Relative power of linkage and transmission disequilibrium test strategies to detect non-HLA linked coeliac disease susceptibility genes

Gut

Volumn 45, Issue 5, 1999, Pages 668-671

  Bevan, S ^a   Popat, S ^a   Houlston, R S ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Coeliac disease; Linkage; Non HLA linked genes; TDT test

Indexed keywords

HLA DQ ANTIGEN;

ARTICLE; CELIAC DISEASE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC MARKER; GENETIC SUSCEPTIBILITY; HLA TYPING; HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 0032693654     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.45.5.668     Document Type: Article

References (27)

1. Marsh MN. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ("celiac sprue"). Gastroenterology 1992;102:330-54.
2. Houlston RS, Ford D. Genetics of coeliac disease. Q J Med 1996;89:737-43.
3. Sollid LM, Thorsby E. HLA susceptibility genes in celiac disease: genetic mapping and role in pathogenesis. Gastroenterology 1993;105:910-22.
4. Pena AS, Mann DL, Hague NE, et al. Genetic basis of gluten-sensitive entropathy. Gastroenterology 1978;75:230-5.
5. Greenberg DA, Hodge SE, Rotter JI. Evidence for recessive and against dominant inheritance at the HLA-linked locus in coeliac disease. Am J Hum Genet 1982;34:263-77.
6. Hernandez JL, Michalski JP, McCombs CC, et al. Evidence for a dominant gene mechanism underlying coeliac disease in the West of Ireland. Genet Epidemiol 1991;8:13-27.
7. Risch N. Linkage stategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990;46:229-41.
8. Spielman RS, Ewens WJ. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 1996;59:983-9.
9. Lander E, Kruglak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-7.
10. Risch N, Merikangas K. The future of genetic studies of complex human disease. Science 1996;273:1516-17.
11. Camp NJ. Genomewide transmission/disequilibrium testing-consideration of the genotypic relative risks at disease loci. Am J Hum Genet 1997;61:1424-30.
12. Mylotte M, Egan-Mitchell B, McCarthy CF, et al. Incidence of coeliac disease in the West of Ireland. BMJ 1973;i:703-5.
13. Logan RFA, Rifkind EA, Busuttil A, et al. Prevalence and "incidence" of celiac disease in Edinburgh and the Lothian region of Scotland. Gastroenterology 1986;90:334-42.
14. Midhagen G, Jarnerot G, Kraaz W. Adult coeliac disease within a defined geographic area in Sweden: a study of prevalence and associated diseases. Scand J Gastroenterol 1988;23:1000-4.
15. Greco L, Tozzi AE, Mayer M, et al. Unchanging clinical picture of coeliac disease presentation in Campania, Italy. Eur J Pediatr 1989;148:610-13.
16. Logan RFA, Tucker G, Rifkind EA, et al. Changes in clinical features of coeliac disease in adults in Edinburgh and the Lothians 1960-70. BMJ 1983;286:95-7.
17. Catassi C, Fabiani E, Ratsch IM, et al. The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects. Acta Paediatr Suppl 1996;412:29-35.
18. Catassi C, Ratsch IM, Fabiani E, et al. High prevalence of undiagnosed coeliac disease in 5280 Italian students screened by antigliadin antibodies. Acta Paediatr 1995;84:672-6.
19. Grodzinsky E. Screening for coeliac disease in apparently healthy blood donors. Acta Paediatr Suppl 1996;412:36-8.
20. Not T, Horvath K, Hill ID, et al. Celiac disease risk in the USA: high prevalence of antiendomysium antibodies in healthy blood donors. Scand J Gastroenterol 1998;33:494-8.
21. Petronzelli F, Bonamico, Ferrante P, et al. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum Genet 1997;61:307-17.
22. Bevan S, Popat S, Ferguson A, et al. Contribution of the MHC region to the familial risk of coeliac disease. J Med Genet 1999 (in press).
23. Zhong F, McCombs CC, Olson JM, et al. An autosomal screen for genes that predispose to celiac disease in the western counties of Ireland. Nat Genet 1996;14:329-33.
24. Greco L, Corazza G, Babron MC, et al. Genome search in celiac disease. Am J Hum Genet 1998;62:669-75.
25. Houlston RS, Tomlinson IP, Ford D, et al. Linkage analysis of candidate regions for coeliac disease genes. Hum Mol Genet 1997;6:1335-9.
26. Muller-Myhsok B, Abel L. Genetic analysis of complex diseases. Science 1997;275:1328-9.
27. Risch N, Merikangas K. Genetic analysis of complex diseases. Science 1997;275:1329-30.