Inhibition of VCAM-1 expression in the arterial wall is shared by structurally different antioxidants that reduce early atherosclerosis in NZW rabbits

Journal of Lipid Research

Volumn 40, Issue 11, 1999, Pages 1958-1966

  Fruebis, Joachim ^a,b   Silvestre, Mercedes ^b   Shelton, Diane ^c   Napoli, Claudio ^b   Palinski, Wulf ^b  

^a Genset Corporation   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adhesion molecules; Antioxidants; Arteriosclerosis; Immunocytochemistry; Oxidation; Oxidize d LDL; PCR; Probucol; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; PROBUCOL; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTERY INTIMA; ARTERY WALL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL INTAKE; CONTROLLED STUDY; DOSE RESPONSE; IMMUNOCYTOCHEMISTRY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SIGNAL TRANSDUCTION; VITAMIN SUPPLEMENTATION;

EID: 0032694422     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0022-2275(20)32419-6     Document Type: Article

References (56)

1. Elices, M. J., L. Osborn, Y. Takada, C. Crouse, S. Luhowskyj, M. E. Hemler, and R. R. Lobb. 1990. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 60: 577-584.
2. Cybulski, M. I., and M. A. Gimbrone. 1991. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science. 251: 788-791.
3. Li, H., M. I. Cybulsky, M. A. Gimbrone, and P. Libby. 1993. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler. Thromb. 13: 197-204.
4. Richardson, M., S. J. Hadcock, M. DeReske, and M. I. Cybulsky. 1994. Increased expression in vivo of VCAM-1 and E-selectin by the aortic endothelium of normolipemic and hyperlipemic diabetic rabbits. Arterioscler. Thromb. Vasc. Biol. 14: 760-769.
5. Fruebis, J., V. Gonzales, M. Silvestre, and W. Palinski. 1997. Effect of probucol treatment on gene expression of VCAM-1, MCP-1 and M-CSF in the aortic wall of LDL receptor-deficient rabbits during early atherogenesis. Arterioscler. Thromb. Vasc. Biol. 17: 1289-1302.
6. Davies, M. J., J. L. Gordon, A. J. Gearing, R. Pigott, N. Woolf, D. Katz, and A. Kyriakopoulos. 1993. The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis. J. Pathol. 171: 223-229.
7. O'Brien, K. D., M. D. Allen, T. O. McDonald, A. Chait, J. M. Harlan, D. Fishbein, J. McCarty, M. Ferguson, K. Hudkins, C. D. Benjamin, R. Lobb, and C. E. Alpers. 1993. Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J. Clin. Invest. 92: 945-951.
8. Li, H., M. I. Cybulsky, M. A. Gimbrone, and P. Libby. 1993. Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma. Am. J. Pathol. 143: 1551-1559.
9. Gerszten, R. E., Y. C. Lim, H. T. Ding, K. Snapp, G. Kansas, D. A. Dichek, C. Cabañas, F. Sanchez-Madrid, M. A. Gimbrone, A. Rosenzweig, and F. W. Luscinskas. 1998. Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis. Circ. Res. 82: 871-878.
10. Ohara, Y., T. E. Peterson, and D. G. Harrison. 1993. Hypercholesterolemia increases endothelial superoxide anion production. J. Clin. Invest. 91: 2546-2551.
11. Quinn, M. T., S. Parthasarathy, and D. Steinberg. 1988. Lysophosphatidylcholine: a new chemotactic factor for human monocytes and its potential role in atherogenesis. Proc. Natl. Acad. Sci. USA. 85: 2805-2809.
12. Kume, N., M. I. Cybulsky, and M. A. Gimbrone. 1992. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J. Clin. Invest. 90: 1138-1144.
13. Vlassara, H., H. Fuh, T. Donnelly, and M. Cybulsky. 1995. Advanced glycation endproducts promote adhesion molecule (VCAM-1, ICAM-1) expression and atheroma formation in normal rabbits. Mol. Med. 1: 447-456.
14. Marui, N., M. K. Offermann, R. Swerlick, C. Kunsch, C. A. Rosen, M. Ahmad, R. W. Alexander, and R. M. Medford. 1993. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 92: 1866-1874.
15. Khan, B. V., S. Parthasarathy, R. W. Alexander, and R. M. Medford. 1995. Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells. J. Clin. Invest. 95: 1262-1270.
