Location and quantification of muscarinic receptor subtypes in rat pons: Implications for REM sleep generation

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 273, Issue 3 42-3, 1997, Pages

  Baghdoyan, Helen A ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Autoradiographic efficiency; Dorsal raphe; Laterodorsal tegmental nucleus; Locus ceruleus; Pedunculopontine tegmental nucleus; Pontine reticular formation

Indexed keywords

MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; CELL INTERACTION; CHOLINERGIC NERVE CELL; CHOLINERGIC SYSTEM; DORSAL RAPHE NUCLEUS; LOCUS CERULEUS; NONHUMAN; NORADRENERGIC NERVE; PONS RETICULAR FORMATION; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; REM SLEEP; SEROTONINERGIC NERVE CELL;

EID: 0030821747     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.273.3.r896     Document Type: Article

References (19)

1. Baghdoyan, H. A. Cholinergic mechanisms regulating REM sleep. In: Sleep Science: Integrating Basic Research and Clinical Practice. Monographs in Clinical Neuroscience, edited by W. J. Schwartz. Basel: Karger. In press.
2. Baghdoyan, H. A., M. A. Fleegal, and R. Lydic. Acetylcholine (ACh) release in the medial pontine reticular formation (mPRF) is regulated by M2 muscarinic autoreceptors (Abstract). Neurosci. Abstr. In press.
3. Baghdoyan, H. A., V. J. Mallios, R. B. Duckrow, and D. C. Mash. Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. Neuroreport 5: 1631-1634, 1994.
4. Baghdoyan, H. A., J. L. Spotts, and S. G. Snyder. Simultaneous pontine and basal forebrain microinjections of carbachol suppress REM sleep. J. Neurosci. 13: 229-242, 1993.
5. Birdsall, N., N. Buckley, H. Doods, K. Fukuda, A. Giachetti, R. Hammer, H. Kilbinger, G. Lambrecht, E. Mutschler, N. Nathanson, A. North, and R. Schwarz. Nomenclature for muscarinic receptor subtypes recommended by symposium. Trends Pharmacol. Sci. December Suppl.: vii, 1989.
6. Bourgin, P., P. Escourrou, C. Gaultier, and J. Adrien. Induction of rapid eye movement sleep by carbachol infusion into the pontine reticular formation in the rat. Neuroreport 6: 532-536, 1995.
7. Bourgin, P., C. Lebrand, P. Escourrou, C. Gaultier, R. Franc, M. Hamon, and J. Adrien. Vasoactive intestinal polypeptide microinjections into the oral pontine tegmentum enhance rapid eye movement sleep in the rat. Neuroscience 77: 351-360, 1997.
8. 35S]GTP[gamma]S binding reveals G protein activation by cholinergic stimulation of brain stem nuclei known to regulate REM sleep. Neurosci. Abstr. In press.
9. Capece, M. L., S. M. N. Efange, and R. Lydic. Vesicular acetylcholine transport inhibitor suppresses REM sleep. Neuroreport 8: 481-484, 1997.
10. Capece, M. L., M. A. Fleegal, and R. Lydic. Cyclic AMP and protein kinase A in the pontine reticular formation contribute to cholinergic rapid eye movement (REM) sleep generation (Abstract). Neurosci. Abstr. 22: 374, 1996.
11. Caulfield, M. P. Muscarinic receptors-characterization, coupling, and function. Pharmacol. Ther. 58: 319-379, 1993.
12. Egan, T. M., and R. A. North. Acetylcholine acts on m2-muscarinic receptors to excite rat locus coeruleus neurones. Br. J. Pharmacol. 85: 733-735, 1985.
13. Eglen, R. M., and N. Watson. Selective muscarinic agonists and antagonists. Pharmacol. Toxicol. 78: 59-68, 1996.
14. Ellis, J., J. Huyler, and M. R. Brann. Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes. Biochem. Pharmacol. 42: 1927-1932, 1991.
15. Ernsberger, P., S. P. Arneric, V. Arango, and D. J. Reis. Quantitative distribution of muscarinic receptors and choline acetyltransferase in rat medulla: examination of transmitter receptor mismatch. Brain Res. 452: 336-344, 1988.
16. 3H]methylscopolamine afford differential labeling and localization of Ml, M2, and M3 muscarinic receptor subtypes in primate brain. Synapse 14: 283-296, 1993.
17. Gerber, U., D. R. Stevens, R. W. McCarley, and R. W. Greene. Muscarinic agonists activate an inwardly rectifying potassium conductance in medial pontine reticular formation neurons of the rat in vitro. J. Neurosci. 11: 3861-3867, 1991.
18. Gnadt, J. W., and G. V. Pegram. Cholinergic brainstem mechanisms of REM sleep in the rat. Brain Res. 384: 29-41, 1986.
19. Greene, R. W., H. L. Haas, U. Gerber, and R. W. McCarley. Cholinergic activation of medial pontine reticular formation neurons in vitro. In: Central Cholinergic Neurotransmission, edited by M. Frotscher and U. Misgeld. Boston, MA: Birkhauser Verlag, 1989, p. 123-137.