Two hot topics in the field of GH therapy: Quality of life in hypopituitary adults, and clinical implications of the somatopause. Report from an interactive discussion

Journal of Endocrinological Investigation

Volumn 22, Issue 5 SUPPL., 1999, Pages 150-156

  Jorgensen J O L ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Growth hormone; Hypopituitary adults; Quality of life; Somatopause

Indexed keywords

HUMAN GROWTH HORMONE;

AGING; COST BENEFIT ANALYSIS; DENMARK; DRUG EFFECT; ECONOMICS; HORMONE SUBSTITUTION; HUMAN; HYPOPITUITARISM; PATHOPHYSIOLOGY; PHYSIOLOGY; QUALITY OF LIFE; REVIEW; SECRETION;

AGING; COST-BENEFIT ANALYSIS; DENMARK; HORMONE REPLACEMENT THERAPY; HUMAN GROWTH HORMONE; HUMANS; HYPOPITUITARISM; QUALITY OF LIFE; SECRETORY RATE;

EID: 0032611308     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Jørgensen J.O.L., Pedersen S.A., Thuesen L., Jørgensen J., Ingemann-Hansen T., Skakkebæk N.E., Christiansen U.S. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989, 1: 1221.
2. Salomon F., Cuneo R.C., Hesp R., Sönksen P.H. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N. Engl. J. Med. 1989, 321: 1197.
3. Rosén T., Bengtsson B.-Å. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990, 336: 285.
4. Bülow B., Hagmar L., Mikoczy Z., Nordström C.H., Erfurth E.M. Increased cerebrovascular mortality in patients with hypopituitarism. Clin. Endocrinol. (Oxf.) 1997, 46: 75.
5. Rosén T., Wirén L., Wilhelmsen L., Wiklund I., Bengtsson B.-Å. Decreased psychological well-being in adult patients with growth hormone deficiency. Clin. Endocrinol. (Oxf.) 1994, 40: 11.
6. Rikken B., van Busschbach J., le Cessie S., Manten W., Spermon T., Grobbee R., Wit J.-M. Impaired social status of growth hormone deficient adults as compared to controls with short or normal stature. Dutch Growth Hormone Working Group. Clin. Endocrinol. (Oxf.) 1995, 43: 205.
7. Bengtsson B.-Å., Edén S., Lönn L., Kvist H., Stokland A., Lindstedt G., Bosaeus I., Tölli J., Sjöström L., Isaksson O.G.P. Treatment of adults with growth hormone deficiency with recombinant human GH. J. Clin. Endocrinol. Metab. 1993, 76: 309.
8. Burman P., Broman J.E., Hetta J., Wiklund I., Erfurth E.M., Hagg E., Karlsson F.A. Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo controlled 21-month trial. J. Clin. Endocrinol. Metab. 1995, 80: 3585.
9. Wirén L., Bengtsson B.-Å., Johannsson G. Beneficial effects of long-term GH replacement therapy on quality of life in adults with GH deficiency. Clin. Endocrinol. (Oxf.) 1998, 48: 613.
10. Whitehead H.M., Boreham C., McIlrath E.M., Sheridan B., Kennedy L., Atkinson A.B., Hadden D.R. Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study. Clin. Endocrinol. (Oxf.) 1992, 36: 45.
11. Attanasio A.F., Lamberts S.W.J., Matranga A.M.C., Birkett M.A., Bates P.C., Valk N.K., Hilsted J., Bengtsson B.-Å., Strassburger C.J. Adult growth hormone (GH) deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment. J. Clin. Endocrinol. Metab. 1997, 82: 82.
12. Baum H.B.A., Katznelson L., Sherman J.C., Biller B.M.K., Hayden D.L., Schoenfeld D.A., Cannistraro K.E., Klibanski A. Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency. J. Clin. Endocrinol. Metab. 1998, 83: 3184.
13. Cuneo R.C., Judd S., Wallace J.D., Perry-Keene D., Burger H., Lim-Tio S., Strauss B., Stockigt J., Topliss D., Alford F., Hew L., Bode H., Conway A., Handelsman D., Dunn S., Boyages S., Cheung N.W., Hurley D. The Australian Multicenter Trial of Growth Hormone (GH) Treatment in GH-Deficient Adults. J. Clin. Endocrinol. Metab. 1998, 83: 107.
14. Rudman D. Growth hormone, body composition and aging. J. Am. Geriatr. Soc. 1985, 33: 800.
15. Holmes S.J., Shalet S.M. Characteristics of adults who wish to enter a trial of growth hormone replacement. Clin. Endocrinol. (Oxf.) 1995, 42: 613.
16. Dean H.J., McTaggart T.L., Fish D.G., Friesen H.G. The educational, vocational, and marital status of growth hormone deficient adults treated with growth hormone during childhood. Am. J. Dis. Child. 1985, 139: 1105.
17. Burman P., Hetta J., Wide L., Månsson J.E., Ekman R., Karlsson F.A. Growth hormone treatment affects brain neurotransmitters and thyroxine. Clin. Endocrinol. (Oxf.) 1996, 44: 319.
18. Deijen J.B., de Boer H., van der Veen E. Cognitive function during growth hormone replacement in adult men. Psychoendocrinology 1998, 23: 45.
19. Blok G.J., de Boer H., Gooren I.J.G., van der Veen E. Growth hormone substitution in adult growth hormone deficient men augments androgen effects on the skin. Clin. Endocrinol. (Oxf.) 1997, 47: 29.
20. Wallymahmed M.E., Baker G.A., Humphris G., Dewey M., MacFarlane I.A. The development, reliability and validity of a disease specific quality of life model for adults with growth hormone deficiency. Clin. Endocrinol. (Oxf.) 1996, 44: 403.
21. Chapman I.M., Hartman M.L., Pezzoli S.S., Harrell F.E., Hintz R.L., Alberti K.G.M.M., Thorner M.O. Effect of aging on the sensitivity of growth hormone secretion to insulin-like growth factor-I negative feedback. J. Clin. Endocrinol. Metab. 1997, 82: 2996.
22. Chan J.M., Stampfer M.J., Giovannucci E., Gann P.H., Ma J., Wilkinson P., Hennekens C.H., Pollak M. Plasma insulin-like growth factor I and prostate cancer risk: a prospective study. Science 1998, 279: 563.