16. Cominacini, L., U. Garbin, A. F. Pasini, A. Davoli, M. Campagnola, G. B. Contessi, A. M. Pastorino, and V. Lo Cascio. 1997. Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells. Free Radical Biol. Med. 22: 117-127.
17. Collins, T. 1993. Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion. Lab. Invest. 68: 499-508.
18. Liao, F., A. Andalibi, F. C. deBeer, A. M. Fogelman, and A. J. Lusis. 1993. Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice. J. Clin. Invest. 91: 2572-2579.
19. Liao, F., A. Andalibi, J. H. Qiao, H. Allayee, A. M. Fogelman, and A. J. Lusis. 1994. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice. J. Clin. Invest. 94: 877-884.
20. Faruqi, R., C. de la Motte, and P. E. DiCorleto. 1994. Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells. J. Clin. Invest. 94: 592-600.
21. Erl, W., C. Weber, C. Wardemann, and P. C. Weber. 1997. Alpha-tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization. Am. J. Physiol. 273: H634-640.
22. Carew, T. E., D. C. Schwenke, and D. Steinberg. 1987. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks slowing the progression of atherosclerosis in the WHHL rabbit. Proc. Natl. Acad. Sci. USA. 84: 7725-7729.
23. Kita, T., Y. Nagano, M. Yokode, K. Ishii, N. Kume, A. Ooshima, H. Yokida, and C. Kawai. 1987. Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc. Natl. Acad. Sci. USA. 84: 5928-5931.
24. Björkhem, I., A. Henriksson-Freyschuss, O. Breuer, U. Diczfalusy, L. Berglund, and P. Henriksson. 1991. The antioxidant butylated hydroxytoluene protects against atherosclerosis. Arterioscler. Thromb. 11: 15-22.
25. Sparrow, C. P., T. W. Doebber, J. Olszewski, M. S. Wu, J. Ventre, K. A. Stevens, and Y. S. Chao. 1992. Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N″-diphenyl-phenylenediamine. J. Clin. Invest. 89: 1885-1891.
26. Sasahara, M., E. W. Raines, A. Chait, T. E. Carew, D. Steinberg, P. W. Wahl, and R. Ross. 1994. Inhibition of hypercholesterolemia-induced atherosclerosis in Macaca Nemestrina by probucol: I. Intimal lesion area correlates inversely with resistance of lipoproteins to oxidation. J. Clin. Invest. 94: 155-164.
27. Fruebis, J., D. Steinberg, H. A. Dresel, and T. E. Carew. 1994. A comparison of the antiatherogenic effects of probucol and of a structural analog of probucol in LDL-receptor-deficient rabbits. J. Clin. Invest. 94: 392-398.
28. Tangirala, R. K., F. Casanada, J. L. Witztum, D. Steinberg, and W. Palinski. 1995. Effect of the antioxidant N,N′-diphenyl 1,4-phenylenediamine (DPPD) on atherogenesis in apoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 15: 1625-1630.
29. Praticò, D., R. K. Tangirala, D. J. Rader, J. Rokach, and G. A. FitzGerald. 1998. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nature Med. 4: 1189-1192.
30. Williams, R. J., J. M. Motteram, C. H. Sharp, and P. J. Gallagher. 1992. Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis. 94: 153-159.
31. Prasad, K., and J. Kalra. 1993. Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am. Heart J. 125: 958-973.
32. Morel, D. W., M. de la Llera-Moya, and K. E. Friday. 1994. Treatment of cholesterol-fed rabbits with dietary vitamins E and C inhibits lipoprotein oxidation but not development of atherosclerosis. J. Nutr. 124: 2123-2130.
33. Fruebis, J., T. E. Carew, and W. Palinski. 1995. Effect of vitamin E on atherogenesis in LDL receptor-deficient rabbits. Atherosclerosis. 117: 217-224.
34. Kleinveld, H. A., H. L. Hak-Lemmers, M. P. Hectors, N. J. de Fouw, P. N. Demacker, and A. F. Stalenhoef. 1995. Vitamin E and fatty acid intervention does not attenuate the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits. Arterioscler. Thromb. Vasc. Biol. 15: 290-297.
35. Steinberg, D. 1997. Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 272: 20963-20966.
36. Berliner, J. A., M. Navab, A. M. Fogelman, J. S. Frank, L. L. Demer, P. A. Edwards, A. D. Watson, and A. J. Lusis. 1995. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation. 91: 2488-2496.
