. FASEB J 1995;9:619-25.
35. Levine RR, Birsdall NJM. Subtypes of muscarinic receptors: proceedings of the 4th international symposium on subtypes of muscarinic receptors. Trends Pharmacol Sci 1989;10 (Suppl 7):S1-S119.
36. Dörje F, Wess J, Lambrecht G, Tacke R, Mutschler E, Brann MR. Antagonist binding profiles of five cloned human muscarinic receptor subtypes. J Pharmacol Exp Ther 1991;256:727-33.
37. Billard W, Binch I, Crosby G, McQuade RD. Identification of the primary muscarinic autoreceptor subtype in rat striatum as m2 through a correlation of in vivo microdialysis and in vitro receptor binding data. J Pharmacol Exp Ther 1995;273:273-9.
38. Ray AP, Hong Y, Gilmor M, Levey AI, Rye DB. Ultrastructural analysis of cholinergic and cholinoceptive cellular profiles in the pontine REM-induction area in rats. Sleep 1999;22:S216.
39. Bourgin P, Escourrou P, Gaultier C, Adrien J. Induction of rapid eye movement sleep by carbachol infusion into the pontine reticular formation. NeuroReport 1995;6:532-6.
40. Marks GA, Birabil CG. Enhancement of rapid eye movement sleep in the rat by cholinergic and adenosinergic agonists infused into the pontine reticular formation. Neuroscience 1998;86:29-37.
41. Baghdoyan HA, Lydic R, Fleegal MA. M2 muscarinic autoreceptors regulate acetylcholine release in the pontine reticular formation. J Pharmacol Exp Ther 1998;286:1446-52.
42. Lydic R, Baghdoyan HA, Wertz R, White DP. Cholinergic reticular mechanisms influence state-dependent ventilatory response to hypercapnia. Am J Physiol 1991;261:R738-R46.