37. Havel, R. J., H. A. Eder, and J. H. Bragdon. 1955. Distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34: 1345-1353.
38. Esterbauer, H., G. Striegl, H. Puhl, and M. Rotheneder. 1989. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radical Res. Commun. 6: 67-75.
39. Fruebis, J., D. A. Bird, J. Pattison, and W. Palinski. 1997. Extent of antioxidant protection of plasma LDL is not a predictor of the antiatherogenic effect of antioxidants. J. Lipid Res. 38: 2455-2464.
40. Tangirala, R. K., E. M. Rubin, and W. Palinski. 1995. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J. Lipid Res. 36: 2320-2328.
41. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorofom extraction. Anal. Biochem. 162: 156-159.
42. Tsukada, T., M. E. Rosenfeld, R. Ross, and A. M. Gown. 1986. Immunocytochemical analysis of cellular components in atherosclerotic lesions. Use of monoclonal antibodies with the Watanabe and fat-fed rabbit. Arteriosclerosis. 6: 601-613.
43. Tsukada, T., D. Tippens, H. Mar, D. Gordon, R. Ross, amd A. M. Gown. 1986. HHF-35: a muscle-actin-specific monoclonal antibody. Am. J. Pathol. 126: 51-60.
44. Williams, R. J., J. M. Motteram, C. H. Sharp, and P. J. Gallagher. 1992. Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis. 94: 153-159.
45. O'Brien, K., Y. Nagano, A. Gown, T. Kita, A. Chait. 1991. Probucol treatment affects the cellular composition but not anti-oxidized low density lipoprotein immunoreactivity of plaques from Watanabe heritable hyperlipidemic rabbits. Arterioscler. Thromb. 11: 751-759.
46. Truskey, G. A., R. A. Herrmann, J. Kait, and K. M. Barber. 1999. Focal increases in vascular cell adhesion molecule 1 and intimai macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding. Arterioscler. Thromb. Vasc. Biol. 19: 393-401.
47. Napoli, C., F. P. D'Armiento, F. P. Mancini, A. Postiglione, J. L. Witztum, G. Palumbo, and W. Palinski. 1997. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimai accumulation of LDL and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J. Clin. Invest. 110: 2680-2690.
48. Vora, D. K., Z. T. Fang, S. M. Liva, T. R. Tyner, F. Parhami, A. D. Watson, T. A. Drake, M. C. Territo, and J. A. Berliner. 1997. Induction of P-selectin by oxidized lipoproteins. Separate effects on synthesis and surface expression. Circ. Res. 80: 810-818.
49. Kim, J. A., M. C. Territo, E. Wayner, T. M. Carlos, F. Parhami, C. W. Smith, M. E. Haberland, A. M. Fogelman, and J. A. Berliner. 1994. Partial characterization of leukocyte binding molecules on endothelial cells induced by minimally oxidized LDL. Arterioscler. Thromb. Vasc. Biol. 14: 427-433.
50. Ricote, M., J. Huang, L. Fajas, A. Li, J. Welsch, J. L. Witztum, J. Auwerx, W. Palinski, and C. K. Glass. 1998. Expression of the peroxisome proliferator-activated receptor γ in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein. Proc. Natl. Acad. Sci. USA. 95: 7614-7619.
51. Ferns, G. A., L. Forster, A. Stewart-Lee, J. Nourooz-Zadeh, and E. E. Anggard. 1993. Probucol inhibits mononuclear cell adhesion to vascular endothelium in the cholesterol-fed rabbit. Atherosclerosis. 100: 171-181.
52. Kaneko, M., J. Hayashi, I. Saito, and N. Miyasaka. 1996. Probucol downregulates E-selectin expression on cultured human vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 16: 1047-1051.
53. Devaraj, S., D. Li, and I. Jialal. 1996. The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium. J. Clin. Invest. 98: 756-763.
54. Devaraj, S., and I. Jialal. 1998. The effects of alpha-tocopherol on critical cells in atherogenesis. Curr. Opin. Lipidol. 9: 11-15.
55. McEvoy, L. M., H. Sun, P. S. Tsao, J. P. Cooke, J. A. Berliner, and E. C. Butcher. 1997. Novel vascular molecule involved in monocyte adhesion to aortic endothelium in models of atherogenesis. J. Exp. Med. 185: 2069-2077.
56. Gurtner, G. C., V. Davis, H. Li, M. J. McCoy, A. Sharpe, and M. I. Cybulsky. 1995. Targeted disruption of the murine VCAM-1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev. 9:1-14.